http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정신분열병, 정신분열형장애 및 분열정동장애 환자에서아리피프라졸 급성기 치료에 대한 유효성 및 안정성 연구:8주 전향적 개방 연구
최정석,김도훈,김용구,김정기,박원명,신재공,윤보현,이정구,전덕인,정영철,윤탁,권준수 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.3
Objectives: The purpose of the present study was to investigate the efficacy, safety, and tolerability of aripiprazole in patients with schizophrenia, schizophreniform disorder, and schizoaffective disorder during acute treatment phase. Methods: Prospective, multicenter, single group, and 8-week study was conducted in patients with schizophrenia, schizophreniform disorder, and schizoaffective disorder. A total of 300 patients were enrolled in the present study. The primary efficacy measure was the Positive and Negative Syndrome Scale (PANSS) total score, and secondary efficacy measures were the PANSS positive and negative subscales scores, and Clinical Global Impression-Severity of Illness (CGI-S) score. Treatment-emergent adverse events, extrapyramidal symptoms (EPS), weight, vital signs, and laboratory tests were assessed as measures of tolerability and safety. Results: Significant improvements in all efficacy measures were achieved by aripiprazole as early as 1-week and sustained through 8-week period. First-episode patients showed greater improvements in PANSS total, positive subscale score, and CGI-S score, compared with recurrent patients. Slightly increased akathisia (+0.32 from baseline score of Barnes Akathisia Rating Scale, p=0.033) and weight gain (1.15 ± 3.44kg, p<0.001) were observed by aripiprazole during 8-week acute treatment phase. Conclusion: The present study demonstrated that aripiprazole was effective in acute treatment of positive and negative symptoms of schizophrenia, schizophreniform disorder, and schizoaffective disorder. In general, aripiprazole showed favorable safety and tolerability profiles, although clinicians needed to pay attention to the possibility of akathisia and weight gain by aripiprazole in first-episode patients during acute treatment phase. 본 연구는 급성 증상을 보이는 정신분열병, 정신분열형장애, 그리고 분열정동장애 환자에서 급성기(8주) 동안의 아리피프라졸의 효과 및 안정성에 대하여 평가해 보고자 한 전향적 다기관 공동 연구였다. 총 300명(남자 132명, 여자 168명)의 환자가 본 연구에 참여하였으며, 일차 유효성 평가 변수는 치료 전후의 PANS 전체 점수의 평균 변화량이었고 이차 유효성 평가 변수로는 PANS의 양성증상 및 음성증상 척도점수, CGI-S, 그리고 치료 반응률이었다. 또한, 부작용을 평가하기 위해 SAS,16) AIMS17)와 BAS18) 등으로 매 방문마다 시행하였으며 활력 징후와 체중도 함께 측정하였다. 모든 유효성 평가 변수에서 치료 첫 주부터 유의한 호전을 보였고 이러한 효과는 8주 기간 동안 유지되었다. 특히 초발 환자군에서는 PANS 전체 점수와 양성증상 점수, 그리고 CGI-S 점수가 재발 환자군에 비하여 더 큰 호전을 나타내었다. 반면, 경도의 정좌불능증과 체중 증가 8주 치료 기간 동안 관찰되었다. 본 연구에서 아리피프라졸은 급성 증상을 보이는 초발 및 재발 정신분열병, 정신분열형장애, 그리고 분열정동장애 환자에서 치료 초기부터 양성증상뿐만 아니라 음성증상에도 유의한 증상의 호전을 나타내었으며, 안정성 및 내약성에서도 우수하였다. 다만 초발 환자군에서는 치료 초기 정좌불능증의 발생 가능성과 체중 증가에 유의해야 함을 시사한다.
