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      • Women's Perceptions and Attitudes about Cervical Cancer in Turkey: Kato's Device as an Alternative to the Pap Smear

        Sahin,,Mustafa,Kursat,Sahin,,Gulay,Dikici,,Mustafa,Fevzi,Igde,,Fusun,Artiran,Yaris,,Fusun Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Aims: To determine the status of women's perception and attitudes about cervical cancer and their thoughts on Kato's self-sampling device. Materials and Methods: This descriptive research was conducted between July-December 2012 with a study populationof married women older than 18 years. Results: A total of 246 women volunteered, with a mean age of $34.9{\pm}9.22$ (19-52). In the last year, 52.0% had been examined by a gynecologist to address a complaint or for a periodic health check. Of the 118 who had not had a gynecological examination, 42.4% indicated negligence, 26.3% stated the reason was no complaint, 14.4% feared they might receive bad results from the examination, and 8.5% stated that were shy or embarrassed. Of all of the women, 35.0% answered that they had information about cervical cancer, and 0.7% had heard about the HPV vaccine. No one in their families had received the vaccine. Of the women, 28.5% had had a Pap smear, and 71.4% of those had normal results. Of those who had never had a Pap smear, 47.2% had never heard about the test; 18.8% explained the reason for not having a test as shyness or embarrassment with a male doctor. None of the women had heard about Kato's device. Once the women were informed, 73.6% expresseed interest in use; 51.9% answered they could use it and not be embarrassed, 30.9% would use it because they did not have to see a doctor, and 17.1% would use it as it allows them to take a smear in all conditions and whenever they want. Of the women, 60.0% thought that they could not successfully use Kato's device; 40.0% thought that a smear should be taken by a doctor. Conclusions: Most of the women in our population had never had a Pap smear and wanted to use the Kato's device.

      • SCIESCOPUSKCI등재

        HOMOLOGY OF CONTACT CR-WARPED PRODUCT SUBMANIFOLDS OF AN ODD-DIMENSIONAL UNIT SPHERE

        Sahin,,Bayram,Sahin,,Fulya Korean Mathematical Society 2015 대한수학회보 Vol.52 No.1

        We show that homology group on a contact CR-warped product submanifold in odd dimensional sphere is zero under certain conditions in terms of warping function and the dimension of the submanifold.

      • SCIESCOPUSKCI등재

        Effects of Dietary Lycopene and Vitamin E on Egg Production, Antioxidant Status and Cholesterol Levels in Japanese Quail

        Sahin,,N.,Sahin,,K.,Onderci,,M.,Karatepe,,M.,Smith,,M.O.,Kucuk,,O. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.2

        Japanese Quails were used to evaluate the effects of dietary supplementation with vitamin E (dl-a-tocopheryl-acetate), lycopene, and their combination on egg production, egg quality, concentrations of malondialdehyde (MDA), vitamin E, A and cholesterol in serum and egg yolk. Quails (n = 120; 55 d old) were divided into four groups (n = 30/group) and fed a basal diet or the basal diet supplemented with lycopene (100 mg/kg diet), vitamin E (250 mg dl-${\alpha}$-tocopheryl-acetate/kg diet) or a combination of lycopene and vitamin E (100 mg/kg lycopene plus 250 mg dl-${\alpha}$-tocopheryl-acetate/kg diet). Vitamin E and lycopene did not affect (p>0.05) body weight, feed intake or egg weight. Egg production and Haugh unit were greater (p<0.05) in each supplemental group compared with the control group (p<0.05). Serum and liver MDA levels were decreased in supplemented groups compared with the control group. Separately or as a combination, supplemental lycopene and vitamin E increased serum and egg yolk vitamin E and A but decreased cholesterol concentrations (p<0.05). In general, when a significant effect was found for a parameter, the magnitude of the responses to vitamin and lycopene supplements was greatest with the combination of the lycopene and vitamin E, rather than that observed with each supplement separately. Results of the present study indicate that supplementing with a combination of dietary lycopene and vitamin E reduced serum and yolk cholesterol concentrations and improved antioxidant status.

