首善全圖의 제작원리에 관한 연구

金妙貞,鄭基浩 한국전통조경학회 2003 한국전통조경학회지 Vol.21 No.1

This study is to find the sketch processes of the Susunjeondo, an old map of Seoul. It is based on studying for a real mapping, to represent historical objects of the Susunjeondo on the present map. To do this, it is analyzed in two ways: comparison of the old map with that of the present, and analysis of drawing the old map. There is a drawing principle in this old map. It can be expressed with a diagram applying two circulars. These two circles show positions of natural elements, the four mountains of the old city Seoul, artificial elements, the city gates, roads and streams of the inner city region. A principle from the map is found with a diagram using two circulars and straight lines. It appears that the map was drawn to form squares and circuls. And it was produced with the concrete and exact map or topographic information. This study could discover the working techniques of the map after grasping the overall outline. This study expects to grasp a city urban structure then, and to collect basic data of studying the base map representing the historic landscape in detail.

청소년기 문제행동과 부모 양육행동에 관한 연구

손석한,노경선,허묘연,정현옥,이소희,김세주 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 일반 청소년의 문제행동(내재화 문제, 외현화 문제)을 평가하고, 그들을 정상 집단과 문제행동 집단으로 나누어 집단간에 부모 각각의 양육행동이 어떠한 차이를 보이는지 알아보고자 한다. 방 법 : 서울 소재의 일반 고등학교 학생 792명을 대상으로 부모 양육행동 척도와 K-YSR을 실시하여 청소년이 지각하는 부모의 양육행동과 청소년의 문제행동을 평가하였다. 부모의 양육행동과 청소년의 문제행동과의 상관관계를 분석하였다. 학생들이 보고한 각 문제행동을 상/하위 25% tile을 기준으로 정상 집단과 문제행동 집단으로 나누어 부모의 양육행도의 차이를 분석하였다. 결 과 : 다음과 같다. 1) 부모의 애정, 합리적 설명, 감독의 긍정적인 양육행동은 대부분의 청소년 문제행동들과 유의한 부적 상관을 보였다. 반면에 학대, 과잉간섭, 과잉기대, 방임, 비일관성이 부정적인 양육행동은 문제행동들과 유의한 정적 상관이 있었다. 2)내재화 문제를 보이는 청소년들은 정상 집단에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 애정을 유의하게 더 적게 받았다고 지각하고 있었다. 외현화문제를 보이는 청소년들은 정상집단의 청소년들에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 감독을 유의하게 더 적게 받았다고 지각하고 있었다. 3) 내재화 및 외현화 문제를 모두 보이는 집단이 내재화 문제만 보이는 집단과 외현화 문제만 보이는 집단에 비해서 양쪽 부모로부터 유의하게 더 많은 과잉간섭을 받을 것으로 지각하고 있었다. 또한, 내재화-외현화 집단과 내재화 집단은 외현화 집단에 비해서 어머니로부터 유의하게 더 적은 애정과 더 많은 방임을 받고 있고, 아버지로부터 유의하게 더 많은 학대를 받은 것으로 지각하고 있었다. 결 론 : 이상의 결과로 미루어 볼 때, 청소녕이 지각한 부모의 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동은 청소년의 내재화 및 외현화 문제 모두와 유의한 연관이 있고, 반면에 부모의 애정, 감독, 합리적 설명의 양육행동은 다양한 청소년기 문제행동을 줄일 수 있음을 시사하고 있다. Objectives : The purpose of this study is to evaluate the problem behaviors of adolescents and to discriminate between parenting behaviors of problem behavior groups and those of non-problem behavior group. Methods : The subjects of this study were 792 high school students in Seoul. We administered 'parenting behavior Inventory' and Korean version of Youth Self-Report(K-YSR) to the subjects in order to evaluate the parenting behaviors perceived by adolescents and the problem behaviors of adolescents. We analzed the relationship between parenting behaviors and problem behaviors. We classified the subjects into problem behavior groups(internalizing group, externalizing group, internalizing-externalizing group) and a non-problem behavior(normal) group. We studied the differences of parenting behaviors among the groups. Results : The results are as follows. 1) There were significant negative correlations between the positive parenting behaviors such as affection, reasoning, and monitoring and the problem behaviors of adolescents. By contrast, there were significant positive correlations between the negative parenting behaviors such as physical abuse, intrusiveness, over-expectation, neglect, and inconsistency and the problem behaviors of adolescents. 2) Adolescents of the internalizing group perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Meanwhile, they perceived significantly less affection than normal adolescents. Adolescents of the externalizing group also perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Also, they perceived significantly less monitoring than normal adolescents. 3) Adolescents of the internalizing-externalizing group perceived significantly more intrusiveness from both parents than those of either the internalizing or the externalizing groups. Adolescents of the internalizing-externalizing group perceived significantly less affection and more neglect from their mothers than those of the internalizing of the externalizing groups. In addition, adolescents of the internalizing-externalizing group perceived significantly more physical abuse from their fathers than those of the internalizing or the externalizing groups. Conclusion : Parenting behaviors such as abuse, intrusiveness, over-expectation, neglect, and inconsistency are associated with both internalizing and externalizing problems. In contrast, our results suggest that parenting behaviors such as affection, monitoring, and reasoning might decrease the various problem behaviors of adolescents.

