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Multi-loculated Empyemas after Acupuncture
Soung Hoon Cho,Do Hyung Kim,Young Mo Yang,Dong Gyu Kim,나동집,Min Soo Han,이양덕 대한응급의학회 2008 大韓應急醫學會誌 Vol.19 No.4
There are several reported possible complications of acupuncture including hepatitis, pneumothorax, and cardiac tamponades, but the development of empyema is unusual. All the previously described cases of empyemas were due to acupuncture needles being inadvertently left in the thoracic cavities. We describe a thirty seven years old female patient who developed empyema after multiple acupuncture sessions whose disease course was unique because the empyema developed without an acupuncture needle being left in the thoracic cavity. This case demonstrates that an acupuncture needle being left in the thoracic cavity is not necessary for the development of empyema after acupuncture sessions as previously described.
Cho, Soung Hoon,Kim, Sang Woo,Kim, Won Chul,Park, Jae Myung,Yoo, Ie Ryung,Kim, Sung Hoon,Oh, Seong Taek WJG Press 2013 World journal of gastroenterology Vol.19 No.22
<P>To assess the clinical significance of incidental focal colorectal ¹???F-fluorodeoxyglucose (¹???F-FDG) uptake on ¹???F-FDG-positron emission tomography/computed tomography (PET/CT).</P>
Feature Article : Mechanical Stimulation of Mesenchymal Stem Cells for Tissue Engineering
( Jang Ho Kim ),( Chong Su Cho ),( Yun Hoon Choung ),( Ki Taek Lim ),( Hyun Mok Son ),( Hoon Seon Woo ),( Soo Jung Baik ),( Soung Hoo Jeon ),( Joo Young Park ),( Pill Hoon Choung ),( Jong Hoon Chung ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Tissue engineering is a rapidly growing field that utilizes cell/scaffolds constructs with chemical signaling molecules as potential therapeutic products for tissue regeneration. Mesenchymal stem cells(MSCs) provide excellent novel strategies for tissue engineering application. Recently, it has been recognized that understanding mechanical stimulation is an important key to the development of efficient and controllable methods as well as chemical signaling for differentiation of MSCs and tissue engineering application. Especially, a number of studies indicated that the mechanical stimuli can enhance the synergy effects for differentiation of MSCs and tissue formation or regeneration. In this review, we introduced the various mechanical stimuli techniques, the effects of mechanical stimuli to MSCs, and tissue engineering applications. Furthermore, we discussed the further research directions of MSCs and mechanical stimuli based on this review for tissue engineering.
( Ki Taek Lim ),( Seon Woo Hoon ),( Hyun Mok Son ),( Soo Jung Baik ),( Jang Ho Kim ),( Soung Hoo Jeon ),( Joo Young Park ),( Yun Hoon Choung ),( Chong Su Cho ),( Pill Hoon Choung ),( Jong Hoon Chung ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.14
In the design of perfusion bioreactor system for tissue engineering, design parameters including fluid dynamics and mass transport as well as scaffolds should be optimized to maximize cell growth. Critical elements in bioreactor systems based on cells and scaffolds include cell seeding, the nutrient and gas supply to cells, and mechanical stimuli. In particular, perfusion flow systems have been shown to enhance cell growth, differentiation, and tissue formation as well as provide for the appropriate and necessary mass transfer of nutrients, gases, metabolites, and regulatory molecules. In this paper, we reviewed the biomechanical models in relation with fluid dynamics, mass transport, and shear stress with scaffolds. Therefore, obtaining a proper oxygen supply, high cell density, and an uniform cell distribution in a three-dimensional growth support are important. Both experiments and quantitative mathematical models of cell culture in perfusion bioreactors are needed to better understand physical, mechanical, and biochemical conditions and for the design of a suitable bioreactor system the mathematical describes the oxygen mass transfer and cell density within a three-dimensional scaffold. This review focuses on biomechanical models in relation with fluid dynamics, mass transport, and shear stress to cells cultured, and cell growth in perfusion bioreactors for tissue engineering.
