6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

TiO₂및 SnO₂계 Spinel 안료의 구성

정윤중,이희수 연세대학교 산업기술연구소 1982 논문집 Vol.14 No.2

For the fabrication of the 2 AO ·BO₂ spinel pigment, each 1 mole of TiO₂, SnO₂and each 2 mole of ZnO, CoO, MgO, MnO, NiO and Fe₂O₃were fired at the temperature ranges from 700˚to 1.300℃ for 2 hours respectively. Analysing the X-ray diffraction, the following results were obtained. ⑴ In case of TiO₂, the spinel structures were formed with ZnO, CoO and in case of SnO₂, the spinel structures were formed with ZnO, CoO and MgO. ⑵ The other 2 valence metal oxides NiO, MnO, CuO and Fe₂O₃made geikielite structures with TiO₂, and SnO₂. ⑶ In order to form the spinel or geikielite structures, SnO₂series required higher firing temperature than TiO₂series. ⑷ Borax decreased the firing temperature in any series, having the spinel or geikielite structure.

일 최저기온 공간내삽을 위한 지형기후학적 최적 공간규모

정유란,서희철,윤진일,이광회 한국농림기상학회 2003 한국농림기상학회지 Vol.5 No.4

Cold air accumulation plays a critical role in formulating daily minimum temperature in complex terrain on radiative cooling nights, and spatial interpolation can be improved by accommodating this important topoclimatic variable. Little is known about the spatial scale for computing cold air accumulation which influences daily minimum temperature. Air temperature was measured at 10-minute intervals during September 2002 - February 2003 at eight locations within a 1 by 1 km hilly orchard area. Minimum temperature data for suspected radiative cooling nights were collected, and the deviations from reference observations at a near-by KMA automated weather station were calculated. A digital elevation model with a 10m cell size was used to calculate the cold air accumulation at 8 locations. Zonal averages of the cold air accumulation were computed for each location by increasing the cell radius from 1 to 10. Temperature deviations were regressed to a common logarithm of the smoothed averages of cold air accumulation to derive a linear relationship between the local temperature deviation and the site topography. The highest coefficient of determination (r² = 0.78) was found at a cell radius of 5, which corresponds to an approximately 1 ha boundary surrounding the point of interest.

有限要素法에 依한 notch部의 應力解析과 光彈性實驗과의 比較

鄭然輝,崔國光 嶺南大學校 工業技術硏究所 1974 연구보고 Vol.2 No.1

The design of machine elements formed with various notched shapes requires accurate predictable stress value of the notched position, therefore, many investigators have dealt with this subject, but they only reached approximate value In this paper, the stress concentration factors of the U-notched plate and V-notched plate subjected to tensile force was calculated by the photo-elasticity experiment and the finite element method, subsequently with equations by above method and many invesgatied equants were compared. The result was as follows. (1) The values of photo-elasticity experiment of the U-notched plate are greater than the values calculated by the finite element method. by 0.5% (2) The values of photo-elasticity experiment of the V-notched plate are 0.4% greater than the values calculate by the finite element method. by 0.4% (3) Trying to compare the values, we applied Armbruster's equation to the U-notched plate and to the V-notched plate and the values calculated by the finite element method. The values of the both theoritical equations are 1.7%, this is 10% greater than the values by finite element method respectively.

