자궁외임신 216례

남상욱,송재경,최종호,홍순도,이종학,허광현,박일영 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

This study was undertaken to review the case series of 216 ectopic pregnancies admitted to the Department of Obstetrics and Gynecology, Pohang Sunrin Hospital from January, 1990 to December, 1991. The incidence of ectopic pregnancy was relatively high, being found to be 1 in 34.4 delivery cases. On the symptomatology, low abdominal pain was encountered in 96.8 percent, amenorrhea in 93.5 percent and vaginal bleeding in 16.2 percent in order. The fallopian tube was the most frequently, being found to be 98.6 percent, followed by the ovary with 0.9 percent and the cervix with 0.5 percent.

마우스 종양발생에서 Nitric Oxide의 역할에 관한 연구 Ⅲ : Helicobacter pylori에 의해 유발된 마우스 위암에서 염증매개인자의 역할 The role of inducible nitric oxide synthase and cyclooxygenase-2 in H. Pylori-associated gastric carcinogenesis

남기택,오상연,조현무,이국경,강진석,제정환,최미나,한상욱,김대용,장동덕,양기화,안병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

feficotorfer fyf☞ri(Hp)가 위암파 관련이 있다는 역학적인 증거는 많이 있지만 이에 대한 정확한 기전에 대해선 밝혀져 있지 않고 있으며 실험동물 모델도 적절하지 못한 것으로 알려져있다. 본 실험에서는 위암의 원인으로 알려져 있는 f, fyforf'(Hp)를 이용하여 마우스에서 위암 모델을 확립하고 만성염증과정 중에 생성되는 리0와 COX-2 등의 발현이 위암발생에 미치는 명향을 통하여 예방과 치료를 위한 점근을 시도하고자 하였다. 마우스를 7군으로 나누어서 1, 2, 3, 4군의 등물은 MNU를 증류수에 200ppm 농도로 음수병득 이용하띤 10주간 격주로 투여하였으며 MHU 음술 투여 1주 휴씩 후 배양한 f. fyrofi 를 약 109cru/rfll 로 맞춰 한 마리당 0.1ml 씩 이틀 간격으로 세 번에 걸쳐 하룻방 금식시킨 1, 2, 3, 5, 6, 7군기 마우스의 위장에 투입하떴다. 균 투입을 마친 후 다응 날부터 2군쏙 6군은 iNOS 억제제인 aminoguanidine(AG)을 음수병으로 툰여하였으며 3군과 7군은 COX-2 척제제인 nimesulide(NSD)를 투여하였다. 위의 종양발생양상을 샅최보면 bfNU와 Hp만을 투여한 1 관 ; (hfNU +Hp), 2군 : iNO을 inhibitor 투여군(MNU+HP+AG'1. 3군 ;CO딘-2 Inilibitor 투여군(MNU누Hp누 NSD), 4군 ,MNlf 단독투여군, 5군 ;Hp 단독투여춘, 6군 ; 러p 단독에 AG투여군, 7군 , Hp 단독에 NSD투여군의 종양발샐을은 각각 쁜.Bff(l1/16), 70.6%f12/ti), 했.9ff(7/18), 10%(1/10), Off(O/IS)0%(O/S), 0%(O/5)의 발쟁율을 보여 iNOS 억제제인 AC은 좁양발생을 억계하지 못하였으며, COX-2억제제인 NSD 는 종양발생을 유의적으로 감소시켰다. 콩양발생개수에서는 2.62±0.36, 1.41츠0.14, 0.44 르0.12, 0.10±0.10을 보여 AC와 NSD에서 유의성 있게 발생개수를 줄였다. Hp 단독투여에 의해즌는 종양발생이 나타나지 않았으며 HP+AG, Hp+ IfSD 추여군에콕 시험증료 시점에 약물에 의해 Hp의 제균효과가 있는지의 여부를 확인끓기 위하여 PCR을 이용하여 확인한 결과 모두 양성인 것으로 나타나 Hp의 제균효과에 의한 촐양발생 억제가 일어나지는 않았다. 위의 결과로 볼 때 Hp는 위암발생을 촉진하는 것으로 나타났고 딘p 감염시 매개되는 염증인자를 억제하였을 때 종양발생을 억제하는 것으로 위암 발생에서 염증매개인자는 종양을 촉진하는 것으로 나타났으며 it,705 억제제쓱 COX-』 억제제의 위알 예밭효과fl는 효과적일 것으로 사료된다 In spite of a large volume of epidemiological evidence indicating significant relationship between H. pylori infection and gastric adenocarcinoma, a doubt still exists on an elevated risk of stomach cancer by H. pylori infection due to lack of direct evidence of their exact mechanistic link. It is, therefore, essential to have an appropriate animal model for detailed analysis of the role of H. pylori played in gastric carcinogenesis. There is a wealth of evidence to support that over production of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) is involved in the pathogensis of various cancer in both rodents and humans. The aim of this study was to establish a mouse model for H. pylori-associated gastric carcinogenesis and to identify the role of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) played during the gastric carcinogenesis in mice. Eighty-three specific pathogen free, six-week-old male C57BL/6 mice were randomly divided into seven groups. Animals of the group 1, 2, 3, 4 were given MNU in their drinking water at the concentration of 200 p.p.m. for total five cycles of one-week regimen with one-week pause. After completion of MNU administration, they were given autoclaved distilled water for one weeks, and groups 1, 2, 3, 5, 6, 7 were inoculated with H. pylori. After completion of H. pylori. inoculation, groups 2 and 6 were given aminoguanidine in their drinking water at concentration of 1000p.p.m. and animals of group 3 and 7 were given the diet containing 200 ppm nimesulide at 12 weeks of age. All animals were killed at 50 weeks of age. The incidences of the glandular stomach tumors in the group 1, 2, 3 and 4 were 87.5%(14/16), 76.4%(13/17), 44.4(8/18), 10.0%(1/10), respectively and the tumor incidence of group 3(MNU→Hp+nimesulide) was significantly lower than those of group 1(MNU→Hp) at the value of P<0.01. The average numbers of tumors of group 2(MNU→Hp+AG : 1.41±0.24) and group 3(MNU→Hp+nimesulide : 0.44±0.12) were significantly lower than those of group 1(MNU→Hp : 2.62±0.36) at the value of P<0.05. Therefore, overproduced iNOS and COX-2 plays an important role in mice gastric carcinogenesis. We concluded iNOS and COX-2 inhibitor have good effects on gastric carcinogenesis.

