Sleep Patterns among South Korean Infants and Toddlers: Global Comparison

안영민,Ariel A. Williamson,서현주,Avi Sadeh,Jodi A. Mindell 대한의학회 2016 Journal of Korean medical science Vol.31 No.2

The purpose of this study was to examine sleep patterns in a large sample of infants and toddlers (ages birth to 36 months) in Korea, and to compare sleep patterns, sleep problems, sleep ecology, and parental behaviors to global sleep data on young children in both predominately Asian (P-A) and predominately Caucasian (P-C) countries/regions. We additionally examined parent and child demographic information, parental behaviors, and aspects of the sleep ecology as predictors of sleep patterns among infants and toddlers in Korea. Parents/caregivers of 1,036 Korean infants and toddlers completed an expanded, internet-based version of the brief infant sleep questionnaire. Consistent with other studies of sleep in early childhood, sleep/wake patterns became increasingly consolidated with older child age for the Korea sample. Compared to both P-A and P-C infants and toddlers, children in Korea had the latest bedtimes, shortest total sleep and daytime sleep durations, and the least frequent rates of napping. Even though half of parents perceive their children’s sleep problematic, parental perceptions of severe child sleep problems were the lowest. Within Korea, breastfeeding and bottle-feeding at sleep resumption were associated with increased nocturnal awakenings. Evening television viewing was associated with later bedtimes, which may have implications for sleep hygiene recommendations in clinical practice. The current study provides important information about sleep/wake patterns, parental behaviors, and aspects of the sleep ecology for infants and toddlers for physicians to support healthy sleep in Korea.

산삼과 산양삼 추출물의 항암 및 항산화 효능

안영민,박희수,권기록,Ahn, Young-Min,Park, Hee-Soo,Kwon, Ki-Rok 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.1

Objectives : The aim of this study was to verify anti-cancer and anti-oxidant efficacies of Korean wild ginseng and cultivated wild ginseng of Korea and China. Methods : For the measurement of anti-oxidation, SOD-like activity was evaluated using xanthine oxidase reduction method under in vitro environment. Subcutaneous and abdominal cancer were induced using CT-26 human colon cancer cells for the measurement of growth inhibition of cancer cells and differences in survival rate. Results : 1. Measurement of anti-oxidant activity of ginseng, Chinese and Korean cultivated wild ginseng, and natural wild ginseng samples showed concentration dependent anti-oxidant activity in HX/XOD system. Anti-oxidant activity showed drastic increase at 1mg/ml in all samples. 2. For the evaluation of growth inhibition of cancer cells after hypodermic implantation of CT-26 cancer cells in the peritoneal cavity of mice, Chinese and Korean cultivated wild ginseng and natural wild ginseng groups showed significant inhibition of tumor growth from the 12th day compared to the control group. Similar inhibitory effects were also shown on the 15th and 18th days. But there was no significant difference between the experiment groups. 3. For the observation of increase in survival rate of the natural wild ginseng group, CT-26 cancer cells were implanted in the peritoneal cavity of mice.

한국의 Amatoxins 중독증

안영민,이동수,이강문,강상범,양진모,박영민,이영석,정규원,선희식,박두호,노현주,강영모,이종명,허정욱,최성곤,김정호,이상인,최승옥,최홍엽,권오선,구창덕,석순자,김양섭 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

