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( Motohiro Ebisawa ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
In October 2005, we released Food Allergy Management Guideline 2005. To cover food allergy from infancy to adulthood, the project committee included not only pediatric researchers, but also internists, dermatologists, and otolaryngologists. The guideline concept was to utilize the data accumulated by the National Food Allergy Research Group, to be plain and as short as a pamphlet, and to be released on internet. The most glowing argument was about relation between infantile atopic dermatitis and food allergy, and how it should be treated in the guideline. To avoid neither overvaluation nor undervaluation, fastidious care was given to the denotation. With the definition of infantile atopic dermatitis associated with food allergy, both dermatologic and pediatric members of the project committee finally came to agreement, which was a landmark between dermatologists and pediatricians in Japan. The guideline explains fundamentals with the least paragraphs and with tables and figures as many as possible. Flowcharts are made largely as a composition in the parts of diagnosis and treatment. I really hope that this guideline is useful for Korean doctors involved in food allergy and that quality of life of food allergy patients and their parents are improved. (Korean J Asthma Allergy Clin Immunol 2006;26:177-185)
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Oral Immunotherapy in Food Allergy: Where Are We Now?
Özdemir Pınar Gökmirza,Sato Sakura,Yanagida Noriyuki,Ebisawa Motohiro 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2
Food allergy (FA) has become more prevalent and problematic in the last 2 decades, and it poses important individual, social, and economic burdens. Besides treating reactions induced by accidental exposure and periodic evaluation for acquiring natural tolerance, the primary management approach is still allergen avoidance as a global standard. However, an active therapeutic approach that can raise the reaction threshold or accelerate tolerance is needed. This review aimed to provide an overview and the latest evidence of oral immunotherapy (OIT), which has recently been used in the active treatment of FA. FA immunotherapy, particularly OIT, is gaining considerable interest, and substantial effort has been made to integrate this active treatment into clinical practice. Consequently, growing evidence has been obtained regarding the efficacy and safety of OIT, particularly for allergens such as peanuts, eggs, and milk. However, several issues need to be addressed regarding the availability, safety, and long-term effects of this intervention. In this review, we summarize currently available information regarding tolerance-inducing immune mechanisms of OIT, data on efficacy and safety, gaps in current evidence, and ongoing research to develop new therapeutic molecules in order to enhance safety.
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Yoko Inoue,Sakura Sato,Tetsuharu Manabe,Eishi Makita,Masako Chiyotanda,Kyohei Takahashi,Hitoshi Yamamoto,Noriyuki Yanagida,Motohiro Ebisawa 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.5
Purpose: Few studies have compared fractional exhaled nitric oxide (FeNO) measurement by NIOX VERO® (NOV) and other devices in children. Moreover, there is no agreement between differences in FeNO values obtained using different devices in adults. Here, we compared FeNO values obtained using NOV and NObreath® (NOB) systems to derive a correction equation for children. Methods: Eighty-eight participants (age 7–15 years) who were diagnosed with atopic bronchial asthma and visited Sagamihara National Hospital as outpatients between January and April of 2017 were included. We measured FeNO values obtained using NOB and NOV, and analyzed them using Wilcoxon tests and Altman-Bland plots. Results: The median age of the participants was 11.5 years, and the scored Asthma Control Test (ACT) or Childhood ACT (C-ACT) was 25 (interquartile range, 24–25) or 26 (24–27). NOB and NOV values were significantly different (31 [14–52] versus 36 [20–59] ppb; P = 0.020) and strongly correlated (r = 0.92). An equation to convert NOB values into NOV values was derived using linear regression as follows: log NOV = 0.7329 × log NOB + 0.4704; NOB for 20, 40, 58, 80 and 100 ppb corresponded to NOV for 27, 44, 59, 73 and 86 ppb. Thus, NOB < 58 ppb suggested NOB < NOV, whereas NOB > 58 ppb suggested NOB > NOV. Conclusions: NOB and NOV values were strongly correlated. Participants whose FeNO values were relatively low represented NOB < NOV, whereas those whose FeNO values were relatively high represented NOB > NOV.
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Takei Mari,Nin Charles,Iizuka Tomona,Pawlikowski Marine,Selva Marie-Ange,Chantran Yannick,Nakajima Yurie,Zheng Jingkang,Aizawa Tomoyasu,Ebisawa Motohiro,Sénéchal Hélène,Poncet Pascal 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.3
The Capsicum genus belongs to the Solanaceae family. Bell or chili peppers are consumed worldwide, but allergy to Capsicum is rare. It is involved in the celery-birch-mugwort-spice syndrome and cross-reactivities were reported with latex. Several allergens have been described, but only 2 are referenced in the World Health Organization/International Union of Immunological Societies allergen data bank, a thaumatin-like protein and a profilin. A patient allergic to bell/chili pepper, peach, orange and Japanese cedar pollen was clinically and biologically analyzed including direct and competitive immunoblots and basophil activation tests (BATs) with allergenic source extracts and recombinant gibberellin-regulated proteins (GRPs). The patient was shown to be sensitized to Cap a 7, the GRP of Capsicum annuum newly described herein. Cross-reactivities were demonstrated between various GRPs from bell/chili pepper, peach, orange and Japanese cedar pollen either in native form in the different extracts or as recombinant allergens. A similar immunoglobulin E reactivity was found also in Capsicum chinense and against snakin-1, the GRP from potato. The patient showed a positive BAT with recombinant Cry j 7, Pru p 7 and Cap a 7, but not with recombinant snakin-1. Despite the ubiquitous nature of GRPs in plants and the immunochemical cross-reactivity observed between different GRPs, clinically relevant sensitization to this protein family seems restricted to some allergenic sources, often associated with Cupressaceae pollen allergy, and to some patients, therefore reflecting very specific and peculiar mechanisms of conditional sensitization.
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