MWPC 위치검출기의 X-선 천체물리학에의 응용

남욱원,최철성,문신행,강희동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

1983 년경 국내에서도 과학탐사 로케트와 인공위성이 발사될 예정에 있으며 이에 따라 X-선 천체물리학을 위한 방사선 센서의 국내 개발이 시급히 요청되는 바이다. 따라서 현재 방사선계측에 많이 이용되고 있는 방사선 센서들 중 국내에서 개발되어온 MWPC위치검출기를 소개하고 인공위성 혹은 과학탐사로케트에 탑재되어 X-선 천체물리학연구에 이용될 경우 연구 개발되어 나가야 할 방향을 제시하고자 한다. Domestic sounding rocket and scientific satellite are scheduled to launch around 1993. The development of radiation sensor is required to observe X-rays coming from celestial bodies by the use of those space vehicleS. In this study we introduce the multi-wire position sensitive detector and the future works of onboard detector for X-ray astrophysics.

천체 관측용 대면적 X-선 비례계수관의 개발(I)

남옥원,최철성,문신행 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1

In order to observe celestial X-ray sources, we are going to develop a large area proportional counter as a payload of space vehicles such as sounding rocket, balloon and scientific satellite. In this study, we reviewed the proporties of X-ray sources and cosmic background, and we studied the conceptual design for a large area proportional counter.