한국의 amatoxins 중독증은 강원 영서 지역이 호발지역으로 알려져 왔으며 최초로 보고된 원인버섯은 알광대버섯이었으나 현재까지 재 확인된 바가 없다. 원인버섯이 확인된 예로는 강원 영서지역이나 대전지역의 독우산광대버섯과 함께 1998년 경북 일원에서 발생한 집단 중독사고의 개나리광대버섯과 대전에서 발생한 1예에서 흰알광대버섯을 들 수 있다. 최근까지 amatoxins 중독증에 관해 보고된 국내의 문헌을 살펴보면 한국에서 발생하는 amatoxins중독증은 사망률에서 외국의 20-40% 와 큰 차이가 있는 것 처럼 보이나 사실상 전체적인 발생빈도나 사망률 등을 산출한 예가 없었을 뿐아니라, 높은 사망률의 원인이 무엇인지를 비교하는 것도 불가능하였다. 저자들은 국내에서 발생하는 amatoxins 중독증의 예방과 보다 효율적인 진단 및 치료를 위해 발생빈도나 사망률 및 원인버섯 등의 기초적인 조사와 함께 문헌을 통해 amatoxins 중독증에 대한 지견을 고찰하고자 하였다. 대상과 방법: 1999년 1년간 원인버섯 식별을 위해 의뢰되었던 증례들과 연례적 호발지역의 의료기관에서 병력 및 임상소견으로 amatoxins 중독증으로 진단 또는 추정된 증례들을 조사하였다. 원인버섯의 식별은 발생지역을 방문하여 원인버섯의 확보가 가능했던 소수의 증례에서는 외관과 현미경적 소견으로 원인버섯을 식별하였으며 원인버섯의 확보가 불가능한 증례에서는 특징적인 외관으로 추정되었다. 결과: 54명의 대상환자들 중 43명에서amatoxins 중독증으로 진단되었으며 그중 35명은 중등도 이상의 중독증으로 간주하였다. 중등도 이상의 중독증에서는 7명이 사망하여 20%의 사망률을 나타내었으며 원인버섯은 독우산광대버섯과 개나리광대버섯이 확인되었다. 흰알광대버섯은 확인되지 않았으나 사실상 독우산광대버섯과의 감별은 이루어지지 않았다. 4예에서는 원인버섯이 확인되지 않아 더 연구 되어야 한다. 사망례에서는 비사망군에 비해 혈소판이 유의하게 감소한 소견을 보였다. 전예에서 간이식등의 치료는 시행되지 않았으며 대부분 수액요법을 근간으로한 보존요법을 실시하였다. 결론: 한국의 amatoxins 중독증은 주로 강원 영서지역과 경북 일원에서 호발하고, 원인버섯은 외국과는 달리 독우산광대버섯과 개나리광대버섯이 주된 원인버섯이며, 1997년 까지의 증례보고를 대상으로한 70%의 사망률과는 달리 중등도 이상의 중독증례를 대상으로 하여도 사망률은 20%로 외국에 비해 높지 않다. 그러나 외국과 달리 간이식과 같은 보다 적극적인 치료를 시도한 예가 없는데, 대부분 갑자기 나빠지기 때문에 준비를 못하는 것이 원인이다. 따라서, 사망률을 더 낮추기 위해서는 혈액이나 소변과 같은 체액에서 단시간 내에 amatoxins을 측정할 수 있는 임상 검사법이 개발되어 조기 진단이 가능해져야 하며, 중독 초기에 나쁜 예후가 예측되는 심각한 증례를 선별하여 전문적인 치료를 받을 수 있는 기회를 제공해야 한다. 아울러 amatoxins 중독증에 대한 보다 정확한 통계를 산출하여야 할 것이다. 저자들은 본 연구에 1999년도에 발생한 대부분의 amatoxins 중독증의 증례가 포함되었으나 포함되지 않은 증례들이 다수 있다고 생각한다. 이러한 기초 조사를 철저히 하기 위해서는 전국 각지에서 발생하는 버섯중독 사고를 의뢰 또는 신고 할 수 있는 일원화 된 창구가 필요하리라고 사료된다. $quot;Background/Aims: From the review of Korean literature most fatal mushroom poisonings have been due to amatoxins with high mortality. So far there have never been investigations on the amatoxins poisonings such as annual incidence, mortality, common causal species, and endemic areas. This study was carried out to develop some basic statistics as part of studies for an effective management of amatoxins intoxications. Method: For the year 1999 authors collected cases of mushroom poisonings which had been mainly gathered from hospitals nation-wide. All of the cases with suggestive amatoxins poisonings were screened by symptomatology and laboratory findings. The causal species of mushrooms were identified grossly and microscopically. Results: A total of 54 victims with mushroom poisonings were evaluated. The causal mushroom toxins were diagnosed or strongly suggested as amatoxins in 43 of 54 victims. Eleven of 54 victims did not conform to the category of amatoxins intoxication due to absent or minimal elevation of aminotransferase. Mean age of the victims was 44.3 23.3 (range: 7-78) with male predominance (1.2 : 1). The causal species were confirmed, or strongly suggested, as Amanita virosa in 25 victims, Amanita subjunquillea in 14, and unknown species in 4. Thirty-five out of a total of 43 were regarded as moderate to severe intoxication (AST or ALT $gt; 1,000 IU/L) with 20% mortality. Most fatal victims showed marked thrombocytopenia (40,000 19,000/mm3) compared to non-fatal victims (109,066 42,245/mm3). A total of 88.4% of victims was developed in the Kangwon and Kyungpuk provinces. Both are west of the Taebaek Mountains (38/43). Conclusions: Although the common causal species for amatoxins poisonings in Korea are different from European countries and North America, the mortality is similar to that of those areas. In order to further reduce the mortality, bedside diagnostic methods using biological fluids and more effective herapy for liver failure should be established$quot;.

