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      • Art Installations for Community Development Jiadong Township, Pingtung County, Taiwan as An Example

        Tzu-Yu Lai,Yi-En Tsai,Shiunn-Der Kuo 세계문화관광학회 2021 International Journal of Culture and tourism Resea Vol.14 No.1

        Jiadong township, located in Pingtung County Taiwan, has the highest density of heritages in this country. People can see five Grade III historical monuments in a ten-minute walk. Geographically, Jiadong township is the only Liudui Hakka community near the seashore. In 1994, Taiwan’s cultural development institution proposes a “Community Development” policy. The policy hopes to proceed from art and culture to cohere the sense of community, to improve community living standard, and to establish the community culture.The study is subject to Jiadong township,to find out the connection between art creation and social development. The art creation ranges from wall painting with Hakka literature, and decoration of house structure. The research methods are through literature, field investigation, and interviews. The gathered data were used to trace the origin of the historical street, and the development of wall painting. We conducted in-depth interviews with related people, such as the chairman of the community association, the project staff, cultural works, artists, village chief, and local residents. The interviews were used to understand the ideas and prospects of participants. From analysis and discovery of research process, we hope the case study can provide useful information for future related community researchers and planners to promote community development.

      • The Analysis about Promotion and Marketing of Hakka Villages -A Case Study of Laijia Community, Jiadong Township, Pingtung County-

        ( Tzu Yu Lai ),( Yi En Tsai ),( Shiunn Der Kuo ) 한국문화관광학회 2013 문화관광연구 Vol.15 No.2

        Recently, the rural and fishing of Taiwan changed rapidly in the industrialization. Due to the aging of population in rural area, and the labor shortage, the land was changed to grow the high economy fruit or fishing. With this change, the local economy developed toward high technology and low labor, and it became the elements of affecting the community. This research used the environment and human as a view to investigate the prosperity and recession of the community by collate document and interviewing the successful case. We used SWOT analysis, countering the Managing mode of Siaputou fish farming production area and try to integrate Hakka exquisite culture and excellent traditional industrial technology to point out feasible solution of local community development. The results showed that Lai family community in Jiadong Township, Pingtung County, mainly farming and growing the rice in early period. They transformed into aquaculture rapidly in several decades. Skillful aquaculture and technique brought abundant production to Jiadong Township. However, it can`t be developed into a Hakka specialty. The main point is that: first, to solve the problem of virus infection, they need to strengthen the anti-virus technology. Second, fishermen must develop self-reliance, learning digital knowledge, developing fishery products; establishing heterogeneity of the product, and develop the local market. Third, we can suggest the government control output in order to protect the fishermen`s income. Through industrial restructuring, we can use storytelling to promote local community to achieve the purpose of marketing Hakka villages.

      • Implementation of Obstacle Avoidance and Target Following based on Machine Learning for Unmanned Aerial Vehicle At Low Altitude

        ( Yu-hung Lin ),( Tzu-fang Lai ),( Po-yen Lin ),( Tse-min Chen ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        This research developed an integrated system that consist of orientation sensing, balance control, machine vision recognition and shape sorting and avoidance of obstacle with which the UVA will meet the requirement of a low altitude shuttle in orchards and forest. This research also focused on employing machine learning as the main control core to achieve the performances of target following and obstacle avoidance for unmanned aerial vehicle (UAV). In order to keep the balance of a quadcopter, the orientation data from gyroscope and accelerometer will be the inputs of a double loop PID controller. Target is recognized by machine vision. Distances and shapes of obstacles are defined by a laser rangefinder that mounted on the vehicle. The control of UAV depending on the shape of the obstacle, execute different obstacle avoidance strategies. The results of experiment indicated that the complementary filter can compensate the defects of the gyroscope and accelerometer since it fixes steady-state error of gyroscope and oscillation in high frequency of accelerometer. Double-loop PID controller is more stable than single-loop PID controller is. Due to the stability of control board and safety of operators in target following and obstacle avoidance experiment, a three wheels omni robot was employed to conduct the performance evaluation. The final results validate that the novel UAV is equipped with the ability of shuttling among orchards in low-altitude, target following, classification of obstacle shape and obstacle avoidance.

      • KCI등재

        Risk of Diabetic Retinopathy between Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists

        Tzu-Yi Lin,Eugene Yu-Chuan Kang,Shih-Chieh Shao,Edward Chia-Cheng Lai,Sunir J. Garg,Kuan-Jen Chen,Je-Ho Kang,Wei-Chi Wu,Chi-Chun Lai,Yih-Shiou Hwang 대한당뇨병학회 2023 Diabetes and Metabolism Journal Vol.47 No.3

