피로를 유발하는 등속성 수축시와 회복기 혈중젖산 및 외측광근의 EMG Power Specturm 변화

정정진,조현철,김기진,윤성원,오수일,홍관이,손태열 龍仁大學校 體育科學硏究所 1991 體育科學硏究論叢 Vol.1 No.1

To examine the change of blood lactate concentration, EMG power spectrum, and Torque during fatiguing isokinetic contraction and recovery phrase, 6 sprinters performed maximal isokinetic knee extension at angular velocity of 3.14 rad.sec??(180°sec??) to 75% decreasing point (25%PT) using CybexⅡ system. In exercise phase, there was significant correlation between the decrement of peak EMG and median frequency and that of torque, and decrement of torque was greater than that of EMG . In recovery phase, EMG was restituded as normal value rapidly in a minute, but torque was restituded more slowly, and blood lactate concentration increased gradually from 50%PT to 3 minute after recovery. As a result of this study, it is suggested that muscle fatique due to decreasing of metabolic substrate and accumulation of metabolic products in peripheral site of muscle, and that inhibitory factors act neuromuscular junction in the end of exercise from rapid restitution of EMG in recovery phase.

국가-기업관계와 경제적 성과

金時潤,金正烈 慶一大學校 1999 論文集 Vol.16 No.4

The consequences of state-business relations and economic performance are disprted. The general presumption is that when the state and business have close relation, economic performance will be reduced. According to Mancur Olson, capitalists and their allies tend to forn distributional coalitions that pressure the government to divert resources to them and away from their most efficient and socially optimal use. Anne Krueger condludes that close relations between the state and business cause economic dissiipation because they both squander rents and invest more resources in pursuit of them. In contrast to them, institutional analyses of development have often concluded that relations between business and the state accouont for the variation in economic performance. Alice Amsden concludes that the more reciprocity that characterizes state-firm relations, the higher the speed of economic growth. Peter Evans also concludes that close ties between tha state and business is the key to the development state's effectiveness. Therefore, close business-state relations either can enhance economic performnce or can degenerate into unproductive, rent-seeking activity. What matters is the quality of relations, not the extent of relations. If so, what makes some state-business relations effective, growth-oriented networks while others devote themselves to rent-seeking? The presence of strong, encompassing business associations and transparency are necessary condijtions. And equally inportant is the autonomy of the state.

교정용 미니스크류의 디자인에 따른 식립 및 제거 토오크

차정열,윤태민,황충주 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.1

교정용 미니스크류의 원추 형태가 식립 후 시기별 안정성에 미치는 영향을 알아보기 위해, 시기별 제거 토오크 및 동요도와 조직시편분석을 시행하였다. 성견 6마리의 하악 협측골에 원통형과 원추형 교정용 미니스크류(Biomaterials Korea, Seoul, Korea) 48개를 식립하고, 식립 시 식립 토오크와 동요도를 측정하고 3주, 12주 동안 교정력을 부여한 후, 제거 시 제거 토오크와 동요도를 측정하였다. 식립 토오크는 원통형 미니스크류에서 13.6 Ncm, 원추형 미니스크류에서 22.3 Ncm로 원추형 미니스크류에서 높은 식립 토오크가 측정되었다 (P < 0.001). 식립 3주째 제거 토오크는 원통형 미니스크류에서 5.7 Ncm, 원추형 미니스크류에서 9.1 Ncm로 유의한 차이가 관찰되었다(P < 0.05). 식립 12주째 원추형 미니스크류의 제거 토오크는 3.6 Ncm로 유의하게 감소하여(P < 0.05) 원통형 미니스크류의 4.2 Ncm와 유의한 차이를 보이지 않았다. 이상의 결과로 미니스크류의 원추 구조는 식립 토오크를 유의하게 증가시켜 식립 후 3주간 안정성에 도움이 되었으나, 12주 후 안정성에 있어서는 원통형 미니스크류와 유사하였음을 시사한다. Objective: This study was designed to analyze the primary and secondary stability characteristics of orthodontic mini-screws of tapered design when compared with the cylinder mini-screw. Methods: A total of 48 mini-screws were placed into the buccal alveolar bone of the mandible in 6 male beagle dogs. Comparison was made between tapered and cylinder type mini-screws (Biomaterials Korea, Seoul, Korea). Maximum insertion torque (MIT) was measured using a torque sensor (Mark-10, MGT50, USA) during installation, and maximum removal torque (MRT) was recorded after 3 and 12 weeks of loading. Results: Taper mini-screws showed a higher MIT value of 22.3 Ncm compared with cylinder mini-screw showing 13.6 Ncm (P < 0.001). The MRT of the taper mini-screw showed a significantly higher value of 9.1 Ncm than those of cylinder mini-screw of 5.7 Ncm at 3-weeks after installation (P < 0.05). However, there was no difference in the MRT value between the taper and cylinder mini-screws at 12 weeks of loading. Conclusions: These results showed that the high insertion torque of the taper mini-screw design increases initial stability until 3 weeks of loading, but does not have any effect on the secondary stability at 12 weeks of loading.