범불안장애 혹은 공황장애 환자에서 Mindfulness에 기반한 인지치료의 장기치료 효과 : 1년 추적관찰

윤지원,이상혁,김용우,김묘정,육근영,류미,최태규,김근향 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives Mindfulness-base cognitive therapy (MBCT) has been used to treat patients with depression to prevent relapse. The purpose of this study was to examine the effectiveness of Mindfulness-Base Cognitive Therapy for patients who suffer with generalized anxiety disorder or panic disorder for 1 year. Methods 19 patients with generalized anxiety disorder or panic disorder were assigned to receive MBCT for a period of 8 weeks. The Hamiltion Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), the Beck Anxiety Inventory (BAI) and the Beck Depression inventory (BDI) were used at 0 weeks, 8 weeks and 1 year to assess the results. Results MBCT demonstrated significantly decreases on all the anxiety scale scores (HAM-A, p=0.00 ; BAI, p=0.00) and depressive scale scores (HAM-D, p=0.99 ; BDI, p=0.00). The patients who received 8-week of MBCT showed a higher remission rate (15/19, 78%) during the 1-year follow-up period. Conclusion MBCT may be effective at relieving the anxiety and depressive symptoms of patients who suffer with generalzed anxiety disorder or panic disorder for 1 year. However, further well-designed controlled trials are needed to assess the value of MBCT.

병리검사 처방오류 개선 시스템 구축

이현임,최영진,구숙희,양승주,김병로,김묘정,신일근,신미옥,서임선 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

문제: 조직병리검사의 처방이 복잡하고 전문화됨에 따라 오류처방이 빈번하게 발생되고 이를 해결하기위한 프로세스가 복잡하여 부서간의 갈등과 업무의 가중, 또한 병원 수입 감소가 초래되었다. 목적: 발생된 오류처방의 유형과 발생율, 오류처방을 해결하기 위한 프로세스를 파악하여 이에 대한 문제점을 개선하여 업무의 효율성과 관련부서간의 부가업무 감소와 갈등해소, 더불어 병원수익을 향상시키는 것에 목표를 두고 활동하였다. 의료기관: 서울시에 소재한 종합병원 질 향상 활동: 조직병리검사 처방의 오류처방 발생 원인과 유형, 발생율을 조사하여 원인을 파악하고 개선을 위한 프로세스를 구축하여 질 향상을 도모하였다. 개선효과: 수술실에서 의뢰한 외과 입원환자의 일반조직병리검사 오류율은 개선 전 7.8%에서 개선 후 3.5%, 동결절편조직검사 오류율은 개선 전 28.6%에서 개선 후 0%로 이전보다 모두 개선되었다. 또한 수술실 간호사의 업무 만족도는 일반조직병리검사의 처방시 95%, 동결절편조직검사 처방시 90%로 높은 만족도를 보였다. 단 병리과의 경우 업무가 증가됨에 따라 초과근무시간이 증가하였다.

