瓦松의 作用機轉에 關한 硏究

朴海根,金光鎭 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Orostachys malacophyllus Fischer is a plant to grow on the tiled roof of the old house, and on the rock in the mountain. And the chemical compositions of the plant have not known yet. But it has transmitted to this day as a kind of medical plant from remote antiquity. Sometimes, it is used in the folk remedies for the treatment of the malignant diseases. This study was attempted to investigate the effects of water extract or water fraction on the Na-K-ATPase activity, on the renal functions, and on the contractility of the cardiac and intestinal muscles. The results obtained were summarized as follows: 1. The activity of Na-K-ATPase purified from the outer medulla of pig was increased at 0. 01%, and was decreased at 0.1% of the water extract. 2. In the study of the renal functions of rabbits, urine volume, glomerular filtration rate (GFR), and renal plasmaflow (RPF) were decreased by water extract, and their decreased phenomena were continued after infusion of physiological saline 3. The free water clearance of rabbit kidneys was decreased significantly by water extract. 4. The contractilities of the isolated ventricular muscles of turtles were increased, and of muscle strips of mice intestine were decreased by the addition of water extract. 5. The contractilities of the isolated ventricular muscles of turtles were decreased, and of the muscle strips of mice intestine were increased by the addition of water fraction from alcohol extract. 6. The increased contractility of the cardiac or intestinal muscle was inhibited significantly by the addition of the mixed solution with verapamil.

胎兒血液의 酸素平衡曲線에 關한 硏究

朴海根 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.1

Fetal respiratory gas equilibria are more complicated than in the case of adult blood because the fetus has several hemoglobins, HbF and HbA, change with gastational age. Despite the great clinically importance of this area, oxygen binding properties of fetal blood currently are known only at one point on the curves i, e, the affinity at halfsaturation, p_50. Continnous dygnamic isocapneic oxygen equilibrium curve (O2EC) was measured on fetal cord blood sample. O2EC was generated by a recently developed dual wavelength (430-453㎚) spectrophotometry and electrode oximetry on thin blood films technique for measuring the complete dynamic ligand equilibrium curve from zero to complete saturation. Affinities and interaction coefficients were determined at all saturations. The goal of this work was to synthesize the results of this measurements into useful practical modified Hill's equation describing oxggen equilibrium curve in normal fetal blood. Results are summarized as follows: 1. HbF content of cord blood was 66.2±1.35% of total Hb by isoelectric focussing. 2. 2. 3-DPG content of cord blood was 5.31 nM/ml of RBC 3. O2EC of normal fetal blood under standard condition (pH=7.4, P_CO_2=40㎜Hg and 37℃) was obtained and p_50 was 22.38±0.026 ㎜Hg. 4. CO_2 Bohr coefficient(△log p_50/△pH) was -0.433±0.025 and fixed acid Bohr coefficient (△log p_50/△pH, øH^+) was -0.208. 5. Hill's constant "n" was 2.714±0.012 and constant K was 2.19×10 exp (-4). 6. Empiric modification of Hill's equation may be used to compute po_2(㎜Hg) from saturation (s) for 0.05∼0.95 in normal fetal blood under standard conditions was as Follow : po_2(s)=〔s/2.19×10 exp (-4)(1-s)〕^1/2·714-〔(2.55(s-0.195))^2〕^2.63+0.06