Kinetics and Mechanism of the Axial Ligation of Hemin. Activation Volume for the Dissociation of Imidazole from Monoimidazole Complex in N,N-Dimethylformamide

김정성,박윤열,HIROSHI TOMIYASU 大邱大學校附設 基礎科學硏究所 1993 基礎科學硏究 Vol.10 No.-

Unusual kinetic behavior was observed in the substitutions of hemin with imidazole and cyanide ion under conditions of [L] S 2[hemin] (L=substituting ligand) in N,N--dimethylformamide. The rates of these reactions were much slower than those the formations of mono- and bis-coordinate complexes. Based on the kinetic results, these slow reactions were interpreted in terms of the dissociations of mono-coordinate complex to solvated hemin. The activation volume was determined to be 24.3 -- 0.4 cm3 mol'1 for the reaction with imidazole by the high pressure stopped flow method. The large positive value of the activation volume strongly supports a limiting dissociative mechanism.

퍼지 이론을 이용한 해저면 분류 기법

조진석,윤관섭,박순식,나정열,석등우 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-

음파를 이용한 해저면 분류를 위하여 2003년 5월 19-25일까지 남해해역에서 음향 실험을 실시하였다. 실험 해역은 해저 구성물질이 각기 다른 6개의정점을 선정하였으며 5개의 주파수(30,50,80,100,12 kHz)를 이용하여 해저면 반사 신호를 측정하였다. 또한 피스톤 코어를 이용하여 해저 퇴적물의 입도분석을 실시하였다. 해저면의 분류를 위해서는 펴지 이론(fuzzy logic)을 사용하였으먀, 이때의 입력 소속함수(input membership function)는 주파수 종속성을 갖는 해저면 반사손실 모텔(HYBRL, Hanyang University Bottom Reflection Loss)이 이용되었으며 출력 소속함수(out membership function)는 해저면의 평균입도 값으로 출력되도록 구성하였다. 퍼지이론을 통해 역산된 평균입도(mean grain size)와 코어 분석 자료를 비교하여 퍼지이론을 이용한 해저면 분류 방법의 가능성을 확인하였다. Acoustic experiments are performed for seafloor classificaton from 19 May to 25 May 2003. The six differnet sites of bottom composition are settled and the bottom reflecton losses with frequencies(30, 50, 80,100,120 kHZ) are measured. The fuzzy logic is used to classify the seabed. In the fuzzy olgic, HYBRL(HanYang Univ. Bottom Refleciton Loss) of frequency dependence is used as a input Membership functions and the output membership functions are composed of the values of the mean grain size of the bottom. The possibility of the seafloor classsification is verified comparing the inversed mean grain size using fuzzy logic with the results of the coring.

