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Zhang Ying,Wang Peng,Jin Mei-xian,Zhou Ying-qi,Ye Liang,Zhu Xiao-juan,Li Hui-fang,Zhou Ming,Li Yang,Li Shao,Liang Kang-yan,Wang Yi,Gao Yi,Pan Ming-xin,Zhou Shu-qin,Peng Qing 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising therapy for immune and inflammatory diseases. However, how to maintain the activity and unique properties during cold storage and transportation is one of the key factors affecting the therapeutic efficiency of hUCMSCs. Schisandrin B (SchB) has many functions in cell protection as a natural medicine. In this study, we investigated the protective effects of SchB on the hypothermic preservation of hUCMSCs. METHODS: hUCMSCs were isolated from Wharton’s jelly. Subsequently, hUCMSCs were exposed to cold storage (4 C) and 24-h re-warming. After that, cells viability, surface markers, immunomodulatory effects, reactive oxygen species (ROS), mitochondrial integrity, apoptosis-related and antioxidant proteins expression level were evaluated. RESULTS: SchB significantly alleviated the cells injury and maintained unique properties such as differentiation potential, level of surface markers and immunomodulatory effects of hUCMSCs. The protective effects of SchB on hUCMSCs after hypothermic storage seemed associated with its inhibition of apoptosis and the anti-oxidative stress effect mediated by nuclear factor erythroid 2–related factor 2 signaling. CONCLUSION: These results demonstrate SchB could be used as an agent for hypothermic preservation of hUCMSCs.
Effects of Ring Pack Friction Heat on Temperature Fields of Piston Set-Liner
Zhou Long,Sun Guang Hua,Guo Ying Ying,Bai Min Li 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.6
To investigate the temperature fields of piston set-liner under the friction heat of ring pack, it is established a friction heat allocation model of ring pack based on the heat transfer theory of semi-infinite body. In this model, the piston ring, lubrication film and liner are treated as a three-layer medium. Furthermore, the distribution model of ring pack friction heat, the unsteady heat-mixed lubrication and friction model of piston ring-liner, and the heat transfer model of piston assembly-liner are also built and coupled with the allocation model to develop a coupled heat transfer model of piston set-liner. Employing the model for 6110 diesel engine, the effects of ring pack friction heat on the temperature fields of piston set-liner are simulated. Numerical results demonstrate that the friction heat allotted to the piston ring, lubrication film and liner accounts for nearly 47 %, 21 % and 32 % of ring pack friction heat, respectively. Due to the effects of friction heat, the maximum temperature rises on the piston ring, piston and liner surfaces run approximately up to 8.5 ℃, 5 ℃ and 5 ℃, separately. The established allocation and distribution models related to friction heat in this paper can be applied to any type of piston set-liner and provide the theoretical foundation for the optimal design of piston ring-liner.
Zhou Ying,Tao Ke,Liu Aimin,Rui Jia,Bao Jianhui,Sun Yufeng,Yang Sanchuan,Wang Qinqin,Zhang Qiang,Yang Songbo,Cao Yujia,Qu Hui 한국물리학회 2020 Current Applied Physics Vol.20 No.7
In this paper, Tunnel Oxide Passivated Contact (TOPCon) silicon solar cells with the industrial area (244.32 cm2) are fabricated on N-type silicon substrates. Both the ultra-thin tunnel oxide layer and phosphorus doped polycrystalline silicon (polysilicon) thin film are prepared by the LPCVD system. The wrap-around of polysilicon is observed on the surface of borosilicate glass (BSG). The polysilicon wrap-around can form a leakage current path, thus degrades the shunt resistance of solar cells, and leads to the degradation of solar cell efficiency. Different methods are adopted to treat the polysilicon wrap-around and improve shunt resistance of solar cells. The experimental results indicate that a chemical etching method can effectively solve the problem of polysilicon wrap-around and improve the performance of solar cells. Finally, a conversion efficiency of 22.81% has been achieved by our bifacial TOPCon solar cells, with Voc of 702.6 mV, Jsc of 39.78 mA/cm2 and FF of 81.62%.
