Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

한강자전거도로 서비스품질이 만족도, 이미지, 충성도 및 재방문의 인과관계분석

윤태훈,강승애 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.1-2

The effect of the relationship the Service qualty of Han-river bicyle road and one of the boys potential for leading the worth intention and revist Han-river bicyle road Therefore this study was intended to investigate the relationship between the recently highlighted service quality of Han-river bicyle road and one of the boys satisfaction, word-of-mouth and revisit and clarify what difference there was in the service quality of Han-river bicyle road according to demographic characteristics. 242 questionnaires except 26 poorly completed ones were employed for final analysis. For purpose of data processing, ANOVA was conducted to test the difference in service quality according to demographic characteristics using SPSSWIN Ver. 15.0 and AMOS 7.0. Finally, structural equation model(SEM) was employed to test the structural research model. As a result, the following findings were obtained: Finally, it was found that there was a difference in service quality related to the convenience of use and the environmental safety factor according to age and in service quality related to the environmental safety factor according to educational level. Second, it was found that accessibility, the sub-factor of service quality of MTB Park had a significant effect on traveller's satisfaction, which had an effect on their image, which had an effect on the revisit and word-of-mouth intentions. at risk of obesity Key words: service of Han-river bicyle road, Satisfaction, Word-of-mouth Intention and Revist

Culex pipiens pallens 모기의 난성숙에 관한 연구

姜奭熙,이승훈 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.2

본 연구에서는 Culex pipiens 모기의 난성숙에 대한 Egg development neurosecretory hormone(EDNH)의 영향과 방출시기를 decapitation을 통한 in vitro fat body incubation과 rocket immunoelectrophoresis 방법에 의해 합성된 난황단백질의 정량과 follicle cell의 성숙정도를 측정하는 방법으로 조사하였다. C. pipiens를 흡혈 후 30분에 decapitation 하였을 때 follicle cell의 성숙은 25% 정도의 모기에서 일어났으며, 흡혈 후 1 시간에 decapitation한 모기에서는 90% 이상의 모기에서 난성숙이 일어났다. A. atropalpus 에서는 우화 후 6시간 이전에 decapitation하였을 때 follicle cell의 성숙이 일어나지 않았다. Decapitation후 in vitro fat body incubation에 의한 ^3H-protein과 ^3H-vitellogein의 정량결과에서도 C. pipiens는 흡혈 후 30분에 decapitation한 모기에서 난황단백질의 합성이 일어났다. 또한 흡혈 후 1시간에 decapitation한 모기에서는 12시간에 decapitation 한 모기와 비슷한 정도의 난황단백질의 합성이 일어났다. Decapitation 후 rocket immunoelectrophoresis 방법으로 난소내에 축적된 vitellin과 지방체내의 vitellogenin을 정량한 결과 흡혈 후 30분에 decapitation한 모기에서는 흡혈 후 18시간 지난 정상모기의 난소와 유사한 양의 vitellin이 축적되었으며, 흡혈 후 1시간에 decapitation한 모기에서는 흡혈 후 24시간 지난 정상모기의 난소와 유사한 양의 vitellin이 축적되었다. 또한 흡혈 후 30분에 decapitation한 모기의 지방체 내에서 10㎍ 이상의 vitellogenin이 합성된 것으로 관찰되었다. 이상의 결과는 흡혈 후, 또는 우화 후 6시간 이후부터 EDNH의 방출이 시작되는 것으로 알려진 A. atropalpus나 A. aegypti 모기와는 달리 C. pipiens 모기에 있어서는 흡혈 후 30분 정도만 되어도 뇌로부터 EDNH의 방출이 시작되어 난성숙에 필요한 난황단백질 합성의 시작을 자극하는 것으로 여겨진다. Synthesis of vitellogenin in the anautogenous mosquito, Culex pipiens pallens was examined by incubating the fat body in vitro. Vitellogenin synthesis began to occur at 6 hours after blood feeding, reached at maximum level by 24 hour, and was completed by 45 hours. Ovarian uptake of yolk was examined by measuring the amount of egg vitellin by rocket immunoelectrophoreisis. Ovarian vitellin level began to rise at 12 hour post blood meal and continued for up to 60 hours. Decapitation within 10 minutes after blood meal completely blocked vitellogenin synthesis by the fat body. When decapitation was performed at 1 hour post blood feeding, more than 90 percent o female produced mature eggs. These results are different from that of Aedes aegypti in which the critical period was found to be 6 hours post blood meal.