      • SCIESCOPUSKCI등재

        Monte Carlo analysis of LWR spent fuel transmutation in a fusion-fission hybrid reactor system

        Sahin,,Sumer,Sahin,,Haci,Mehmet,Tunc,,Guven Korean Nuclear Society 2018 Nuclear Engineering and Technology Vol.50 No.8

        The aim of this paper is to determine neutronic performances of the light water reactor (LWR) spent fuel mixed with fertile thorium fuel in a FFHR. Time dependent three dimensional calculations for major technical data, such as blanket energy multiplication, tritium breeding ratio, cumulative fissile fuel enrichment and burnup have been performed by using Monte Carlo Neutron-Particle Transport code MCNP5 1.4, coupled with a novel interface code MCNPAS, which is developed by our research group. A self-sustaining tritium breeding ratio (TBR>1.05) has been kept throughout the calculations. The study has shown that the fissile fuel quality will be improved in the course of the transmutation of the LWR spent in the FFHR. The latter has gained the reusable fuel enrichment level conventional LWRs between one and two years. Furthermore, LWR spent fuel - thorium mixture provides higher burn-up values than in light water reactors.

      • KCI등재SCIESCOPUS

        Thermo-Electrical Properties in Pb-Sb Hypereutectic Alloy

        M.,¸Sahin,E.,Çadırlı,Y.,Sürme,D.,Özkır 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.3

        Pb-17 wt% Sb hypereutectic alloy was directionally solidified upward with three different growth rates (8μm/s, 18 μm/s, 42 μm/s, 166 μm/s and 497 μm/s) at a constant temperature gradient (3.6 K/mm) in the Bridgman-type growth apparatus. The dependence of characteristic microstructure parameters such as primary dendrite arm spacing (λ1) and secondary dendrite arm spacing (λ2) on the growth rate (V) were determined by using a linear regression analysis. Variations of electrical resistivity (ρ) for cast samples for temperatures in the range of 300-550 K were measured by using a standard dc four-point probe technique. The variations of thermal conductivity with temperature for the same alloys were determined from the WiedemannFranz and SmithPalmer equations by using the measured values of electrical resistivity. The enthalpy of fusion for the same alloys were determined by means of a differential scanning calorimeter from a heating trace during the transformation from solid to liquid. The corrosion resistance was analyzed by Tafel extrapolation and linear polarization resistance methods conducted in a 5% sodium chloride solution in contact with air maintained at room temperature. Effects of the growth rate on the electrical resistivity and corrosion resistance were also investigated.

      • KCI등재

        Zinc Picolinate in the Prevention of Leiomyoma in Japanese Quail

        Nurhan,Sahin,Mehmet,Tuzcu,İbrahim,Ozercan,Kazim,Sahin,Ananda,S.,Prasad,Omer,Kucuk 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6

        Epidemiologic studies suggest that zinc deficiency may be associated with increased risk of cancer. We investigated the effects of zinc picolinate supplementation on the development of leiomyomas, malondialdehyde (MDA), 8-isoprostane, 4-hydroxyalkenal (HAE), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, and heat shock protein 70 (Hsp70) expression in Japanese quails. One hundred fifty quails (6 months old) were assigned to three treatment groups consisting of 50 birds in each group. Birds were fed either a basal diet or the basal diet supplemented with 30mg or 60mg of zinc/kg of diet. The animals were sacrificed after 350 days, and the tumors were identified. Zinc picolinate supplementation did not affect the number of leiomyomas compared to control birds (P>.05). However, the tumors in zinc-fed birds were smaller than those found in control birds (P=.01) Serum MDA, 8-isoprostane, and HAE levels were lower in the treatment groups than in the control group: MDA, 1.95 versus 0.93μmol/L; 8-isoprostane, 108 versus 85pg/mL; HAE, 1.55 versus 0.96μmol/L (P=.01 for all three parameters). The concentrations of serum 8-OHdG, which is a marker of oxidative damage, in the groups were 28.5, 23.6, and 20.1ng/mL, respectively (P=.01). Hsp70 expression was significantly decreased in zinc-treated birds (P<.01). The results indicate that dietary zinc picolinate supplementation reduces the growth of spontaneously occurring leiomyomas of the oviduct in the Japanese quail. Clinical trials should be conducted to investigate the efficacy of zinc supplementation in the prevention and treatment of uterine leiomyoma in humans.

      • KCI등재

        Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens

        Kazim,Sahin,Engin,Yenice,Mehmet,Tuzcu,Cemal,Orhan,Cengizhan,Mizrak,Ibrahim,H.,Ozercan,Nurhan,Sahin,Bahiddin,Yilmaz,Birdal,Bilir,Bulent,Ozpolat,Omer,Kucuk 대한암예방학회 2018 Journal of cancer prevention Vol.23 No.1

        Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans. Methods: In this study, a total of 150 laying hens at age of 102 weeks were randomized into groups of 50: a control group (0 mg of lycopene per kg of diet) and two treatment groups (200 mg or 400 mg of lycopene per kg of diet, or ~26 and 52 mg/d/hen, respectively). At the end of 12 months, blood, ovarian tissues and tumors were collected. Results: We observed that lycopene supplementation significantly reduced the overall ovarian tumor incidence (P < 0.01) as well as the number and the size of the tumors (P < 0.004 and P < 0.005, respectively). Lycopene also significantly decreased the rate of adenocarcinoma, including serous and mucinous subtypes (P < 0.006). Moreover, we also found that the serum level of oxidative stress marker malondialdehyde was significantly lower in lycopene-fed hens compared to control birds (P < 0.001). Molecular analysis of the ovarian tumors revealed that lycopene reduced the expression of NF-B while increasing the expression of nuclear factor erythroid 2 and its major target protein, heme oxygenase 1. In addition, lycopene supplementation decreased the expression of STAT3 by inducing the protein inhibitor of activated STAT3 expression in the ovarian tissues. Conclusions: Taken together, our findings strongly support the potential of lycopene in the chemoprevention of ovarian cancer through antioxidant and anti-inflammatory mechanisms. (J Cancer Prev 2018;23:25-36)

      • KCI등재후보SCOPUS

        Effects of Dietary Lycopene and Vitamin E on Egg Production, Antioxidant Status and Cholesterol Levels in Japanese Quail

        N.,Sahin,K.,Sahin,M.,Onderci,M.,Karatepe,M.,O.,Smith,O.,Kucuk 아세아·태평양축산학회 2006 Animal Bioscience Vol.19 No.2

        Japanese Quails were used to evaluate the effects of dietary supplementation with vitamin E (dl-a-tocopheryl-acetate), lycopene, and their combination on egg production, egg quality, concentrations of malondialdehyde (MDA), vitamin E, A and cholesterol in serum and egg yolk. Quails (n = 120; 55 d old) were divided into four groups (n = 30/group) and fed a basal diet or the basal diet supplemented with lycopene (100 mg/kg diet), vitamin E (250 mg dl-慣-tocopheryl-acetate/kg diet) or a combination of lycopene and vitamin E (100 mg/kg lycopene plus 250 mg dl-慣-tocopheryl-acetate/kg diet). Vitamin E and lycopene did not affect (p>0.05) body weight, feed intake or egg weight. Egg production and Haugh unit were greater (p<0.05) in each supplemental group compared with the control group (p<0.05). Serum and liver MDA levels were decreased in supplemented groups compared with the control group. Separately or as a combination, supplemental lycopene and vitamin E increased serum and egg yolk vitamin E and A but decreased cholesterol concentrations (p<0.05). In general, when a significant effect was found for a parameter, the magnitude of the responses to vitamin and lycopene supplements was greatest with the combination of the lycopene and vitamin E, rather than that observed with each supplement separately. Results of the present study indicate that supplementing with a combination of dietary lycopene and vitamin E reduced serum and yolk cholesterol concentrations and improved antioxidant status.

      • Slide Session : OS-ONC-07 ; Oncology : Violence Among Cancer Patients in Eastern Turkey

        ( Hanim Guler Sahin ), ( Gulnihal Guvendi ), ( Huseyin Avni Sahin ), ( Dilek Kusaslan ), ( Erkan Dogan ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Health-care providers generally remain unaware of violence In Turkey and there are limited numbers of studies focuses on violence and there is no data regarding violence among cancer patients in Eastern Turkey. The aim of this study was to estimate the prevalence of violence and to investigate its related factors in Eastern Turkey. Methods: This cross-sectional descriptive study was performed in medical school of Yuzuncu Yil University, in Turkey. All patients who attended the medical oncology clinics were included in the study. The patients were interviewed face to face by a physician in complete privacy. Data were evaluated by using SPSS computer software version 21. Results: Between May and June 2014, all cancer patients attending the major tertiary hospital were included in this descriptive study. Of the 100 participants 61 (61%) were women 39 (39%) were men. 61 (%61) of the respondents were not able to read and write. 62 patients (62 %) were aware of his/her disease and 59 (96.7 %) of them had learned the disease from a physician. Main supporters were the daughters/son (41%) and couples (38%) during the illness. Although 16% were threatened to be abandon, 79% were afraid of being abandon. 45% of the patients thought that they were neglected. Only female patients stated physical violence and before the illness rate was 18% (100% by the male partner) and it decreased to 8% (87.5% by the partner and 12.5 % by the son) after the illness. Conclusions: Even though violence rate among cancer patients decreased during the illness period it is still a serious public health problem. Health-care providers should increase their awareness to protect the cancer patients from violence. Education and improvements in economic autonomy and society`s attitudes may also reduce violence towards cancer patients.

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