Stent삽입을 이용한 관동맥성형술로 치료한 내장역위가 동반된 우심증의 급성 심근경색증환자 1예

황경화,김태용,김준영,최유정,최홍엽,오재인,임상욱,차동훈 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

Improved thermal stability of Ag reflector for GaN-based flip-chip LED by the electron beam irradiation

Yu Lim LEE,Yu Jung CHA,Seung Kyu OH,Tae Kyoung KIM,In Yeol HONG,Joon Seop KWAK 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

A Study on Stress and Immunity of Young Children with Atopic Skin

( Yu-lim Cha ),( Young-jae Choi ),( Myung-won Joo ),( Gang-jin Lee ) 한국미용예술경영학회 2012 미용예술경영연구 Vol.6 No.2

The purpose of this study is to survey the stress difference of young children with the symptoms of the atopic dermatitis and provide base data to moderate the stress from the atopic dermatitis of young children. This study was implemented for young children who have obtained the atopic examination around the first birthday in hospitals with certain atopic symptoms now for young children (36 months - 60 months) residing in the New City of Dongtan, Gyeonggi-do for a total of 60 days from June 1, 2011 to July 30, 2011. Depending on the age of the child, age of parents, residence type and monthly income of the household, the stress was shown with meaningful level following the time of initial examination of the atopic dermatitis, level of disease, health condition, sleeping hours, and improvement method. The difference of immunity was meaningful in accordance with the level of disease, health condition, and improvement method for the age of child and monthly income of the household. After this study, it is desired to have continuous studies on moderating the stress of young children with the atopic dermatitis.

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

Cha, Yu-Jung,Lim, Kyoung Soo,Park, Min-Kyu,Schneider, Stephen,Bray, Brian,Kang, Myung-Chol,Chung, Jae-Yong,Yoon, Seo Hyun,Cho, Joo-Youn,Yu, Kyung-Sang Dove Medical Press 2014 Drug design, development and therapy Vol.8 No.-

<P><B>Background</B></P><P>KM-023 is a new second-generation nonnucleoside reverse-transcriptase inhibitor that is under development for the treatment of human immunodeficiency virus (HIV) type 1 infection.</P><P><B>Objective</B></P><P>This study determined KM-023 tolerability and pharmacokinetic characteristics in healthy subjects.</P><P><B>Materials and methods</B></P><P>A randomized, double-blinded, placebo-controlled, dose-escalation study was conducted in 80 healthy South Korean male volunteers. The subjects were allocated to single- or multiple-dose (once daily for 7 days) groups that received 75, 150, 300, or 600 mg drug or placebo in a 4:1 ratio. Safety and pharmacokinetic assessments were performed during the study. Plasma and urine concentrations were quantified using liquid chromatography–tandem mass spectrometry.</P><P><B>Results</B></P><P>The average maximum concentration (C<SUB>max</SUB>) and area under the concentration–time curve from time 0 to infinity (AUC<SUB>∞</SUB>) values of KM-023 for the 75–600 mg doses in the single-dose study ranged from 440.2 ng/mL to 1,245.4 ng/mL and 11,142.4 ng · h/mL to 33,705.6 ng · h/mL, respectively. Values of the mean C<SUB>max</SUB> at a steady state and AUC within the dosing interval ranged from 385.1 ng/mL to 1,096.7 ng/mL and 3,698.9 ng · h/mL to 10,232.6 ng · h/mL, respectively, following 75–600 mg doses in the multiple-dose study. Dose proportionality was not observed for KM-023. KM-023 showed a 0.6-fold accumulation after multiple doses in the 600 mg dose group. The mean half-life values ranged between 20.7 and 31.2 hours. KM-023 was generally well tolerated without serious adverse events.</P><P><B>Conclusion</B></P><P>KM-023 demonstrated dose- and time-dependent nonlinear pharmacokinetic characteristics after single or multiple doses over a dose range (75–600 mg) in healthy subjects. KM-023 showed favorable tolerability in this study. This Phase I clinical trial information can be used to design further clinical studies appropriately to evaluate KM-023 in patients with HIV-1 infection.</P>

Improvement of thermal stability of Ag-based reflector in GaN-based flip chip LEDs by electron-beam irradiation : Improvement of thermal stability of Ag-based reflector by irradiation

