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백상현,박재성,차장규,홍현숙,김대호,박성진,조준희,이혜경,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2
Purpose: BOOP and NSIP also share similar clinical features such as subacute flu-like illness, the finding of bronchoalveolar lavage, the result of pulmonary function test and more favourable outcome than usual interstitial pneumonia(UIP). The author try to compare the HRCT findings of NSIP with BOOP by pattern and distribution of diseases. Materials and Methods: HRCT findings of histopathologically proven NSIP(Group Ⅰ; 6, Group Ⅱ; 7, Group Ⅲ; 2) in 15 patients(5 male, 10 female, age range, 39-69 years; mean age, 53 years), BOOP in 15 patients(6 male, 9 female, age range, 26-76 years; mean age, 52 years) were reviewed retrospectively. Results: The common pattern of the two diseases was admixed consolidation, ground glass attenuation & reticular densities with/without architectural distortion(NSIP; 53.3%, BOOP; 46.7%). The main component of the pattern wan predominantly consolidation(NSIP; 46.7%, BOOP; 73.3%) and ground glass attenuation(NSIP; 40.0%, BOOP;20.0%). Architectural distotion was more provinent finding with NSIP(mild ; 3, moderate ; 4, severe; 2) compared with BOOP(mild; 7, moderate; 2, severe; 0). The predominant overall distribution was lower lung, peribronchovascular & peripheral lung field in both of the two entities(NSIP;73.3%, BOOP; 73.3%). Peribronchovascular involvement was more common with NSIP(100%) than BOOP(80%), whereas peripheral involvement was more common with BOOP(93.3%) than NSIP(80%). Conclusion: The HRCT findings of NSIP and BOOP were similar in pattern and distribution. But NIP manifested more frequently ground-glass attenuation, whereas BOOP showed more frequently consolidation. Architectural distortion was more severe with NSIP than BOOP. NSIP invoved more frequently peribronchovascular space and BOOP were more common in peripheral lung field.
CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication
박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2
Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.
( Sung Guy Jin ),( Kyeong Soo Kim ),( Dong Wuk Kim ),( Dong Shik Kim ),( Youn Gee Seo ),( Toe Gyung Go ),( Yu Seok Youn ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
To develop a novel sodium fusidate-Ioaded triple polymer hydrogel dressing (TPHD). numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method. and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA The effect of selected PVP:SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of sodium fusidate-Ioaded PVA-based TPHDs were assessed. As the ratio of PVP:SA increased in PVA-Ioaded TPHD, the swelling capacity, mechanical properties, drug release. permeation and deposition were improved. The TPHD containing PVA. PVP, SA and sodium fusidate at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties. release. permeation and deposition of drug. Within 24 h, 71.8 ± 1.3% of drug was released. It permeated 625.1 ±81.2μg/cm<sub>2</sub> through the skin and deposited of 313.8 ± 24.1 fLgfcm2 within 24 h. The results of in vivo pharmacodynamic studies showed that sodium fusidate-Ioaded TPHD was more effective in improving the repair process than was a commercial product. Thus, this sodium fusidate-Ioaded TPHD could be a novel tool in wound care.
Lee, Jin-Hyung,Kim, Yong-Guy,Shim, Sang Hee,Lee, Jintae Elsevier 2017 Phytomedicine Vol.36 No.-
<P>Conclusion: These findings strongly suggest that harmaline and norharmane could have potential use in antibiofilm strategy against persistent bacterial infections.</P>
결핵성 림프절염에 의한 담관 폐쇄 및 문맥압항진증 1 예
김진일,김영수,양진모,이정민,김선명,송동섭,박두호,박진노,장은덕,방춘상,권낙기,오귀염 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3
Common causes of biliary tract obstruction are mostly choledocholithiasis and neoplastic diseases. Enlargement of adjacent lymph nodes due to malignant tumors or lymphoma can occasionally ob struct the biliary duct, but obstructive jaundice and portal hypertension produced by periportal tuber culous lymphadenitis are quite rare. Its diagnosis is difficult because symptoms and signs are non specific and clinical tests are not conclusive. Additionally, the lesion mimic a malignancy clinically and radiologically. However, it is important to differentiate it from malignancy. We describe a patien who presented with jaundice and portal hypertension caused by biliary obstruction due to tuberculous lymphadenitis involving distal portion of the common bile duct.
김성수(Kim, Sung-Soo),공일천(Kong, Il-Chean),이장원(Lee, Jang-Won),김진수(Kim, Jin-Su),박일규(Park, Il-Guy),이동호(Rie, Dong-Ho) 한국화재소방학회 2012 한국화재소방학회 학술대회 논문집 Vol.2012 No.춘계
포소화약제는 물과 혼합시, 물의 표면장력을 저하시켜 공기와 혼합 교반을 통하여 거품을 발생시키는 약제로 소화에 이용되는 소화용수의 효율적 이용을 위하여 이용된다. 특히, 유류화재에 사용시 유면을 거품으로 덮어 질식소화에 적합한 특성을 가지고 있다. 포소화약제는 발포 방식에 따라 저발포, 중발포, 고발포로 나누어지는데 국내의 포소화약제 기준에는 저발포와 고발포의 2가지만을 규정하고 있어, 소화에 더욱 효과적이라 평가되는 중발포 소화기의 이용이 어렵다. 본 연구에서는 휴대용 중발포 소화기를 이용하여 발포실험과 소화실험을 실시하고, 저발포, 중발포, 고발포의 특성을 분석하였다. 결과로 3% 농도로 중발포 소화기 이용시 26.1배의 팽창률을 보였으며, 20단위 화재모형을 32초에 소화시킴으로써 중발포 소화기의 발포, 소화능력을 검증하였다.