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Genetical and Pathological Studies of the Gracile Axonal Dystrophy(gad) Mice
Suh, Jun-Gyo 가톨릭의과학연구원 2000 가톨릭 의과학연구원 국제학술대회 Vol.4 No.-
The gracile axonal dystrophy (gad) mouse is an autosomal recessive mutant that shows sensory ataxia at an autosomal recessive mutant that shows wensory ataxia at an early stage, followed by motor ataxia at a later stage. Pathologically, the mutant is characterized by 'dying-back' type axonal debeneration and formation of spheroid bodies in nerve terminals.