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윤태숙,전명숙,김승주,이아영,문병철,천진미,추병길,김호경 한국약용작물학회 2010 한국약용작물학회지 Vol.18 No.1
Glycyrrhiza uralensis (Leguminosae) is a well-known herbal medicine that has long been valued as a demulcent to relieve inflammatory disorders. To compare the influence of different solvents on the anti-inflammatory efficacy of G. uralensis, we measured the inhibition of pro-inflammatory mediators such as NO, TNF-α, and PGE2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells by extracts produced using different solvents (water, methanol, ethanol, or n-hexane). The results showed that methanol was the most effective solvent for the inhibition of both NO and PGE2 production in RAW 264.7 cells. However, there was no difference among the extracts for inhibition of TNF-α. Further study must be performed for the analysis of correlation between the anti-inflammatory activity of extracts produced using different solvents and the content of major bioactive compounds in G. uralensis, such as glycyrrhizin and liquiritin. The present study suggests that methanol may be a more appropriate solvent of G. uralensis than other solvents (water, ethanol, and n-hexane) to yield the greatest anti-inflammatory activity for food additives and medicine.
The Effects of Glehnia littoralis on the Inflammatory mediators in Mouse Macrophage Cells
윤태숙,전명숙,이아영,최고야,김승주,문병철,추병길,김호경 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.3
Glelmia littoralis (Umbellife rae) is the medicinal plant used traditionally for treatment of immune-related di seases. Prostaglandins and ni tric oxide (NO) have been implicated as important mediators In the processes of inflammation and carcinogenesis. For understanding the mechani sms for pharmacological activities of Glehnia littoralis, we evaluated the inhibitory activity of Glehnia littoralis on lipopolysaccharide (LPS) -induced prostaglandin E2 (PGE2) and NO production in mouse macrophage RAW264.7 cell s. The results showed that the extract of Glehnia littoralis inhibited LPS- induced PGE2 production effectively, but not NO. Additional study revealed that the extract of GJehnia Jittoralis suppressed cyclooxygenase - 2 (COX- 2) expression in a dose-dependent manner. Present study suggests that GJehnja littoralis may have anti -inflammatory and/or cancer chemopreventive activity through the inhibition of PGE2 production by the suppression of COX-2 activity.
Pharmacological activities of Glehnia littoralis
윤태숙,추병길,전명숙,이도연,최고야,채성욱,이아영,김호경 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
Glehnia littoralis (Umbelliferae). a perennial herb distributed along the coastline of northern Pacific countries, is the medicinal plant used traditionally for treatment of various diseases. This review focuses on the various pharmacological activities of Glehnia lIttoralis for understanding about its traditional medicinal applications, medicinal uses in the modem society, and potentials for drug development. Glehnia littoralis was reported to have anti-oxidant, anti-tumor, anti-amnesic, blood circulation-promoting, irnrnunomodulatory, anti-microbial, and allelopathic activities. However, their mechanisms remain to be clarified. Because Glehnia littora/is has been prescribed in traditional Oriental medicine as a tonic herb, Glehnia httoralis can be better than other chemical drugs and medicines which exert the equal pharmacological activities. Although the activities of Glehnia IIttoralis are not specifically high-potent with unique mode of action, it may turn out that it can be beneficial to exert multiple pharmacological activities. In view of low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of Glehnia littorah's, it needs to be prudent to evaluate its properties and applications further.
윤태숙,성윤영,장자영,양원경,지윤의,김호경 韓國藥用作物學會 2010 한국약용작물학회지 Vol.18 No.3
Obesity has become one of the main public health problems. Saussurea lappa (Asteraceae), syn Aucklandia lappa and Saussurea costus, is a well-known herbal medicine that has been used for treating various ailments, such as inflammatory and gastrointestinal diseases. The present study examined the anti-obesity effect of S. lappa extract (SLE) in 3T3-L1 adipocytes and high fat diet (HFD)-induced obese mouse model. SLE significantly inhibited the differentiation from preadipocytes to adipocytes of cultured 3T3-L1 in dose-dependent manner. In addition, SLE significantly decreased the body weight gain and the food efficiency ratio of mice fed HFD during 9 weeks. Further study must be performed for the pharmacological mechanism and safety of SLE as well as the identification of active compound in SLE. Our results revealed that S. lappa suppresses the adipogenesis in cultured cells and the obesity in rodent models. Therefore, S. lappa may be useful toward the development of new potent anti-obesity drugs.
