모 컴퓨터 회사 근로자 건강증진 사업 전개를 위한 수요조사

임현우,안병용,최환석,박정일,김경수,이강숙,김정아,구정완 가톨릭대학산업의학쎈타 산업의학연구소 1997 韓國의 産業醫學 Vol.36 No.4

Before conducting the health promotion program, we surveyed the health risk appraisal(HRA) of 210 workers (186 men and 24 women) in a computer company, for the need assessment, selection of target population, priority setting, and as a standard for comparision after performing the program. The smokers were 115(88.6%), and drinkers (over 1 bottle of Soju per week) were 91(44.8%) in men. Entire women and 148(78.0%) men never or irregularly exercise. Type A personality were 73(39.2%) in men, 8(33.3%) in women, and 26(14.0%) of men and 6(25.0%) of women were high stress risk group. 53(25.2%) of men and 2(8.3%) of women were obese (BMI ≥25kg/m²), and workers who consumed exess of total calory compared with recommendation were 142(76.3%) in men and 18(75%) of women. By the health risk appraisal, it was suggested that smoking cessation program, drinking counselling, exercise prescription, stress management, and weight control program should be conducted effectively for the high risk group.

청소년 지도학의 활동영역 활성화 연구

육현철,장갑석,최강진 한국체육대학교 2001 韓國體育大學校 敎養敎育論文集 Vol.- No.6

The Curriculum of National Cooking(Guidance) for the Youth Had Been established at the Myungji University in 1994 for the first time in the history of Korean college, and 8 universities Has, Recently and operate the course, These days the curriculum mostly concentrates on the subject of pedagogy and educational psychology. (ⅰ) To vitalize the juvenile's physical activity, the government concerned needs to make a political support in order each university to found the curriculum for the youth.And each university must open the course which the teenager can make physical activities free of charge. (ⅱ) The educational policy researching and developing the activity area of the youth is required.By educating them based upon the activity area, the youth can have a healthy body which results from sound spirit. (ⅲ) The youth Activity Centre is to be established and operated at each community or local district to vitalize the section for sport activity which the juvenile prefer.Physical promotion is needed to be desirable adult. (ⅳ) Today the computer system like internet and dlectronic entertainment/game give the large influence on all the juvenile.Herein we need to remind that almost young generation study by day and indulge in computer without Physical activity that lead to weak body and feeble spirit.Under those circumstances, we can find out the juvenile delinquent from to time. (ⅴ) Finally, it is greatly important and imperative to foster lots of professional experts/coaches who can understand the youth and guide them in a sound way.

S.D. Rats를 이용 1, 1-Dichloro-1-fluoroethane의 아민성 흡입독성 연구

김현영,이성배,임철홍,김철우,점용현,한정희,전윤석,최수영,강대봉,이용묵 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1

There were no specific effects for test materials on Sprague-Dawley (S.D.) rats in clinical symptoms, amounts of food intakes, weight changes, laboratory findings, and pathology after whole body l, l-Dichloro-1 -fluoroethane (used as coolant, metal cleaner and solvents) exposure(0, 1,500, 3,000, and 6,000 ppm) for 13 weeks (6 hour/day, 5 days/week). However, the loss of capillary vessels in eyeball (pupil) was observed in a female rat among 6,000 ppm group. Though there was a tendency for MCHC (Mean Corpuscular Hemoglobin Concentration) in rat to be decreased (p<0.05), it was not regarded as abnormal because the values were within normal limits. In asthma-stimulation related evaluations, there was also a tendency for inflammatory cell counts in bronchoalveolar lavages to be increased. But it had no statistical significance, and also no dependency on sex and the exposed concentration. Based on this result, the non observed effect level (NOEL) induced by 1, 1-Dichloro-l -fluoroethene inhalation was evaluated in groups with 3,000 ppm below (S .D. Rats, 13 weeks). Finally, it was concluded that the short term exposal of 1, 1-Dichloro-l-fluoroethane is not considered as a asthma stimulant by inhalation despite of some study limitations such as test animals use and short-term exposure .

