殺戮與救贖的兩難抉擇 -余華和金英夏的父權意識比較分析

정동매 ( Dong-mei Zheng ),김학철 ( He-zhe Jin ) 중국어문연구회 2015 中國語文論叢 Vol.0 No.72

There are two similar features about Jin Yingxia, a writer from South Korea and Yu Hua from China. Both of them explore the thing of death in aesthetic style, and they also get the critical consciousness to fathers. This paper takes their novels as sample to study the features and differences of patricide consciousness in these works, to analyze the patricide impulsion and perplexity of these young writes who grew in cultural atmosphere of patriarchal system and matured in industrialized society of great change, and then reveals their introspection and seeking on social order. The two writers both grew in East Asian society with background of traditional Confucian culture, but because of different social system and culture, there are profound differences in their understanding on fathers. Jin Yingxia denied the capitalistic New Order based on interest relationship, but he still hovered in imaginative reconstruction of ideal society, while Yu Hua focused on history by revealing tininess of individual. The figure of fathers are ridiculed and deleted in Jin’s novels, while investigated and blamed in Yu’s work. As contemporary writers, they both took themselves in a contradiction of patricide impulsion and fear of lost their fathers. That is, when they attempted the new possibility of patricide consciousness, it’s hard to hide their restlessness and anxiety, and then showed their intention to do redemption for their fathers.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

Synergistic Effects of Leflunomide and Benazepril in Streptozotocin-Induced Diabetic Nephropathy

Jin, Hua,Piao, Shang Guo,Jin, Ji Zhe,Jin, Ying Shun,Cui, Zhen Hua,Jin, Hai Feng,Zheng, Hai Lan,Li, Jin Ji,Jiang, Yu Ji,Yang, Chul Woo,Li, Can S.Karger 2014 The Nephron Journals Vol.126 No.3

<P>Abstract</P><P><B><I>Background:</I></B> Leflunomide (LEF) and benazepril have renoprotective effects on diabetic nephropathy (DN) through their anti-inflammatory and anti-fibrotic activities. This study investigated whether combined treatment using LEF and benazepril affords superior protection compared with the respective monotherapies. <B><I>Methods:</I></B> Diabetes was induced with streptozotocin (STZ, 65 mg/kg) by intraperitoneal injection in male Wistar rats. Two weeks after STZ injection, diabetic rats were treated daily for 12 weeks with LEF (10 mg/kg), benazepril (10 mg/kg), or a combination of both. Basic parameters (body weight, fasting blood glucose level, and 24 h urinary protein excretion), histopathology, inflammatory [inflammatory cell infiltration (ED-1), monocyte chemoattractant protein-1 (MCP-1), and Toll-like receptor-2 (TLR-2)] and glomerulosclerotic factors [transforming growth factor-β<SUB>1</SUB> (TGF-β<SUB>1</SUB>) and connective tissue growth factor (CTGF)], and oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-OHdG) were studied. <B><I>Results:</I></B> Benazepril or LEF treatment significantly prevented body weight loss and 24 h urinary protein excretion induced by diabetes; combined treatment with LEF and benazepril further improved these parameters compared with giving each drug alone (all p < 0.01). Increased expression of inflammatory (MCP-1 and TLR-2) and glomerulosclerotic (TGF-β<SUB>1</SUB> and CTGF) factors in diabetic rat kidney was reduced by treatment with either LEF or benazepril and was further reduced by the combined administration of the two drugs (p < 0.01). These effects were accompanied by suppression of urinary 8-OHdG excretion. There was no significant between-group difference in blood glucose level. <B><I>Conclusions:</I></B> LEF treatment lessens DN, and combined treatment with LEF and benazepril provides synergistic effects in preventing DN.</P><P>© 2014 S. Karger AG, Basel</P>

L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

( Hai Yan Zhao ),( Hui Ying Li ),( Jian Jin ),( Ji Zhe Jin ),( Long Ye Zhang ),( Mei Ying Xuan ),( Xue Mei Jin ),( Yu Ji Jiang ),( Hai Lan Zheng ),( Ying Shun Jin ),( Yong Jie Jin ),( Bum Soon Choi ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0

Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would provide renoprotection in a rat model of unilateral ureteral obstruction (UUO) and in vitro. Methods: Sprague-Dawley rats that underwent UUO were treated daily with LC for 7 or 14 days. The influence of LC on renal injury caused by UUO was evaluated by histopathology, and analysis of gene expression, oxidative stress, mitochondrial function, programmed cell death, and phosphatidylinositol 3-kinase (PI3K)/ AKT/forkhead box protein O 1a (FoxO1a) signaling. In addition, H₂O₂-exposed human kidney cells (HK-2) were treated with LC. Results: LC treatment inhibited expression of proinflammatory and profibrotic cytokines, and was followed by a significant attenuation of tubulointerstitial inflammation and fibrosis. The increased oxidative stress caused by UUO was associated with mitochondrial dysfunction and excessive apoptosis and autophagy via PI3K/AKT/FoxO1a-dependent signaling, and this was abrogated by administration of LC. In H₂O₂-exposed HK-2 cells, LC decreased intracellular production of reactive oxygen species, and suppressed expression of profibrotic cytokines and reduced the number of apoptotic cells. Conclusions: LC protects against the progression of tubulointerstitial fibrosis in an obstructed kidney.

Role of peripheral vestibular receptors in the control of blood pressure following hypotension

Jin, Guang-Shi,Li, Xiang-Lan,Jin, Yuan-Zhe,Kim, Min Sun,Park, Byung Rim The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4

Hypotension is one of the potential causes of dizziness. In this review, we summarize the studies published in recent years about the electrophysiological and pharmacological mechanisms of hypotension-induced dizziness and the role of the vestibular system in the control of blood pressure in response to hypotension. It is postulated that ischemic excitation of the peripheral vestibular hair cells as a result of a reduction in blood flow to the inner ear following hypotension leads to excitation of the central vestibular nuclei, which in turn may produce dizziness after hypotension. In addition, excitation of the vestibular nuclei following hypotension elicits the vestibulosympathetic reflex, and the reflex then regulates blood pressure by a dualcontrol (neurogenic and humoral control) mechanism. In fact, recent studies have shown that peripheral vestibular receptors play a role in the control of blood pressure through neural reflex pathways. This review illustrates the dual-control mechanism of peripheral vestibular receptors in the regulation of blood pressure following hypotension.

Molecularly Imprinted Solid-Phase Extraction of Caffeine from Green Tea(Short Communication)

Jin, Yin-Zhe,Row, Kyung-Ho 한국공업화학회 2006 Journal of Industrial and Engineering Chemistry Vol.12 No.3

A Revocable Fingerprint Template for Security and Privacy Preserving

( Zhe Jin ),( Andrew Beng Jin Teoh ),( Thian Song Ong ),( Connie Tee ) 한국인터넷정보학회 2010 KSII Transactions on Internet and Information Syst Vol.4 No.6

With the wide deployment of biometric authentication systems, several issues pertaining security and privacy of the biometric template have gained great attention from the research community. To resolve these issues, a number of biometric template protection methods have been proposed. However, the design of a template protection method to satisfy four criteria, namely diversity, revocability and non-invertibility is still a challenging task, especially performance degradation when template protection method is employed. In this paper, we propose a novel method to generate a revocable minutiae-based fingerprint template. The proposed method consists of feature extraction from fingerprint minutiae pairs, quantization, histogram binning, binarization and eventually binary bit-string generation. The contributions of our method are two fold: alignment-free and good performance. Various experiments on FVC2004 DB1 demonstrated the effectiveness of the proposed methods.

Dryocrassin ABBA Induces Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells Through a Caspase-Dependent Mitochondrial Pathway

Jin, Zhe,Wang, Wen-Fei,Huang, Jian-Ping,Wang, He-Meng,Ju, Han-Xun,Chang, Ying Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: Biological and pharmacological activities of dryocrassin ABBA, a phloroglucinol derivative extracted from Dryopteris crassirhizoma, have attracted attention. In this study, the apoptotic effect of dryocrassin ABBA on human hepatocellular carcinoma HepG2 cells was investigated. Materials and Methods: We tested the effects of dryocrassin ABBA on HepG2 in vitro by MTT, flow cytometry, real-time PCR, and Western blotting. KM male mice were used to detect the effect of dryocrassin ABBA on H22 cells in vivo. Results: Dryocrassin ABBA inhibited the growth of HepG2 cells in a concentration-dependent manner. After treatment with 25, 50, and $75{\mu}g/mL$ dryocrassin ABBA, the cell viability was 68%, 60% and 49%, respectively. Dryocrassin ABBA was able to induce apoptosis, measured by propidium iodide (PI)/annexin V-FITC double staining. The results of real-time PCR and Western ting showed that dryocrassin ABBA up-regulated p53 and Bax expression and inhibited Bcl-2 expression which led to an activation of caspase-3 and caspase-7 in the cytosol, and then induction of cell apoptosis. In vivo experiments also showed that dryocrassin ABBA treatment significantly suppressed tumor growth, without major side effects. Conclusions: Overall, these findings provide evidence that dryocrassin ABBA may induce apoptosis in human hepatocellular carcinoma cells through a caspase-mediated mitochondrial pathway.