한국제조산업의 총요소생산성의 측정

강주훈,김승화 관동대학교 기업경영연구소 2004 경영논집 Vol.22 No.-

최근까지 총요소생산성(TFP)성장율 추정치의 결과는 국가마다, 그리고 분석기간에 따라서 상당한 차이를 보이고 있다. 기본적인 솔로우 잔차항에 근거한 TFP의 추정은 세 가지 점을 고려하지 않은 단점을 지니고 있다. 즉 표준적인 솔로우 잔차항에 근거한 총요소생산성은 완전경쟁시장, 규모의 보수불변(constant returns to scale), 자원의 완전고용을 전제로 추정되기 때문에, 현실적으로 시장지배력(market power), 규모의 경제, labor and capital hoarding의 문제를 도외시하고 있다. 본 논문은 Hall(1990)의 비용분배(cost based)모형에 근거하여 한국의 총요소생산성을 18개의 제조산업별로 추정하였다. 특히 한국의 제조산업은 중간재의 수입에 대한 해외의존도가 큰 점을 고려하여 중간재를 국내중간재와 해외로부터 수입되는 해외중간재로 나누어 분석하였다. Basu(1996)의 경우 중간재를 대리변수로 이용하여 TFP를 추정하였으나 본 논문은 제조업 가동율이 경기변동을 나타내는 주요 지표임을 감안하여 제조업 가동율을 이용하여 생산요소의 Hoarding의 문제를 제거하였다. 추정결과, 규모의 보수는 분석기간(1970-1995)에서 제조업 비내구재 0.83, 내구재는 0.98, 그리고 제조업 전체는 0.91의 보수감소를 보이고 있다. 총요소생산성 증가는 같은 기간에서 비내구재 3.15%, 내구재 -0.56%, 그리고 제조업전체는 2.12%로 추정되었다. 한국제조산업의 경우 총요소생산성 증가율는 약한 경기역행성을 나타내고 있으며 또한 시장지배력이 큰 산업에서 그리고 해외중간재의 투입비중이 큰 산업에서 기술진보가 상대적으로 크게 증가했다고 결론지을 수 있다.

자궁경부 상피암에서 Human Papillomavirus(HPV) 감염에 관한 연구

강현욱,김창진,오승훈 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The uterine cervical carcinoma is the most common malignant tumor among Korean women. The pathogenic mechanisms have not been elucidated so far. Several lines of evidence suggest that sexually transmittable agents are responsible for the pathogenesis of uterine cervical carcinoma. Among them, human papillomavirus(HPV) was considered to be the most possible oncogenic agent. The HPV types 6, 11, 16, 18, 31, 33 and 35 are the most important types involved in cervical lesion among 70 HPV types so far known. The uterine cervical carcinomas containing HPV-18 gene in the nuclei are more aggressive than those comtaining other types of HPV genes. It would be helpful to type the HPV in the uterine cervical carcinoma for the prediction of prognosis. In this study, the types of HPV were determned in the uterine cervical carcinoma, comprising 30 cases of cervical intraepithelial neoplasia(CIN), 10 cases of microinvasive carcinoma and 15 cases of invasive carcinoma, by polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP). The results were as follows: 1. HPV DNA was detected in 19 cases(63.3%) of 30 if CIN. The types 16, 18, 33 and other high risk HPVs were 33.3%, 6.7% and 10% respectively. 2. In CIN Ⅱ and CIN Ⅲ, HPV-16, 18 were 54.4%, 28.6% and 9.1%, 21.4% respectively. 3. In microinvasive carcinomas, HPV-16 and 18 were 50% and 20% respectively. 4. In invasive carcinomas, HPV-16 and 18 were 26.7% and 33.3% respectively. Above results suggest that HPV infections have positive relationship with uterine cervical carcinoma. And as the HPV-18 type DNA has some role for the progression of the carcinoma, it would be feasible to type HPV in uterine cervical carcinoma for the prediction of the prognosis.

下水處理場의 效率的인 管理를 위한 基礎的 硏究

姜善泰,徐承敎,李南勳 대구산업정보대학 1989 논문집 Vol.3 No.-

The main purposes of this study are to analyse the characteristics of effluent water qualities BOD, COD, SS and ES-by types of sewer system and season for treatment plants in separate sewer system and combined sewer system, and to identify the variables which exert great influences on them run in a standard activated sludge process. The characteristice of effluent water qualities by types of sewer system ad season were analysed by t-test which tests the difference in subpopulation means of 2groups, and by correlation analysis. The results thereof could be obtained as follows; (1) While there was no difference by types of sewer system in COD, there were much differences in BOD, SS, ES. (2) While BOD, SS, and ES were influenced by season in separate sewer system, in combined sewer system, BOD presented difference just between autumn and winter SS between spring and summer, spring and autumn, summer and winter, autumn and winter, and ES did not show any difference save spring.

