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Cyclopeptides from the Sponge <i>Stylissa flabelliformis</i>
Kwon, Oh-Seok,Kim, Chang-Kwon,Byun, Woong Sub,Oh, Joonseok,Lee, Yeon-Ju,Lee, Hyi-Seung,Sim, Chung J.,Oh, Dong-Chan,Lee, Sang Kook,Oh, Ki-Bong,Shin, Jongheon American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.6
<P>Three new cyclopeptides, phakellistatins 20-22 (<B>1</B>-<B>3</B>), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge <I>Stylissa flabelliformis</I>. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (<B>1</B>) and two epimeric cyclodecapeptides (<B>2</B> and <B>3</B>) related to the phakellistatins. The cyclopeptides were evaluated for <I>in vitro</I> cytotoxicity against a variety of cancer cell lines, and compounds <B>2</B> and <B>3</B> exhibited significant activity.</P> [FIG OMISSION]</BR>