제주도 양식넙치, Paralichthys olivaceus의 스쿠티카충병 발생 동향

진창남,이창훈,오상필,정용욱,송춘복,이제희,허문수 한국어병학회 2003 한국어병학회지 Vol.16 No.2

The research was carried out to know the occurrence trend of scuticociliatosis and mortality of fingerlings in flounder. The diseased fish were collected from on-land rearing farms and hatcheries of flounder in Jeju Island form January 1991 to December 2001. Occurrence of scuticociliatosis was about 10% of total occurred diseases for 1991 to 1996, but increased to 34.5% in 2001. Although monthly occurrence of seuticociliatosis was not related to season from 1999 to 2001, the highest occurrence was revealed in July and August. Mixed infections of bacteria including Vibrio sp., Edwardsiella tarda, Streptococcus sp., and Flexibacter sp., with seuticociliates were observed. Among the bacteria, Vibrio sp., was the highest frequency(40.1%), and the lowest one(10.1%) was Streptococcus sp., Mortality of fingerlings by seuticociliates was different sharply according to size of fish. Mortality of infected fingerlings below 7㎝ of total length was 53.8%, while that of normal fingerling above 7㎝ of total length was 13.2%. When fish were grown above 25㎝, mass mortality by seuticociliates infection was decreased markedly.

초기 성공적인 심폐소생술후 혈청 Interleukin-6 농도의 발현양상

박규남,박승현,황두영,김형국,이환,최경호,이원재,정욱성,김학주,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Objective : To investgate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL-6 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR). Methods : We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2, 4, 12, 24, 48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay. Results : Serum IL-6 concentrations in the severe neurolgically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurolgic disabled group showed dual peak at 4 and 24 hours. Conclusion : Our study demonstrates significant increase of serum IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.

초내식성 스테인리스강의 교정용 브라켓에의 적용

추성욱,김경남,김광만,이원유,박용수,이상배 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3

Esthetic has become an indispensable factors to consider when choosing a orthodontic fixed appliances. However, most of the brackets used on orthodontics are made of metallic materials because those esthetic alternatives showed several controversies like brittleness, deformation and discoloration. The AISI austenitic classes, 303, 304, 316 and 317 type of stainless steels are frequently used for orthodontic metallic brackets fabrication. The composition of this type of alloy is 18 wt% of chrome, 8 wt% of nickel, 2 to 3 wt% of molybdenum and low carbon contents. They seemed to show relatively good characteristics to fabricate the orthodontic brackets in previous study. But in hostile condition such as low pH containing chlorine ion like saliva they might to be attacked by localized corrosion. The purposes of this study were to evaluate the microstructure, microhardness, corrosion resistance, frictional resistance and cytotoxocity of 316L(MD), AISI 304(AC) and experimentally produced super stainless stell bracket(SS). The results from this study were as follows; 1. MD and AC showed (Cr, Fe)23C6 precipitating in austenite matrix. SS showed small ferrite island forming in matrix. 2. SS showed the highest polarization resistance(Rp). SS seemed to have the highest corrosion resistance since SS showed 0.9 ×10-3 MPY, MD showed 3.7 ×10-3 MPY and AC showed 7.4×10-3 MPY. 3. The friction resistance decreased from 3 days to 4 weeks for SS(p<0.05). MD showed significant differences for the measurement of 3 days, 2 weeks and 4 weeks. AD did not showed significant differences to 3 days but increased at 2 weeks(p<0.05). 4. SS seemed to have the best biocompatibility since SS showed response index of 0/1 (mild), AC showed 1/2 (mild+) at cytotoxicity test. According to these results, SS seemed to have sufficient characteristics to fabricate the orthodontic brackets and superior corrosion resistance compare to AISI 300 type stainless steel which could lower the chance of nickel allergic reaction.

