The Comparison of Clinical Outcomes between Inactive Chronic Hepatitis B and HBeAg Negative Hepatitis B with Virologic Response

( Seong Kyun Na ),( Byung-cheol Song ),( Eun Kwang Choi ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Nucleos(t)ide analogues (NA) suppress HCC development in chronic hepatitis B (CHB) patients. This study is aimed to compare incidence of hepatocellular carcinoma and survival between inactive chronic hepatitis B (CHB) patients and HBeAg(-) CHB patients with virologic response. Methods: We retrospectively analyzed NA-naïve inactive CHB patients (n=80) and HBeAg(-) CHB patients on entecavir with virologic response (VR, DNA<2000 IU/mL) (n=72) at Jeju National University Hopital in Jeju, Korea, between March 2007 and December 2010. Decompensated liver cirrhosis patients were excluded. Results: Median follow-up duration was 8.1 years (interquartile range[IQR] 7.0 - 9.0). Age, sex distribution were not different between two groups, however, patients with liver cirrhosis was higher in HBeAg(-) CHB group (8.8% versus 30.6%, P=0.001). During the follow up, one HCC (1.3%) and 10 HCCs (13.9%) were developed, in inactive group and HBeAg(-) CHB group, respectively. Estimated 10-year HCC incidence rates were 1.5% in inactive group and 25.4% in HBeAg(-) CHB group (P<0.001). Progression to decompensation was comparable (no event in inactive group, one hepatic encephalopathy in HBeAg(-) CHB group, P=0.278). Liver-related death was also similar (no death in inactive group, one death in HBeAg(-) CHB group, P=0.278). In multivariable analysis, HBeAg(-) CHB (adjusted hazard ratio[aHR] 10.17 (95% confidence interval[CI] 1.20-86.29), P=0.034) and liver cirrhosis (aHR 11.02 (95% CI 2.61-46.63), P=0.001) were significant risk factors for HCC. Conclusions: Between inactive CHB patients and HBeAg(-) CHB patients on entecavir with VR, overall survival was comparable. However, HCC incidence was significantly higher in HBeAg(-) CHB patients with VR.

設計洪水量의 誘導를 위한 冪變換과 頻度分布分析의 比較

李淳赫,羅性均 충북대학교 농업과학기술연구소 1990 農業科學硏究 Vol.8 No.2

This study was conducted to pursue the normalization of frequency distribution by approaching the coefficient of skewness to zero through power transformation to the annual maximum series of four watersheds along Han, Guem, Nag Dong river basin. Analysis for the comparison of design flows according to the return periods were carried out between the best fitted probability distribution and power transformation. The results were analyzed and summarized as follows. 1. Power transformation has found to be best one in comparison with log and square root transformation for being the coefficient of skewness into closer zero as a means of getting the normalization of frequency distribution in the annual maxium series for the applied watersheds. 2. The best fitted probability was acknowledged as three paramater lognormal destribution for Jeong sun of Han, Im Ha of Nag Dong river basin and type 1 extremal distribution for Seok Hwa, Gyu Am of Geum river, respectively. 3. Empirical formulas for the probable flood flows and design flows according to the return periods were derivated for the applied watersheds. 4. Relative errors of three parameter lognormals and type 1 extermal distribution to power transformation which was acknowledged as a best fitted probable flows were shown to be within 10 percent in common for all watersheds from two to two hundred years of return period. 5. The part of higher nonexceedance probabilities, i.e. probable flood flows for power transformation leas found to be more approached to the observed data in comparison with the results of other fitted distributions in view of relative suitability.

The Response to Transarterial Chemoembolization According to the Post-Operative Recurrence Patterns in Combined Hepatocellular-Cholangiocarcinoma

( Seong Kyun Na ),( Han Chu Lee ),( Gwang Hyeon Choi ),( Jihyun An ),( Dan Bi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Young-suk Lim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Combined HCC-CC (cHCC-CC) is presented as hypervascular tumor or peripheral enhancing tumor in dynamic CT scan. We evaluated the effect of transarterial chemoembolization (TACE) and prognosis according to the post-operative recurrence imaging patterns of cHCC-CC. Methods: We retrospectively analyzed 43 cHCC-CC patients who were treated with TACE for 1^st post-operative recurrence after curative surgical resection between January 2000 and May 2016 and 59 hepatocellular carcinoma (HCC) patients between January 2008 and June 2008 at Asan Medical Center in Korea. Tumor with arterial enhancement more than 50% of tumor volume in CT was classified as hypervascular tumor, in contrast, tumor with peripheral enhancement were classified as peripheral enhancing tumor. Tumor responses were evaluated according to RECIST 1.1 criteria. Results: The median follow up duration was 53.5 months (interquartile range: 23.2 - 101.8 months). In cHCC-CC group, primary hypervascular and peripheral enhancing tumor were in 19 patients and 24 patients. Hypervascular recurred tumor and peripheral enhancement recurred tumor were in 26 patients and 17 patients. Agreement of imaging patterns between primary tumor and recurred tumor was 78.9% in hypervascular tumor, and 54.2% in peripheral enhancement tumor. After TACE, disease control rate was 84.7% in HCC, 88.5% in hypervascular recurred tumor, and 58.8% in peripheral enhancing recurred tumor (P-value = 0.034). The median survival time after recurrence for HCC was 67.5 months (95% CI 34.5 - 100.6 months) and 52.8 months (95% CI 6.4 - 99.2 months) for hypervascular recurred tumor and 12.4 months (95% CI 8.5 - 16.3 months) for peripheral enhancement recurred tumor (P-value < 0.001). In multivariable Cox regression, peripheral enhancing recurred tumor (HR 3.827, 95% CI 1.544 - 9.489, P-value = 0.004), progressive disease after TACE (HR 3.099, 95% CI 1.208 - 7.950, P-value = 0.019), and recurred tumor size > 2 cm (HR 2.882, 95% CI 1.250 - 2.644, P-value = 0.013) were significant prognostic factors. Conclusions: Recurred cHCC-CC with peripheral enhancement showed poor tumor response for TACE and poor prognosis after recurrence than hypervascular recurred tumor.

