정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

점화시기가 LPG 엔진의 배기특성에 미치는 영향

한덕수,장영민,전봉준,김성준 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

As an automobile fuel, LPG has many environmental advantages compared to gasoline or diesel. However, current LPG engine which is provided with LPG fuel as gas form has lower power and worse fuel efficiency than gasoline engine. These problems of low power and bad fuel efficiency come from lower volumetric efficiency. Also there is a new rising problem of high failure ratio in an engine emission test. Although there are many factors which affect engine performance of exhaust gas emission, one believes that the fact that ECM of gasoline engine is used for LPG engine when retrofitting gasoline engine to LPG engine is one of the main problems, which lower engine power and emit more noxious gas due to wrong ignition timing. To solve these problems, one studied the effects ignition timing on the exhaust gas to find out the optimum condition of ignition timing. The experimental results show that noxious exhaust gas is reduced and engine power is increased if the optimum control of ignition timing is applied in accordance to the revolution speed of engine.

양극성장애환자의 정신사회적 스트레스에 관한 연구

한상우,권영준,한선호 순천향대학교 1990 Journal of Soonchunhyang Medical Science Vol.13 No.1

준안정 오스테나이트의 가공유기 변태 계산모델

한흥남,이창길,김성준,오창석,이태호 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3

A computational model, which can describe the mechanically-induced martensite transformation of metastable austenite, is suggested. The strain originated from the transformation of metastable austenite into martensite is evaluated by assessing the difference of the nucleation rate of variants, which was determined from the interaction energy between externally applied stress state and lattice deformation based on the K-S relationship. A self-consistent model with the Eshelby's solution is employed to predict the deformation behavior. A simple iterative calculation was carried out to predict the stress-strain behaviors under the uniaxial stress state. The calculated results are compared with the experimental data for various strain rates. Good agreement is found between the calculated and experimental values of transformation kinetics and stress-strain behavior.

中等學校 체육교사의 敎職觀에 關한 硏究 : 江原道를 中心으로 Focused on Gang Weon Province

韓相俊 江原大學校附設體力硏究所 1981 江原大學校附設體育科學硏究所論文集 Vol.- No.6

The purpose of this research is to offer the basic materials necessary to develope Educator's temperament and to show an opportunity of self-instrospection, by grasp an actual state about physical Educator's view of teaching profession. Under the purpose, 27 questionnairs-common view of the teaching profession, the view concern about physical education course of study, temperament, etc-were answered by 150 men among 313 and 20 women among 36(total 170 persons) physical educators in Gang Weon province, from July, 5th to Oct. 30th, 1981, gained data were presented into percentage. Conclusion from analysed answers were as follow ; 1. Common view of physical educator 1) Motive to choose teaching profession are following orders : "wish to be a teacher" (41.77%), " Honorable vocation"(10.9%) 2) Worth to teaching profession are following orders : "to nurture a pupil"(68.81%), "Honored by society"(2.95) 2. View of teaching profession for the course of P.E study 1) Physical Educators with career of player were 43.53 percent 2) Satisfication about teaching profession were 27.65% and the reasons for satisfication are in following order : "Can develope whole personality"(48.23%), "Vocational aptitude"(32.94%) On the other hand, the reasons for dissatisfication are "no prospect"(37.65%) and the rest(28.82%). 3) Worth to physical educators are "because they can live eneryetic and dynamic life", "teaching for physical development and health education to their students." 3. Temperament of Physical Educator 1)Physical Educators : are deemed not important in view of common people(66.47%) and are not respected(15.29%). Answer in the question about "how do you think if any person who wish to educator in your family" are following order : "Let choose them-selves"(63.53%), "Invitate to other profession"(26.47%). 2) 56.47 percents among physical educators are cooperative relationship with other subject's teachers, "positive relationship with other subject's teachers" are 30 percent and presented that "Intramural interrelationship is well" are 77.06 percent. 3) Opinion on opportunity about reeducation : "moderate"(49.41), "Insufficient"(34.21%). 4) Actual state to use of guiding principles are in the following orders : "Always make the most of it(37.65%)", "Utilizing its main point"(39.41%).