Lee, Yu Lim,Cha, Yu-Jung,Oh, Seung Kyu,Kim, Tae Kyoung,Hong, In Yeol,Kim, Yoon Seok,Kwak, Joon Seop Wiley - VCH Verlag GmbH & Co. KGaA 2017 Physica Status Solidi. A Vol.214 No.8

새롭게 진단된 제 2 형 당뇨병 환자에서의 좌심실 이완기 기능 장애

차영수(Young Soo Cha),최홍엽(Hong Yup Choi),박진경(Jin Kyoung Park),이준(Jun Lee),임상욱(Sang Wook Lim),차동훈(Dong Hoon Cha),홍은경(Eun Kyoung Hong),박석원(Seok Won Park),김유리(Yu Lee Kim),조용욱(Yong Wook Cho),이상종(Sang Jong Le 대한내과학회 2002 대한내과학회지 Vol.62 No.4

목적 : 심부전증은 당뇨병 환자에서의 중요한 사망 원인이며 자율신경병증, 고인슐린 혈증, 고지방 혈증 등에 의해 유발될 수 있는 좌심실 이완기 기능 장애는 심부전증의 위험 요인으로 알려져 있다. 또한 유병 기간이 1년 이내인 제2형 당뇨병 환자에서도 이러한 변화가 있다는 보고가 있다. 이에 저자들은 처음 제2형 당뇨병을 진단 받은 환자를 대상으로 심초음파를 시행하여 좌심실 이완기 기능 장애 여부를 평가하였다. 방법 : 1996년 12월부터 1998년 6월까지 분당 차병원에 내원하여 처음으로 제2형 당뇨병을 진단 받은 환자들을 대상으로 하였다 (n=20, 당뇨병 환자군). 대상 환자들은 어떠한 치료도 받지 않은 상태에서 심초음파를 시행하였다. 대조군은 분당 차병원 건강 검진에 내원한 환자 중 아무런 질환이 없는 20명의 환자를 대상으로 하여 당뇨병 환자군과 같은 방법으로 심초음파를 시행하였다. 모든 대상 환자들의 혈압, 심박수, 혈중 콜레스테롤, 중성지방, 고밀도 지단백, 저밀도 지단백을 측정하였다. 결과 : 연령, 혈압, 심박수, 혈중 콜레스테롤, 중성지방, 고밀도 지단백, 저밀도 지단백 등의 임상적 특징은 양군간에 유의한 차이를 보이지 않았다. 심초음파 검사 결과에서 심구혈율, 좌심실 질량 지표, 좌심실 이완기말 직경도 양군간에 유의한 차이를 보이지 않았다. 그러나 E/A ratio는 당뇨병 환자군에서 1.06±0.28로 대조군의 1.60±0.27에 비해 유의하게 감소되어 있었으며 (p<0.01) 등용성 이완 시간도 당뇨병 환자군과 대조군이 각각 90.8±18.7 ms, 75.0±15.2 ms로 당뇨병 환자군에서 유의하게 증가되어 있었다 (p<0.01). 마지막으로 감속 기간은 양군간에 유의한 차이를 보이지 않았다. 결론 : 제2형 당뇨병 환자에서 진단 당시에 자율신경병증, 고지혈증, 고인슐린 혈증에 의한 좌심실 질량의 증가에 선행하여 좌심실 이완기 기능의 장애가 나타날 수 있다고 생각되므로 당뇨병 환자에서 동반될 수 있는 당뇨병성 심근증은 당뇨병의 초기부터 특별한 관심과 추적 관찰이 필요하다고 생각된다. Background : Heart failure is one of the major cause of premature mortality and morbidity in diabetes mellitus. It has been well recognized that left ventricular diastolic dysfunction caused by autonomic neuropathy, hyperinsulinemia, hyperlipidemia might be a preceding underlying mechanism of heart failure in diabetes. Also, an impairment of diastolic function in early diabetic patients has been reported in some literature. So, we evaluated the diastolic function in newly diagnosed diabetics with echocardiography. Methods : All patients with newly diagnosed NIDDM in Pundang Cha general hospital from December 1996 to June 1998 were enrolled (n=20). The 20 healthy volunteers comparable for age, sex, body surface area were enrolled as a control group. The echocardiography was performed in all patients before any treatment. Blood pressure, pulse rate, fasting and postprandial sugar and insulin level, serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol were also checked in all patients. Results : There were no significant difference in blood pressure, pulse rate, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol level between both groups. E and A ratio of mitral inflow and peak diastolic velocity of pulmonary vein flow were significantly decreased in NIDDM group compared with control group (p<0.01). But there were no significant difference in left ventricular mass index, isovolumic relaxation time, deceleration time and peak atrial reversal velocity. Conclusion : This study demonstrates that an impairment of left ventricular diastolic function occurs early in the NIDDM and investigation of diastolic function should be performed in the clinical evaluation of early diabetic patients.(Korean J Med 62:422-429, 2002)

