구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

Probe 위치 변화에 따른 이음향방사의 변화

장봉익,이재욱,김상렬,강명구,김리석 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

공작 기계의 신뢰성 평가를 위한 웹 기반 해석 프로그램 개발

강태한,김봉석,이수훈,송준엽,강재훈 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

Web-based analysis programs for reliability assessment of machine tools were developed in this study. First, the reliability data analysis program was developed to search for failure rate using failure data and reliability test data of mechanical part. Second, failure mode analysis was developed through performance tests like circular movement test vibration test for machine tools. This analysis program shows correlation between failure mode and performance test result. Third, tool life was predicted by correlation between flank wear and cutting time, using the extended Taylor tool life equation in turning data and the equivalently converted equation in order to apply ball endmill data to Taylor tool life equation in milling data. All the information related to input and result data can be stored in theses programs.

백색부후균 전처리에 의한 목재 칩의 Biopulping

강규영,김형진,양봉숙,조병묵,오정수 동국대학교 생명자원과학대학 연습림 2000 연습림논문집 Vol.- No.6

Pulping process is to mainly obtain lignocellulosic fibers for papermaking from wood resources. Three types of pulping method have been basically employed, such as chemical pulping, mechanical pulping, and their combination methods. Biopulping technique has been mainly applied in mechanical pulping by pretreatment of white-rot fungi into the ultrastructure of wood cell wall. The main purpose of biopulping is to improve the pulp qualities, paper properties, and to reduce the energy costs and environmental impact, compared to traditional pulping systems. Nowadays, biopulping is frequently tried in chemical pulping operation for environmental concept, fiber modification, improvement of physical properties of paper and economic savings. The pretreatment of white-rot fungi prior to chemical pulping could affect the swelling and softening of wood cell walls by the behaviors of modification and depolymerization of ligin compounds. This study was carried out to investigate the effectiveness of biological treatment to wood chips by white-rot fungus and its structural change of lignocellulosic fiber via kraft pulping. A rotary bioreactor was applied for pretreatment of biological action. The treatment of white-rot fungus was shown in weight loss of chips. After bio-kraft pulping, kappa number and total yield of pulps were measured, and reduced. Freeness(CSF) values were also decreased. Whereas brightness values were increased, compared to untreated control. The physical strength of handsheets was shown a slight increase in tensile, tear, burst, and folding endurance, with bio-treatments.

저가 후막 EL소자 제조 및 신뢰성 평가

강계원,김대연,이영훈,강봉석,박정현,최병호 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-

AC powder electroluminescence(EL) device consists of seven layers : PET substrate, transparent electrode, phosphor layer, dielectric layer, two layer metal electrodes and protective layer. Etch layer needs to control to improve electrical and optical properties. Both phosphor and dielectric layer among them is more important to increase its properties. For long-time reliability, proper choices of passivation and sealing material are essential. In this paper, influence of phosphor and dielectric layer thickness on EL performance is studied. Type of cellulos is selected as a sealing material to avoid moisture. To add two type of plasticizer to resin improves flexibility and passivation of EL devices. Through this experiments, technologies of fabrication low-cost thick film EL device can be established.

공작기계 주축용 베어링 결함 자동진단시스템의 개발

정의식,강형모,류봉조,임경빈,고준빈,박수규 한밭대학교 산업과학기술연구소 1995 논문집 Vol.3 No.-

This paper deal with a method of detecting localized defects on taper roller bearing in main spindle of machine tool system. The statistical parameters in time-domain signal processing techniques have been calculated to extract useful features from bearing vibration signals. Emloying these features, the statiscical parameters have been established to detect defects on the rollers of bearings, respectively, and used by the input feature of an artificial neural nerwork. As a result that the proposed bearing defects monitoring system could be successfully performed by using the statistical parameters of acceleration signals.