생물학적 질산화의 영향 인자에 따른 알칼리도 변화

한동준,강성환 도립 강원전문대학 1998 道立 江原專門大學 論文集 Vol.1 No.1

Although many factors such as ammonia nitrogen concentration, pH, temperature and dissolved oxygen were revealed to influence on the biological nitrification, so far the influence is not wellknown in detail. This study was focused to find how each factors effect on the biological nitrification and alkalinity consumption in wastewater treatment under high ammonia nitrogen concentration. Batch reactors in aerobic conditions were used to test the treatment efficiency of mixed liquor, nightsoil and piggery wastewater. The results of this experiment, the alkalinity consumption rates were showed the range of 1.9∼7.1 mg alk./mg NH_(4)-N.

體格要因과 重心高의 相關分析 : -女高生을 中心으로- -Focused on High school girls-

韓相俊 江原大學校附設 體力硏究所 1982 江原大學校附設體育科學硏究所論文集 Vol.- No.7

To examine closely the relationships between the Height of Center of Gravity and Physical fitness of women players who should have the fast shifting ability of the Height of Center of Gravity, 29 girls of high school players(Volley ball ; 17. Basket ball ; 12) and same number girls of 2nd grade in High school were volunteered as subjects from July, 10. 1982. to July, 20. 1982. The results of measured and analyzed on the records of Standing Height, Body Weight, Height of Center of Gravity, Back-Strength, Flexibility, Standing Broad Jump, and Coordination were as follow : 1. The Height of Center Gravity(H.C.G) of Non-Athletic High school girls were 54.92% and that of Athletic who should have high ability in Power were 57.71%. 2. The H.C.G. were higher in Volley ball player than in Basket ball player. 3. Correlation coefficients between Age and H.C.C. represented negative correlation, Especially, represents the certainty negative correlation(r=-.55) in Athletic group. Thus, H.C.G, is lower and lower by increasing of age. 4. Correlation coefficients between H.C.G. and Physiques and Fitness factors were represented as following order ; # Age : r=-.55(P< .01) # Bodyweight : r=-.39(P <.05) # Coordination : r= .44(P <,01) 5. Athletic group who should have superiority in H.C.C. represented more strong records in Power. 6. Correlation coefficients between H.C.G. and Physique and fitness of all subjects represented following order ; 1) Positive correlation a. Career : r=.51(P<.01) b. Flexib. : r=.51(P<.01) c. Power : r=.41(P<.01) 2) Negative correlation a. Coordination : r=-.33(P<.05) b. Age : r=-.30(P<.05) 7. The analyzed results from the relationship between H.C.G. and Physique and Fitness factors represents no correlation in Non-athletic group.

점화시기가 LPG 엔진의 배기특성에 미치는 영향

한덕수,장영민,전봉준,김성준 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A

As an automobile fuel, LPG has many environmental advantages compared to gasoline or diesel. However, current LPG engine which is provided with LPG fuel as gas form has lower power and worse fuel efficiency than gasoline engine. These problems of low power and bad fuel efficiency come from lower volumetric efficiency. Also there is a new rising problem of high failure ratio in an engine emission test. Although there are many factors which affect engine performance of exhaust gas emission, one believes that the fact that ECM of gasoline engine is used for LPG engine when retrofitting gasoline engine to LPG engine is one of the main problems, which lower engine power and emit more noxious gas due to wrong ignition timing. To solve these problems, one studied the effects of ignition timing on the exhaust gas to find out the optimum condition of ignition timing. The experimental results show that noxious exhaust gas is reduced and engine power is increased if the optimum control of ignition timing is applied in accordance to the revolution speed of engine.

인터넷을 이용한 유도홍보 활성화 방안

한이석,김도준,정상윤 용인대학교 무도연구소 2000 武道硏究所誌 Vol.11 No.1

This study analyzed current issues by theoretical investigation on and by the research of current situation and actual condition on all the matters for public relation of Judo. I suggested the importance of internet, a method for future public relation, researched methods for its utilization and system for making up contents and approached internet to the public relation of judo. The strategies for the public relation of judo are as below. First, it should consist of better rich contents ill order for people to know the records of judo match current conditions on its players, public relation of the matches, etc.. Also, the chiefs of private judo halls should have interests in the public relation through internet and make assurance doubly sure of public relation of private judo halls since it is thought that all the people can easily approach it no matter what their majors are considering that today the number of people using internet are increasing in geometric progression and internet maintains lots of consumers regardless of social classes owing to rapidly spreading internet pervasion, technology development of various multi media and commercialization of information. Second, internet can quickly and exactly transmit accurate information needed for the target group with cheap price and with no limits of time and space though almost all methods such as telephone line, cable television, earth satellite, wireless communication information expressway, etc. and thus can obtain feedback for the simple and convenient addition of new technology or revised regulations to the existing data.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.