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RISS 인기검색어
- 검색키워드
- 저자 : ( Wan Mohd Nuzul Hakimi Wan Salleh ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Wan Mohd Nuzul Hakimi Wan Salleh,Farediah Ahmad,Khong Heng Yen 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
The present study aimed to examine thechemical compositions of the essential oils of Beilschmiediamadang and their antioxidant, antibacterial, antifungal,anticholinesterase and anti-tyrosinase activities. The majorconstituents of the essential oils of leaf and bark of B. madang were d-cadinene (17.0 and 20.5 %), b-caryophyllene(10.3 and 6.7 %), a-cubebene (11.3 and 15.6 %), anda-cadinol (5.8 and 10.6 %). The essential oils werescreened for their antioxidant activities using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, b-carotene/linoleic acidbleaching, and total phenolic content. The bark oil showedthe highest b-carotene/linoleic acid bleaching(90.3 % ± 0.2) and DPPH radical scavenging (IC50212.0 lg/mL), while the highest phenolic content wasexhibited by the leaf oil (94.5 % ± 0.3 mg GA/g). Theantibacterial and antifungal activities were investigated bythe disc diffusion and micro dilution method. The leaf andbark oils showed moderate activity towards Bacillus subtilisand Staphylococcus aureus with minimum inhibitoryconcentration (MIC) value 125 lg/mL. For antifungalassay, the bark oil showed strong activity towards Aspergillusniger and Aspergillus fumigatus with MIC value62.5 lg/mL. Anticholinesterase and anti-tyrosinase activitieswere evaluated against Ellman method and mushroomtyrosinase, respectively. The results showed that leaf oilgave significant percentage inhibition (I%: acetylcholinesterase55.2 %, butyrylcholinesterase 60.4 %, tyrosinase53.1 %).
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Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm
Wan Mohd Nuzul Hakimi Wan Salleh,Farediah Ahmad,Khong Heng Yen,Razauden Mohamed Zulkifli 한국생약학회 2016 Natural Product Sciences Vol.22 No.4
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 - 504.2 μM and 21.0 - 59.4 μM, respectively.
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