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Case of Raynaud Syndrome after the Use of Methimazole
( Yunkyung Kim ),( Hee-sang Tag ),( Geun-tae Kim ),( Seung-geun Lee ),( Eun-kyung Park ),( Ji-heh Park ),( Seong-min Kweon ),( Song-i Yang ),( Jeong-hoon Kim ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.3
Raynaud syndrome is a medical condition that causes pain, numbness, and changes in skin color at the distal extremities. Raynaud syndrome can be subdivided into primary Raynaud's and secondary Raynaud's. The former is diagnosed when the cause is unknown and the latter is caused by an underlying condition, such as connective tissue diseases, injury, smoking, or certain medications. Both cancer chemotherapy and β-blockers are relatively common causes of Raynaud syndrome but there are no reports of its association with methimazole administration. The authors encountered a 43-year old woman with hyperthyroidism who developed digital ulcers associated with Raynaud syndrome after a methimazole treatment. Her digital ulcers and Raynaud syndrome were improved after methimazole was replaced with propylthiouracil and conventional therapy. This paper reports this case along with a review of the relevant literature. (J Rheum Dis 2018;25:203-206)
Yunkyung Kim,Geun-Tae Kim,Young Sun Suh,Hyun-Ok Kim,Han-Na Lee,이승근 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.3
Objective. To investigate the impact of the amendment of the Korean National Health Insurance (KNHI) reimbursement criteria for anti-tumor necrosis factor-α (TNF-α) agents based on from conventional clinical and laboratory measurements to disease activity score of 28 joints (DAS28) on treatment pattern, clinical response, and persistence rate in patients with rheumatoid arthritis (RA). Methods. This multicenter retrospective cohort study evaluated 148 RA patients eligible for the initiation of anti- TNF-α agents as the first-line biologics by either the past (n=95) or current (n=53) KNHI reimbursement criteria. Persistence was defined as the duration between the initiation and discontinuation of anti-TNFα agents. Results. In total, 106 (71.6%), 35 (23.6%), and 7 (4.7%) RA patients started treatment with adalimumab, etanercept, and infliximab, respectively. RA patients who received anti-TNF-α agents under the current reimbursement criteria had a significantly lower mean DAS28-erythrocyte sedimentation rate (ESR) (6.02 vs. 6.95, p<0.001) and daily prednisolone-equivalent glucocorticoid dose (4.51 vs. 6.17 mg, p<0.001) than those who received anti-TNF-α agents under the past reimbursement criteria. No significant differences in the 1-year remission rate defined by DAS28-ESR<2.6 (17.9% vs. 30.2%, p=0.085) and the persistence rate (p=0.703) between the past and current reimbursement criteria was observed. Conclusion. Our data suggest that less active RA patients can receive reimbursement for anti-TNF-α agents under the current criteria, and the amendment of the KNHI reimbursement criteria may improve access to anti-TNF-α agents without affecting the treatment response and persistence rate.
A Double-Layered Microlens for High-Sensitivity CMOS Image Sensors
Yunkyung Kim 한국정보기술학회 2016 한국정보기술학회논문지 Vol.14 No.8
Pixel sizes of CMOS image sensors continue to decrease to below 1.0 μm for high-resolution applications. However, the sensitivity of pixels is declining and the crosstalk is increasing as the size of the pixel pitch is reduced. In this paper, a double-layered microlens for a high-sensitivity CMOS image sensor is suggested. The double-layered microlens is formed by four microlenses on the top layer and one microlens on the bottom layer. To investigate the performance of the suggested structure, we used three-dimensional optical simulation to compare the absorptivity of backside-illuminated 0.9 μm, 1.0 μm, and 1.4 μm pixels with the typical microlens and the double-layered microlens. The finite-difference time-domain (FDTD) method was used for a numerical analysis on the optical characteristics. Having compared the typical pixel with the suggested pixel, the double-layered microlens shows excellent crosstalk performance at an oblique incident light for 0.9 μm, 1.0 μm, and 1.4 μm pixels.
Kim, Jinwoo,Heo, Yunkyung,Jung, Youngeun,Lee, Jinu,Kim, Ikyon Pergamon Press 2017 Tetrahedron Vol.73 No.39
<P><B>Abstract</B></P> <P>A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Investigation of Silver Nanowires with a PEDOT:PSS Layer for Haze Reduction
Yunkyung Kim 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.8
Silver nanowires (AgNWs) are often used as transparent electrodes because they contribute sheet resistance and mechanical flexibility to the electrodes. However, the optical haze still needs to be improved in order for AgNWs to be suitable for display applications. In this study, we investigated the optimal structure of AgNW films with a capping layer for reducing haze. We investigated the haze of AgNWs covered by poly (3, 4-ethylenedioxithiophene):poly (styrenesulfonate) (PEDOT:PSS) and/or indium tin oxide (ITO), which were simulated to investigate the reduction of haze in the visible spectrum. A finite-difference time-domain (FDTD) simulation showed that optimized Ag- NWs with an insulating capping layer showed less optical haze than AgNW films alone. The haze reduction was 6 % maximum for a AgNW with a radius of 70 nm with 20-nm-thick PEDOT:PSS added. Also, a haze reduction of 0.7 % was achieved by adding the surrounding PEDOT:PSS with a thickness of 20 nm, and one of 0.3 % was achieved as the thickness of PEDOT:PSS was increased from 20 nm to 60 nm when the radius of the AgNW was fixed at 20 nm. From the simulation results, we confirmed that the capping layer was responsible for the haze reduction.
이미지 분석기법을 이용한 콘크리트 구조물의 결함 검출 시스템 개발
김윤경(Yunkyung Kim) 한국정보기술학회 2016 한국정보기술학회논문지 Vol.14 No.10
Recently, unpredictable natural disaster such as an earthquake occurs more frequently than before. The need for an accurate detection system for potential risk such as cracks in concrete structures has emerged as major importance. Several researches have been conducted on an automatic crack inspection system, using image processing for concrete structures. However it is still insufficient for large scaled structures such as nuclear containment buildings. In this paper, we introduce a crack detection system appropriate for a large scaled structure utilizing image processing. This system, applied in high resolution camera, can recognize cracks as small as 0.3mm at the surface of the actual width of 1 meter and more. It will ensure safety by recognizing possible risk such as cracks and ruptures more efficiently and preemptively.