전기도금을 이용한 스테인레스스틸 각형 선재의 굵기 증가 후 물성 변화

이정석,황현식,최광철,문재동 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.1

The purpose of this study was to evaluate clinical applications of electroplating method through investigation of the physical properties of orthodontic rectangular wires according to varying their cross section. For the study, it was accomplished to electroplate the 0.016-inched orthodontic rectangular stainless steel wire. The cross section of stainless steel orthodontic rectangular wire increased from 0.016 X 0.016 inch to 0.017 X 0.017 inch by electroplating. The wire was heat treated to improve an adhesion between the wire and electroplated metal. A three-point bending test and torsion test were conduced in order to compare physical properties among three wire groups; 0.016 X 0.016 wires(group 016P) and 0.017 X 0.017 wires(group 017). Through the investigations of each wire group, following results were obtained. 1. At three-point bending test, the group 016P showed higher tendency in the degree of stiffness, yield strength and ultimate tensile strength than the group 016. Stiffness and ultimate tensile strength showed statistically significant differences between two groups at three-point bending test(p<0.05). 2. Stiffness, yield strength, and ultimate tensile strength of the group 016P showed lower tendency than those of the group 017. Stiffness showed statistically significant differences between two groups at three-point bending test(p<0.05). 3. Torque/twist rate, yield torsional moment, and ultimate torsional moment of the group 016P showed higher tendency than those of the group 016. All measurements showed statistically significant differences between two groups after torsion test(p<0.05). 4. Torque/twist rate, yield torsional moment, and ultimate torsional moment of the group 016P showed lower tendency than those of the group 017. Yield torsional moment, and ultimate torsional moment showed statistically significant differences between two groups after torsion test(p<0.05). Xylitol is a 5-carbons carbohydrate, which can be replaced with sucrose for preventing caries. The replication of Streptococcus mutans and its formation of artificial plaque were studied in the media containing xylitol. The combined effect of xylitol and other carbohydrates on Streptococcus mutans was also studied. The replication of Streptococcus mutans was inhibited according to the increased concentration of xylitol. Streptococcus mutans replicated at the initial stage of incubation in the media contaning glucose, fructose or lactose, while replication from the beginning of incubation in the media containing fructose as combining with xylitol. The formation of artificial plaque by Streptococcus mutans was significantly reduced in the media containing with xylitol and fructose. These results indicated that the replication of Streptococcus mutans was inhibited according to the increased concentration of xylitol, and the formation of artificial plaque by Streptococcus mutans was significantly inhibited in the media containing xylitol and fructose.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

상위인지 전략훈련이 독해부진아의 독해력과 자기효능감에 미치는 효과

여광응,박현옥,최환석 한국특수교육문제연구소 2003 특수교육저널 : 이론과 실천 Vol.4 No.4

독해는 특정 교과에 한정되는 교과 활동이기보다는 모든 교과학습의 기초이기 때문에 초등학교 아동의 독해학습부진은 반드시 해결해야 할 중요한 과제이다. 기존에는 독해력 결함의 원인을 주로 상징과 소리 협응에 대한 법칙학습 장애나 시지각 장애로 귀착시켰으나, 최근에는 정보처리 과정상의 결함 내지 읽기에 관한 배경지식의 결함과 글을 읽고 이해하는 데 필요한 상위인지 전략의 선택 및 활용 부족을 원인으로 보는 경향이 유력하다. 이 연구는 상위인지 전략훈련(자기교시 전략훈련과 자기조절 전략훈련)이 초등학교 고학년 독해부진아의 독해력 향상과 유지, 자기효능감에 미치는 효과를 밝히기 위한 것이다. 연구 결과, 상위인지 전략훈련은 독해부진아의 독해력 향상과 유지에 긍정적인 영향을 미쳤으나, 자기효능감의 경우 양 집단 모두 뚜렷한 효과를 보였으나 양집단 간에는 효과의 차이가 나타나지 않았다. Recently, the strategy training for learning disabled children is widely applied so that learners themselves can set up self-planning, self-monitoring and self- evaluation, self-instruction and self-regulation strategy training methods that are based on the explicit instruction have proved their effectiveness. The purpose of this study is to compare the effect of self-regulation and self-instruction training methods for reading-comprehension on poor reader, and to investigate the improvement of the perception of self-efficacy for reading- comprehension of the children. In order to accomplish this purpose were 4th, 5th, and 6th graders of registered two primary schools within Daegu and selected 48 students who are delayed more than 1.5 year in their reading comprehension ability by the Reading Ⅱ(Reading Comprehension Test) of the fundamental learning ability test(by Park, Kyong-sook and others, 1985) and they were divided into two groups by 24 children at random. The children were randomly assigned to three conditions of self-regulation strategy training, self-instruction strategy training. The experimental group subjects were trained by two teachers at each experimenting school for 30 minutes, 5 times a week for 20 times in all by utilizing the self-study hours in the morning and lunch time. The following conclusion were obtained from the results and discussions of this study: First, the self-regulation and self-instruction strategy training is effective. The expected improvement of reading-comprehension ability of the self-regulation strategy training is higher than that of the self-instruction strategy training. Second, the effect of the self-instruction strategy training and the self-regulation strategy training is transferred to the effect maintains. The expected improvement of reading-comprehension ability of the self-regulation strategy training is maintained for a long time. Third, a relationship is revealed between the methods of the self-regulation and self-instruction strategy training is transferred to the improvements of self-efficacy for reading comprehension.

