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Transcriptomic analysis of endoplasmic reticulum stress in roots of grapevine rootstock
Aydemir Birsen Çakır,Ergül Ali 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.5
Grapevine roots are largely subjected to adverse environmental stresses. To maintain cellular hemostasis during different environmental conditions, cells develop reponse known as endoplasmic reticulum (ER) stress response. However, the cel- lular mechanism of grapevine rootstocks roots has not been studied in detail under conditions of ER stress. In this study, transcriptome analysis has been performed to determine ER-related transcripts in grapevine rootstock induced with tunica- mycin (TM) or dithiothreitol (DTT), causing proteins misfolding in ER, and consequently triggers ER stress. According to the results, 640 genes were expressed differently in the two treatment groups. Out of these, 397 transcripts were found to be associated with tunicamycin treatment. Among tunicamycin-responsive genes increased expression profiles were recorded for 287 genes while the remaining and 110 genes showed decreased expression profile. In contrast, in DTT-treated plants, a total of 557 genes were differentially expressed, 345 of which were upregulated, and 212 were downregulated. In addition, we identified 50 transcripts common to both TM and DTT treatments. TM and DTT treatments increased the expression of transcription factors, the hormone biosynthesis pathway genes. Gene ontology classified genes in groups involving protein folding, oxidative stress, protein phosphorylation, transmembrane transport, transcription and proteolysis regulation. Gene transcripts results revealed genes that may play a significant effect in the response to ER stress of rootstocks root. Considering the results reported here explaining the possible mechanisms of how plants adapt to environmental stresses, an important information gap has been bridged by providing new insights into the ER stress mechanisms in plant roots.
Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy
Nurullah Koç,ak,Bilge Eraydın,Mustafa Turunç,,Volkan Yeter,İ,nci Gü,ngö,r 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.6
Purpose: To evaluate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyteratio (PLR), and systemic immune-inflammation index (SII) in patients with non-arteritic anterior ischemic optic neuropathy(NAION). Methods: Fifty-six patients with NAION and 60 age-sex matched healthy controls were included in the study. Demographiccharacteristics and laboratory findings of the patients and the controls were obtained from the electronic medical records. NLR, PLR, MLR, and SII were calculated and compared between the groups. Cutoff values were also determined. Results: Neutrophil, monocyte and platelet counts were higher in the NAION group than in the control group, but the differencewas not statistically significant (p > 0.05). The mean NLR and SII were higher in the NAION group than in the controlgroup (p = 0.004 and p = 0.011, respectively). In the receiver operating characteristic curve analysis, the areas under thecurve for NLR were 0.67, and NLR >1.79 predicted NAION with a sensitivity of 71% and specificity of 59%. The areas under thecurve for SII was 0.66, and SII of >417 predicted NAION with a sensitivity of 71% and specificity of 49%. There was no significantdifference in PLR and MLR between the groups (p = 0.105 and p = 0.347, respectively). Conclusions: The current study demonstrated that NAION patients had increased NLR and SII levels compared with controlsubjects. Elevated NLR and SII might serve as readily available inflammatory predictors in NAION patients.
Karhan Mustafa,Çakır Musa Faruk,Uğur Mukden 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3
In this study, vented type water trees were initiated and grown in laboratory environment. A smart test platform was used to accelerate the initiation and growth of vented type water trees. 6 kV/4 kHz voltage was applied to the specimens to initiate and grow water trees. Mel-frequency cepstral coeffi cients of the vented type water tree images are obtained after 2 h and 10 h of aging respectively. The insignifi cant regions in the vented type water tree images were removed by using morphological fi ltering method before MFCC feature extraction. Finally, the statistical values of these features were analyzed. Scatter plots of the standard deviations and mean values of the cepstral coeffi cients were plotted. As expected, it has been observed that the points in the scatter plot are clustered in a certain area. MFCC is a popular and frequently used feature extraction method in speech recognition, however there are some studies which employs MFCC as a successful feature extraction method in image processing applications. This study provides a new approach to the analysis of vented water treeing using image processing techniques. The other new approach is using MFCC as a feature extraction method in microscopic water tree images.
Tardive Dyskinesia Associated with Bupropion
Taha Can Tuman,Uğur Çakır,Osman Yı ıd ldı ır rı ı m,Mehmet Akif Camkurt 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.2
Present report describes a 46 year old male patient with a diagnosis of major depression who developed tardive dyskinesia during bupropion therapy. Our patient had no history of neuroleptic use and his laboratory and neurologic examinations were normal. He had no family history of neurologic diseases. Although bupropion induced dyskinesia has been previously reported in the literature, it is rare and our case is the first case regarding tardive dyskinesia.
Ayşe Yılmaz Baştuğ,Ceyda Özçakır Tomruk,Elif Güzel,İlkay Özdemir,Gonca Duygu,Esma Kütan,Gül Merve Yalçın Ülker,Fatma Özen Arıcı 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.3
Purpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG–infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.
Sevil Albayrak,Biriz Çakır,Fatma Nisancı Kılınç,Ozge Vergili,Yurdagül Erdem 한국간호과학회 2018 Asian Nursing Research Vol.12 No.4
Purpose: The purpose of this study is to investigate adaptation, validity, and reliability of the Turkish version of the Child and Adolescent Social Support Scale for Healthy Behaviors (CASSS-HB). Methods: The CASSS-HB was translated using translation and back-translation. This was a methodological study conducted with 860 students (11-14 years old). Content and construct validity were assessed to test the validity of the CASSS-HB. Exploratory and confirmatory factor analysis of the scale was performed and the reliability of the scale over time (the test-retest method) was examined. Results: Psychometric analyses of the Turkish version of the CASSS-HB indicate high reliability and good content and construct validity. Conclusions: It can be seen that the items comprising the scale appear to be acceptably capable of measuring the variable of social support in terms of healthy behavior in children and adolescents. Healthcare professionals can thus use the scale for determining the degree of social support students of the ages 11-14 receive in terms of developing healthy behavior.
KIC 3858884: a hybrid<i>δ</i>Scuti pulsator in a highly eccentric eclipsing binary
Maceroni, C.,Lehmann, H.,da Silva, R.,Montalbá,n, J.,Lee, C.-U.,Ak, H.,Deshpande, R.,Yakut, K.,Debosscher, J.,Guo, Z.,Kim, S.-L.,Lee, J. W.,Southworth, J. EDP Sciences 2014 Astronomy and astrophysics Vol.563 No.-
Accessory Hepatic Lobe: A Rare Cause of Prehepatic Portal Hypertension in a Child
Elif Sağ,Mustafa İmamoğlu,Murat Çakır 대한소아소화기영양학회 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.4
Accessory hepatic lobe is noted as and considered a rare disease in children. It can manifest with various symptoms and complications depending on the location, volume, type and position of the disease as presented on a child. The patient presented as a 14-month-old girl who was seen with a notable hepatosplenomegaly and portal hypertension. A diagnosis was made after taking an extensive medical history, observation and radiological examinations. The formal diagnosis was a prehepatic portal hypertension associated with accessory hepatic lobe.