컴퓨터 소프트웨어를 이용한 수학 학습

차재선,심상길,유진호,임문수,최재용 단국대학교 교과교육연구소 1999 교과교육연구 Vol.- No.3

Doppler ultrasound를 이용한 교정적 치아 이동 시 치수 혈류량의 변화의 측정 : 예비실험

임경섭,배영민,차정열,유형석,황충주 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.6

교정적 치아 이동 시 지속되는 압력에 의해 혈류변화가 발생하게 되며, 이러한 변화양상에 있어서 선학들의 연구 방법 및 그 결과의 다양성이 존재하였다. 본 연구에서는 Doppler ultrasound를 이용하여, 교정치료 전과 교정치료 시작 3주, 6주 후 치수 혈류량의 연속적인 변화를 알아보고자 하였다. 만 15세 이상 환자 18명을 연구대상으로 Doppler ultrasound를 이용하여 상, 하악 6전치 중 경도의 총생(2 mm 미만)을 보이는 치아(총생측정: required space-available space)와 인접치아를 포함한 3개의 치아를 대상으로 치수 혈류량의 변화를 알아보았다. 연구결과 부위별(상, 하악), 치아별, 기간에 따른 치수 혈류량의 변화는 교정 치료 시작 전과 시작 후 3주, 6주 혈류량에 유의한 차이가 없었다. 또한 치수 생활력 상실의 내재적 위험성을 비교하고자 교정 치료 시작 전 치아별로 치수혈류량을 비교하였을 때, 상악에서는 측절치, 하악에서는 견치에서 통계학적으로 유의한 차이는 나타나지 않았지만, 모든 항목에서 적은 값을 나타냈다 (p > 0.05). 본 연구의 결과는 이후에 진행될 Doppler ultrasound의 치아이동유형, 환자의 연령을 고려한 세부적인 실험 시 방법론적인 기초 자료로서 뿐만 아니라, 교정치료 시 치수 생활력의 상실에 대한 참고 자료가 될 수 있을 것이다. Objective: This study was to change of pulp blood flow among maxillary and mandibular anterior tooth with mild crowding and adjacent teeth using Ultrasound Doppler graphy. Methods: The change of pulp blood flow was measured three times using Ultrasound Doppler graphy; before the attachment of brackets, after 3 week, and after 6 week. The sample consists of 15 year old eighteen patients. Results: Before the attachment of brackets, after 3 weeks, and after 6 weeks, there were no significant differences in the change of pulp blood flow in each part (maxilla and mandible) and each tooth according to period. In addition, to compare internal dangerousness of loss of the pulp vitality, when pulp blood flow is compared in each tooth before orthodontic treatment, there were no statistically significant differences in maxillary lateral incisor and mandibular canine but it showed low values in all measurement items (p > 0.05). Conclusions: Results of this study can be not only methodological preliminary data in further study such as tooth movement type of Ultrasound Doppler graphy and particular study considered the patient age, but also reference materials for the loss of pulp vitality in orthodontic treatment.