발레무용수의 실수원인과 대처방안 탐색

정지혜,한윤희 숙명여자대학교 건강·생활과학연구소 2009 生活科學硏究誌 Vol.- No.25

A purpose of the study is to find when ballerinas make mistakes in the state of practice and performance and to find how to overcome mistakes by researching qualitatively and making useful information for reducing mistakes by developing effective guide studies. This research took 13 professional ballerinas and specialists on ballet to find causes of mistakes and how to cope with them. They are all interviewed and contents of interview has been analysed as follows. The causes of mistakes in practice and performance are divided into four parts by physical working capacity, psychological working capacity, environmental working capacity and ability working capacity. The cause of mistakes by ballerinas in practice is branched in physical working capacity are fatigue, lake of physical strength and an injury. In mental working capacity are distractibility, uneasiness of insufficient movement, lake of tension, a fall of motive, self-admiration, lake of confidence, uneasiness about mistakes that are made in the past, uneasiness about their role, an inferiority complex, note to the shortage of the sight and too much desire. In environmental working capacity are poor environment, lake of teamwork, lake of partnership, too much anticipation from the and condition of toe shoes. Lastly, ability working capacity are lake of rhythmic sense, too much movement in the fast music, lake of the sense of balance and lake of high techniques. To overcome the mistakes that are made by physical working capacity, to control their condition, act alternatively and self-controlling. To overcome the mistakes that are made by mental working capacity, to concentrate on the theme, mental training, control themselves, regulation of practice, avoidance of circumstances, act positively, consultation with a coach, do the assignment first, control their condition and act alternatively. To overcome the mistakes that are made by environmental working capacity, regulation of practice, adoption, act alternatively, talk, prepare beforehand, be friendly and counsel. Finally to overcome the mistakes that are made by ability working capacity, act alternatively, control themselves, regulation of practise, talk to the couch, concentrate on theme. In the performance, physical working capacity are classified as a lack of physical stamina and injury, in psychological working capacity ate classified as lack of concentration, lack of excitement, immoderation of ambition, lack of tension, lack of self-confidence, note on the shortage of vision, an inferiority complex, being uneasy about mistakes that are made in the past, being uneasy about insufficiency of the movement, a responsibility of their role and self-admiration. Environmental working capacity are classified as a problem with clothes, lack of preparation of properties, the condition of tie-shoes, a quality of sounds, setting of stage, lights on stage, floor of stage, mistakes that are made by their partners and colleges, response from the audience and lack of partnership. Lastly in ability working capacity is classified as lack of learning skills and the sense of balance. In the performance, plans for coping with mistakes that are made by physical working capacity are to act alternatively, modulation of condition, to control themselves, slackness. Plans for coping with mistakes that are made by psychological working capacity are to control themselves, to act alternatively, practice beforehand, self-suggestion, self-talking, concentrate on a theme, concentrate on the performance, control their condition, meditation, preparation beforehand, acting alternatively, a sense of responsibility and enough recess. Plans for coping with mistakes that are made by environmental working capacity are preparation beforehand, act alternatively, encouragement, mental training, concentration on the theme, requesting beforehand and adaption. Finally plans for coping with mistakes that are made by ability working capacity are to concentrate on theme and preparation beforehand. Based on the results, to reduce mistakes, regulation oause of mistakes in four branches and learning all the plans for each mistakes.ause of mistakes in four branches and learning all the plans for each mistakes.

CaO-SiO₂-slag계의 수열반응 속도와 기구

정윤중,이희수,이형복 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.1

The molar ratio of CaO/SiO₂was made to be 0.8 and slag was combined with the same weight percentage of CaO/SiO₂mixture, for the study of kinetics and the reaction controlled steps on the CaO-SiO₂and CaO-SiO₂-slag system. Free lime, free silica and combined water of the specmens were determined with the quantitative methods. The chemical composition of the products, rates of reaction and activation energies were calculated from the above experimental data. The results are followed. 1. For the chemical composition of the products CSHn, CaO-SiO₂-slag system has C/S=1.42, n=1.8 and CaO-SiO₂system has C/S=1.29, n=1.5 2. The reaction controlled steps are changed from phase boundary to diffusion in the process of 10 hours at 152 and 181℃ for CaO-SiO₂-slag system and at 80 and 152℃ for CaO-SiO₂-slag system and at 80 and 152℃ for CaO-SiO₂system. 3. The activation energy for CaO-SiO₂-slag system is 12.2 kcal/mole and for CaO-SiO₂system is 6.6 kcal/mole.

사업장 근로자의 건강위험 평가도구 개발

정규철,이용애,홍윤철,조희숙,박혜숙,임현술,하은희 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps: one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

구릉지 과원의 고도에 따른 기온변이

정유란,서희철,윤진일 한국농림기상학회 2003 한국농림기상학회지 Vol.5 No.1

2001년 9월부터 2002년 6월까지 소규모 집수역 내고도가 다른 3개 지점(해발 49,104, 253m)에서 30분 간격으로 기온을 측정하여 다음과 같은 결과를 얻었다. 평균기온은 100m 당 0.2℃씩 하강하였으며, 이 감율양상은 낮 시간대 지형에 의한 일사 수광량변이에 의해 증폭되었다. 그러나 감율양상은 일몰시점부터 고도가 높을수록 기온이 더 높아지는 역전양상으로 전환되어 다음 날 일출시점까지 지속되었다. 이에 따라 계곡기저의 일 최저기온이 253m 지점에 비해 더 낮은 날이 연중 67%를 차지하였고 연평균 기온편차는 1.4℃ 이었다. 맑은 날의 최저기온 역전강도는 겨울보다 봄가을에 더 커지며 대상지역에서 관측된 최대값은 6℃ 이었다. 흐리고 비온 날의 최저기온은 감율양상이 지속되었으며 봄가을보다 겨울철의 기온감율이 더 컸다. Air temperature was continuously measured in hilly pear orchards at 4 sites with elevations of 10, 49, 104 and 253 m above sea level. The mean air temperature, averaged over the 10-month period from August 2001 to June 2002, decreased as the site elevation increased by 0.2℃ per 100 m. This weak lapse condition was amplified during daytime by sun-slope geometry. But on most days an inversion condition began by sunset and persisted until the next sunrise. During the observation period, daily minimum temperature at the valley bottom was lower than that of the hilltop on 67% of the days, and the average temperature difference was 1.4℃. Inversion of daily minimum temperature under clear sky conditions was stronger in spring and autumn than in winter with a maximum of 6℃. Lapse condition was predominant in daily minimum temperature on rainy days, and the lapse rate was strongest in winter.