Tobit 모형을 이용한 CVM 분석

강주훈,강희용,정승진 관동대학교 기업경영연구소 2004 경영논집 Vol.22 No.-

There, in general, exists a difficulty in evaluating the external effect of economic activities by measures. It is simply because the external economic effect often fails to reflect the market price in real market transactions. Because evaluating the social expenses or benefits from public goods or environmental pollution often relies heavily on indirect, individual and subjective decision, it often tends to be over or underestimated. This paper adopted a closed Contingent Valuation Approach; if a respondent agrees on a specific price at the first stage that makes it possible to advance with an increased price to the second stage in which the respondent may accept the increased price. Then the respondent pays the highest price In the regression analysis, the Probit Model and the Logit Model is used in case that the dependent variable is considered as the appropriate selectable variable. The Tobit Model can be more of an appropriate model than the Probit and Logit in terms of describing the highest paying price at the second stage through the closed and contingent valuation approach.

파트너십에 의한 옥상녹화조성 사례연구 : 부산광역시 서구를 사례로

강훈,한창석,김승환 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.31 No.1

The study aims at suggesting a new model of rooftop greening by the partnership. For this purpose, this study was applied in the rooftop of Amnam Park Office and investigated application process of planning, design and construction under rooftop greening system by the partnership. We have also examined the validity of the system and the roles and effects of the partnership. The study was proceeded as follows ; First, it was described the purpose and method of the study. Second, it was considered on the concept, trend, type of rooftop greening with research paper. Third, it was designated the rooftop of Amnam Park Office as the best place in order to apply in rooftop greening, and then suggested a new model of the rooftop greening was planned, designed and constructed as the application of the rooftop greening by the partnership. Finally, it was estimated the rooftop greening model as designed by the partnership.

사회적 변화에 따라 정신질환자들의 피해망상 속에 나타난 박해자 유형변화

강승범,황인복,김한석,김승곤,김학렬,박상학,김상훈,황걸 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Objective: The authors investigated the frequency of persecutors in persecutory delusions of the psychiatric patients who didn't undergo the arrest or traumatic injury, reside in Gwangju Jeonnam area, and were admitted to the hospital after the 5.18 prodemocracy movement in Gwangju in 1980 upward 10 years. Also this study investigated the frequency of the persecutors before and after the prodemocracy movement and in capital and Gwangju Jeonnam area. Subjects and Methods: Among the 896 patients who were admitted to department of psychiatry, Chosun University Hospital from Jan. 1. 1989 to Dec. 31. 1991, we choosed 144 patients with persecutory delusion who had lived in Gwangju Jeonnam area for 10 years after 5.18 prodemocracy movement as subjects. Persecutors were classified into 7 class: unspecified, family, neighbors, communist or spy, police or army or secret agent, impersonal, others. Results: 1) In our study, the frequency of persecutors was family, unspecified, neighbors, police or army or secret agent, impersonal, others, communist or spy in descending order. As compared to previous studies (1956-2003) including our study about frequency of persecutor at capital area and Gwangju Jeonnam area, and before and after 5.18 prodemocracy movement, 2) At capital area, in the early 1980s, police, family, neighbors, unspecified person was frequent in descending order. In the both of early 1970s, 1990s, neighbors, family, unspecified person, police was frequent in descending order. 3) At Gwangju Jeonnam area, in the early 1970s, family, unspecified person, neighbors, police was frequent in descending order. In the early 1990s, unspecified person and family, neighbors, police was frequent in descending order. 4) The police class was most frequent at capital area in the early 1980s. Conclusions: We suppose that class of persecutor in persecutory delusions of psychiatric patients are changing according to social change, and frequency of police class was decreasing in both of capital and Gwangju, Jeonnam area.

마이크로 드릴링 M/C에 의한 미세구멍가공특성에 관한 연구

민승기,이동주,이응숙,강재훈,김동우 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

Recently, the trends of industrial products grow more miniaturization, variety and mass production. Micro drilling which take high precision in cutting work is requested more micro hole and high speed working. Especially, Micro deep hole drilling is becoming more important in a wide spectrum of precision production industries, ranging from the production of automotive fuel injection nozzle, watch and camera parts, medical needles, and thick multi-layered Printed Circuit Boards(PCB) that are demanded for very high density electric circuitry. This paper shows the tool monitoring results of micro drill with tool dynamometer. And additionally, microscope with built-in monitor inspection show the relationship between burr in work piece and chip form of micro drill machining.