Poster Session : PS 0810 ; Upper GI Tract : Polydeoxyribonucleotide Affecting Gastric Ulcer Healing in Mongolian Gerbils

( Yu Mi Oh ),( Jung Won Jeon ),( Joung Il Lee ),( Hyun Phil Shin ),( Jae Myung Cha ),( Kwang Ro Joo ),( Jun Uk Lim ),( Il Hyun Baek ),( Myung Joon Chae ),( June Ho Bae ),( Chang Ju Kim ),( Il Gyu Ko ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Polydeoxyribonucleotide(PDRN) interacts with adenosine A2A-receptor,resulting in stimulating VEGF expression and facilitating wound healing. However,t he effects of PDRN on the gastric ulcer (GU) healing are still unknown. Methods: 60 Adult male Mongolian gerbils were used in this experiment.They were randomly divided into six groups (n = 10 each group):the sham-operation group,GU-induced group,GU-induced and 2,4,8,and16 mg/kg PDRN-treated group.GU was induced by injection of acetic acid into the subserosal surface of the stomach.After convalescent period of 2 days,gerbils in the PDRN-treated groups underwent intraperitoneal injection of 100 μl distilled water,which included PDRN of each concentration,once a day for 14 consecutive days.The sham-operation group and GU-induced group received an equal amount of distilled water without PDRN for the same duration.The gerbils were sacrifi ced after 16 days since the induction of GU.We investigated the effects of PDRN on the size of ulcer and VEGF expression in GU-induced Mongolian gerbils.In addition,we evaluated the effects of PDRN on apoptosis in GU using TUNEL-positive cells,caspase-3 positive cells,and Bax/Bcl-2 ratio in the gastric tissues. Results: PDRN administrations of 8 mg/kg and 16 mg/kg signifi cantly decreased the size of GU.Compared with GU-induced group,8 mg/kg and 16 mg/kg PDRN-treated group showed signifi cant overexpression of VEGF protein.In terms of anti-apoptosis,8 mg/kg and 16 mg/kg PDRN-treated group significantly decreased the number of TUNEL-positive cells in the stomach.In addition,8 mg/kg PDRN-treated group significantly suppressed caspase-3 expression.Induction of GU signifi cantly enhanced the ratio of Bax to Bcl-2.PDRN treatment suppressed Bax to Bcl-2 ratio.The suppressing effect of PDRN on Bax to Bcl-2 ratio appeared most potent at the 8 mg/kg dose. Conclusions: PDRN of 8 mg/kg overexpressed VEGF protein on acetic acid-inducedGU in Mongolian gerbils.This alteration is considered to promote GU healing.In addition, VEGF overexpressed by PDRN of 8 mg/kg inhibited apoptosis,and this effect is considered to prevent gastric ulcer or injury.

Evaluation of antibacterial activity against Candida albicans according to the dosage of various denture cleansers

Cha-Hwan Bae,Yun-Kyong Lim,Joong-Ki Kook,Mee-Kyoung Son,Yu-Ri Heo 대한치과보철학회 2021 The Journal of Advanced Prosthodontics Vol.13 No.2

PURPOSE. The purpose of this study is to compare the antibacterial activity of currently purchasable denture cleansers against Candida albicans. Materials and methods. This study used tablet-type denture cleansers, Polident(R), Coolingdent(R) and Fittydent(R), along with liquid denture cleansers, Hexamedine(R), Listerine(R) and Apple vinegar(R). The antibacterial activities of denture cleansers were evaluated based on the number of C. albicans and concentrations of the denture cleansers. Results. In the 0.5 × 106 cfu/㎖ culture medium, the C. albicans’ death rate of Polident(R) was significantly lower than those of Fittydent(R), Hexamedine(R), Listerine(R), and Apple vinegar(R)(P <.05). In the 0.5 × 107 cfu/, the C. albicans ’ death rates of Polident(R) and Coolingdent(R) were significantly lower than those of Fittydent(R), Hexamedine(R), Listerine(R) and Apple vinegar(R)(P <.05). The C. albicans death rates of Polident(R) and Coolingdent(R) were significantly decreased at 0.02 g and 0.01 g. The C. albicans death rate of Fittydent(R) was significantly decreased at 0.005 g (P <.05). The C. albicans death rate of Hexamedine(R) was significantly decreased at 1/16 dilution. The C. albicans death rate of Listerine(R) was decreased at 1/8 dilution, and the antibacterial activity of Apple vinegar(R) was decreased at 1/4 dilution (P <.05). Conclusion. As the number of C. albicans increased, the antibacterial activities of the denture cleansers decrease. In the tablet-type denture cleanser, all denture cleansers showed 100% C. albicans death rate when used at a dose of 1 tablet. One denture cleanser showed the same antibacterial effect with only 1/3 of a tablet. In the liquid type denture cleanser, the level of dilution required was different for each denture cleanser.