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      • KCI등재

        Cohort profile: congenital Zika virus infection and child neurodevelopmental outcomes in the ZEN cohort study in Colombia

        Maritza Gonzalez,Van T,Tong,Helena Rodriguez,Diana Valencia,Jacqueline Acosta,Margaret A,Honein,Martha L,Ospina1 The ZEN Study Team 한국역학회 2020 Epidemiology and Health Vol.42 No.-

        Zika en Embarazadas y Niños (ZEN) is a prospective cohort study designed to identify risk factors and modifiers for Zika virus (ZIKV) infection in pregnant women, partners, and infants, as well as to assess the risk for adverse maternal, fetal, infant, and childhood outcomes of ZIKV and other congenital infections. ZIKV infection during pregnancy may be associated with long-term sequelae. In the ZEN cohort, 1,519 pregnant women and 287 partners were enrolled from 3 departments within Colombia between February 2017 and January 2018, as well as 1,108 infants born to the pregnant women who were followed to 6 months. The data include baseline questionnaires at enrollment; repeated symptoms and study follow-up questionnaires; the results of lab tests to detect ZIKV and other congenital infections; medical record abstractions; infant physical, eye, and hearing exams; and developmental screening tests. Follow-up of 850 mother-child dyads occurred at 9 months, 12 months, and 18 months with developmental screenings, physical exams, and parent questionnaires. The data will be pooled with those from other prospective cohort studies for an individual participant data meta-analysis of ZIKV infection during pregnancy to characterize pregnancy outcomes and sequelae in children.

      • KCI등재

        Type 2 Autoimmune Pancreatitis: Consensus and Controversies

        Zen Yoh 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.3

        Autoimmune pancreatitis (AIP) has attracted much attention in the last two decades, and due to the diagnostic value of immunoglobulin G4 (IgG4), the number of cases diagnosed in clinical practice has markedly increased. However, in contrast to prototypic IgG4-related type 1 AIP, a minor subtype of AIP, referred to as type 2 AIP, is less widely known and has thus not yet been characterized in detail. Type 2 AIP is unrelated to IgG4 and is a completely distinct entity from type 1 AIP. One confusing factor is that the two types of AIP share patterns of clinical presentation (e.g., acute pancreatitis and painless jaundice) and imaging abnormalities (e.g., diffuse or segmental enlargement). Since there are currently no established serum markers, the diagnosis of type 2 AIP is highly challenging and requires the tissue confirmation of neutrophilic injury to the pancreatic ducts, a finding designated as a granulocytic epithelial lesion. Approximately one-third of cases are associated with inflammatory bowel disease, particularly ulcerative colitis; however, the pathological relationship between these two conditions has not yet been clarified. Unanswered questions relate to its pathophysiology, the potential development of a similar granulocytic injury in other organs, and the characteristics of pediatric cases. This review summarizes consensus and controversies surrounding type 2 AIP, with the aim of increasing awareness and highlighting the unmet needs of this underrecognized condition.

      • Superconducting Strip Ion Detectors for Time-of-flight Mass Spectrometer

        Zen, N.,Suzuki, K.,Shiki, S.,Ukibe, M.,Koike, M.,Casaburi, A.,Ejrnaes, M.,Cristiano, R.,Ohkubo, M. The Korean Superconductivity Society 2012 Progress in superconductivity Vol.14 No.2

        Superconducting detectors are promising as ion detectors for time-of-flight mass spectrometers (TOF MS). They can achieve mass-independent detection efficiency even for macromolecular bombardments, because output signals are produced through the deposited kinetic energy at ion impact instead of secondary electron emission that is the ion detection mechanism of conventional microchannel plate (MCP) detectors or secondary electron multipliers (SEM). Among the superconducting detectors, the superconducting strip ion detectors (SSIDs), which consist of several hundreds of superconducting lines with a width of a few hundreds nm and a thickness of a few tens of nm, have a fast response time of less than 1 ns. Inherently, the response time of SSIDs is determined by kinetic inductance, so that it was difficult to realize a fast SSID with a large detection area. However, we succeeded in realizing the detector size up to $5{\times}5mm^2$ without response time degradation by using a parallel configuration.