運動選手의 肺容積, 最大換氣能 및 二酸化炭素呼吸時의 呼吸 및 循環系反應에 關한 硏究

朴海根,朴喆斌,尹貞愛,吳亨錫,金熙胄 大韓體育會 스포츠과학연구소 1964 스포츠科學硏究報告書 Vol.1 No.1

靑少年 學生의 體力管理

朴海根 대한의학협회 1969 대한의학협회지 Vol.12 No.1

韓國人의 末梢神經 傳導速度에 關한 硏究

朴海根,張石鍾 충남대학교 의과대학 지역사회의학연구소 1975 충남의대잡지 Vol.2 No.2

The purpose of this investigation was to measure the peripheral nerve conduction velocities in a limited number of Korean subjects of various ages and then compare with the data obtained in other countries. The 26 male and 24 female subjects were randomly selected and divided three groups whose ages ranged from 14 to 50 years. Subjects were carefully positioned so that were comfortable with supine position and studies were done at room temperature with no attempt at specific temperature control other than to keep the subjects sympathetic output minimzed by psychologic encouragement. After the skin temperature was measured in each case over the forearm and lower leg using the telethermometer (Yellow Springs Inc.), motor nerve conduction velocity of the median, ulner, peroneal, tibial nerves and sensry neve conduction velocity of median, ulner and radial nerves were measured using Deca electromyography(Model 2-B, Teca Corporation). In addition, in order to establish the correlation between the temperature and motor nerve conduction velocity, frog sciatic nerve conduction velocity was measured in various body temperature at 5C interval from 10C to 35C. The results are summerized as follows: 1. Motor nerve conduction velocities of median and ulnar nerves in the male twenties were 62.9±0.8 and 60.2±1.0 m/sec. respectively and there was no significant differences between ages or sexes. 2. Sensory nerve conduction velocities of median, ulnar and radial nerves in the male twenties were 66.1±0.6, 61.4±0.4 and 64.2±1.9m/sec. and median nerve sensory conduction velocity was sinificantly higher (p<0.001) than that of the motor nerve in all age groups except female teenager. 3. Motor nerve conduction velocities of the peroneal and tibial nerve in the male twenties were 48.7±1.9 and 48.8±1.2m/sec, respectively and both of these value were significantly lower(p<0.001) than that of the median and u1nar nerves. 4. Distal latency of sensory nerve in upper extremity was significantly lower(p<0.001) than that of the motor nerve. 5. Conduction velocity of the frog sciatic nerve found to be 51.3±2.2m/sec at 25C. It was determined that nerve conduction velocity decreased at a rate of 1.91m/sec for each 1-degree centigrade drop in body temperature. From the above results, the motor and sensory nerve conduction velocities and distal latenices were comparable with reported data, may be used for the stadards of normal adult Koreans.

企業의 競爭力 强化와 原價管理

朴海根 啓明大學校 會計情報硏究所 1997 會計情報리뷰 Vol.- No.2

大學生 運動選手의 肺換氣能에 關한 硏究

朴海根,金光鎭 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

This study was attempted to evaluate the lung functions and physical fitness of the athletes of college students. For this investigation, 148 athletes(126 male and 22 female) beeing in Chungnam National University, were selected as an experimental group and 121 healthy students (76 male and 45 female) as a control group. The athletes were divided into nine special fields. The measurement was made on the vital capacity, maximum voluntary ventilation, maximum mid-expiratory flow and forced expiratory volumes by means of spirometry and Harvard step-up test for physical fitness test. The results are summarized as follows; 1. The physical charcteristics of athletes were excellent to compared. with the control group. 2. The vital capacity of the athletes showed higher values than that of the control group, except shooting. And the differences were significant in male valley ball, basket ball, athletics and female athletes. 3. The maximum voluntary ventilation of the all athletes showed higher values than that of the control group and the differences were significant, except male soccer and base ball players. 4. The forced expiratory volumes of all athltes at 0.5, 1.0, 2.0 and 3.0 sec showed higher values than that of the control group and the differences were significant, except total vital capacity at each sec were similar to the control group during expiratory period. 5. The values of maximum mid-expiratory flow showed no differences between athletes and control group. 6. Harv and step-up test scores of the athletes showed no differences with that of the control group, except rugby players was significant difference. From the above results, it was suggested that athletes of college students stowed significantly improved lung functions while similar physical fitness with that of the control group.

製造環境變化에 따른 設備投資案 評價方式의 發展方向

朴海根 啓明大學校 産業經營硏究所 1997 會計情報리뷰 Vol.- No.3

제조업체들이 공장에서 자동화 설비를 효과적으로 사용하게 되면 보다 높은 품질, 보다 낮은 재고수준, 원활한 생산라인의 흐름 등을 통해 기업의 경쟁력을 높일 수 있다는 주장이 설득력을 얻으면서 자동화 설비투자에 대한 논의가 활발하게 일고 있다. 그러나 자동화 설비투자의 명백한 잇점들에도 불구하고 투자의 경제적 정당화는 쉬운 문제가 아니다. 새로운 제조환경에서 기업들은 경쟁력을 높이기 위해 자동화 설비투자를 필요로 하게 되는데 자동화 설비투자는 그 투자에 따라 발생하는 원가와 효익의 금액 및 발생시기가 불확실하고 측정하기 어렵기 때문에 관리회계담당자가 그러한 투자의 타당성을 검토할 때, 기존의 투자안 평가방식을 그대로 답습할 수 없게 된다. 본고에서는 새로운 제조환경에서 기업의 경쟁력 제고를 위해 필요하게 되는 CAD/CAM, FMS, CIM 등 자동화 설비에 대한 투자의 특징과 그 투자에 따라 발생하는 원가와 효익을 밝히고, 그러한 자동화 설비투자안을 평가할 때 전통적인 평가방식을 사용하면 어떤 문제점들이 있는지 살펴보고 그러한 문제점들을 해소하기 위하여 관련문헌에서 제안된 평가방식들을 비교·검토하여 가장 바람직한 발전 방향을 제시하고자 한다.

