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생쥐 대장 평활근에서 막전압-의존성 이온 전류에 대한 tamoxifen 효과
박찬국,허광식,장성종,김만우,윤영,박도영,양경철,신무경,차경훈,염철호,윤평진,전제열 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Tamoxifen is a widely used anticancer drug for breast cancer causing frequent gastrointestinal side effects. The change of gastrointestinal motility is associated with the alteration of activities of membrane ion channels. The ion channel is found to play an important role in regulating membrane potential and cell excitability. This study was performed to investigate the effects of tamoxifen on the membrane ionic currents in colonic myocytes. Materials and Methods : Single colonic myocytes were isolated by using a collganase from murine proximal colon. The membrane currents were recorded by using a whole-cell patch clamp method at room temperature. Results : Two types of voltage-dependent K+ currents (A-type and delayed rectifier K+ currents) were recorded. Tamoxifen inhibited both types of voltage-dependent K+ currents (10 μM). However, tamoxifen did not change the half-inactivation potential and the recovery time of voltage-dependent K+ currents. Chelerythrine, a protein kinase C inhibitor, and phorbol-12,13-dibutyrate, a protein kinase C activator, did not affect the voltage-dependent K+ currents Guanosine 5-O-2-thiodiphosphate (GDPβS, a G-protein inhibitor), also did not affect on tamoxifen-induced inhibition of voltage-dependent K+ currents. In audition, tamoxifen completely inhibited the voltage-dependent Ca²+ currents in whole-test ranges. Conclusion : These results suggest that tamoxifen inhibits the voltage-dependent membrane ionic currents in colonic smooth muscle cells, and that this action may be relevant to the gastrointestinal side effects
박찬국 대한한의학원전학회 2004 대한한의학원전학회지 Vol.17 No.4
筆者通過對韓醫和西醫學術思想的比較,從陰陽觀點進行分析,試批判對這種狀況沒能找到相應對策的韓醫界的教育及臨床醫學的各種問題,找出適當對策,并且考作爲內經研究人員該做什麼. 第一 首先我們應該反省現在所實施的教育是否符合現實.爲此應當對現今社會的陰陽均衡狀態進行分析,教育模式也應隨著這種狀態的改變而變化.現今世界逐漸轉變爲陽盛陰衰的狀態,据此我們不能繼續使用舊的教育和臨床模式.第二我們應當對富含哲學思想的傳統醫學擁有自信心,加強韓醫學理論教育.這樣才能正確教導學生,不使他們因爲西醫內容好學,而隨派逐流.第三 不論是在學校還是在研究機關從事內經研究的人員,都俱有重富的古漢語智識,對內經的研究傾注了心血,但是有人認爲當今時代不符合內經思潮.看一下韓國情況,認爲不必要學內經,應將西醫內容植入到韓醫學當中,這種傾向不少見.這不單純是各種社會條件的作用結果,我們作爲內經研究人員也無法推掉責任.雖然不是件輕松的事情,但將內經內容應用到臨床的努力還很欠缺,并且沒能研究出更多成果提供給臨床工作者我們對此有不可推卸的責任.爲了不將我們這一帶在研究內經過程當中所承受的難處轉給後代,我們應該們心自問并且要深思都做了些什麼?以後又將做什麼?韓醫學教育不僅要在大學校園內進行,在入大學之前,應該更積極的提供韓醫學基礎教育環境,爲發展韓醫學做更多的準備工作. none
생쥐 소장의 interstitial cells of Cajal에서 ATP-민감성 K^(+)통로를 통한 향도잡이 전류의 조절
박찬국,김만우,김형석,최석,전제열 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1
Objectives: This study was performed to investigate whether ATP-sensitive K^(+) channels exist in interstitial cells of Cajal (ICC) of mouse small intestine and the physiological role of ATP-sensitive K^(+) channels in gastrointestinal motility. Methods: ICC were isolated from mouse small intestine and cultured for 2 days. Electrical activities of ICC were recorded using the whole-cell patch-clamp technique at 30°C. Results: ICC displayed rhythmic slow waves and spontaneous inward currents (pacemaker currents). Pinacidil, an ATP-sensitive K^(+) channel opener, induced membrane hyperpolarization and decreased amplitude of slow waves in current clamping mode. Also, pinacidil inhibited amplitude and frequency of pacemaker currents and activated outward currents at a holding potential of -70 mV. Pinacidil effects on slow waves and pacemaker currents were blocked by glibenclamide, a specific blocker of ATP-sensitive K^(+) channel. Forskolin, an activator of adenylate cyclase, induced membrane hyperpolarization and inhibited pacemaker currents like as pinacidil and blocked by glibenclamide. Conclusions: These results suggest that ATP-sensitive K^(+) channels exist in ICC and may be play an important role in regulating gastrointestinal motility through the modulation of pacemaker activities of ICC.
박찬국,용태석 한국정보화진흥원 2012 정보화정책 Vol.19 No.4
다양한 기술의 융합 형태인 스마트그리드는 결국 다양한 기술부문 산업주체의 협력과 공정한 경쟁을 통해 구축 가능하다. 산업 및 기업 간 갈등이 조정되지 않고 심각하게 유지된다면 사업 추진이 지연되고 투자가 미흡할 수밖에 없다. 이에 본 연구는 스마트그리드 사업이 추진되면서 발생하는 갈등 원인과 관련 사안을 살펴보며, 주요 이슈별 정책방안을 제시한다. 스마트그리드 부문의 주요 갈등원인을 파악하기 위해 AHP 분석을 실시한 결과, 설문 응답자들은 스마트그리드 분야에서 갈등을 유발하는 주요 원인 중 ‘역할과 권한의 모호성’에 가장 높은 우선순위를 두었다. ‘역할과 권한의 모호성’ 다음으로는 ‘가치의 차이’ 와 ‘의사소통 장애’를 주요 갈등원인으로 지적하였다. 스마트그리드 갈등 조정과 관련해서는 현 시점에서는 특히, 스마트그리드 이해관계자 간 이해 조율에서 정부의 리더십을 강화해 나가야 한다. 정부는 스마트그리드 시장 활성화 차원에서 법제도 개선과 함께 이해관계자 간 이해 조율에 주력하고, 국가적 차원에서 이해관계자간 바람직한 역할에 대한 공감대 형성의 장을 제공해야 한다. Smart grid, which is a sort of convergence of numerous technologies, can be deployed only with cooperation and fair competition among various stakeholders. If the interest conflicts were not coordinated properly, related business and investment would become delayed and inactive. Therefore, this study analyzes the causes of interest conflicts and related issues in smart grid sector and suggests policy directions by issue. As the result of AHP analysis, the majority of respondents surveyed said that ambiguity of the role and authority is the key problem causing conflicts of interest in smart grid deployment process. Differences in values, communications problems, etc. are pointed as additional main reasons of the interest conflicts. To resolve interest conflicts in smart grids, the Korean government should enhance its leadership in the coordination of stakeholders’interests. Government should make efforts to coordinate the various interests in terms of the development of the smart grid market and win stakeholders’ sympathy of their desirable roles in the smart grid market.