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재유화형 폴리머와 백시멘트의 조성비가 자기수평모르타르의 물리적 특성에 미치는 영향에 관한 실험적 연구
( Shao Xu-dong ),곽규성 ( Kwak Kyu-sung ),채우병 ( Chae Woo-byung ),오상근 ( Oh Sang-keun ) 한국구조물진단유지관리공학회 2009 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.13 No.2
This study investigates the physical properties of the self-leveling mortar according to variable composition set of redispersible polymers and white Portland cement. This materials have to be composed of many types of binders and chemical additives. So it is difficult to decide suitable mixing proportion of composition materials. The self-leveling materials using "0, 2, 4, 6, 8kg" of EVA polymer dispersion ranges are prepared with three types of white Portland cement rations which respectively rangs from "290, 300, 310kg", and were tested for basic characteristics such as flowability, flexural, and compressive strength, bond strength.
재유화형 폴리머와 백시멘트의 조성비가 자기수평모르타르의 물리적 특성에 미치는 영향에 관한 실험적 연구
邵旭東(Shao, Xu-Dong),곽규성(Kwak, Kyu-Sung),채우병(Chae, Woo-Byung),오상근(Oh, Sang-Keun) 한국구조물진단유지관리학회 2009 한국구조물진단학회 학술발표회논문집 Vol.2009 No.2
This study investigates the physical properties of the self-leveling mortar according to variable composition set of redispersible polymers and white portland cement. This materials have to be composed of many types of binders and chemical additives. So it is difficult to decide suitable mixing proportion of composition materials. The self-leveling materials using "0, 2, 4, 6, 8kg" of EVA polymer dispersion ranges are prepared with three types of white portland cement rations which respectively rangs from "290, 300, 310kg", and were tested for basic characteristics such as flowability, flexural, and compressive strength, bond strength.
Dong-Wei Liu,Jia-Hui Zhang,Feng-Xun Liu,Xu-Tong Wang,Shao-Kang Pan,Deng-Ke Jiang,Zi-Hao Zhao,Zhang-Suo Liu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The number of patients with diabetic nephropathy (DN) is still on the rise worldwide, and this requires the development of new therapeutic strategies. Recent reports have highlighted genetic factors in the treatment of DN. Herein, we aimed to study the roles of long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and histone 3 lysine 27 trimethylation (H3K27me3) in DN. A model of DN was established by inducing diabetes in mice with streptozotocin. Mouse podocyte clone 5 (MPC5) podocytes and primary podocytes were cultured in normal and high glucose media to observe cell morphology and to quantify PVT1 expression. The roles of PVT1 and enhancer of zeste homolog 2 (EZH2) were validated via loss-of-function and gain-of-function in vitro experiments to identify the interactions among PVT1, EZH2, and forkhead box A1 (FOXA1). The podocyte damage and apoptosis due to PVT1 and FOXA1 were verified with in vivo experiments. PVT1 was highly expressed in MPC5 and primary podocytes in DN patients and in cultures grown in high glucose medium. A large number of CpG (C-phosphate-G) island sites were predicted at the FOXA1 promoter region, where PVT1 recruited EZH2 to promote the recruitment of H3K27me3. The silencing of PVT1 or the overexpression of FOXA1 relieved the damage and inhibited the apoptosis of podocytes in DN, as was evidenced by the upregulated expression of synaptopodin and podocin, higher expression of Bcl-2, and lower expression of Bax and cleaved caspase-3. The key findings of this study collectively indicate that the suppression of lncRNA PVT1 exerts inhibitory effects on podocyte damage and apoptosis via FOXA1 in DN, which is of clinical significance.
THE APPLICATION OF THE ADAPTIVE NOISE ELIMINATOR IN OIL LOGGING
Xu, Song Yuan,Zhou, Wei Dong,Xu, Shao Qing 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
This paper presents the principle of the adaptive noise eliminator, addaptive algorithm, and simulation results. The simulation results display that useful signals can be efficiently extracted from strong noises by the adaptive noise eliminator on the condition that we have little prior knowledge about signal and noises.
Dong-Feng Chen,Xican Li,Zhiwei Xu,Xiaobing Liu,Shao-Hui Du,Hui Li,Jian-Hong Zhou,He-Ping Zeng,Zi-Chun Hua 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Buzhong Yiqi decoction (BYD) is a well-known ancient tonic prescription in traditional Chinese medicine (TCM). The purpose of this study is to identify active components of BYD involved in promoting proliferation of mesenchymal stem cells (MSCs) and to investigate its mechanism. BYD was extracted with petroleum ether, ethanol, and water. Evidence provided by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, bromodeoxyuridine, proliferation cell nuclear antigen immunoreactivity, cell cycle analysis, and gas chromatography-mass spectrometry indicated that hexadecanoic acid (HA) in BYD extracted with petroleum ether is the active compound responsible for increasing proliferation of MSCs. Western blot analysis show that HA significantly increase retinoic acid receptor (RAR) levels of MSCs, but not estrogen receptor, thyroid hormone receptor, vitamin D receptor, glucocorticoid receptor, and peroxisome proliferator-activated receptor. Reverse transcription-polymerase chain reaction revealed that HA significantly increased RAR mRNA levels. Furthermore, the mechanism of HA action depends on RAR pathway and up-regulates expression of mRNA for insulin-like growth factor-I, the target gene of RAR. Our findings have now allowed for a refinement in our understanding of TCM with respect to pharmacological regulation of stem cells and may be useful to stem cell biology and therapy.