Ying Zhou,Long Wang,Chaojia Wang,Yilin Wu,Dongmei Chen,Tae Ho Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
Glioma is the most common type of primarybrain tumor, and it has a high mortality rate. Currently,there are only a few therapeutic approaches for gliomas, andtheir effects are unsatisfactory. Therefore, uncovering thepathogenesis and exploring more therapeutic strategies forthe treatment of gliomas are urgently needed to overcomethe ongoing challenges. Cellular redox imbalance has beenshown to be associated with the initiation and progression ofgliomas. Among reactive oxygen species (ROS), hydrogenperoxide (H2O2) is considered the most suitable for redoxsignaling and is a potential candidate as a key moleculethat determines the fate of cancer cells. In this review, wediscuss the potential cellular and molecular roles of H2O2in gliomagenesis and explore the potential implications ofH2O2in radiotherapy and chemotherapy and in the ongoingchallenges of current glioma treatment. Moreover, we evaluateH2O2as a potential redox sensor and potential driver molecule of nanocatalytic therapeutic strategies for gliomatreatment.
Zhou, Ying,Jung, Ji Young,Jeon, Hye Ryeong,Kim, Youngmee,Kim, Sung-Jin,Yoon, Juyoung American Chemical Society 2011 Organic letters Vol.13 No.10
<P>Tris(2-((ethylimino)methyl)pyren-1-ol)amine (<B>1</B>) was synthesized and introduced as the first tetrameric vanadate fluorescence sensor, the entire binding of which was successfully accomplished in two steps with distinct colorimetric changes and “off-on” fluorescent enhancement.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2011/orlef7.2011.13.issue-10/ol200846a/production/images/medium/ol-2011-00846a_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol200846a'>ACS Electronic Supporting Info</A></P>
Zhou, Ying,Kim, Ji Whan,Nandhakumar, Raju,Kim, Min Jung,Cho, Eunae,Kim, Youn Soo,Jang, Yoon Hee,Lee, Chongmok,Han, Seungwu,Kim, Kwan Mook,Kim, Jang-Joo,Yoon, Juyoung Royal Society of Chemistry 2010 Chemical communications Vol.46 No.35
<P>OLEDs employing <B>CMB1</B>, a novel binaphthyl-containing bi-nuclear boron complex, as the emitter exhibited bright yellow emission with a luminous efficiency of 2.1 cd A<SUP>−1</SUP>.</P> <P>Graphic Abstract</P><P>OLEDs employing <B>CMB1</B>, a novel binaphthyl-containing bi-nuclear boron complex, as the emitter exhibited bright yellow emission with a luminous efficiency of 2.1 cd A<SUP>−1</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc01715a'> </P>
Clinical Significance of Expression and Amplification of the DcR3 Gene in Pancreatic Carcinomas
Zhou, Jian,Song, Shi-Duo,Li, De-Chun,Zhou, Jin,Zhu, Dong-Ming,Zheng, Shi-Ying Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
This study aimed to investigate the clinical significance of expression and amplification of decoy receptor 3 (DcR3) in pancreatic carcinomas (PC). mRNA expression was detected by PQ-PCR, and amplification was determined. DcR3 protein expression was detected by immunohistochemistry and ELISA. Correlations between DcR3 expression and clinical pathological factors were analyzed. The relative amount of DcR3 in PC tissues and non-cancerous tissues showed a statistically significant difference, 21 cases displaying more than two fold DcR3 amplification, while no such amplification was found in normal pancreatic tissues. DcR3 positive cell staining was located in the cytoplasm. The positive rate of DcR3 in PC and non-cancerous tissues showed a significant difference. DcR3 mRNA expression was correlated with clinical staging, size of the tumor, lymph node metastasis and histological staging, while protein expression was correlated with clinical data like tumor size. DcR3 gene amplification only correlated with tumor size. The level of DcR3 in serum of the PC resectable group before operation was $72.2{\pm}10.2$ pg/ml, showing a significant difference compared to gallbladder carcinoma group (GC) or pancreatic benign tumor (PBT) group (P < 0.01). In conclusion, DcR3 amplification is correlated with DcR3 expression in PC tissues, especially those clinical pathological factors which reflect tumor progression. Assessment of DcR3 level in sera of PC patients may be helpful for the early diagnosis and prognostic judgement.