금호강수계 수질과 하천유역의 토양 및 농작물의 중금속루 오염에 관한 연구(II)

金相烈,李萬正,趙康烈,崔閏壽,石敬順,禹美姬,李蘭姬 대구효성 가톨릭 대학교 1984 연구논문집 Vol.29 No.2

Soil are mostly sandy and it has a little clay below 10%. In the fine sand fraction, quartz, plagioclase and alkali-feldspar are dominant in almost all samples. Small amounts of altered-feldspar, muscovite, biotite, hornblende and plant opal are present in some samples. They are mainly derived from weathering prodructs df granite, granodiorite and arkose or is mixture. The clay minerals are mainly expanding or nonexpanding 14A˚minerals, illite and kaolin minerals. Nonexpanding 14A˚minerals seems to be dioctahedral vermicurite which sandwiches gibbsite or chlorite.

교정력 부하시기에 따른 교정용 미니 임플란트의 안정성

이승연,차정열,윤태민,박영철 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

본 연구는 미니 임플란트 식립 후 교정력 부하시기와 관련하여 임플란트 주위골의 치유과정을 조사하였다. 성견8마리의 하악 협측골에 교정용 미니 임플란트(ORLUS, Ortholution CO, Korea) 48개를 식립한 후 교정력을 주지 않은 대조군과 식립 후 즉시 교정력을 준 즉시 부하군, 그리고 식립 후 3주간의 치유기간을 두고 교정력을 준 지연 부하군으로 나누어 각각의 군에 대해 3주, 6주, 12주가 경과된 시점에 임플란트 주위골의 변화를 조직 계측학적으로 관찰하였다. 골 접촉률은 즉시 부하군에서 시기에 따른 유의한 변화가 없었으며 지연 부하군은 3주에 비해 12주에서 유의하게 증가하였다 (p < 0.05). 각 시점에서 군 간의 골 접촉률을 비교했을 때 12주째 지연 부하군이 즉시 부하군보다 유의하게 높았다 (p < 0.05). 골 면적비율은 즉시 부하군의 경우, 시기에 따른 유의한 변화가 없었으며, 지연 부하군과 대조군은 6주에 비해 12주째 유의한 증가를 보였으며 (p < 0.05), 12주째 실험군 간에 유의한 차이는 관찰되지 않았다 (p > 0.05). 동요도는 12주째 즉시 부하군과 지연 부하군 간에 유의한 차이는 없었다 (p > 0.05). 위의 결과에서 즉시 부하가 self drilling형 미니 임플란트 주위골의 안정성에 부정적인 영향을 주지 않았으므로 식립 즉시 교정력을 부여하여 사용하는 데 임상적으로 문제가 없을 것으로 판단된다. Objective: The purpose of this study was to investigate the stability of mini-implants in relation to loading time. Methods: A total of 48 mini-implants (ORLUS, Ortholution, Korea) were placed into the buccal alveolar bone of the mandible in 8 male beagle dogs. Orthodontic force (200 - 250 gm) was applied immediately for the immediate loading group while force application was delayed for 3 weeks in the delayed loading group. For the subsequent loading periods (3, 6, 12 weeks), BIC (bone implant contact) and BV/TV (bone volume/total volume) and mobility test were carried out. Results: The immediate loading group showed no changes in BIC from 3 to 12 weeks, while the delayed loading group showed a significant increase in BIC between 3 and 12 weeks (p < 0.05). The BV/TV of the delayed loading group significantly increased from 6 to 12 weeks of loading (p < 0.05), while the BV/TV of the immediate loading group decreased from 3 to 12 weeks of loading. However, there was no significant difference in BV/TV between experimental groups. The mobility of the immediate loading group was not significantly different from that of the delayed loading group after 12 weeks of loading (p < 0.05). Conclusions: These results showed that immediate loading does not have a negative effect on the stability of mini-implants compared to the early loading method in both the clinical and histomorphometric point of view.