최정석,Sumi Park,이준영,정희연,Hae-Woo Lee,Chong-Hyeon Jin,강도형 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.2
Objective Smoking related cues may elicit smoking urges and psychophysiological responses in subjects with nicotine dependence. This study aimed to investigate the effect of repeated virtual cue exposure therapy using the surround-screen based projection wall system on the psychophysiological responses in nicotine dependence. Methods The authors developed 3-dimensional neutral and smoking-related environments using virtual reality (VR) technology. Smoking-related environment was a virtual bar, which comprised both object-related and social situation cues. Ten subjects with nicotine dependence participated in 4-week (one session per week) virtual cue exposure therapy. Psychophysiological responses [electromyography (EMG), skin conductance (SC), and heart rate] and subjective nicotine craving were acquired during each session. Results VR nicotine cue elicited greater psychophysiological responses and subjective craving for smoking than did neutral cue, and ex-posure to social situation cues showed greater psychophysiological responses in SC and EMG than did object-related cues. This responsiveness decreased during the course of repeated therapy. Conclusion The present study found that both psychophysiological responses and subjective nicotine craving were greater to nicotine cue exposure via projection wall VR system than to neutral cues and that enhanced cue reactivity decreased gradually over the course of repeated exposure therapy. These results suggest that VR cue exposure therapy combined with psychophysiological response monitoring may be an alternative treatment modality for smoking cessation, although the current findings are preliminary
최정석 한국해양수산개발원 2019 해양정책연구 Vol.34 No.2
The purpose of this study is to evaluate the value of the BDI, which is an intangible asset. Baltic Exchange was established in 1744 to become the center of global shipping transactions through issuing BDI since 1985. BDI is an intangible asset that is recognized worldwide for being used as a basic asset for shipping transactions. To date, research that evaluates the correct value of these intangible assets has not been carried out systematically. Therefore, the economic value of BDI was evaluated in this study using the discounted cash flow method. According to the valuation, the BDI was evaluated at GBP 13,286,379. The implications of this study are firstly, it became aware of the importance of the knowledge and information industry by conducting a valuation of the BDI. Secondly, the practical economic value of BDI was determined by using the discounted cash flow method. Thirdly, a systematic arrangement of the key factors used to value the BDI provided the basis for valuation of various intangible assets in the future. 본 연구의 목적은 무형재화에 속하는 BDI지수에 대한 경제적 가치를 정량적으로 산출하는데 있다. 우리나라는 최근 해운산업의 체질 개선을 위한 고부가가치 산업 육성이라는 화두가 대두되고 있지만 국내 인프라는 열악한 상황이다. 영국의 경우 1744년 발틱해운거래소를 설립하여 글로벌 해운거래의 중심국으로 자리 잡고 있으며, 1985년부터 BDI지수를 발표하며 정보 기반의 해운거래 중심기능을 수행하고 있다. BDI지수는 해운거래의 기초자산으로 활용되어 전 세계적으로 그 가치가 인정받고 있는 무형자산이다. 이러한 지식가치 기반의 무형자산에 대한 정확한 가치를 평가하는 연구는 지금까지 체계적으로 진행되지 않고 있다. 따라서 본 연구에서는 수익접근법을 활용하여 BDI지수의 경제적 가치를 평가하였다. BDI지수 가치평가를 위해 발틱해운거래소의 사업가치를 바탕으로 기술기여도를 반영하여 최종적인 경제적 가치를 평가하였다. 가치평가 결과 BDI지수는 GBP 14,560,407로 한화 기준 약 210억원 이상의 경제적 가치를 갖고 있는 것으로 분석되었다. 본 연구의 의의는 첫째, 그동안 선박이나 항만 등 유형자산 중심의 가치평가 행태에서 벗어나 무형자산에 속하는 지수에 대한 가치평가를 실시함으로써 지식정보산업의 중요성을 인지하게 되었다. 둘째, 기술가치평가에 수익접근법을 활용함으로써 지수와 같은 무형자산에 대한 현실적인 경제적 가치를 산정하였다. 셋째, BDI지수의 기술 가치에 사용되는 주요 요인들에 대한 체계적인 정리를 통해 향후 BDI지수 이외에도 다양한 무형자산에 대한 가치평가의 토대를 마련하였다.
최정석,이지윤,문영규,문석환,박재길,문미형 대한흉부외과학회 2020 Journal of Chest Surgery (J Chest Surg) Vol.53 No.3
Background: Accurate intraoperative assessment of mediastinal lymph nodes is a critical aspect of lung cancer surgery. The efficacy and potential for upstaging implicit in these dissections must therefore be revisited in the current era of uniportal video-assisted thoracoscopic surgery (VATS). Methods: A retrospective study was conducted in which 544 patients with stage I (T1abc–T2a, N0, M0) primary lung cancer were analyzed. To assess risk factors for nodal upstaging and to limit any imbalance imposed by surgical choices, we constructed an inverse probability of treatment-weighted (IPTW) logistic regression model (in addition to non-weighted logistic models). We also evaluated risk factors for early locoregional recurrence using IPTW logistic regression analysis. Results: In the comparison of uniportal and multiportal VATS, the resected lymph node count (14.03±8.02 vs. 14.41±7.41, respectively; p=0.48) and rate of nodal upstaging (6.5% vs. 8.7%, respectively; p=0.51) appeared similar. Predictors of nodal upstaging included tumor size (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.12–2.70), carcinoembryonic antigen level (OR, 1.11; 95% CI, 1.04–1.18), and histologically confirmed pleural invasion (OR, 3.97; 95% CI, 1.89–8.34). The risk factors for locoregional recurrence within 1 year were found to be number of resected N2 nodes, age, and nodal upstaging. Conclusion: Uniportal and multiportal VATS appear similar with regard to accuracy and thoroughness, showing no significant difference in the extent of nodal dissection.
