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( Tuan Hiep Tran ),( Thiruganesh Ramasamy ),( Duy Hieu Truong ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
The aim of this study is to investigate the potential of nanostructured lipid carriers (NLCs) in improving the oral bioavailability of a lipid lowering agent, fenofibrate (FEN). FEN-loaded NLCs (FENNLCs) were prepared by hot homogenization followed by an ultrasonication method using Compritol 888 ATO as a solid lipid, Labrafil M 1944CS as a liquid lipid, and soya lecithin and Tween 80 as emulsifiers. NLCs were characterized in terms of particle size and zeta pote\ntial, surface morphology, encapsulation efficiency, and physical state properties. Bioavailability studies were carried out in rats by oral administration of FEN-NLC. NLCs exhibited a spherical shape with a small particle size (84.9±4.9 nm). The drug entrapment efficiency was 99% with a loading capacity of 9.93±0.01% (w/w). Biphasic drug release manner with a burst release initially, followed by prolonged release was depicted for in vitro drug release studies. After oral administration of the FEN-NLC, drug concentration in plasma and AUCt-∞ was fourfold higher, respectively, compared to the free FEN suspension. According to these results, FENNLC could be a potential delivery system for improvement of loading capacity and control of drug release, thus prolonging drug action time in the body and enhancing the bioavailability.
( Tuan Hiep Tran ),( Thiruganesh Ramasamy ),( Hyuk Jun Cho ),( Yong Ll Kim ),( Bijay Kumar Poudel ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
The main aim of this study was to improve the oral bioavailability of raloxifene (RXF), a selective estrogen receptor modulator, by incorporation into solid lipid nanoparticles (SLN). RXF-loaded SLN was prepared by homogenization-sonication technique and characterized through physicochemical, pharmacokinetic, and cytotoxicity studies. The optimized SLN formulation exhibited a spherical shape with average size around 140 nm, easing its transport across the lymphatic system. Augmentation in the profiles of C(max) (308%) and AUC (270%) indicated a significant enhancement in the rate and extent of bioavailability by SLN formulations compared to free drug. In vitro cytotoxicity study performed in NIH-3T3 cells revealed that RXF-SLN was cytocompatible, and SLN remained unchanged during the freeze-drying process. Furthermore, the optimized formulation was quite stable at room temperature for more than two months, exemplifying its superior performance. In conclusion, SLN provides a promising platform for the pronounced enhancement of RXF bioavailability.
( Tuan Hiep Tran ),( Hanh Thuy Nguyeon ),( Tung Thanh Pham ),( Ju Yeon Choi ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Despite tremendous progress in chemotherapy, drug resistance remains a major challenge for anticancer treatment. The combinations of chemo-photothermal and chemo-chemo treatments have been reported to be potential solutions to overcome drug resistance. In this study, we developed a dual-in-dual synergistic therapy based on the use of dual anticancer drug-loaded graphene oxide (GO) stabilized with poloxamer 188 for generating heat and delivering drugs to kill cancer cells under near-infrared (NIR) laser irradiation. The nanocomparable system is stable and uniform in size, generating sufficient heat to induce cell death. Dual drugs (doxorubicin and irinotecan)-loaded GO (GO-Dl) in combination with laser irradiation caused higher cytotoxicity than that caused by the administration of a free single drug as well as a combination of drugs and blank GO in various cancer cells, especially in MDA-MB-231 resistant breast cancer cells. Exposure to "hot" NIR and GO-DI activated the intrinsic apoptosis pathway, which was confirmed based on changes in the morphology of cell nuclei and overexpression of apoptosis-related proteins. On the basis of the results, the combined treatment showed a synergistic effect compared to the effect of chemotherapy or photothermal treatment alone, demonstrating higher therapeutic efficacy to overcome one of the most severe problem in anticancer therapy, that of intrinsic resistance to chemotherapeutics.