지형기후모형에 근거한 서리경보시스템 구축

정유란,서희철,윤진일 한국농림기상학회 2004 한국농림기상학회지 Vol.6 No.3

A spatial interpolation scheme incorporating local geographic potential for cold air accumulation (TOPSIM) was used to test the feasibility of operational frost warning in Chatancheon basin in Yeoncheon County-, where the introduction of new crops including temperate zone fruits is planned. Air temperature from April to June 2003 was measured at one-minute intervals at four locations within the basin. Cold-air accumulation potentials (CAP) at 4 sites were calculated for 3 different catchment scales : a rectangular area of 65 x 55 km which covers the whole county, the KOWACO (Korea Water Corporation) hydrologic unit which includes all 4 sites, and the sub-basins delineated by a stream network analysis of the digital elevation model. Daily minimum temperatures at 4 sites were calculated by interpolating the perfect prognosis (i.e., synoptic observations at KMA Dongducheon station) based on TOPSIM with 3 different CAPs. Mean error; mean absolute error; and root mean square error were calculated for 45 days with no precipitation to test the model performance. For the 3 flat locations, little difference was detected in model performance among 3 catchment areas, but the best performance was found with the CAPs calculated for sub-basins at one site (Oksan) on complex terrain. When TOPSIM loaded with sub-basin CAPs was applied to Oksan to predict frost events during the fruit flowering period in 2004, the goodness of fit was sufficient for making an operational frost warning system for mountainous areas.

Rat H-Y 抗體가 생쥐 수정란의 발달단계에 따른 체외배양에 미치는 영향

鄭場龍,朴喜成,朴玉潤 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

本 硏究는 免疫學的 방법에 의하여 性을 調節할 수 있는 방법을 개발하고자 近郊系統의 Wistar흰쥐의 수컷비장을 摘出하여 均質化시킨 다음 상충액을 취하여 同種의 암컷 腹膣內에 接種함으로서 H-Y抗原에 대한 H-Y 抗 血淸을 제조하였으며, 제조된 H-Y抗 血淸과 함유한 培養液에 ICR系統의 생쥐로부터 각 발달단계별로 채란한 수정란을 NaHCO3-BMOC-3 배양액에 H-Y항 혈청과 보체를 첨가하여 CO_2 incubator에서 24∼30시간 배양을 실시하였다. 본 연구에서 얻은 결과는 다음과 같다. H-Y 抗體의 形成은 rat 10마리중 8마리에서 抗體가 형성되어 80%의 形成率을 보였으며, 427개의 수정란을 H-Y 抗體를 處理하여 이중 182개(43%)가 파괴 되었다. H-Y 抗血淸 및 補體의 存在下에서 培養된 2-, 4-, 8-, 16-세포기, 상실배 및 胞胚期 수정란의 파괴율은 각각 0.0, 42.9, 54.1, 47.0, 48.1 및 47.5%로서 2-세포기와 4-세포기 以上間에는 유의적 (P<0.05)인 差異가 있었으나, 4-세포기 이상과 胞胚期 受精卵間에는 H-Y 항체가 미치는 영향은 유의적(P<0.05)인 차이가 없었다. This experiment was carried out to develop a new technique of identifying XX or XY-bearing mouse embryos by immunological method. H-Y antiserum prepared in inbred Wistar female rats by repeated immunization with spleen cells from males of the same strain. The reactivity of H-Y antibody was confirmed by culturing mouse embryos in the medium containing H-Y antiserum and complement obtained from the guinea pig. The optimal condition for the activity of H-Y antibody was also investigated by culturing embryos under the concentration or affected H-Y antibody and in vitro culture rate. The bilological test with the 8- or 16-cell stge embryos showed H-Y antibody was formed in all female rats immunized with spleen cell, but it was formed only in 80% female rats immunized with the antigen. When the embryos were in vitro cultured in the medium of H-Y antiserum and complement the lysis rate of 2-, 4-, 8-, 16-, morula and blastocyst was 0.0, 42.9, 54.1, 47.0, and 47.5% respectively, but significantly(P<0.05) low than that of 2-cell stage.