Development and surveillance of hepatocellular carcinoma in patients with sustained virologic response after antiviral therapy for chronic hepatitis C

Seong Kyun Na,송병철 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.3

Hepatitis C virus (HCV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC), and is a leading cause of liver-related deaths worldwide. Recently available direct-acting antiviral agent is very safe and highly effective (>95% sustained virologic response, SVR) against all genotypes of HCV. Achievement of SVR has been associated with a significant reduction of hepatic decompensation, development of HCC, and liver-related mortality. However, HCC risk is not eliminated even after SVR. The annual incidences of HCC in advanced fibrosis or cirrhosis have been estimated to be up to 2.5–4.5% even in patients with SVR. Therefore, surveillance for HCC is recommended in this high-risk patients. In this review, we will describe the clinical outcomes and the risk of HCC in patients with SVR and suggest who should receive surveillance for HCC.

증례 중심으로 보는 간기능 이상 환자의 접근

나성균 ( Seong Kyun Na ) 대한간학회 2023 간질환 연수강좌 Vol.2023 No.1

경동맥화학색전술 및 방사선 치료에 불충분한 반응을 보인 문맥 침범간세포암 환자에서 성공적인 수술적 구제 치료 1예

나성균 ( Seong Kyun Na ),임형준 ( Hyung Joon Yim ),서상준 ( Sang Jun Suh ),정영걸 ( Young Kul Jung ) 대한간암학회 2016 대한간암학회지 Vol.16 No.2

Hepatocellular carcinoma (HCC) with portal vein invasion has a poor prognosis. Treatments such as transarterial chemoembolization (TACE), radiation therapy (RT), sorafenib are done as a first line treatment. But in case of incomplete response to first line treatment, there’s no established guideline about salvage treatment. We present a 47 year-old male who was diagnosed as HCC with portal vein invasion. He was treated with RT and repeated TACE, but remnant viable tumor was observed. Surgical resection was performed as a salvage treatment, and HCC was completely removed. He has been followed up over 3 years, but there was no recurrence. (J Liver Cancer 2016;16:118-122)

증례 : 감염 ; 낼리딕산 내성 Salmonella enteritidis에 의한 급성 대퇴골 골수염 1예

나성균 ( Seong Kyun Na ),김태준 ( Tae Jun Kim ),이정아 ( Jeong A Lee ),이승순 ( Seung Soon Lee ),고성혜 ( Sung Hye Koh ),김태영 ( Tae Young Kim ),김한성 ( Han Sung Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3

비장티푸스성 살모넬라균은 주로 급성 위장염을 일으키고 자연 호전되는 경우가 많지만 균혈증이나 전이성 국소감염을 일으킨 경우 항생제 치료가 필요하다. 3세대 cephalosporin, fluoroquinolone이 1차 치료제로 사용되나 1990년대부터 낼리딕산 내성 균주에 의한 감염이 보고되었고 이 경우 fluoroquinolone에 감수성임에도 불구하고 임상적으로 치료 반응이 지연되거나 치료에 실패하는 경우가 발생했다. 국내에서도 낼리딕산 내성 균주가 빠르게 증가하고 있으며 비장티푸스성 살모넬라 감염에서 혈청형 또는 낼리딕산 내성을 확인하여 항생제를 선택하는 것이 치료 실패를 줄이기 위한 방법이 될 것으로 생각된다. 저자들은 건강한 환자에서 발생한 낼리딕산 내성 S.enteritidis에 의한 골수염 및 골막 농양을 골조직 투과력 및 경구 흡수율이 좋은 고용량 flu-oroquinolone을 16주간 투여로 부작용 없이 성공적으로 치료한 예를 경험하여 문헌고찰과 함께 보고하는 바이다. Infection with nontyphoidal Salmonella most often results in self-limited acute gastroenteritis. However, occasionally it causes bacteremia and localized infection requiring antibiotic treatment. A third-generation cephalosporin or fluoroquinolone is often the first choice of antibiotic. However, there has been an increase in nalidixic-acid-resistant nontyphoidal Salmonella with decreased fluoroquinolone susceptibility. Although there have been many cases reported of nontyphoidal Salmonella, no cases of nalidixic- acid-resistant nontyphoidal Salmonella have been reported in Korea. Here, we report on the case of a 61-year-old man with a diagnosis of acute osteomyelitis and periosteal abscess of the femur caused by nalidixic-acid-resistant Salmonella enteritidis. He was treated successfully with prolonged administration of a high-dose of ciprofloxacin and drainage of the abscess. (Korean J Med 2015;88:340-345)