Acceptor Specificity of Amylosucrase from Deinococcus radiopugnans and Its Application for Synthesis of Rutin Derivatives

( Myo-deok Kim ),( Dong-hyun Jung ),( Dong-ho Seo ),( Jong-hyun Jung ),( Ean-jeong Seo ),( Nam-in Baek ),( Sang-ho Yoo ),( Cheon-seok Park ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.11

The transglycosylation activity of amylosucrase (ASase) has received significant attention owing to its use of an inexpensive donor, sucrose, and broad acceptor specificity, including glycone and aglycone compounds. The transglycosylation reaction of recombinant ASase from Deinococcus radiopugnans (DRpAS) was investigated using various phenolic compounds, and quercetin-3-O-rutinoside (rutin) was found to be the most suitable acceptor molecule used by DRpAS. Two amino acid residues in DRpAS variants (DRpAS Q299K and DRpAS Q299R), assumed to be involved in acceptor binding, were constructed by site-directed mutagenesis. Intriguingly, DRpAS Q299K and DRpAS Q299R produced 10-fold and 4-fold higher levels of rutin transglycosylation product than did the wild-type (WT) DRpAS, respectively. According to in silico molecular docking analysis, the lysine residue at position 299 in the mutants enables rutin to more easily position inside the active pocket of the mutant enzyme than in that of the WT, due to conformational changes in loop 4.

Embryonic development in human oocytes fertilized by split insemination

( Myo Sun Kim ),( Ja Yeon Kim ),( Hye Won Youm ),( Jung Yeon Park ),( Hwa Young Choi ),( Byung Chul Jee ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.3

Objective To compare the laboratory outcomes of intracytoplasmic sperm injection (ICSI) and conventional insemination using sibling oocytes in poor prognosis IVF cycles where ICSI is not indicated. Methods Couples undergoing IVF with following conditions were enrolled: history of more than 3 years of unexplained infertility, history of ≥3 failed intrauterine insemination, leukocytospermia or wide variation in semen analysis, poor oocyte quality, or ≥50% of embryos had poor quality in previous IVF cycle(s). Couples with severe male factor requiring ICSI were excluded. Oocytes were randomly assigned to the conventional insemination (conventional group) or ICSI (ICSI group). Fertilization rate (FR), total fertilization failure, and embryonic development at day 3 and day 5 were assessed. Results A total of 309 mature oocytes from 37 IVF cycles (32 couples) were obtained: 161 were assigned to conventional group and 148 to ICSI group. FR was significantly higher in the ICSI group compared to the conventional group (90.5% vs. 72.7%, P<0.001). Total fertilization failure occurred in only one cycle in conventional group. On day 3, the percentage of cleavage stage embryos was higher in ICSI group however the difference was marginally significant (P=0.055). In 11 cycles in which day 5 culture was attempted, the percentage of blastocyst (per cleaved embryo) was significantly higher in the ICSI group than the conventional group (55.9% vs. 25.9%, P=0.029). Conclusion Higher FR and more blastocyst could be achieved by ICSI in specific circumstances. Fertilization method can be tailored accordingly to improve IVF outcomes.

Increased Volume of Surgery for Lumbar Spinal Stenosis and Changes in Surgical Methods and Outcomes: A Nationwide Cohort Study with a 5-Year Follow-Up

Kim, Chi Heon,Chung, Chun Kee,Kim, Myo Jeong,Choi, Yunhee,Kim, Min-Jung,Shin, Sukyoun,Jung, Jong-Myung,Hwang, Sung Hwan,Yang, Seung Heon,Park, Sung Bae,Lee, Jun Ho Elsevier 2018 World neurosurgery Vol.119 No.-

