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- 저자 : ( Tolga Yildirim ) (검색결과 1 건)
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( Tolga Yildirim ),( Hadim Akoglu ),( Rahmi Yilmaz ),( Gonca Eldem ),( Tuncay Hazirolan ),( Tuncay Aki ),( Mustafa Arici ),( Bulent Altun ),( Yunus Erdem ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Immunosuppressive protocols decreased the rates of acute rejection in kidney transplantation however long term graft survival has not changed signifi cantly. Nephron underdosing may be one of the factors affecting the long term prognosis of the transplanted kidney. Aim of this study was to determine the impact of volume of transplanted kidney on long term allograft functions. Methods: The study was conducted among sixty-two living renal transplant recipients (41 male, 21 female; mean age 30.6±10.2 years) who underwent transplantation between years 2003-2007 and their respective donors (22 male, 40 female; age 41.9±9.9 years). Patients that suffered graft loss due to any cause within fi ve years after transplantation were excluded. Volume of the transplanted kidneys had been measured preoperatively via 3-D helical computerized tomography. Transplanted kidney volume/ recipient weight (Vol/weight) was calculated for each donor-recipient pair. Subjects were divided into two groups according to the median value of Vol/weight (2.35 cm3/ kg). Glomerular fi ltration rates (GFR) of the recipients were calculated for fi ve years. Results: First and third year GFR`s of the patients was significantly higher in Vol/ weight>2.35 cm3/kg group compared to Vol/weight<2.35 cm3/kg group (73.7±17.6 vs. 61.6±19.3, p=0.01 and 72.3±20.7 vs. 60.0±17.3, p=0.01 respectively). However fi fth year GFR was similar in both groups (64.5±16.9 and 56.6±21.7, p=0.11). There was a signifi cant correlation between Vol/weight and both fi rst and third year GFR`s (r=0.409, p<0.001 and r=0.429, p<0.001; respectively). The correlation was not observed with the fi fth year GFR (r=0.133, p=0.303). Conclusions: Volume of transplanted kidney adjusted for recipient weight is a signifi - cant predictor of early but not late graft functions.
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