Feature Article : Novel Perfusion Bioreactor Systems for Tissue Engineering
( Ki Taek Lim ),( Chong Su Cho ),( Yun Hoon Choung ),( Jang Ho Kim ),( Hyun Mok Son ),( Hoon Seon Woo ),( Soo Jung Baik ),( Soung Hoo Jeon ),( Joo Young Park ),( Pill Hoon Choung ),( Jong Hoon Chung ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Bioreactor systems that use a new aeration concept have recently been introduced. Bioreactors can assist in the development of new tissues in vitro by providing appropriate stimuli to the cell cultures. The design of bioreactors for tissue engineering is very complex and is often tailored to individual cell- engineered-tissue products. Critical elements in bioreactor systems based on cells and scaffolds include cell seeding, the nutrient and gas supply to cells, and mechanical stimuli. Flow perfusion systems have been shown to enhance cell growth, differentiation, and tissue formation as well as provide for the appropriate and necessary mass transfer of nutrients, gases, metabolites, and regulatory molecules. The beneficial effects of fluid flow induced convective transport and shear stress have been exploited in various types of bioreactors because fluid flow-through cell and tissue engineered constructs increase nutrient transport. These systems are called flow-perfusion bioreactors. In this paper, we review the characteristics of bioreactor systems used for cell culture in tissue engineering, and provide a schematic design for a novel bioreactor system that incorporates the elements we deem critical for such systems.
Cho, Seongji,Sodnom-Ish, Buyanbileg,Eo, Mi Young,Lee, Ju Young,Kwon, Ik Jae,Myoung, Hoon,Yoon, Hye Jung,Kim, Soung Min The Korean Association of Oral and Maxillofacial S 2022 대한구강악안면외과학회지 Vol.48 No.5
The specific muscular structure of the tongue greatly affects margin shrinkage and tumor invasion, making the optimal surgical margin controversial. This study investigated surgical margin correlated prognosis of TSCC (tongue squamous cell carcinoma) according to margin location and its value, and the histopathologic factors which are suggestive of tumor invasion. And we would like to propose defining of the surgical margin for TSCC via prognosis according to location and margin values. We reviewed 45 patients diagnosed with TSCC who visited Seoul National University Dental Hospital (SNUDH) (Seoul, Republic of Korea) from 2010 to 2019, who were managed by a single surgical team. Patient clinical and pathological data of patients were retrospectively reviewed, and in 36 out of 45 patients, the pathologic parameters including the worst pattern of invasion (WPOI) and tumor budding were investigated via diagnostic histopathology slide reading. When standardized with as 0.25 cm anterior margins, as 0.35 cm deep margin, there was no significant difference in disease specific survival (DSS) or loco-regional recurrence-free survival (LRFS). Additionally, there was a non-significant difference in DSS and LRFS at the nearest margin of 0.35 cm (P<sub>DSS</sub>=0.276, P<sub>LRFS</sub>=0.162). Aggressive WPOI and high tumor budding showed lower survival and recurrence-free survival, and there were significant differences in close margin and involved margin frequencies. In TSCC, the value and location of the surgical margin did not have a significant relationship with prognosis, but WPOI and tumor budding suggesting the pattern of muscle invasion affected survival and recurrence-free survival. WPOI and tumor budding should be considered when setting an optimal surgical margin.
Usefulness of Interferon-Gamma Release Assay for Diagnosis of Tuberculous Fistulae in Ano
Soung-Ho Kim,Do-Yeon Hwang,Seok-Gyu Song,Hyeok-Jin Kwon,Sun-Yeon Cho,Duk-Hoon Park,Jung-Dal Lee,Jong Kyun Lee 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.3
Purpose: Interferon gamma release assays (QuantiFERON-TB Gold in Tube test [QFT-GIT]); Cellestis Limited, Victoria, Australia) have been studied for diagnosing pulmonary tuberculosis (TB) or latent TB but there have been no reports on the usefulness of this assay in diagnosing tuberculous anal fistula in actual clinical practices. In this study, we evaluated its diagnostic usefulness in patients with suspected tuberculous anal fistula. Methods: We conducted a retrospective analysis of 119 patients with suspected tuberculous anorectal fistula from May 2007 to May 2009. Diagnosis of tuberculous fistula was concluded by identification of acid-fast bacilli, typical caseating granuloma and successful clinical response to anti-TB chemotherapy. All patients underwent the QFT-GIT and all patients diagnosed with tuberculous anal fistula were analyzed. Results: Of the 119 patients with suspected TB fistula, 51 (43%) patients were classified as having TB fistula, including 31 with confirmed tuberculosis and 20 with probable tuberculosis, and other 68 (57%) were classified as not having tuberculosis. Among the 51 patients with TB fistula, Chronic caseating granuloma, acid-fast bacilli stain, and successful clinical response to anti-TB treatment were positive in 27 (52.9%), 4 (7.8%), and 20 (39.2%), respectively. Of the 51 with TB fistula, 44 had positive QFT-GIT results and 7 had negative results. The sensitivity and specificity of the assay were 86% and 85%, and positive predictive value (PPV) and negative predictive value (NPV) were 81% and 89%, respectively. Conclusion: QFT-GIT is a simple, sensitive, and specific method for the diagnosis of clinically highly suspected TB fistula.