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
Tran, Tuan Hiep,Ramasamy, Thiruganesh,Choi, Ju Yeon,Nguyen, Hanh Thuy,Pham, Thanh Tung,Jeong, Jee-Heon,Ku, Sae Kwang,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, which was then shielded with the pH-responsive block co-polymer polyethylene glycol-<I>b</I>-polyaspartic acid (PEG-<I>b</I>-PAsp) using a modified emulsion method. The optimized LPH nanoparticles were ~200 nm and had a narrow size distribution. Drug release from DTX-loaded LPH (DTX-LPH) nanoparticles was pH-sensitive, which is beneficial for tumor targeting. More importantly, DTX-LPH nanoparticles were able to effectively induce apoptosis in cancer cells. The negative surface charge and PEG shell of vehicle remarkably enhanced the blood circulation and physiological activity of DTX-LPH nanoparticles compared with that of free DTX. The nanoparticles were also found to reduce the size of tumors in tumor-bearing xenograft mice. The in vivo anticancer effect of DTX-LPH nanoparticles was further confirmed by the elevated levels of caspase-3 and poly ADP ribose polymerase found in the tumors after treatment. Thus, the results suggest that this novel LPH system could be an effective new treatment for cancer.</P>
Tran, Tuan Hiep,Tran, Thi Thu Phuong,Truong, Duy Hieu,Nguyen, Hanh Thuy,Pham, Tung Thanh,Yong, Chul Soon,Kim, Jong Oh Elsevier Science B.V. Amsterdam 2019 ACTA BIOMATERIALIA Vol. No.
<P><B>Abstract</B></P> <P>The expression of Toll-like receptors (TLRs) on antigen presenting cells, especially dendritic cells, offers several sensitive mediators to trigger an adaptive immune response, which potentially can be exploited to detect and eliminate pathogenic objects. Consequently, numerous agonists that target TLRs are being used clinically either alone or in combination with other therapies to strengthen the immune system in the battle against cancer. This review summarizes the roles of TLRs in tumor biology, and focuses on relevant TLR-dependent antitumor pathways and the conjugation of TLR agonists as adjuvants to nano- and micro-particles for boosting responses leading to cancer suppression and eradication.</P> <P><B>Statement of Significance</B></P> <P>Toll-like receptors (TLRs), which express on antigen presenting cells, such as dendritic cells and macrophages, play an important role in sensing pathogenic agents and inducing adaptive immunity. As a result, several TLR agonists have been investigating as therapeutic agents individually or in combination with other treatment modalities for cancer treatment through boosting the immune system. This review aims to focus on the roles of TLRs in cancer and TLR-dependent antitumor pathways as well as the use of different nano- or micro-particles bearing TLR agonists for tumor inhibition and elimination.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives
Tuan Hiep Tran,Raj Kumar Thapa,Hanh Thuy Nguyen,Tung Thanh Pham,Thiruganesh Ramasamy,김동식,용철순,김종오,최한곤 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.6
Photodynamic (PDT) and photothermal (PTT) therapy are proven effective strategies for the treatment of cancer. PDT, a photochemistry-based therapy, utilises light energy based photosensitiser for the production of cytotoxic species via electron transfer to biological substrates and potential excitation or energy transfer to molecular oxygen. On the other hand, PTT utilises substances that can convert light energy into heat for efficient tumour ablation. This review provides an insight into the current research investigations of different nanocarriers utilising the synergistic effects of PTT and PDT for anticancer therapy.
Tuan Hiep Tran,Bijay Kumar Poudel,Nirmal Marasini,우종수,최한곤,용철순,김종오 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1
The purpose of this study was to develop araloxifene-loaded solid dispersion with enhanced dissolutionrate and bioavailability via spray-drying technique. Solid dispersions of raloxifene (RXF) were prepared withPVP K30 at weight ratios of 1:4, 1:6 and 1:8 using a spraydryingmethod, and characterized by differential scanningcalorimetry, X-ray powder diffraction, scanning electronmicroscopy, and solubility and dissolution tests. The bioavailabilityof the solid dispersion in rats was also evaluatedcompared to those of RXF powder and commercial product. Results showed that the RXF-loaded solid dispersion was inamorphous form with increased solubility and dissolutionrate. The absorption of RXF from solid dispersion resultedin approximately 2.6-fold enhanced bioavailability comparedto pure drug. Moreover, RXF-loaded solid dispersiongave similar AUC, Cmax and Tmax values to the commercialproduct, suggesting that it was bioequivalent to the commercialproduct in rats. These findings suggest that anamorphous solid dispersion of RXF could be a viable optionfor enhancing the oral bioavailability of RXF.
