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박한솔,( Sonita Afrita Purba Siboro ),이시윤,임권택 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
The current study aimed to report the effect of hydrogel porosity, which may be controlled by the design of crosslinkers, on drug release behavior. Porous alginate-based hydrogels were prepared from the inverse electron demand Diels-Alder reaction of alginate-norbornene (Alg-Nb) and disulfide-tetrazine (S-Tz). The porosity of hydrogels could be controlled by adjusting the amount of S-Tz crosslinker. Gel formation was facilitated by a “click” reaction between Nb and Tz, which produced nitrogen gas, which in turn, acted as an in-situ pore generator. Proportion of crosslinker and porosity were concluded to be significant factors for drug release behavior of hydrogels.
Effect of Porosity in Alginate Hydrogels on the Drug Release Behavior
조성우,Sonita Afrita Purba Siboro,이시윤,박찬,임권택 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
In this study, two kinds of alginate-based hydrogel were prepared: alginate-furfuryl amine (Alg-F) crosslinked by disulfide-maleimide (S-Ma) and alginate-norbornene (Alg-Nb) crosslinked by disulfide-tetrazine (S-Tz). The “click” chemistry between Alg-Nb and S-Tz during gelation was producing N2 gas and led to the formation of hydrogels with porous structure, in which the porosity could be tuned by adjusting the proportion of crosslinker. As for the crosslinking reaction between Alg-F and S-Ma was performed by DA reaction, which did not produce any by-product and led to the formation of non-porous hydrogel. The drug release study revealed that hydrogel porosity affected drug loading capacity and played a significant role in the kinetics of drug release. days in a sustained manner.