Biological Activity of Waxy and Non Waxy Type Barley (Hordeum vulgare L.) and Barley Byproduct Extracts

Na-Young Lee,Mi-Ja Lee,In-Duck Choi,Yang-Kil Kim,Sang-Kyun Cho,Jae-Seong Choi,Kee-Jong Kim 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04

Barley (Hordeum vulgare L.) and barley byproduct, waxy and non waxy genetic type, were prepared and investigated for its biological activity. The total phenolic contents, tyrosinase and xanthin oxidase inhibition activity of the barley extracts were measured and compared with those of a barley byproducts extracts powder. The contents of total phenolic compounds of the barley byproducts, waxy and non waxy type, were 18.60 and 17.92 mg/g of sample, respectively. Inhibition rates (%) of the mushroom tyrosinase of the waxy type barley and barley byproducts extracts powder were 16.30 and 33.60% at 250 ppm, respectively. Tyrosinase inhibition activity of barley byproduct extracts regardless of waxy and non waxy type showed higher than that of arbutin (5%). The samples showed an inhibition effect of xanthin oxidase. At 2,500 ppm of sample concentration, the inhibition effect of xanthine oxidase of waxy type barley (WB), non waxy type barley (NB), waxy type barley byproducts (WBP), and non waxy type barley byproducts (NBP) was 9.92, 16.06, 14.11, and 13.86%, respectively.

Implant surface treatments affect gene expression of Runx2, osteogenic key marker

Na, Young,Heo, Seong-Joo,Kim, Seong-Kyun,Koak, Jai-Young 대한치과보철학회 2009 The Journal of Advanced Prosthodontics Vol.1 No.2

STATEMENT OF PROBLEM. The aim of this study was to study the effects of various surface treatments to a titanium surface on the expression of Runx2 in vitro. MATERIAL AND METHODS. Human Osteosarcoma TE-85 cells were cultured on machined, sandblasted, or anodic oxidized cpTi discs. At various times of incubation, the cells were collected and then processed for the analysis of mRNA expression of Runx2 using reverse transcription-PCR. RESULTS. The expression pattern of Runx2 mRNA was differed according to the types of surface treatment. When the cells were cultured on the untreated control culture plates, the gene expression of Runx2 was not increased during the experiments. In the case of that the cells were cultured on the machined cp TI discs, the expression level was intermediate at the first day, but increased constitutively to day 5. In cells on sandblasted cpTi discs, the expression level was highest in the first day sample and the level was maintained to 5 days. In cells on anodized cpTi discs, the expression level increased rapidly to 3 days, but decreased slightly in the 5-th day sample. CONCLUSION. Different surface treatments may contribute to the regulation of osteoblast function by influencing the level of gene expression of key osteogenic factors.

Antioxidant Activity and Biological Activity of Specialty Barley (Hordeum vulgare L.) Extracts

Na Young Lee,Yang-Kil Kim,Induck Choi,Sang-Kyun Cho,Hun-Jung Kweon,Kwang-Won Lee,Jong-Nae Hyun,Jae-Seong Choi,Ki-Hun Park,Kee-Jong Kim,Mi-Ja Lee 韓國作物學會 2010 Korean journal of crop science Vol.55 No.2

Specialty barley extracts were prepared and investigated for its antioxidant activity and biological activity. Hunter L* values of the Iksan 86 extracts had higher than that of the Iksan 87 and Zasoojeongchal extracts. The extraction yields of Iksan 86, Iksan 87, and Zasoojeongchal was 8.08, 6.62, and 7.30%, respectively. The contents of total phenolic compounds of the Iksan 86, Iksan 87, and Zasoojeongchal extracts were 16.24, 15.51, and 13.95 GAE mg/g of sample, respectively. The DPPH radical scavenging activity of Iksan 86, Iksan 87, and Zasoojeongchal extracts were 50.00, 33.27, and 7.56% at a 500 ppm, respectively. The samples showed an inhibition of xanthin oxidase. ACE inhibition effect of specialty barley extracts, Iksan 86, Iksan 87, and Zasoojeongchal, was 39.81, 41.06, and 27.78%, respectively. Tyrosinase inhibition rates (%) of Iksan 86, Iksan 87, and Zasoojeongchal extracts were 26.21, 24.57, and 20.00%, respectively. Results indicated that specialty barley extracts possesses various biological activities including antioxidative capacity, xanthin oxidase inhibition activity, angiotensin converting enzyme inhibition activity, and tyrosinase inhibition activity.