Rad51 Maintains Chromosome Integrity and Mitochondria Distribution during Porcine Oocyte Maturing In Vitro

Zhe-Long Jin,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2

DNA repair protein Rad51 homolog 1 (Rad51) plays a central role in Homologous recombination (HR) repair. HR depends on the formation of a Rad51 recombinase filament that facilitates strand invasion. However, whether Rad51 influences the porcine oocytes during maturation is unknown. The objective of this study is to investigate the expression and function of Rad51 during porcine oocytes maturing in vitro. Rad51 was mainly localized at the nuclear in the germinal vesicle (GV) stage and widely distributed in the cytoplasm form GV breakdown (GVBD) to MII stage. DNA damage inducing by the Etoposide was identified by the Rad51 foci formation which was localized with γH2AX. Inhibition of Rad51 increased the DNA damage, and induced metaphase I arrest with spindle defects, chromosomal misalignments and abnormal spindle assembly checkpoint (SAC) activity. Inhibition of Rad51 also increase ROS level and induced the abnormal mitochondrial distribution. Our results indicate that Rad51 play a critical role to maintain chromosome integrity as well as mitochondria activity during the porcine oocyte maturation.

Sino-Korea Trade Pattern Has Changed in East Asia: the Reasons and Confrontation Strategies

Jin, Cheng-zhe,Zhang, Yu-he,Park, Eui-burm 江原大學校 經營硏究所 2005 經營科學硏究 Vol.31 No.-

한중 무역형태에 관한 연구는 대부분 상호보완에 초점을 두고 경쟁적 관점은 간과하고 있다. 이 논문은 세 가지 측면에서 한중 무역의 경쟁적 관점을 기술하였다. 즉, 한중 상품의 수출입구조, 주요 수출시장, 상호 국내시장 내 경쟁 등이다. 이 논문은 급속히 향상된 중국의 경쟁력, 한중 수출구조의 유사성, 과학적 연구와 수출시장의 중복에 관해 후술하였으며, 특히 그 원인으로서 한중 발전모형과 산업구조의 동질성을 지적하였다. 따라서 첫째, 양국은 서로 조심스런 태도변화를 통해 대립보다는 협력에 의한 상생(相生)의 결과를 도출해야 하며, 둘째로 양국은 석유개발, 철광석 구매, 그리고 신(新) 하이테크기술 연구개발 등 분야에서 중앙정부, 산업, 기업 차원의 협력을 강화해야 한다. 한중 무역형태는 1992 년 이후 보완관계에서 경쟁상태로 변화되어 왔으며, 아직은 한국이 중국에 비해 다소 경쟁적 우위를 유지하고 있는 것으로 평가된다. Research on Sino-Korea trade almost focuses on mutual complement and avoids competition. This paper discusses Sino-korea trade competition from three aspeets: Sino-Korea import-export structure by commodity, both main export markets & competition on mutual domestic markets. Later this paper will explain this phenomenon from China's competitive ability being enhaneed quickly, Sino-Korea export structure alike, scientific research and export market overlap, especially we will point out that the deep reason is Sino-Korea developing pattern homology & industrial structure alike. At last we suggest that both countries should change their precautious attitude to each other and use cooperation instead of confrontation and get a win-win result firstly; secondly both sides should strengthen cooperation on central government's level, industrial level & firm's level especially in these prior areas: petroleum exploitation, metal orals purchase and high-new technologies' R&D. Etc. Overall Sino-korea trade pattern has been changing from complement to competition since 1992 generally, although South Korea still has minor competitive advantages over China at present.