마우스 Raw 264.7 세포에 대한 4종 대황류 추출물의 항염증 활성 비교
전명숙,윤태숙,최고야,김승주,이아영,문병철,추병길,김호경 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.2
Rhubarb is the well-known and frequently used herbal medicine for the treatment of constipation, inflammation, and cancer. As described in the Korea and Chinese Pharmacopoeia, rhubarb consists of the roots and rhizomes of Rheum palmatum, R. officinale, and R. tanguticum. However, the pharmacological differences among rhubarb have not been scientifically established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts from R. palmatum (RPE), R. officinale (ROE), R. nobile (RNE), and R. franzenbachii (RFE) on the production of inflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), interlukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) in RAW 264.7 macrophage cells. ROE, RNE, and RFE significantly inhibited the release of NO, PGE2, IL-1β, and TNF-α. RPE significantly reduced the release of IL-1β, but not NO, PGE2, and TNF-α. Overall, RFE was found to inhibit the release of PGE2 and IL-1β, to a far greater degree than RPE, ROE, and RNE. Our results indicate that RFE possess the strongest anti-inflammatory activity among 4 tested rhubarb.
한의학 고문헌의 단방용례 분석을 통한 천문동의 기대효능 연구
최고야(Choi Goya),윤태숙(Yoon Taesook),추병길(Choo Byungkil),문병철(Moon Byeongcheol),채성욱(Chae Sungwook),김호경(Kim Hokyoung) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
We referred to twenty-two Korean medicinal literatures for application of a single-medicine prescription using Asparagi Tuber(Asparagus cochinchinensis) to form the groundwork for scientific modernization of Korean medicine. Our study revealed the following. 1. Principle expectant effects of Asparagi Tuber were prolong life; elevation of stamina or activity; improvement of asthenia; remedy of epilepsy, mental disease or convulsions; relief of xerosis; treatment of tumor, abscess or intumescence; extermination of endoparasite; solution of numbness, etc. 2. The records show that 95% of directions are per oral. 3. 38% of the cases, Asparagi Tuber was used without its jacket or core. 4. Alcohol and honey were generally used as solvent and additive. We suggest to perform the further studies for the scientific verification of the expectant effects of Asparagi Tuber and its different efficacy by processing, solvent and additives.
한의학 고문헌 분석을 통한 무궁화의 약용부위와 기대효능 연구
최고야(Choi Goya),윤태숙(Yoon Taesook),추병길(Choo Byungkil),이아영(Lee Ayeong),채성욱(Chae Sunguk),주영승(Ju Youngsung),김호경(Kim Hokyoung) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2
Hibiscus syriacus is rarely used herb. For finding up new applications of this herb, the medicinal parts and expected efficacys that recorded in 24 classics of oriental medicine were inquired. As a result of the literature review, medicinal parts and expected efficacys of Hibiscus syriacus were as follows: The medicinal parts were mainly flower and bark But the root, branch, leaf and fruit were mentioned too. Some unidentified medicinal parts seemed to be branch or bark. The mentioned symptoms that prescribed Hibiscus syriacus are intestinal 'wind', red-white dysentery, thirst with fever after dysentery, insomnia, 'wind' syndrom, leukorrhea, regurgitation, etc. And this herb was mentioned that applied externally for scabies, hemorrhoids, prolapse of the rectum, headache, extracted tooth, etc. Therefore, bleeding intestinal diseases, insomnia, vaginal or uterine hemorrhage(for internal use), scabies or mycosis, hemorrhoids, anal fistula, prolapse of the rectum, headache(for external use) were presented as expected efficacys of Hibiscus syriacus. In future, studies for verifying the efficacys are needed.