http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yun Hyun Kim,Jeong Yeop Ryu,Joon Seok Lee,Seok Jong Lee,Jong Min Lee,Sang Yub Lee,허승,Ji Yoon Kim,Ho Yun Chung 대한성형외과학회 2021 Archives of Plastic Surgery Vol.48 No.6
Background Venous malformations (VMs) are the most common type of vascular malformations. Intramuscular venous malformations (IMVMs) are lesions involving the muscles, excluding intramuscular hemangiomas. The purpose of this study was to compare clinical outcomes between patients with IMVMs who were treated with sclerotherapy and those who were treated with surgical excision. Methods Of 492 patients with VMs treated between July 2011 and August 2020 at a single medical center for vascular anomalies, 63 patients diagnosed with IMVM were retrospectively reviewed. Pain, movement limitations, swelling, and quality of life (QOL) were evaluated subjectively, while radiological outcomes were assessed by qualified radiologists at the center. Complication rates were also evaluated, and radiological and clinical examinations were used to determine which treatment group (sclerotherapy or surgical excision) exhibited greater improvement. Results Although there were no significant differences in pain (P=0.471), swelling (P=0.322), or the occurrence of complications (P=0.206) between the two treatment groups, the surgical treatment group exhibited significantly better outcomes with regard to movement limitations (P=0.010), QOL (P=0.013), and radiological outcomes (P=0.017). Moreover, both duplex ultrasonography and magnetic resonance imaging showed greater improvements in clinical outcomes in the surgical excision group than in the sclerotherapy group. Conclusions Although several studies have examined IMVM treatment methods, no clear guidelines for treatment selection have been developed. Based on the results of this study, surgical excision is strongly encouraged for the treatment of IMVMs.
( Sang-yeop Lee ),( Sung Ho Yun ),( Geul Bang ),( Chang-seop Lee ),( Seung Il Kim ) 한국질량분석학회 2021 Mass spectrometry letters Vol.12 No.3
Scrub typhus is an acute febrile disease caused by the pathogenic bacterium Orientia tsutsugamushi, belonging to the Rickettsiaceae family. The shotgun proteomic analysis was performed using the sera of scrub typhus patients to identify the proteins having their origin in O. tsutsugamushi. Three different databases approaches were used for the identification of the proteomes. We identified the RsmD, an RNA methyltransferase as the commonly detected protein from all three approaches. This protein was not detected in the sera of healthy negative controls. We believe that this protein is a potential biomarker of Orientia tsutsugamushi present in the sera of scrub typhus patients.
( Yun Peng Wang ),( Goung Ran Yu ),( Mi Jin Lee ),( Sang Yeop Lee ),( In Sun Chu ),( Sun Hee Leem ),( Dae Ghon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Backgrounds/Aims: Lipocalin-2 is preferentially expressed in hepatocellular carcinoma. However, the functional role of Lcn2 in HCC progression is still poorly understood, particularly with respect to its involvement in invasion and metastasis. The purpose of this study was to investigate whether Lcn2 is associated with the EMT change of HCC and to elucidate its signaling pathway. Methods: Lcn2 mRNA expression was confirmed by RT-PCR analysis. Lcn2 protein expression was investigated by immunohistochemistry or Western blot analyses. The proliferation, migration, and invasion ability were measured by MTT, wound healing and invasion assays in HCC cells (SH-J1) stably expressing Lcn2. Tumor growing and metastasis by Lcn2 was tested in vivo animal model. Results: Lcn2 is preferentially expressed in well differentiated HCC versus liver cirrhosis tissues, and its expression is positively correlated with the Edmondson differentiation grade of HCC. The characteristics of EMT are reversed by adenoviral transduction of Lcn2 into SH-J1 cells, including the down-regulation of N-cadherin, vimentin, a-SMA, and fibronectin, and the concomitant up-regulation of CK8, CK18, and desmoplakin I/II. Knock-down of Lcn2 by shRNA in HKK-2 cells highly expressing Lcn2 was associated with EMT change. EGF or TGF-β1 treatment resulted in down-regulation of Lcn2, subsequently accompanied by Twist1 expression and EMT change in HCC cells. Stable Lcn2 expression in HCC cells reduced Twist1 expression, led to inhibition of cell proliferation and invasion in vitro, and suppressed tumor growth and metastatic ability in a mouse model. Furthermore, EGF or TGF-β1 treatment barely changed EMT marker expression in the SH-J1 cells ectopically expressing Lcn2. Ectopic expression of Twist1 induced EMT marker expression even in cells expressing Lcn2, indicating that Lcn2 functions downstream of growth factors and upstream of Twist1. Conclusions: These findings suggest that Lcn2 can negatively modulate the EMT change in HCC cells through the EGF (or TGF-β1)/Lcn2/Twist1 pathway. Thus, Lcn2 may be a candidate metastasis suppressor and a potential therapeutic target in HCC.
A Tutorial for Energy-efficient Communication for XMPP-based Internet of Things
Sung-Chan Choi,Jaeho Kim,Jaeseok Yun,Il-Yeop Ahn 한국산학기술학회 2013 SmartCR Vol.3 No.6
This paper introduces the Extended Messaging Presence Protocol and shows how it is adapted to support the small and power-constrained devices that will make up the Internet of Things by requiring low energy consumption. Soon, everything in the world will be connected via the Internet, from simple machines to humans. Every machine that we can see in our surroundings, such as the air conditioner, heater, or even home electricity meter will have a communication and network hardware module installed to be a part of the Internet of Things. So, machines will produce data to be delivered to service users of the Internet of Things who needed the data. In this communication and network paradigm, it is considered that the Extended Messaging Presence Protocol is a good candidate for connecting machines and delivering messages among them. In addition, the Extended Messaging Presence Protocol provides real-time communication and network accessibility to the devices in private network as well. However the Presence message of the Extended Messaging Presence Protocol causes a large amount of network traffic overhead. Therefore, small, battery-powered Internet of Things devices would consume a great deal of energy in a short period of time. So this paper provides an energy-efficient communication scheme based on the Extended Messaging Presence Protocol for resource constrained devices.
Routine barium enema prior to closure of defunctioning ileostomy is not necessary
Sung Yeon Hong,Do Yun Kim,Seung Yeop Oh,Kwang Wook Suh 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.2
Purpose: The use of barium enemas to confirm the anastomotic integrity prior to ileostomy closure is still controversial. The purpose of the study was to determine the utility of routine contrast enema prior to ileostomy closure and its impact on patient management in patients with a low pelvic anastomosis. Methods: One hundred forty-five patients had a temporary loop ileostomy constructed to protect a low colorectal or coloanal anastomosis following low anterior resection for rectal cancer. All patients were evaluated by physical examination, proctoscopy, and barium enema prior to ileostomy closure. Results: The median time from ileostomy creation to closure was 8 months. Five (3.5%) of the 144 patients were found to have clinically relevant strictures at the colorectal anastomosis on routine barium enema. One patient (0.7%) showed anastomotic leak on their barium enema. Overall, 141 patients (97.9%) had an uncomplicated postoperative course. Postoperative complication occurred in three patients (2.1%). None of them showed abnormal barium enema finding, which suggested that routine contrast enema examination did not predict postoperative complication. Conclusion: Routine barium enema evaluation of low pelvic anastomoses before loop ileostomy closure did not provide any additional information for postoperative colorectal anastomotic complication.