TRAN, The Tuan,LE, Tuan Hiep,DO, Phuong Thu Thi,DO, Tho Thi Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.10
Improving the quality of teaching staff in universities is an important goal of most universities. Therefore, it is necessary to evaluate the factors affecting the quality improvement of lecturers at universities. There are many factors affecting the improvement of this quality of human resources. This article uses the survey method to assess the factors affecting the improvement of the quality of lecturers in education and training institutions of the Ministry of Transport of Vietnam. Currently, the Ministry of Transport of Vietnam has 4 educational institutions. The research team has assessed the impact factors at these 4 facilities. The research team conducted a survey for faculty members of the Ministry of Transport. The result was 446 votes. The authors have performed factor evaluation by multivariate regression model. The influencing factors include Professional competence, the virtue of teaching staff, scientific research capacity, participating in building a democratic educational environment, Professional support policy, Instructor's income, and Information technology support. Research results show that most of the factors have a positive impact on improving the quality of lecturers. Based on the survey results, the authors also make policy suggestions to further improve the quality of teaching staff of the schools in the coming time.
Preparation and Characterization of Spray-Dried Gelatin Microspheres Encapsulating Ganciclovir
Tuan Hiep Tran,김종오,Thiruganesh Ramasamy,Bijay Kumar Poudel,Nirmal Marasini,문보경,조혁준,최한곤,용철순 한국고분자학회 2014 Macromolecular Research Vol.22 No.2
The aim of this study was to prepare ganciclovir (GCV)-loaded cross-linked gelatin microspheres byspray-drying method. The microspheres were characterized in terms of particle size, surface morphology, loadingefficiency, thermal behavior, physical characteristics, swelling properties, and the release profile in vitro. The majorprocess and formulation parameters were optimized to obtain smaller particles with high loading capacity. The physicalstate examination confirmed the molecular-level dispersion of drug in the polymer. The loading efficiency determinedby high-performance liquid chromatography (HPLC) was around 68%. The in vitro release experimentsrevealed that the GCV released from the gelatin microspheres was related to the extent of swelling, which was proportionalto the drug-to-polymer ratio. These results suggest that cross-linked gelatin microspheres could be a suitabledrug-delivery system for GCV.
( Tuan Hiep Tran ),( Bijay K Poudel ),( Nirmal Marasini ),( Sang Cheol Chi ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble drug, raloxifene by solid dispersion (SD) nanoparticles using the spray-drying technique. These spray-dried SD nanoparticles were prepared with raloxifene (RXF), polyvinylpyrrolidone (PVP) and Tween 20 in water. Reconstitution of optimized RXF-loaded SD nanoparticles in pH 1.2 medium showed a mean particle size of approximately 180 nm. X-ray diffraction and differential scanning calorimetry indicated that RXF existed in an amorphous form within spray-dried nanoparticles. The optimized formulation showed an enhanced dissolution rate of RXF at pH 1.2, 4.0, 6.8 and distilled water as compared to pure RXF powder. The improved dissolution of raloxifene from spray-dried SD nanoparticles appeared to be well correlated with enhanced oral bioavailability of raloxifene in rats. Furthermore, the pharmacokinetic parameters of the spray-dried SD nanoparticles showed increased AUC(0-∞) and C(max) of RXF by approximately 3.3-fold and 2.3-fold, respectively. These results suggest that the preparation of RXF-SD nanoparticles using the spray drying technique without organic solvents might be a promising approach for improving the oral bioavailability of RXF.ⓒ2013 Elsevier B.V.All righrs reserved.