        Background: To compare risk of diabetic retinopathy (DR) between patients taking sodium-glucose cotransporter-2 inhibitors (SGLT2is) and those taking glucagon-like peptide-1 receptor agonists (GLP1-RAs) in routine care.Methods: This retrospective cohort study emulating a target trial included patient data from the multi-institutional Chang Gung Research Database in Taiwan. Totally, 33,021 patients with type 2 diabetes mellitus using SGLT2is and GLP1-RAs between 2016 and 2019 were identified. 3,249 patients were excluded due to missing demographics, age <40 years, prior use of any study drug, a diagnosis of retinal disorders, a history of receiving vitreoretinal procedure, no baseline glycosylated hemoglobin, or no follow-up data. Baseline characteristics were balanced using inverse probability of treatment weighting with propensity scores. DR diagnoses and vitreoretinal interventions served as the primary outcomes. Occurrence of proliferative DR and DR receiving vitreoretinal interventions were regarded as vision-threatening DR.Results: There were 21,491 SGLT2i and 1,887 GLP1-RA users included for the analysis. Patients receiving SGLT2is and GLP-1 RAs exhibited comparable rate of any DR (subdistribution hazard ratio [SHR], 0.90; 95% confidence interval [CI], 0.79 to 1.03), whereas the rate of proliferative DR (SHR, 0.53; 95% CI, 0.42 to 0.68) was significantly lower in the SGLT2i group. Also, SGLT2i users showed significantly reduced risk of composite surgical outcome (SHR, 0.58; 95% CI, 0.48 to 0.70).Conclusion: Compared to those taking GLP1-RAs, patients receiving SGLT2is had a lower risk of proliferative DR and vitreoretinal interventions, although the rate of any DR was comparable between the SGLT2i and GLP1-RA groups. Thus, SGLT2is may be associated with a lower risk of vision-threatening DR but not DR development.

      • KCI등재

        Maintenance of pegylated liposomal doxorubicin/carboplatin in patients with advanced ovarian cancer: randomized study of an Asian Gynecologic Oncology Group

        Chyong-Huey Lai,Elizabeth Vallikad,Hao Lin,Lan-Yan Yang,Shih-Ming Jung,Hsueh-Erh Liu,Yu-Che Ou,Hung-Hsueh Chou,Cheng-Tao Lin,Huei-Jean Huang,Kuan-Gen Huang,Jiantai Qiu,Yao-Ching Hung,Tzu-I Wu,Wei-Yang 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.1

        Objectives: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. Methods: Between 2007 and 2014, 45 newly-diagnosed ovarian cancer patients were enrolled after complete remission and randomized (1:1) to arm A (4-weekly carboplatin area under the curve 4 and pegylated liposomal doxorubicin [PLD] 30 mg/m2, n=24) for 6 cycles or arm B (observation, n=21). The primary end-point was PFS. A post hoc translational study was conducted to deep sequence BRCA/homologous recombination deficiency (HRD) genes, because BRCA/HRD mutations (BRCA/HRDm) are known to be associated with better prognosis. Results: Enrollment was slow, accrual was closed when 7+ years had passed. With a median follow-up of 88.9 months, the median PFS was significantly better in arm A (55.5 months) than arm B (9.2 months) (hazard ratio [HR]=0.40; 95% confidence interval [CI]=0.19–0.87; p=0.020), yet the median overall survival was not significantly different in arm A (not reached) than arm B (95.1 months) (p=0.148). Overall grade 3/4 adverse events were more frequent in arm A than arm B (60.9% vs 0.0%) (p<0.001). Quality of life was generally not significantly different. Distribution of BRCA1/2m or BRCA/HRDm was not significantly biased between the two arms. Wild-type BRCA/non-HRD subgroup seemed to fare better with maintenance therapy (HR=0.35; 95% CI=0.11–1.18; p=0.091). Conclusions: Despite limitations in small sample size, it suggests that maintenance carboplatin-PLD chemotherapy could improve PFS in advanced ovarian cancer.

      • KCI등재

        Anti-Melanogenic Effect from Submerged Mycelial Cultures of Ganoderma weberianum

        ( Ying-jang Lai ),( Kai-di Hsu ),( Tzu-jung Huang ),( Chang-wei Hsieh ),( Yu-hin Chan ),( Kuan-chen Cheng ) 한국균학회 2019 Mycobiology Vol.47 No.1

        Compounds from Lingzhi has been demonstrated the ability for inhibiting tyrosinase (a key enzyme in melanogenesis) activity. In this study, we investigated the anti-melanogenic activity from the submerged mycelial culture of Ganoderma weberianum and elucidated the skin lightening mechanism by B16-F10 murine melanoma cells. From the cellular context, several fractionated mycelium samples exhibited anti-melanogenic activity by reducing more than 40% extracellular melanin content of B16-F10 melanoma cells. In particular, the fractionated chloroform extract (CF-F3) inhibited both secreted and intracellular melanin with the lowest dosage (25ppm). Further analysis demonstrated that CF-F3 inhibited cellular tyrosinase activity without altering its protein expression. Taken together, our study has demonstrated that the chemical extracts from submerged mycelial culture of G. weberianum have the potential to serve as an alternative anti-melanogenic agent.

      • Art Community and Community Development Study

        Yi-En Tsai,Tzu-Yu Lai,Shiunn-Der Kuo 세계문화관광학회 2013 International Journal of Culture and tourism Resea Vol.6 No.1

        In 1994, Taiwan's Council for Cultural Affairs proposes a "Community Empowerment" policy. A "community space transformation" as the theme of "Counselling beautify local traditional culture building space plans" for the community diversified development opens up new milestone. The study is subject to Jiadong Township, Pingtung County, Taiwan, to find out the connection between Art mural painting and Hakka Literature Poetry. Beautify residential walls, windows and doors for the study of topics,to explore the space of art involved in community relations reform on community development. Research methods through literature searches and depth of field fieldwork interviews, to trace the origin of the historical street, and the development of wall painting. The interviews were used to understand the ideas and prospects of participants, to find out the advantages and opportunities of local conditions and in a community's weaknesses and threats factors, make a record of the research process and analysis of proposals, we hope the case study can provide useful information for future related community researchers and planners to promote community development.

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