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생체적합성과 생분해성을 갖는 Polypeptide Copolymers의 합성과 물성에 관한 연구(Ⅲ): Polypeptide Hydrogels의 약물조절방출
강인규,권대룡,성용길 동국대학교 자연과학연구소 1991 자연과학연구 논문집 Vol.11 No.-
Poly(γ-benzyl L-glutamate) (PBLG)의 측쇄에 polyethylene glycol(PEG) 또는 ethanolamie(EA)을 반응시켜 적심성이 서로 다른 몇가지 폴리펩티드 공중합체를 합성하였고, 이들 공중함체의 약물방출특성을 살펴보았다. 합성된 폴리펩티드공중합체의 수분흡수율은 공중합체 중의 PEG 또는 EA 함량이 높아짐에 따라 증가하였다. PEG-PBLG-EA 공중합체로부터의 5-fluorouracil의 방출속도는 PEG-PBLG 공중합체로부터의 방출속도보다 크게 나타났으며, 이러한 결과는 팽윤성의 폴리펩티드를 합성하고자 할 때 사용되는 치환제로서는 PEG보다도 EA가 더욱 효과적이라는 것이 나타났다. 한편, PEG를 가교시킨 PBLG 공중합체막상에서는 5-fluorouracil의 방출에 기인하여 작은 pores를 명료하게 나타나고 있음을 알 수 있었다. Several copolypeptides having different swellabilities are are synthesized by introducing polyethylene glycol(PEG) or ethanolamine(EA) to the side chains of poly(γ-benzyl L-glutamate) (PBLG) and their drug release characteristics are examined. The degree of swelling of copolypeptide is increased by increasing PEG or EA content in the polymer. The release rate of 5-fluorouracil from the PEG-PBLG-EA copolymers was higher than that of the PEG-PBLG copolymers. This results indicated that EA is more effective than PEG for the preparation of the swellable polypeptides. It was observed, from the morphological study by scanning electron microscope, the pores are generated on the PEG-crosslinked PBLG, but not on the PEG-grafted-PBLG.
양말단에 서로 다른 관능기를 갖는 PEO를 합성하기 위한 Sila-protected Amino Functionality Initiator의 합성
김용주,한애란,성용길 동국대학교 자연과학연구원 1994 자연과학연구 논문집 Vol.14 No.-
A new initiator, potassium N-[2-(2,2,5,5-tetramethyl-1-aza-2,5-disila cylopentyl) ethyl] methyl amide, was synthesized with sila-protected amino functionality for well-defined heterobifunctional PEO. The synthesized initiator was identified by IR, ¹H-NMR, GC-Mass and GC.
Poly-β(1,4)-D-glucosamine-g-polyethyleneoxide의 합성 및 물성에 관한 연구
주상명,장광태,성용길 동국대학교 자연과학연구원 1995 자연과학연구 논문집 Vol.15 No.-
Poly-β(1,4)-D-glucosamine derived from poly-β(1,4)-N-acetyl-D-glucosamine by treating with alkaline solution has been reported to be a promising polymer not only in the chemical field but also in biomedical area. Poly-β(1,4)-D-glucosamine used in this experiment was seen about 93 percentage of degree of deacetylation by heterogeneous alkaline soultion. Poly-β(1,4)-D-glucosamine-g-polyethyleneoxide was synthesized by homogeneous method. Various molecular weights of polyethyleneoxide as a hydrophilic and flexible spacer were introduced to Poly-β(1,4)-D-glucosamine to produce Poly-β(1,4)-D-glucosamine-g-polyethyleneoxide. The synthesized copolymers are characterized by FT-IR, elemental analysis, thermogravimetric analyzer, and differential scanning calorimetry.
Poly(2-Hydroxyethyl Methacrylate-co-2-Methacryloxyethyl-1,1,1-Trifluoroacetate)의 합성 및 물성에 관한 연구
성용길,성대경 동국대학교 1987 論文集 Vol.26 No.-
Swollen or unswollen synthetic polymeric films are suitable for separation techniques such as hyperfiltration, ultrafiltration, dialysis, electrodialysis, and piezodialysis. They have also found major uses in biomedical problems(artificial kidney membranes, etc.), enzyme related processes, ion-exchange, dental and pharmaceutical applications(controlled release system). Poly (2-hydroxyalkyl methacrylate)s are being considered as useful materials for various membranes and medical applications. The radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) with 2-methacryloxyethyl-1, 1, 1-trifluoroacetate (METFA) has been investigated to understand their reactivities and to improve the physical properties of homopolymer. The monomer METFA was synthesized by esterification of 2-hydroxyethyl methacrylate with 1,1,1-trifluoroacetic acid(TFA). Azobisisobutyronitrile (AIBN) was used as an initiator in the radical copolymerization of HEMA with METFA. The compositions of unreacted monomers were determined by the intensity of each peak by gas chromatographic analysis. The monomer reactivity ratios were determined by Kelen-Tu¨do~s method. The values of the reactivity ratios are r_1=2.35 and r_2=0.21 for the HEMA(1)-METFA(2) system. The values of Q and e factors calculated by Alfrey-Price equation are 0.29 and-0.64, respectively. The characterization of the copolymers has been carried out by FT-IR spectrophotometer and thermal analysis techniques. The thermal stability and melting temperature(Tm) of the copolymers were increased, as the amounts of hydrophilic HEMA in the copolymers increased. The enthalpic changes associated with endothermic transition were evaluted by differential scanning calorimetry. The activation energies of poly (HEMA-co-METFA) were evaluated from the thermogravimetric data by Freeman and Carroll method. The equilibrium water swelling quantities of the homopolymers and copolymers are also measured and discussed on the basis of hydrophobicity and hydrophilicity.
Acrylonitrile-Styrene 공중합체의 합성 및 열적성질에 관한 연구
양정성,오세찬,성용길 慶南大學校 附設 基礎科學硏究所 1989 硏究論文集 Vol.1 No.-
Ammonium peroxidisulfate was used as an initiator in the free radical polymerization of acrylonitrile. Benozyl peroxide was used as an initiator in the free radical polymerization of styrene and in the free radical copolymerization of styrene with acrylonitrile. The synthesized polymers and copolymers have been identified by FT-IR spectrophotometer. The thermal properties and glass transition temperature(Tg) of the polymers and copolymers were measured by differential scanning calorimetry and thermogravimetry. The activation energies of thermal decomposition for the polymers and copolymers were evaluated from the thermogravimetric data by Freeman and Carroll method.
성용길,송대경,이종섭 동국대학교 대학원 1991 大學院硏究論集-東國大學校 大學院 Vol.21 No.-
Poly(1,4-butanediol dilactate succinate)and poly (1,4-butanediol dilactate 2-acetoxy succinate) were prepared by the polycondensation of 1,4-butanediol dilactate with succinic anhydride and 2- acetoxy succinic acid. 1,4-Butanediol dilactate was synthesized from L-lactic acid in the presence of 1,4-butanediol as a difunctional initiator. 2-Acetoxy succinic acid was synthesized from L-malic acid by protecting hydroxyl group using acetic anhydride. The monomers and polymers were identified by ^1h-NMR spectrometer and FT-IR spectrophotometer. The molecular weights and molecular weight distributions of synthetic polymers were measured by gel permeation chromatography. The glass transition temperatures and thermal decomposition temperatures of the polymers were measured by differential scanning calorimetry and thermogravimetry, respectively.