Atypical Unilateral Posterior Reversible Encephalopathy Syndrome Mimicking a Middle Cerebral Artery Infarction

lkay Çamlıdag,조양제,박미나,이승구 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.5

Posterior reversible encephalopathy syndrome (PRES) is usually a reversible clinical and radiological entity associated with typical features on brain MR or CT imaging. However, the not-so-uncommon atypical radiological presentations of the condition are also present and they may go unrecognised as they are confused with other conditions. Here, we report a very rare case of atypical, unilateral PRES in a 49-year-old uremic, post-transplant female patient who presented with seizures. Initial MRI showed high-grade occlusion of the left middle cerebral artery (MCA) and lesions suggestive of subacute infarction in the ipsilateral frontotemporoparietal lobe. Patient symptoms had resolved a day after the onset without any specific treatment but early follow-up CT findings suggested hemorrhagic transformation. Follow-up MRI performed 2 years later showed complete disappearence of the lesions and persisting MCA occlusion.

Maulana and sekanjabin (oxymel): a ceremonial relationship with gastronomic and health perspectives

Orhan Halil İbrahim,Yılmaz İlkay,Tekiner İsmail Hakkı 한국식품연구원 2022 Journal of Ethnic Foods Vol.9 No.-

Sekanjabin , also known as  Oxymel , is an ancient beverage including honey, fermented vinegar, water, and various fruits and herbs. Great physicians Hippocrates, Galen, and Avicenna recommended treating gastrointestinal disorders, pain, asthma, thoracic, cough, sore throat, foul, and breath. Furthermore, Maulana, a symbol of tolerance that is humanism-flexible and non-violent, frequently mentions this beverage in his great masterpieces “ Divan-ı Kebir ” and “ Masnavi .” Therefore, it can be evaluated as an intangible cultural heritage of Western and near Asian civilizations and has a significant and ceremonial role in Maulana and Maulawi Culture. From a gastronomic and health perspective, this study explored the ceremonial relationship between Maulana and sekanjabin.

Comparison of two different lung ultrasound imaging protocols in COVID-19 pneumonia

Korgün Ökmen,Durdu Kahraman Yildiz,Emel Soyaslan,İlkay Ceylan,Halil Erkan Sayan,Cihan Sedat Aytünür 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.1

Purpose: The aim of this study was to determine the effectiveness of two different lung ultrasonography (LUS) methods that can be used in the diagnosis of coronavirus disease 2019 (COVID-19) and to investigate their correlations with computed tomography (CT). Methods: In this prospective, randomized, and single-blind study, 60 patients with COVID-19 were included. The patients were randomized to either the 12-zone LUS group (n=30) or the 14- zone LUS group (n=30). The correlation between LUS and thoracic CT scores was evaluated. As a secondary outcome measure, the characteristic features of the findings of thoracic CT and LUS were examined. Results: The study was completed with a total of 59 patients. Moderate and high correlations were found between the total CT and LUS scores in the 12-zone and 14-zone study groups. There were no statistically significant differences in the lesion types detected in patients using LUS and CT (P>0.05). The left lung lower lobe CT scores were statistically significantly lower in the 14-zone study group than in the 12-zone group (P=0.019). The left lower lobe CT and LUS scores were highly correlated in the 14-zone group (P<0.001, r=0.902). Conclusion: The results of our study indicated that the two different LUS examination methods performed in different patients had similar findings in terms of the diagnosis and their correlations with CT results. Purpose: The aim of this study was to determine the effectiveness of two different lung ultrasonography (LUS) methods that can be used in the diagnosis of coronavirus disease 2019 (COVID-19) and to investigate their correlations with computed tomography (CT).Methods: In this prospective, randomized, and single-blind study, 60 patients with COVID-19 were included. The patients were randomized to either the 12-zone LUS group (n=30) or the 14-zone LUS group (n=30). The correlation between LUS and thoracic CT scores was evaluated. As a secondary outcome measure, the characteristic features of the findings of thoracic CT and LUS were examined.Results: The study was completed with a total of 59 patients. Moderate and high correlations were found between the total CT and LUS scores in the 12-zone and 14-zone study groups. There were no statistically significant differences in the lesion types detected in patients using LUS and CT (P>0.05). The left lung lower lobe CT scores were statistically significantly lower in the 14-zone study group than in the 12-zone group (P=0.019). The left lower lobe CT and LUS scores were highly correlated in the 14-zone group (P<0.001, r=0.902).Conclusion: The results of our study indicated that the two different LUS examination methods performed in different patients had similar findings in terms of the diagnosis and their correlations with CT results.

Geological and mineralization characteristics of the Kestanelik epithermal Au-Ag deposit in the Tethyan Metallogenic Belt, NW Turkey

Nilay Gülyüz,Erhan Gülyüz,Zoe K. Shipton,İlkay Kuşcu,Richard A. Lord 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.4