외안각 절제술과 경결막 절개에 의한 안와 접근법

정종철,김성범,서지훈,송민석,전창훈,최세훈,김현민 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Various surgical approaches to the orbits have been used. But the transconjunctival approach, also called the inferior fornix incision, provides adequate access to the orbital floor with esthetic results. Additionally, transconjunctival approach with lateral canthotomy allows more wide surgical field and good access to the orbital area. Generally, preseptal approach is more used rather than postseptal approach in the transconjunctival incision for the prevention of fat herniation during surgery. There are some complications in transconjunctival approaches but these complications can be prevented with careful surgical techniques. We report clinical results in 12 patients who were treated by preseptal transconjunctival incision with lateral canthotomoy for the treatment of orbital trauma. We were satisfied with this technique for reduction and reconstruction of the orbital trauma and we could also observe relatively good esthetic results.

Tumor Necrosis Factor-producing T-regulatory Cells Are Associated With Severe Liver Injury in Patients With Acute Hepatitis A

Choi, Yoon Seok,Jung, Min Kyung,Lee, Jeewon,Choi, Seong Jin,Choi, Sung Hoon,Lee, Hyun Woong,Lee, Jong-Joo,Kim, Hyung Joon,Ahn, Sang Hoon,Lee, Dong Hyeon,Kim, Won,Park, Su-Hyung,Huh, Jun R.,Kim, Hyoung Elsevier 2018 Gastroenterology Vol.154 No.4

<P><B>Background and Aims</B></P> <P>CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis A (AHA), and examined the characteristics of these cells and association with clinical factors.</P> <P><B>Methods</B></P> <P>We analyzed blood samples collected from 63 patients with AHA at the time of hospitalization (and some at later time points) and 19 healthy donors in South Korea. Liver tissues were collected from patients with fulminant AHA during liver transplantation. Peripheral blood mononuclear cells were isolated from whole blood and lymphocytes were isolated from liver tissues and analyzed by flow cytometry. Cytokine production from Treg cells (CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP>) was measured by immunofluorescence levels following stimulation with anti-CD3 and anti-CD28. Epigenetic stability of Treg cells was determined based on DNA methylation patterns. Phenotypes of Treg cells were analyzed by flow cytometry and an RORγt inhibitor, ML-209, was used to inhibit TNF production. Treg cell suppression assay was performed by co-culture of Treg-depleted peripheral blood mononuclear cells s and isolated Treg cells.</P> <P><B>Results</B></P> <P>A higher proportion of CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells from patients with AHA compared with controls produced TNF upon stimulation with anti-CD3 and anti-CD28 (11.2% vs 2.8%). DNA methylation analysis confirmed the identity of the Treg cells. TNF-producing Treg cells had features of T-helper 17 cells, including up-regulation of RORγt, which was required for TNF production. The Treg cells had reduced suppressive functions compared with Treg cells from controls. The frequency of TNF-producing Treg cells in AHA patients’ blood correlated with their serum level of alanine aminotransferase.</P> <P><B>Conclusions</B></P> <P>Treg cells from patients with AHA have altered functions compared with Treg cells from healthy individuals. Treg cells from patients with AHA produce higher levels of TNF, gain features of T-helper 17 cells, and have reduced suppressive activity. The presence of these cells is associated with severe liver injury in patients with AHA.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Why Engage in Public Service Co-production for Conflict Prevention? : A Case of Seoul