국민학교 아동에서 흡입성 항원 9종에 대한 피부단자시험 및 집먼지 진드기 ( D . Farinae ) 에 대한 특이 IgE 항체 검사 결과

안영민,최은영 대한천식알레르기학회 1990 천식 및 알레르기 Vol.10 No.3

To assess the prevalence of allergen sensitiz ation and know the significance of the positive reactions, we performed skin prick tests with 9 common aeroallergene in randomly aelected 6- 12 yearold 661 children at a school in Seoul and specific IgE antibody was checked in 197 children who showed larger than +++ skin reactions to Dermatophagoides farinae. The following results were obtained, 1. The overall positive reaction was observed in 53.1%(>=++), 42.4%o(>=+++) and a incre- sing positive reaction rate in relation to increasing age was apparent, but no difference in the prevalence was found among boys and girls. 2. The most common allergen which caused positive skin reactions was D.farinae (44.3%) followed by D.pte ronyssinus (40.7%), house dust (33.7%), cat fur (32.7%), dog hair (20.0%), Alternaria (15.3%), mugwort (8.6%), ragweed (6.5%) and cockroach (5.7%) 3. The reaction which was same or larger than the wheal size of histamine reference( ++ +) is better related to allergic symptoms than over ++ reactions. 4. Positive skin test reaction was positively aasociated with history of allergic histories and artificial feeding. 5. D.farinae specific IgE antibody was found to correlate closely with skin prick test in randomly selected schoolchildren as an overall positivity of 81.2% was observed with +++ SPT reaction. Also the titer of RAST is increased according to the presence of allergic histories. Such a high positive skin reactivities and RAST positioty suggests the significant prevalence and sensitization of house dust mite in general childhood population in Seoul and the possibility of increasing allergic disease. Also, when the result of positive skin reaction and RAST is interpreted, we must include correlationg history and provocation test before we apply the result to the patient. Because there are asymptomatic populaton with position SPT and RATST.

국민학교 아동에서 흡입성 항원 9종에 대한 즉시형 피부반응 및 집먼지 진드기에 대한 특이 IgE 항체의 검사결과

안영민,최은영,육정위 대한천식알레르기학회 1988 추계학술대회 초록집 Vol.1988 No.-

소아 결핵 진단에 있어서 결핵 특이항원자극 인터페론 감마 측정검사의 임상적 의의

안영민,이희우,박화영,손근찬 대한소아감염학회 2010 Pediatric Infection and Vaccine Vol.17 No.2

Purpose : The purpose of this study is to evaluate the usefulness and limitation of QuantiFERON-TB Gold (QTB) for diagnosis of latent tuberculosis in children. Methods : The medical records of 112 children who were tested by tuberculin skin test (TST) and QTB for detection of latent tuberculosis (TB) in Eulji General Hospital during the period from January 2007 to June 2009 were retrospectively reviewed. Results : Of the 112 participants, the clinical TB group included 15 (13.4%), the contact group included 43 (38.4%), and the non-contact group included 54 (48.2%). Positive rates of TST and QTB were 100% and 80% in the clinical TB group, 64%and 14% in the close contact group, 27% and 0% in the casual contact group, and 52% and 2% in the non-contact group,respectively. Sensitivity of QTB was 80.0% and specificity was 92.6%. Agreement between QTB and TST was poor (κ=0.209). We also confirmed that the positive rate of QTB increased as the age of the patient increased (P =0.011). A QTB indeterminate result was observed in 11 (9.8%) subjects. QTB was retested in 15 subjects. In 5 of the 6 subjects who had positive results initially, positive results persisted for a median 2.2 months after termination of treatment. Conclusion : Although QTB was associated with several problems, including low sensitivity and a high rate of indeterminate results, it had clinical importance due to its high specificity. We found good correlation with regard to exposure and QTB positivity, including that of young children under 5 years of age. However, clinical application of interferon-γ releasing assay for young children for diagnosis of active and latent tuberculosis will require additional prospective studies. 목 적 : 본 연구는 소아에서 QuantiFERON-TB Gold (QTB) 검사의 임상적 유용성과 문제점을 평가하기 위해 시행되었다. 방 법: 2007년 1월부터 2009년 6월까지 본원에서TST와 QTB를 시행 받은 소아청소년 112명의 의무 기록을 후향적으로 조사하였다. 결 과: TST와 QTB의 양성률은 각각 59.8%, 15.2%였고, 두 검사의 일치도는 낮았다(κ=0.209). QTB의 민감도와 특이도는 각각 80.0%, 92.6%였다. QTB 양성율은 임상적 결핵군, 긴밀 접촉군, 일반 접촉군, 비접촉군에서 각각 80%, 14%, 0%, 2% 였으며, 판정보류의 빈도는 9.8%였다. QTB 추적 관찰이 시행된 환자 중, 초기QTB 양성이었던 6명 중 5명은 치료 종료 후 평균 2.2개월까지 양성이 지속되었다. 결 론:소아에서 QTB는 민감도가 낮고, 판정보류의빈도가 높다는 단점이 있으나, 특이도가 높은 장점이 있으므로, TST의 특이도가 낮은 점을 보완하여 결핵의 진단 및 치료 결정에 활용될 수 있을 것으로 생각된다.