Thromboexclusion Treatment for Recurrent Aortic Aneurysm: Still an Option in Select Cases
최정석,김환욱 대한흉부외과학회 2019 Journal of Chest Surgery (J Chest Surg) Vol.52 No.6
Flow reversal and thromboexclusion constitute a valuable alternative for aortic surgeons to have within their technical armamentarium for the treatment of aortic aneurysmal disease. Although not usually a preferred treatment for general aortic pathologies, this technique can be considered as a treatment option in select situations, such as mycotic aneurysm, a hostile surgical field, and a poor condition of the patient. Here, we present a case of extra-anatomic bypass and thromboexclusion for recurrent aortic aneurysm after previous extra-anatomic bypass and thromboexclusion surgery.
최정석,최석규 한국중국문화학회 2019 中國學論叢 Vol.0 No.63
This study examines the changes in the labor market in recent years, the Korean firms' entry into China/Vietnam. The results of the studies of China and Vietnam are as follows. First of all, in China, the labor market has been fully completing lawssince the implementation of the labor contract law in 2008. Next, in Vietnam the labor market is expected to increase because demand for foreign manpower, as the advancement of retail, finance, tourism services, Smart factories in the textile and sewing- do. The limitations of this study, however, are that there is not enough data to utilize official data for labor market analysis in China and Vietnam. If a practical investigation is conducted for analyzing the labor market in Vietnam due to the changes in the labor market in the future, it will be possible to use it as data for the advancement of Korean companies and job seekers overseas. 본 연구에서는 중국 노동시장의 변화에 베트남 노동시장의 변화에 대한 제도고찰을 하고자 한국기업의 중국과 베트남 진출추이에 대한 노동시장 연관성을 살펴보았다. 구체적으로 중국과 베트남의 연구결과를 살펴보면 다음과 같다. 우선 중국을 살펴보면, 중국의 노동시장은 2008년 노동계약법 실행 이후 법률과 제도를 완비해가고 있는 상황으로, 한국기업의 중국진출도 증가하고 있다. 구체적으로 노동계약, 직원채용, 최저임금 방면에서 살펴보았다. 다음으로 베트남을 살펴보면, 베트남은 과거의 노동집약적 산업에서 3차, 4차 산업이 급격하게 발전하고 있는 국가이다. 특히, 베트남의 노동시장은 기존의 섬유 및 봉제 중심의 제조업에서 유통업, 금융, 관광서비스, IT스타트업, 스마트 팩토리 등의 진출이 더욱더 활기를 띨 것으로 보여 외국 인력에 대한 수요가 당분간 증가할 것으로 예상된다. 다만, 본 연구의 한계점은 중국과 베트남의 노동시장 분석을 위한 공식적인 데이터를 활용하는데 자료가 충분하지 않다는 점이다. 향후 중국 노동시장 변화에 따른 베트남 노동시장 분석을 위한 실제적인 조사가 이루어진다면 한국 기업 및 구직자들의 해외진출을 위한 자료로 활용이 가능 할 것으로 보인다.
최정석,권준혁,강성현,류윤기,최원석,오종건,조재우 대한골절학회 2023 대한골절학회지 Vol.36 No.4
Acute fracture-related infection (FRI) is a common and serious complication of fracture treatment. The clinical symptoms of the patient and the results of the serological, radiological, and histopathological examinations can be divided into ‘Confirmatory’ criteria and ‘Suggestive’ criteria, allowing for the diagnosis of FRI. Treatment principles can be broadly categorized into (1) the DAIR (Debridement, Antimicrobial therapy, Implant Retention) method and (2) the staged reconstruction method. The choice of treatment depends on factors such as the time elapsed after infection, stability of the internal fixation device, reduction status, host physiology, and virulence of the pathogens. Thorough surgical debridement and irrigation, ensuring stability at the fracture site, reconstruction of bone defects, and appropriate soft tissue coverage, along with antibiotic therapy, are essential to suppress or eradicate the infection. The restoration of limb function should be promoted through proper soft tissue coverage and bone union at the fracture site.
스테비아와 숯이 급여된 비육돈의 사양성적, 면역력 및 도체특성
최정석,정동순,이주호,최양일,이재준 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.2
This study was conducted to determine the effects of stevia (Stevia rebaudiana bertoni) and charcoal supplementation on growth performance, immune response and carcass characteristics of finishing pigs. A total of 420 pigs (LYD) were randomly allocated into 7 treatments with 3 replications. Dietary treatments were 1) T1 (basal diet), 2) T2 (basal diet+0.3%stevia), 3) T3 (basal diet+0.6%stevia), 4) T4 (basal diet+0.3% charcoal), 5) T5 (basal diet+0.6% charcoal), 6) T6 (basal diet+0.3% stevia+0.3% charcoal) and 7) T7 (basal diet+0.6% stevia+0.6% charcoal). During the experimental period, average daily gain (ADG) was higher in T2 and T6 groups than the other treatments (p