Seok Hyeon Choi 위기관리 이론과 실천 2020 Crisisonomy Vol.16 No.2

본 연구는 공공서비스 생산에 있어 지역 내 주민들의 갈등을 방지하는 한편 서비스의 효과성을 높이기 위해 논의되고 있는 공동생산에 대한 시민참여 요인을 파악하는 목적을 가지고 있다. 본 연구는 서울시의 대표적인 공동생산 모델에 기반을 둔 사업인 마을공동체 사업과 공유도시 사업에서 서울시민들의 참여 결정에 영향을 미치는 심리적, 관계적 요인들을 파악하고자 하였다. 분석에 따르면 서울 시민들은 서울시민으로서의 정체성, 즉 장소정체성을 가지고 있을 시 공동생산 사업에 참여할 가능성이 높으며, 이러한 장소정체성은 직접적으로 사업 참여 결정에 영향을 미치기도 하지만 관계적 요인인 지역사회 소속감과 이웃에 대한 신뢰를 매개로 사업 참여 결정에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구의 분석결과는 지역사회 내 갈등 관리를 위한 공공서비스에 공동생산 모델을 도입하기 위해서는 시민들의 지역민으로서의 정체성과 애착심을 고취할 수 있는 교육과 지역문화 활성화에 대한 지원이 필요함이 필요함을 보여주고 있다. This research aims to explore the mechanism of citizen participation for co-production as an innovative provision of public services. Recently, co-production in public service provision has drawn attention from researchers and policymakers around the world as it may prevent social conflict in the local society. Unlike the previous studies that focused on adopting the co-production model to the public service provision, this research focuses on the question of why citizens participate in co-production of public services. This research develops the theoretical and analytical models to deal with the question based on attitude theory and social capital theory. The model explains that citizens motivations of participating in the provision of co-production are associated with citizens identity for the region where they live or mediated by their trust and hospitality for the community. This research also discusses the academic relevance of the findings and policy suggestions for policymakers.

Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism

Choi, Ihn-Geun,Son, Hyun-Gyun,Yang, Byung-Hwan,Kim, Seok Hyeon,Lee, Jun-Suk,Chai, Young-Gyu,Son, Bong Ki,Kee, Baik Seok,Park, Byung Lae,Kim, Lyoung Hyo,Choi, Yoo Hyun,Shin, Hyoung Doo Wiley Subscription Services, Inc., A Wiley Company 2005 Human mutation Vol.26 No.3

<P>Alcoholism is a multifactorial and polygenic disorder involving complex gene-to-gene and gene-to-environment interactions. Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. These genetic polymorphisms are believed to influence drinking behavior and development of alcoholism. Direct DNA sequencing of whole ADH1B and ADH1C genes revealed 36 sequence variants, including six nonsynonymous and 14 novel polymorphisms. Seventeen polymorphisms among them were selected for genotyping in a larger study (n=352) based on linkage disequilibria (LDs) among SNPs, locations, and frequencies. Hardy-Weinberg equilibrium (HWE) analyses of polymorphisms revealed severe deviations only in alcoholics, which strongly suggest that a selection bias (or pressure) may be involved. The analyses of genotype distribution in alcoholics (n=106) and normal controls (n=246) showed dramatic associations with the risk of alcoholism. Fourteen polymorphisms in ADH1C and ADH1B showed a series of different strengths of association and magnitudes of risk. Based on referent and subgroup analysis, it was strongly suggested that the genetic effects come from the ADH1B*47Arg/*47Arg genotype, and that the positive signals from other sites are just tracking the genetic effect of ADH1B His47Arg. In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism. The information derived from this study could be valuable for understanding the genetic factors involved in the risk of alcoholism and facilitate further investigation in other ethnic groups. Hum Mutat 26(3), 224–234, 2005. © 2005 Wiley-Liss, Inc.</P>