Kestanelik epithermal gold deposit is situated in the Biga Peninsula, which hosts numerous metallic deposits belonging to the Tethyan Metallogenic Belt. In the Biga peninsula the Tethyan Metallogenic Belt is represented by a Neo-Tethyan suture zone. Discovered deposits along the belt are commonly associated with Cenozoic magmatism ranging between 52 and 18 Ma in age, formed due syn- to post-collisional tectonics. In this study, we focus on the deposit-scale geological and mineralization characteristics of Kestanelik in order to determine the formation and evolution of the deposit within the tectono-magmatic history of the Biga Peninsula. We (1) mapped the geology of the deposit area (2) conducted paleostress analyses, (3) observed and examined the macroscopic and petrographical textural, mineralogical and alteration characteristics of the mineralization and (4) interpreted geophysical resistivity survey and geochemical assay data. The stratigraphic age of the Kestanelik deposit, bracketed by cross cutting relations and supported by the geophysical data, is middle Lutetian–early Priabonian which also implies that the deposit has a genetic link with the Cenozoic post-collisional calc-alkaline magmatism. A NE-SW oriented compressional regime determined from the paleostress analyses is consistent with the kinematics of the vein system and is attributed to the collision and further convergence after the closure of the northern branch of the Neo-Tethys Ocean. The fracture system provided structural pathways for the transport of the hydrothermal fluids. The common presence of pseudo-bladed quartz and hydrothermal breccias, and the low total sulphide and base metal contents in the mineralized veins indicate that the Kestanelik is a low sulphidation epithermal-type gold deposit. Boiling, mixing (hypogene oxidation) and supergene enrichment are the likely gold deposition and enrichment processes respectively.

Management and Outcome of Intracranial Dural Arteriovenous Fistulas That Have Caused a Hemorrhage in the Posterior Fossa : A Clinical Study

Rıfat Akdag,Uğur Soylu,Ergün Dağlıoğlu,İlkay Akmangit,Vedat Açık,Ahmet Deniz Belen 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6

Objective : We evaluated the diagnosis, treatment, and long-term results of patients with dural arteriovenous fistula (dAVF), which is a very rare cause of posterior fossa hemorrhage. Methods : This study included 15 patients who underwent endovascular, surgical, combined, or Gamma Knife treatments between 2012 and 2020. Demographics and clinical features, angiographic features, treatment modalities, and outcomes were analyzed. Results : The mean age of the patients was 40±17 years (range, 17–68), and 68% were men (11/15). Seven of the patients (46.6%) were in the age group of 50 years and older. While the mean Glasgow coma scale was 11.5±3.9 (range, 4–15), 46.3% presented with headache and 53.7% had stupor/coma. Four patients (26.6%) had only cerebellar hematoma and headache. All dAVFs had cortical venous drainage. In 11 patients (73.3%), the fistula was located in the tentorium and was the most common localization. Three patients (20%) had transverse and sigmoid sinus localizations, while one patient (6.7%) had dAVF located in the foramen magnum. Eighteen sessions were performed on the patients during endovascular treatment. Sixteen sessions (88.8%) were performed with the transarterial (TA) route, one session (5.5%) with the transvenous (TV) route, and one session (5.5%) with the TA+TV route. Surgery was performed in two patients (14.2%). One patient (7.1%) passed away. While there were nine patients (64.2%) with a Rankin score between 0 and 2, the total closure rate was 69.2% in the first year of control angiograms. Conclusion : In the differential diagnosis of posterior fossa hemorrhages, the differential diagnosis of dAVFs, which is a very rare entity, should be considered, even in the middle and elderly age groups, in patients presenting with good clinical status and pure hematoma. The treatment of such patients can be done safely and effectively in a multidisciplinary manner with a good understanding of pathological vascular anatomy and appropriate endovascular treatment approaches.

The effect of local application of thymoquinone, Nigella sativa’s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis

Ayşe Yılmaz Baştuğ,Ceyda Özçakır Tomruk,Elif Güzel,İlkay Özdemir,Gonca Duygu,Esma Kütan,Gül Merve Yalçın Ülker,Fatma Özen Arıcı 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.3

Purpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG–infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.

Medium and Long-Term Data from a Series of 96 Endoscopic Transsphenoidal Surgeries for Cushing Disease

Buruç Erkan,Muhammed Bayındır,Ebubekir Akpınar,Osman Tanrıverdi,Ozan Haşimoğlu,Lütfi Şinasi Postalcı,Didem Acarer Bugün,Dilara Tekin,Sema Çiftçi,İlkay Çakır,Meral Mert,Ömür Günaldı,Esra Hatipoğlu 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.2

Objective : Postoperative data on Cushing’s disease (CD) are equivocal in the literature. These discrepancies may be attributed to different series with different criteria for remission and variable follow-up durations. Additional data from experienced centers may address these discrepancies. In this study, we present the results obtained from 96 endoscopic transsphenoidal surgeries (ETSSs) for CD conducted in a well-experienced center. Methods : Pre- and postoperative data of 96 ETSS in 87 patients with CD were included. All cases were handled by the same neurosurgical team between 2014 and 2022. We obtained data on remission status 3−6 months postoperatively (medium-term) and during the latest follow-up (long-term). Additionally, magnetic resonance imaging (MRI) and pathology results were obtained for each case. Results : The mean follow-up duration was 39.5±3.2 months. Medium and long-term remission rates were 77% and 82%, respectively. When only first-time operations were considered, the medium- and long-term remission rates were 78% and 82%, respectively. The recurrence rate in this series was 2.5%. Patients who showed remission between 3−6 months had higher longterm remission rates than did those without initial remission. Tumors >2 cm and extended tumor invasion of the cavernous sinus (Knosp 4) were associated with lower postoperative remission rates. Conclusion : Adenoma size and the presence/absence of cavernous sinus invasion on preopera-tive MRI may predict long-term postoperative remission. A tumor size of 2 cm may be a supporting criterion for predicting remission in Knosp 4 tumors. Further studies with larger patient populations are necessary to support this finding.