      • SCOPUSKCI등재

        역삼투압법에 의한 양파착즙액의 휘발성 성분 변화

        심재언(Zen Shim),전명희(Myeong-Hee Jeon ),이대희(Dae-Hee Lee),김영석(Yong-Seok Kim),이상미(Sang-Mi Lee),최정민(Jung-Min Choi),장은지(Eun-Ji Jang) 한국식품과학회 2019 한국식품과학회지 Vol.51 No.1

        비가열 방식의 역삼투압법으로 제조한 양파농축액의 휘발성 성분 변화를 알아보기 위하여 양파착즙액과 역삼투압 양파농축액을 SAFE로 휘발성 성분을 추출하였고, 이를 GC-MS로 분석하였다. 양파착즙액과 양파농축액에서 각각 48종과 62종의 휘발성성분을 동정하였다, 휘발성 성분 중 sulfur-containing compounds를 19종 검출하였고. 양파의 특징적인 향기성분으로 알려진 11종은 약 1.7-1,664배로 증가하였으며, 또한 양파착즙액에서 검출되지 않았던 휘발성 성분이 양파농축액에서 14종이 검출되었다. 이는 역삼투압법을 이용한 양파 농축액이 향미성분의 변성이 적어, 양파 고유의 향미를 갖는 농축액 제조에 응용할 수 있으며, 미량의 휘발성 성분을 분석하는 전처리 방법으로 바람직한 영향을 줄 것으로 생각한다. Reverse osmosis (RO) was applied to onion juice to produce concentrated onion juice with improved flavor. The volatile compound profiles of concentrated onion juice and onion juice were compared using solvent-assisted flavor evaporation followed by gas chromatography-mass spectrometry. Onion juice and RO-concentrated onion juice contained 48 and 62 distinct volatile compounds, respectively, and included alcohols, aldehydes, esters, terpenes, furans, ketones, acids, hydrocarbons, and sulfur-containing compounds. The RO-concentrated onion juice contained a greater number of volatile flavor compounds than did onion juice. Notably, sulfur-containing compounds, which are characteristic volatile flavor compounds in raw onions, were more abundant in the RO-concentrated onion juice than in onion juice. The volatile compound composition indicates that RO-concentration produces good quality onion juice.

      • KCI등재

        공기연장 또는 공기지연으로 인한 공법적 쟁점: 교육을 받을 권리와 계약자유의 원칙의 조화를 중심으로

        전지수 ( Zen Zi Soo ) 대한교육법학회 2018 敎育 法學 硏究 Vol.30 No.2

        건설공사 중에 공기연장 또는 공기지연이 발생하면 발주자 또는 수급인의 귀책사유여부에 따라 민사법적 해결이 가능하다. 하지만 공공공사의 경우에는 또 다른 공법적 문제로 점철될 수 있다. 대표적으로 학교공사의 경우 정해진 기일에 준공되지 않으면 정상적인 교육이 불가능해진다. 예컨대 학생들을 인근 학교로 임시배치 하는 문제, 입학과 등교를 못하는 문제, 그리고 학기 중 공사로 발생되는 안전문제 등이 있다. 이로 인하여 학교를 정해진 기일에 이용해야 될 주체인 학생에 대하여 불편 내지 쾌적한 교육환경에서 안전하고 ‘균등하게’ 교육을 받을 권리의 침해가 발생될 여지를 간과할 수 없다. 그렇다면 학교공사에서 공기연장 또는 공기지연으로 인하여 발생되는 문제로부터 학생의 교육을 받을 권리와 계약당사자 간의 계약자유의 원칙이 헌법현실에서 조화롭게 구현되기 위한 방향성은 무엇인지 검토하는 것이 본고의 목적이다. 이를 위해 학생, 발주자 또는 수급인의 입장을 종합적으로 고려하여 헌법적 과제를 도출하고 헌법이 지향하는 방향에 부합할 수 있는 입법을 제언하고자 하였다. If extension of the construction period or construction delay occurs during the construction work, civil legal settlement is possible depending on the reason of project owner or contractor. However, public construction leads to another public problem. Typically, in case of school construction, normal education can not be done unless it is completed on a fixed date. For example, temporary placement of students to a nearby school, lack of attendance and entrance to school, and safety problems during the school term. This may result in inconvenience to students who use school at a fixed date or infringement of their ‘equal’ right to receive an education in a pleasant and a safe educational environment. The right to receive an education the student and the liberty to contract between the contraction parties should be implemented harmoniously in the reality of the Constitution for the problems arising from extension of the construction period or construction delay at the school construction. To do this, draw a conclusion a constructional task considering the position of the student, project owner or contractor comprehensively, and propose legislation that meets the direction pursued by the Constitution.

