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Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling
Ramesh, T.P.,Kim, Young-Dae,Kwon, Min-Sung,Jun, Chang-Duk,Kim, Sang-Wook The Korean Association of Immunobiologists 2009 Immune Network Vol.9 No.6
Background: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in vitro and in vivo. Methods: The expression of cytokines and swiprosin-1 were determined by by real time PCR and conventional PCR. Pharmacological inhibitors were treated to investigate potential mechanism of swiprosin-1 in mast cell activation. Actin content was evaluated by confocal microscopy and flow cytometry. Results: The swiprosin-1 augmented PMA/A23187-induced expression of cytokines and release of histamine. However, knock-down of swiprosin-1 showed only a modest effect on PMA/A23187-induced cytokine expression, suggesting that swiprosin-1 has gain-of-function characteristics. Swiprosin-1 was found in microvilli-like membrane protrusions and highly co-localized with F-actin. Importantly, either disruption of actin by cytochalasin B or inhibition of PI3 kinase, an enzyme involved in actin remodeling, by wortmannin blocked cytokine expression only in swiprosin-1-overexpressing cells. Conclusion: These results suggest that swiprosin-1 modulates mast cell activation potentially through actin regulation.
Interface control of bulk ferroelectric polarization.
Yu, P,Luo, W,Yi, D,Zhang, J X,Rossell, M D,Yang, C-H,You, L,Singh-Bhalla, G,Yang, S Y,He, Q,Ramasse, Q M,Erni, R,Martin, L W,Chu, Y H,Pantelides, S T,Pennycook, S J,Ramesh, R National Academy of Sciences 2012 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.109 No.25
<P>The control of material interfaces at the atomic level has led to novel interfacial properties and functionalities. In particular, the study of polar discontinuities at interfaces between complex oxides lies at the frontier of modern condensed matter research. Here we employ a combination of experimental measurements and theoretical calculations to demonstrate the control of a bulk property, namely ferroelectric polarization, of a heteroepitaxial bilayer by precise atomic-scale interface engineering. More specifically, the control is achieved by exploiting the interfacial valence mismatch to influence the electrostatic potential step across the interface, which manifests itself as the biased-voltage in ferroelectric hysteresis loops and determines the ferroelectric state. A broad study of diverse systems comprising different ferroelectrics and conducting perovskite underlayers extends the generality of this phenomenon.</P>
Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling
T.P. Ramesh,김영대,권민성,전창덕,김상욱 대한면역학회 2009 Immune Network Vol.9 No.6
Background: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in vitro and in vivo. Methods: The expression of cytokines and swiprosin-1 were determined by by real time PCR and conventional PCR. Pharmacological inhibitors were treated to investigate potential mechanism of swiprosin-1 in mast cell activation. Actin content was evaluated by confocal microscopy and flow cytometry. Results: The swiprosin-1 augmented PMA/A23187- induced expression of cytokines and release of histamine. However, knock-down of swiprosin-1 showed only a modest effect on PMA/A23187-induced cytokine expression, suggesting that swiprosin-1 has gain-of-function characteristics. Swiprosin-1 was found in microvilli-like membrane protrusions and highly co-localized with F-actin. Importantly, either disruption of actin by cytochalasin B or inhibition of PI3 kinase, an enzyme involved in actin remodeling, by wortmannin blocked cytokine expression only in swiprosin-1-overexpressing cells. Conclusion: These results suggest that swiprosin- 1 modulates mast cell activation potentially through actin regulation. Background: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in vitro and in vivo. Methods: The expression of cytokines and swiprosin-1 were determined by by real time PCR and conventional PCR. Pharmacological inhibitors were treated to investigate potential mechanism of swiprosin-1 in mast cell activation. Actin content was evaluated by confocal microscopy and flow cytometry. Results: The swiprosin-1 augmented PMA/A23187- induced expression of cytokines and release of histamine. However, knock-down of swiprosin-1 showed only a modest effect on PMA/A23187-induced cytokine expression, suggesting that swiprosin-1 has gain-of-function characteristics. Swiprosin-1 was found in microvilli-like membrane protrusions and highly co-localized with F-actin. Importantly, either disruption of actin by cytochalasin B or inhibition of PI3 kinase, an enzyme involved in actin remodeling, by wortmannin blocked cytokine expression only in swiprosin-1-overexpressing cells. Conclusion: These results suggest that swiprosin- 1 modulates mast cell activation potentially through actin regulation.
Detection of Defects on Steel Surface for using Image Segmentation Techniques
S. M. Ramesh,B. Gomathy,T.V.P.Sundararajan 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5
An online surface inspection system m of hot rolled strips is introduced. This system is designed t o detect such main Surface defects on hot rolled strips as scar, scratches, pits, water drops Cracks. Cross hatchings, and so on. Multiple CCD area scan cameras are adopted to capture images of strip surface simultaneously, and all the images are processed by parallel computation system Real-time, which is supported by fast image process techniques and parallel computation techniques, in order to snap main defect regions on the surface of strips. At last, the defects will be classified to several types. The application of the system to practical production line shows that it can detect main defects of hot rolled strips more effectively than traditional method, and it is easily to be maintained.
Hybrid Differential Evolution Technique for Economic Dispatch Problems
T. Jayabarathi,V. Ramesh,D. P. Kothari,Kusuma Pavan,Mithun Thumbi 대한전기학회 2008 Journal of Electrical Engineering & Technology Vol.3 No.4
This paper is aimed at presenting techniques of hybrid differential evolution for solving various kinds of Economic Dispatch (ED) problems such as those including prohibited zones, emission dispatch, multiple fuels, and multiple areas. The results obtained for typical problems are compared with those obtained by other techniques such as Particle Swarm Optimization (PSO) and Classical Evolutionary Programming (CEP) techniques. The comparison of the results proves that hybrid differential evolution is quite favorable for solving ED problems with no restrictions on the shapes of the input-output functions of the generator.
T. Manovah David,P. Wilson,C. Ramesh,P. Sagayaraj 한국물리학회 2014 Current Applied Physics Vol.14 No.6
The formation of highly ordered, vertically aligned titania (TiO2) nanotubes (NTs) via the cost effective galvanostatic and potentiostatic anodization techniques is reported. In both the approaches, the variation of water content in terms of fresh and used ethylene glycol based electrolyte has been considered as a significant parameter to genuinely investigate each of the anodization modes. Noteworthy differences and influences were clearly observed in terms of anodization kinetics and the resulting tubular morphology, such as architecture and arrangement during the development TiO2 NTs arrays. The assynthesized samples were characterized by powder X-ray diffraction (XRD), Field emission scanning electron microscope (FESEM) and Energy dispersive X-ray analysis (EDX).
Hybrid Differential Evolution Technique for Economic Dispatch Problems
Jayabarathi, T.,Ramesh, V.,Kothari, D. P.,Pavan, Kusuma,Thumbi, Mithun The Korean Institute of Electrical Engineers 2008 Journal of Electrical Engineering & Technology Vol.3 No.4
This paper is aimed at presenting techniques of hybrid differential evolution for solving various kinds of Economic Dispatch(ED) problems such as those including prohibited zones, emission dispatch, multiple fuels, and multiple areas. The results obtained for typical problems are compared with those obtained by other techniques such as Particle Swarm Optimization(PSO) and Classical Evolutionary Programming(CEP) techniques. The comparison of the results proves that hybrid differential evolution is quite favorable for solving ED problems with no restrictions on the shapes of the input-output functions of the generator.