持續的 品質改善과 品質原價의 測定

朴海根 啓明大學校 會計情報硏究所 1995 會計情報리뷰 Vol.- No.1

이 논문은 품질원가정보가 비용/효익 비교의 관점에서 품질개선 활동을 평가하는 수단이 될 수 있음을 밝히고 품질원가정보가 그러한 평가수단으로서의 기능을 제대로 수행하기 위해서는 품질원가의 분류와 측정이 적절하게 이루어져야 함을 강조하고 있다. 점차 심해지는 국내외 시장의 경쟁에서 살아남고 성장하기 위해서 기업들은 무결함 품질수준에 이르기까지 지속적으로 품질개선노력을 기울여야 한다. 그런데 주지하듯이 기업의 궁극적이 목표는 장기적인 이익의 극대화에 있으므로 기업은 품질개선을 통하여 보다 큰 이익을 얻을 수 있다는 확신이 설 때에만 품질개선노력을 할 것이다. 그러한 확신은 품질개선활동으로 인한 효익이 품질개선활동에 따른 비용을 능가하리라는 기대에서 나온다. 따라서 기업이 품질개선활동을 계속할 것인가, 계속한다면 어떤 개선활동에 자원을 더욱 배분할 것인가를 결정하려면 비용/효익 비교의 관점에서 품질개선 활동을 평가해야 할 것이다. 이때 품질원가정보는 중요한 평가수단을 제공한다. 이 논문에서는 높은 품질과 낮은 원가를 동시에 이루어 낼 수 있는 품질관리의 성숙단계와 품질원가모델을 소개한 후 그러한 관련문헌에 비추어 우리나라의 한 제조회사의 품질원가사례를 검토하여 품질원가의 분류 및 측정상의 문제점을 지적하였다. This paper clarified that quality cost information can be used as a means to evaluating firms' quality improvement activities based on the cost/benefit consideration, and emphasized that those companies evaluation their improvement activities should classify and measure their quality costs properly to take advantage of the usefulness of the quality cost information. Ever increasing competition facing manufacturing companies in domestic and global markets in recent years forces those firms to make every effort to continuously improve the quality of their products up to the level of zero defects for their survival and growth. However, business managers will try to improve the quality of their products only when they are convinced that their improvement efforts help them earn a higher income, assuming they serve their firm's eventual goal of maximizing its long-term profit. Such a confidence comes from their expectation that the benefits from their quality improvement activities will exceed the costs incurred for performing the activities. Thus managers should evaluate their quality improvement activities based on the cost/benefit consideration when they decide whether to continue performing their activities of where to allocate their resources. Quality cost information provides an important means to the evaluation. This paper introduced a matured step of quality management and a quality cost model in which a firm can accomplish both a higher level of quality and a lower level of cost. The paper reviewed a case of quality cost system of a Korean manufacturing business and indicated some problems in the classification and measurement of its quality costs.

저산소환경 및 운동훈련이 흰쥐의 운동능력향상에 미치는 영향

박해근 고려대학교 의과대학 1972 고려대 의대 잡지 Vol.9 No.2

This experiment was carried out to investigate systematically how physical training and exposure of experimental animals to hypoxic environment are correlated. A question was raised whether hypoxic stimuli in tissue during strenous physical exercise is the one of the factors which improve physical performance. Sixty male Albino rats were divided into 5 groups consisting of 12 rats in each group. Each group was exposed to one of the following various oxygen contents, i.e., 27.5, 21.0, 15.7, 12.0 and 8.1% oxygen mixture for 4 hours daily during 4 weeks. Each group was subdivided into two groups, i.e., training and control group. Training groups were trained with a program of forced running in a motor driven treadmill at the speed of 40 m/min with 10% grade for 20 min. during each 4 hrs exposure, while untrained rats were placed under the identical condition. Body weight, resting heart rate by means of EKG recorded with a polygraph (Grass Model 7) and maximum endurance running time on the treadmill at the speed of 40m/min with 15% grade were measured every week. Hematocrit ratio, glycogen content of the heart, liver and gastrocnemius muscle and oxygen consumption of liver mitochondria were determined at the end of experiment. The results are summarized as follows: 1. The endurance running time with exhaustive running on the treadmill was increased as the physical training and hypoxic exposure continued, and endurance running time at the end of 4 weeks for the trained group exposed to 12% of oxygen and for the untrained group exposed to 8.1% oxygen were significantly greater (p<0.05) than the rest of the experimental groups. 2. Glycogen content of skeletal muscle was significantly higher (p<0.05) in the trained group than in that of the untrained group except for the one exposed to 27. 5% oxygen. On the other hand, no significant changes were observed in the glycogen content of the liver and heart muscle among any experimental groups. 3. Oxygen consumption of liver mitochondria was higher for trained rats than that of the untrained group, and the former group also showed a high level of respiratory control in oxidative phosphorylation. From the above findings, it may be speculated that an improved work performance with physical training may be partly brought by hypoxic stimulus at the tissue level. However, additional factors such as increased oxidative phosphorylation of mitochondria and energy storage in working muscle might contribute to the improvement of the work performance.