      • KCI등재

        고등교육법상 인권센터 조사업무의 법적 성격에 관한 연구

        전지수(ZEN, ZI SOO) 대한교육법학회 2022 敎育 法學 硏究 Vol.34 No.1

        대학 모든 구성원의 인권을 보호하기 위한 목적으로 고등교육법 제19조의3과 동법 시행령 제9조의3이 신설되어 2022년 3월 24일부터 시행하게 되었다. 그래서 대학 인권센터는 인권 보호 및 권익 향상을 위하여 진정사건에 관한 조사업무를 수행한다. 그런데 고등교육법상 인권센터 조사업무의 법적 성격에 대한 논의는 부재한 상황이다. 검찰과 경찰이 범죄의 혐의 여부를 밝히거나 국가정보원이 안보를 위한 업무로서의 ‘수사’와 고등교육기관에서 발생된 인권침해행위 등 진정에 관한 인권센터의 ‘조사’는 법적 성격이 구분된다. 단, 인권보호기구인 국가인권위원회와 마찬가지로 대학 인권센터의 조사업무도 준사법적 성격을 내포한다. 그렇다면 인권센터의 조사업무는 목적 달성을 위한 최소한의 범위 내에서 진행되어야 함에도 불구하고, 진술 및 수집된 자료 등을 통해 지득된 사항 일체에 대하여 적법한 관리가 이뤄지지 않을 경우 조사대상자의 사생활의 자유 및 개인정보보호권 등을 침해할 여지가 있다. 이처럼 진정사건에 관한 조사는 수사와 다른 법적 성격을 갖기 때문에 명확한 범위와 한계의 설정이 요구되는 시점이다. 따라서 수사의 사법적 성격과 조사의 행정적 성격을 구분하여 살펴보고, 준사법적 성격을 갖는 인권센터 조사업무의 명확한 범위와 한계를 논증하여, 결과적으로 조사대상자의 인권을 보호할 수 있도록 법적 성격에 부합한 지도원리를 도출하는 것이 본 연구의 목적이다. From March 24, 2022, Article 19-3 of the Higher Education Act and Article 9-3 of the Enforcement Decree of the Higher Education Act were implemented in order to protect the human rights of all university members. Therefore, the University Human Rights Center conducts investigations on petition case. However, studies on the legal nature of investigations under the Higher Education Act are lacking. Investigations are the task of the prosecution and the police to reveal whether a crime is suspected or the National Intelligence Service for security purposes. Contrary to this, the investigation of the Human Rights Center on petition at universities is different from the legal nature. Like the National Human Rights Commission of Korea, a human rights protection body, the investigation work of the university Human Rights Center has a quasi-judicial nature. If so, the investigation work of the Human Rights Center should be carried out within the minimum scope to achieve the objective. This is because, if the data collected through the statements of the subject of investigation are not properly managed, the right to privacy and privacy will be violated. As such, the investigation of a petition case has a different legal nature from that of an investigation, so it is necessary to establish a clear scope and limit. Therefore, the judicial nature of the investigation and the administrative nature of the investigation are distinguished and examined. And the scope and limitations of the investigation work of the Human Rights Center were argued according to the quasi-judicial nature. As a result, the purpose of this study is to derive a guiding principle suitable for the legal nature to protect the human rights of the subject of investigation.

      • KCI등재후보

        Microstructure development and properties of alumina-Ti aluminide interpenetrating composites

        Ching Zen Han,Ian W.M. Brown,D.L. Zhang 한국물리학회 2006 Current Applied Physics Vol.6 No.3

        Interpenetrating phase Al2O3Ti3Al composites have been fabricated by reaction sintering of 2 and 4-h discus milled composite pow-ders containing Al and TiO2 using controlled heat-treatment in non-oxidizing atmospheres. Pressureless sintering and hot pressing of thepowders has been carried out under vacuum and argon at temperatures between 1278.C and 1500 .C and a heating rate of 5.C/min.pressing compared to pressureless sintering.The microstructure development and mechanical properties of dense Al2O3Ti3Al composites fabricated by hot pressing of AlTiO2powder blends were examined. Fully dense microstructures could be achieved by hot pressing at 1387.C under vacuum. An increase ofVickers hardness was observed with increasing temperature, which can be attributed to the increase of density and the decrease in the2O3particle size and porosity level. Fracture toughness of 6.3 ± 0.8 MPa m1/2 and Vickers hardness of 13.6 ± 0.4 GPa were achieved forthe fully dense composite produced by hot pressing discus milled powder.

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