전국 관청의 금연프로그램 실시 현황과 문제점

이상욱,오희철,이지전,김태욱,허남욱 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

The purpose of this study is to investigate the conditions and problems of anti-smoking education programs in government offices for civil servants. A mail-in survey was carried out for the chief of the general affairs of 248 government offices. 1. There were 154 responses to the surveys. Only 34 govermental offices have carried out anti-smoking education programs for civil servants. 2. Only one office has a department to supervise an anti-smoking program. 17 offices have 1 worker and thirteen offices have no manpower to supervise anti-smoking program. 3. Only eight offices have budgeted for anti-smoking programs. The average budget was 3,750,000Won. Expected budget for smoking cessation program was 7,500,000 Won. 4. 25 offices have an anti-smoking lecture program for civil servants. Only five offices have an anti-smoking counseling services for smokers. 5. Only seven surveys responded that civil servants had a positive response to anti-smoking programs. 6. The most important problem of anti-smoking programs in governmental offices was the lack of concern of civil servants. Governmental offices have to provide the greatest administrative services and services concerning the quality of life for citizens. Anti-smoking education programs in governmental offices for civil servants was the beginning of an activity of the services concerning the quality of life for citizens. Governmental offices have to actively implement anti-smoking programs for civil servants.

水稻의 登熟向上에 關한 硏究

諸商律,李寅杰,김랑춘,李準琸,張南日,洪鍾旭 慶北大學校 1974 論文集 Vol.18 No.-

This study was made to get the cultural information for increasing yield with recently improved variety, investigating the effects of different transplanting date and seed size, the number of plant per hill on the growth, and the yield and yield components in rice. The results obtained were summaried as follows: 1. In larger seed, the percentage of germination was higher and the early growth was more vigorous. However, there appeared no effects of seed size in the later growing period. 2. When the young plants sown on April 26 were transplanted on 5th, 15th, 25th of June and 5th of July with 10-days interval, the heading date was promoted in earlier transplanted plots. The days to heading, however, was shortend. 3. In the case of the earlier transplanting in Tongil variety, the maximum number of tillers was increased, the percentage of effective tillers was decreased, and the rate of ripened grains was slightly higher. The yield was the highest in the transplanted plot of June 25. The next came the transplanted plots of 25th, 5th of June and 5th of July. In the early transplanted plot of Palkweong variety, heading was also promoted. The days required for heading were also proportionly shortend, the number of the effective tillers was smaller and the percentage of ripened grains also decreased. The productivity was the highest in transplanted plot of June 25. 4. When the number of plants per hill was increased, the heading date was promoted, the number of panicles was high and the number of grains per panicles was decreased. In the early transplanting of Tongil variety, the yields was the highest in 4-plants plot. When transplanted late, it was the highest in 6-plant plot. In Palkweong variety, there was general tendency of increasing of yield as the number of plants per hill increased. 5. The dwarf disease of Tongil variety and the stripe disease of Palkweong variety occurred much in case of the lesser number of plants per hill and the earlier transplanting.

Al₂O₃-TiO₂ 복합체의 기계적 및 열적 특성에 미치는 MgO의 첨가효과

박재성,이상욱,남효덕 영남대학교 재료기술연구소 2000 재료기술연구 Vol.1 No.1

Aluminum titanate(Al₂O₃TiO₂ ) was known to low thermal expansions over wide temperature ranges, but showed poor mechanical properties. The present studies have been concerned with the thermal and mechanical properties of aluminum titanate based on the ceramics containing MgO. The addition of MgO powder to Al₂O₃-TiO₂ inhibited the grain growth and this result can be increased sintering density and vickers hardnes s. The thermal expansion of Al₂TiO_(5) increased with the addition of MgO and also increased with temperature up to 1000℃, however, it decreased in the temperature range between 1000℃ and 1200℃ during heating. The test of thermal shock showed that the addition of 10 wt% MgO generated macrocrack of 25%.