Distributed Consensus Control for Automatic Gauge Control of Hot Strip Mills
Xiao-Dong Zhang,Shao-Shu Gao,Wei-Xi Gao,Xu-Ying Wang,Wei Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.5
In this study, the distributed control strategy is proposed for the automatic gauge control(AGC) system, which is a typical multi-agent system. The distributed control protocol is developed with the subspace identification method using the measurements of the local agent and its neighbors directly,without any knowledge of the AGC system dynamics. The stability analysis of the multi-agent system with the proposed control protocol is given. In addition, the consensus control protocol with communication time delay is investigated. Finally, simulation results are carried out to verify the feasibility and effectiveness of the proposed control strategy.
Juan Zhang,Dong-Ling Xu,Xiao-Bo Liu,Shao-jie Bi,Tong Zhao,Shu-Jian Sui,Xiao-Ping Ji,Qing-Hua Lu 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2
Purpose: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2 inhibitor) could reduce the elevated Lp-PLA2 and Rho kinase activity in atherosclerosis. Materials and Methods: Studies were performed in male Sprague-Dawley rats. The atherosclerosis rats were prepared by feeding them with a high-cholesterol diet for 10 weeks. Low-dose darapladib (25 mg·kg-1·d-1) and high-dose darapladib (50 mg·kg-1·d-1) interventions were then administered over the course of 2 weeks. Results: The serum levels of triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoproteincholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), and Lp-PLA2, significantly increased in atherosclerosis model groups, as did Rho kinase activity and cardiomyocyte apoptosis (p<0.05 vs. sham group), whereas nitric oxide (NO) productionwas reduced. Levels of TC, LDL-C, CRP, Lp-PLA2, and Rho kinase activity were respectively reduced in darapladib groups, whereas NO production was enhanced. When compared to the low-dose darapladib group, the reduction of the levels of TC, LDL-C, CRP, and Lp-PLA2 was more prominent in the high-dose darapladib group (p<0.05), and the increase of NO productionwas more prominent (p<0.05). Cardiomyocyte apoptosis of the high-dose darapladib group was also significantly reduced compared to the low-dose darapladib group (p<0.05). However, there was no significant difference in Rho kinase activity between the low-dose darapladib group and the high-dose darapladib group (p>0.05). Conclusion: Darapladib, a Lp-PLA2 inhibitor, leads to cardiovascular protection that might be mediated by its inhibition of both Rho kinase and Lp-PLA2 in atherosclerosis.
Structural Evolution of Sub-10 nm Octahedral Platinum–Nickel Bimetallic Nanocrystals
Chang, Qiaowan,Xu, Yuan,Duan, Zhiyuan,Xiao, Fei,Fu, Fang,Hong, Youngmin,Kim, Jeonghyeon,Choi, Sang-Il,Su, Dong,Shao, Minhua American Chemical Society 2017 NANO LETTERS Vol.17 No.6
<P>Octahedral Pt alloy nanocrystals (NCs) have shown excellent activities as electrocatalysts toward oxygen reduction reaction (ORR). As the activity and stability of NCs are highly dependent on their structure and the elemental distribution, it is of great importance to understand the formation mechanism of octahedral NCs and to rationally synthesize shape-controlled alloy catalysts with optimized ORR activity and stability. However, the factors controlling the structural and compositional evolution during the synthesis have not been well understood yet. Here, we systematically investigated the structure and composition evolution pathways of Pt-Ni octahedra synthesized with the assistance of W(CO)(6) and revealed a unique core-shell structure, consisting of a Pt core and a Pt-Ni alloy shell. Below 140 degrees C, sphere-like pure Pt NCs with the diameter of 3-4 nm first nucleated, followed by the isotropic growth of Pt-Ni alloy on the seeds at temperatures between 170 and 230 degrees C forming Pt@Pt-Ni core-shell octahedra with {111} facets. Owing to its unique structure, the Pt@Pt-Ni octahedra show an unparalleled stability during potential cycling, that is, no activity drop after 10 000 cycles between 0.6 and 1.0 V. This work proposes the Pt@Pt-Ni octahedra as a high profile electrocatalyst for ORR and reveals the structural and composition evolution pathways of Pt-based bimetallic NCs.</P>
( Xin Liu ),( Ying Dong ),( Jingquan Wang ),( Long Li ),( Zhenmin-zhong ),( Yun-pan Li ),( Shao-jun Chen ),( Yu-cai Fu ),( Wen-can Xu ),( Chi-ju Wei ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.6
Vesicular stomatitis virus G glycoprotein (VSV-G) has been widely used for pseudotyping retroviral, lentiviral, and artificial viral vectors. The objective of this study was to establish a potential approach for large-scale production of VSV-G. To this end, VSV-G was cloned with an N-terminal His-tag into Pichia pastoris expression vector pPIC3.5K. Three clones (Mut<sup>s</sup>) containing the VSV-G expression cassette were identified by PCR. All clones proliferated normally in expansion medium, whereas the proliferation was reduced significantly under induction conditions. VSV-G protein was detected in cell lysates by western blot analysis, and the highest expression level was observed at 96 h post induction. VSV-G could also be obtained from the condition medium of yeast protoplasts. Furthermore, VSV-G could be incorporated into Ad293 cells and was able to induce cell fusion, leading to the transfer of cytoplasmic protein. Finally, VSV-G-mediated DNA transfection was assayed by flow cytometry and luciferase measurement. Incubation of VSV-G lysate with the pGL3-control DNA complex increased the luciferase activity in Ad293 and HeLa cells by about 3-fold. Likewise, incubation of VSV-G lysate with the pCMV-DsRed DNA complex improved the transfection efficiency into Ad293 by 10% and into HeLa cells by about 1-fold. In conclusion, these results demonstrate that VSV-G could be produced from P. pastoris with biofunctionalities, demonstrating that large-scale production of the viral glycoprotein is feasible.