고주파 해저면 반사손실의 주파수 종속성 측정

박순식,최지웅,윤관섭,나정열 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.5 No.-

During the last several decades, although there have been lots of efforts to develope the high-frequency bottom reflection loss model, the frequency dependence of bottom loss was not considered in most cases because the sea bottom was assumed to be generally much smoother and lower gradient than the sea surface. However, if the sea bottom is rougher than acoustic wavelength, the scattered field will be increased and the reflected field will be decreased. In this paper, the high-frequency bottom reflection losses were obtained through the measurement of reflected waves from the artificially-made-flat sandy bottom. The experimental data were compared with the values calculated by the forward loss model of Mourad & Jackson. Conseouently, we suggest the frequency dependence of bottom reflection loss. 기존 해저면 반사손실 모델들은 해저면을 해수면에 비해 거칠기와 경사도가 매우 평탄하거나 완만한 경계면으로 가정하므로 주파수에 따른변화를 고려하지 않거나 미약하다고 가정하였다. 그러나 고주파를 사용하는 소오나 시스템의 경우, 음파의 파장에 비해 해저면이 거칠다면 음파는 산란 영향이 증가하게 되므로 상대적으로 반사손실 또한 증가하게 된다. 따라서 본 논문에서는 임의로 모의된 사질 성분의 해저면에서 수십 ㎑ 이상의 고주파들을 사용하여 주파수별 반사손실을 계산하고, 이를 기존의 해저면 반사손실 모델과 비교하였으며, 해저면 반사손실의 주파수 종속성을 제시하고자 한다.

개량된 초임계수 산화법에 의한 염소계 유기물 (PCB, 4-DCBz)의 완전분해반응

이상환,박기철,박윤열,양종규,김정성,富安博 한국환경과학회 2005 한국환경과학회지 Vol.14 No.5

For the destruction of toxic chlorinated organic compounds, this study proposes improved supercritical water oxidation method (multistep oxidation) using sodium nitrate as an oxidizer. This method solves the problems involved in the existing supercritical water oxidation method. Multistep oxidation means that NaNO₃ is oxidized to N₂ via NaNO₂ and NO. Toxic and hard to destroy organic substances like para-dichlorobenzen(4-DCBz), polychlorinate biphenyl(PCB) ware oxidized to non toxic substances in a condition, in which rapid pressure and temperature rise is restrained as much as possible. 4-dichlorobenzene(4-DCBz) and Polychlorinate biphenyl(PCB) in condition(450℃, p_(w)=0.25g/cm³, 30min) Was discomposed perfectly.

Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide

Jung‑Woo Bae,Kyung‑Yul Oh,So‑Jung Yoon,Hyo‑Bin Shin,Eui Hyun Jung,Chang‑Keun Cho,Chang Woo Lim,Pureum Kang,Chang‑Ik Choi,Choon‑Gon Jang,Seok‑Yong Lee,Yun Jeong Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.11

Metoclopramide inhibits the central and peripheralD2receptors and is frequently prescribed in adults andchildren as an antiemetic or a prokinetic drug to controlsymptoms of upper gastrointestinal motor disorders. Metoclopramideis predominantly metabolized via N-dealkylationand it is primarily mediated by CYP2D6 which is highlypolymorphic. Thus, the effects of CYP2D6 genetic polymorphismon the pharmacokinetics of metoclopramide wereevaluated in this study. All volunteers were genotyped forCYP2D6 and divided into four different genotype groups(CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10). Each subjectreceived a single oral dose of metoclopramide 10 mg. Plasma concentrations of metoclopramide were measuredby using HPLC-UV. Compared to CYP2D6*wt/*wt, AUC infof CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10significantly increased by 1.5-, 2.3-, and 2.5-fold, respectively. Cmaxalso increased significantly in comparison toCYP2D6*wt/*wt across all genotype groups, with 1.5-, 1.7-, and 1.7-fold increases seen in CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10 groups, respectively. The CL/F of metoclopramide decreased in CYP2D6 genotypegroups with decreased function alleles, as decreasesof 37%, 56% and 61% were observed in CYP2D6*wt/10,*10/10, and *5/*10 genotype groups in comparison to theCYP2D6*wt/*wt group. In conclusion, the genetic polymorphismsof CYP2D6 significantly affected metoclopramidepharmacokinetics.