<P><B>Objective</B></P> <P>Examining spine surgery patterns over time is crucial to provide insights into variations and changes in clinical decision making. Changes in the number of surgeries, surgical methods, reoperation rates, and cost-effectiveness were analyzed for all patients who underwent surgery for lumbar spinal stenosis without spondylolisthesis in 2003 (2003 cohort) and 2008 (2008 cohort).</P> <P><B>Methods</B></P> <P>The national health insurance database was used to create the 2003 cohort (n = 10,990) and 2008 cohort (n = 27,942). The surgical methods were classified into decompression and fusion surgery. The cumulative reoperation probability between those surgeries was calculated using the Kaplan-Meier method in the 2003 cohort and 2008 cohort. Comparison of the incremental cost-effectiveness ratios showed the additional direct cost of a 1% change in the reoperation probability.</P> <P><B>Results</B></P> <P>The surgical volume increased 2.54-fold in the 2008 cohort. The age-adjusted number of surgeries per 1 million people increased 2.6-fold (from 154 in the 2003 cohort to 399 in the 2008 cohort) in aged patients and 1.9-fold (from 154 in the 2003 cohort to 291 in the 2008 cohort) in patients 20–59 years old in the 2008 cohort. The proportion of fusion surgeries increased from 20.3% in the 2003 cohort to 37.0% in the 2008 cohort. In total, the 5-year reoperation probabilities increased from 8.1% in the 2003 cohort to 11.2% in the 2008 cohort. Fusion decreased the reoperation probability by 1% at the cost of 1,711 U.S. dollars.</P> <P><B>Conclusions</B></P> <P>The increased numbers of spinal surgeries, fusion surgeries, and surgeries in older patients in a recent cohort were noteworthy. However, the increased surgical volume and fusion surgeries did not reduce the reoperation rate.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Examining patterns of spine surgery over time is crucial. </LI> <LI> The national health insurance database was analyzed. </LI> <LI> Increased surgical volume and fusion surgeries failed to reduce the reoperation. </LI> </UL> </P>

Molecular cloning and expression of amylosucrase from highly radiation-resistant Deinococcus radiopugnans

Kim, Myo-Deok,Seo, Dong-Ho,Jung, Jong-Hyun,Jung, Dong-Hyun,Joe, Min-Ho,Lim, Sangyong,Lee, Ju-Hoon,Park, Cheon-Seok Springer-Verlag 2014 Food Science and Biotechnology Vol.23 No.6

The effect of granule surface area on hydrolysis of native starches by pullulanase

Jung, Kyung‐,Hee,Kim, Min‐,Jeong,Park, So‐,Hae,Hwang, Hye‐,Sun,Lee, Suyong,Shim, Jae‐,Hoon,Kim, Myo‐,Jeong,Kim, Jae‐,Cherl,Lee, Heeseob WILEY‐VCH Verlag 2013 Die Stärke Vol.65 No.9

<P><B>Abstract</B></P><P>Various native starch granules were reacted as substrates for a debranching enzyme, pullulanase, from <I>Bacillus acidopullulyticus</I>, and the kinetic mechanism was investigated in initial rate studies. The apparent <I>K</I><SUB>m</SUB> values of the native starch hydrolysis reactions decreased in the order of rice, corn, and potato, whereas <I>V</I><SUB>max</SUB> remained constant for all starches. Assuming that starch granules were spherical, the double reciprocal of the initial rates of the hydrolysis reactions along with the surface area of the three native starch granules could be described in a linear function. Therefore, enzymatic hydrolysis of native starches during the initial stage is mainly affected by particle size of starch granules. Further, the surface area as well as particle size of granules have important effects on the initial rate at which native starch is digested by debranching enzyme. We believe that this is the first systematic study reporting kinetic data on the effect of granule surface area on hydrolysis of native starches by α‐1,6‐glucan hydrolase.</P>

Increased Volume of Lumbar Surgeries for Herniated Intervertebral Disc Disease and Cost-Effectiveness Analysis: A Nationwide Cohort Study

Kim, Chi Heon,Chung, Chun Kee,Kim, Myo Jeong,Choi, Yunhee,Kim, Min-Jung,Hahn, Seokyung,Shin, Sukyoun,Jong, Jong-myung,Lee, Jun Ho Lippincott Williams & Wilkins 2018 Spine Vol.43 No.8

<P>Conclusion. The choice of surgical method might not always be consistent with cost-effectiveness strategies, and a high proportion of medium-sized hospitals may be responsible for this change.</P>