어린이 급성기관지염의 예방과 치료

安永敏 藥業新聞社 1991 (月刊) 醫藥情報 Vol.1991 No.2

Thyroid function in obese Korean children and adolescents: Korea National Health and Nutrition Examination Survey 2013–2015

안영민,문순정,김순기,서영주,이지은 대한소아내분비학회 2018 Annals of Pediatirc Endocrinology & Metabolism Vol.23 No.3

Purpose: In recent years, there has been an increasing focus on thyroid function in pediatric obese patients, but no nationwide study evaluating the relationship between thyroid function and obesity has yet been conducted in Korea. We aimed to evaluate thyroid dysfunction in obese Korean children. Methods: We analyzed the associations between obesity and thyroid hormone levels among 975 Korean boys and girls aged 10–18 years and who participated in the Korean National Health and Nutrition Examination Survey VI (2013–2015). Results: Average serum thyrotropin (TSH) and serum free thyroxine (fT4) levels in the nonobese group were 2.7±0.1 µIU/mL and 1.3±0.0 ng/dL, respectively, and those in the overweight group were 3.1±0.2 µIU/mL and 1.2±0.0 ng/dL. Serum TSH level was significantly higher in the abdominal obesity group than in the normal group (P=0.023). fT4 level was significantly lower in both the overweight and abdominal obesity groups than in the normal group (P<0.001, P=0.014). Serum TSH level was associated positively with abdominal obesity and levels of high-density lipoprotein cholesterol and triglyceride. Serum fT4 level was negatively correlated with abdominal obesity (P=0.014). Conclusion: Korean children with abdominal obesity showed increased TSH and decreased fT4 levels compared to normal children.

편도 및 아데노이드 절제에 대한 고찰 내시경의 유용성에 대하여

안영민,김미정,신윤정,문여옥,동은실,장성희 대한소아알레르기호흡기학회 1999 Supplement Vol.9 No.2

N/A

뇌동맥류 수술결과의 분석

안영민,조경기,조기홍,윤수한,안영환 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

This study was conducted to evaluate the overall outcome after intracranial aneurysm surgery operated at the Ajou University Hospital in 17-month period from June 1994 to October 1995. We operated 110 intracranial aneurysms from 96 patients. Two to fourteen months follow-up revealed 63 cases(57.3%) of good outcome, 14 cases(12.7%) of fair outcome, 14 cases(12.7%) of poor outcome, and 19 cases(17.3%) of dead outcome or discharge against advise. There was close relationship between the preoperative Hunt and Hess grade and outcome. The rate of good outcome in patients with Grade I, II, and III was 80.0%, 68.6%, and 65.0% respectively, while it was 24.4% in patients with Grade IV. There was no statistical difference of the rate of good outcome between patients operated at 0 to 3 days, 41010 days, .and 11 days or more after subarachnoid hemorrhage. The cause of poor outcome in order of frequency were initial hemorrhagic insult, hydrocephalus, intraoperative vascular occlusion, delayed ischemic deficits, and subdural hygroma.