효소 전처리 BCTMP 시트의 노화 거동

양봉숙,김형진,강규영,조병묵,오정수 동국대학교 생명자원과학대학 연습림 2000 연습림논문집 Vol.- No.6

It was generally known that the aging treatment of paper is accompanied with the reductions in physical and optical properties of individual fibers and sheet. In particular, the paper prepared with mechanical pulps occurs the yellowing of sheet, during aging, due to the absorption of light or temperature, and finally has limitation in widely applicable functions of paper. The aging behaviors of paper can be discussed with three groups of factor. One is considered to external factors, like heat, light and moisture. Another is commented with environmental factors, like oxygen, nitrogen, sulfur, and other air pollutant materials. The other is explained by internal factors, like pulp types, lignin contents, and so on. In this paper, the aging behaviors of paper prepared with BCTMP were studied in order to know how to affect in physical and optical properties of paper. For modification of fibers properties, a commercial enzyme was pretreated in the slurry of BCTMP, before handsheet-making. Sheets were aged by accelerated heat treatment. The comparisons were carried out in mechanical strength properties and color reversions. Aging treatments were resulted in higher brightness reductions, in enzyme pretreated paper.

Quaternary Ammonium Salt Cephalosporin계 抗生劑 合成

高捧奭,高玉鉉,姜馨龍 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

For the development of quaternary ammonium salt cephalosporin antibiotics with improved antimicrobial activities, a series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(methox yimi no) acetamido]-3-[4-alkyl (or aryl)-3- thiosemicarbazid-1- nicotinonium] methyl -3- cephem -4- carboxylate were synthesized. Antimicrobial activities of these new compounds were examined against Gram(+) and Gram(-)bacteria. It was found that the moiety synthesized cephalosporin derivatives were good antibacterial activities against Escherichia coli. Almost these compounds were more antibacterial activities than cefazoline. These new compounds showed lower activity than cefotaxime against Pseudomonas aeruginosa.

일부 생산직 근로자의 소음과 사회심리적 요인이 혈압에 미치는 영향

박종구,강명근,차봉석,고상열,장세진,고상백 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

This study was conducted to assess the effects of noise exposure and psychosocial factor on blood pressure in manufacturing workers. The study subjects are 414 workers(243 males, 171 females) employed at the noisy department. The mean age of low exposed group(<85dB) was 34.65±9.53 years, and that of high exposed group(≥85dB) was 36.37±11.15 years. The difference in mean age was not significant. The mean and distribution of working duration, smoking status, drinking status were not significantly different between two groups. The mean systolic blood pressure of the low exposed group was 120.01±12.06 mmHg, and that of high exposed group was 126.27±13.84mmHg. The mean diastolic blood pressure of the low exposed and the high exposed group were 77.18±10.83 mmHg, and 83.46±11.22mmHg respectively. These differences of blood pressure were statistically significant(p<0.05). The workers in noisy department have significantly less work environmental satisfaction, higher job demand, and higher social support. The mean values of psychosocial distress were higher in the workers of the noisy department, but the difference was not statistically significant. This study was to speculate whether the work environmental satisfaction and social support modify the association between the noise exposure level and the blood pressure. The result showed that work environmental satisfaction could not modify the association between the blood pressure and the noise exposure. Social support at work did not modify the association. Furthermore, we evaluated the high job strain from a combination of ratio of the high job strain group for hypertension in diastolic blood pressure were statistically significant, but not in systolic blood pressure. Hierarchical multiple regression analysis was used to determine whither the independent variables contributed to explaining the blood pressure. After controlling for possible confounders, we found that the noise exposure level was a correlated of the diastolic blood pressure. But no association between the noise exposure level and the systolic blood pressure. No significant result was found for psychosocial factor.

Al₃Sc 나노 석출물이 ARB 가공한 Al-0.2 wt% Sc 합금의 고경각립계 형성에 미치는 영향

민복기,김형욱,강석봉 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.12

The cold rolled Al-0.2 wt% Sc alloy sheets were pre- heat treated: (1) as solution treated at 630℃ for 1 hour and (2) as artificial aged at 300℃ for 5 hours, and the following accumulative roll bonding was conducted up to the 8 cycles at ambient temperature. The interconnecting boundary spacing of the aged alloys was narrow and maintained constantly at each ARB cycle. While, the spacing of solution treated alloy was relatively broad and decreased rapidly with increasing ARB cycles. The fraction of high angle boundaries in both alloys increased gradually with increasing equivalent strain, however the age-ARB alloys showed relatively higher fraction of HAGBs than the solution treat-ARB alloys at the same strain levels. And the former shows faster development of lamellar structure than the later. These variations are attributed to the fact that the nano-scale, semi-coherent A13Sc hinders the migration of dislocation. However, those precipitates cannot apply pinning effect sufficiently during static recrystallization above 350℃ because the driving pressure for recrystallization overcomes the Zener pinning pressure. (Received September 30, 2004)