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CASE REPORT : Crohn`s Disease Complicated with Duodenocolic Fistula: A Case Report
( Meng Tzu Weng ),( Shu Chen Wei ),( Yu Wen Tien ),( I Lun Shih ),( Jau Min Wong ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Fistula formation is common during the course of Crohn`s disease, whereas duodenocolic fistulas are very rare. The management of internal fistulas in Crohn`s disease is a complex issue. Herein, we report a case of duodenocolic fistula manifested by increasing frequency of diarrhea and loss of body weight. The fistula was diagnosed by upper gastrointestinal tract barium series, magnetic resonance enterography, and panendoscopy and was treated with a right hemicolectomy and Whipple procedure because of the simultaneous occurrence of pancreatic head tumor. Subsequent treatment with adalimumab, azathioprine, and mesalazine was prescribed for the maintenance of disease remission, and the patient was well until 18 months after the surgery. (Intest Res 2013;11:299-302)
( Meng-tzu Weng ),( I-lun Shih ),( Chien-chih Tung ),( Yew-loong Leong ),( Ming-jium Shieh ),( Cheng-yi Wang ),( Jau-min Wong ),( Yen-hsuan Ni ),( Shu-chen Wei ) 대한장연구학회 2022 Intestinal Research Vol.20 No.2
Background/Aims: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods: This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively. Results: In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679). Conclusions: A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD. (Intest Res 2022;20:224-230)
( Meng Tzu Weng ),( Shu Chen Wei ),( Chun Che Lin ),( Yuk Min Tsang ),( Chia Tung Shun ),( Jann Yuan Wang ),( Ming Jium Shieh ),( Cheng Yi Wang ),( Jau Min Wong ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1
Since Taiwan is an endemic area for tuberculosis (TB), differential diagnosis between the intestinal TB and Crohn`s disease is an important issue. The steering committee of Taiwan Society of Inflammatory Bowel Disease (TSIBD) has arranged a seminar accordingly on May 24th, 2014 and the different point of views by gastroenterologist, radiologist, pathologist and infectious dis-ease specialist were suggested to help the proper diagnosis and management of these two diseases. (Intest Res 2015;13:6-10)
Hsu-Heng Yen,Meng-Tzu Weng,Chien-Chih Tung,Yu-Ting Wang,Yuan Ting Chang,Chin-Hao Chang,Ming-Jium Shieh,Jau-Min Wong,Shu-Chen Wei 대한장연구학회 2019 Intestinal Research Vol.17 No.1
Background/Aims: Incidences of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn’s disease (CD), havebeen increasing in Asia. In this study, we report the relevant clinical characteristics and determined the epidemiological trend ofIBD in Taiwan from 2001 to 2015. Methods: A retrospective study was conducted to analyze data recorded from January 2001through December 2015 in the registered database compiled by the National Health Insurance and provided by the Ministry ofHealth and Welfare, Taiwan. Results: A total of 3,806 patients with catastrophic IBD illness were registered from 2001 to 2015 inTaiwan (CD, 919; UC, 2,887). The crude incidence of CD increased from 0.17/100,000 in 2001 to 0.47/100,000 in 2015, whereasthat of UC increased from 0.54/100,000 in 2001 to 0.95/100,000 in 2015. The prevalence of CD increased from 0.6/100,000 in2001 to 3.9/100,000 in 2015, whereas that of UC increased from 2.1/100,000 in 2001 to 12.8/100,000 in 2015. The male-to-femaleratio in the study sample was 2.19 for CD and 1.62 for UC. The median age of those registered with CD was lower than that ofthose registered for UC: 38.86 and 44.86 years, respectively. A significantly greater increase in CD incidence rate was identifiedamong 20 to 39-year-old compared with other age groups. Conclusions: Using Taiwan’s nationwide insurance database, we determinedthat the number of patients with CD increased more rapidly during the study period than the number of patients withUC, especially among age 20 to 39-year-old, resulting in a decreased UC-to-CD ratio. (Intest Res 2019;17:54-62)
Maria Janina Carrera Espinoza,KUEN-SONG LIN,Meng-Tzu Weng,Sikhumbuzo Charles Kunene,Shin-Yun Liu,You-Sheng Lin 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
The current study presents the synthesis and characterization of magnetic silica nanocomposites(MSNCs) decorated with Pluronic F127. The nanocomposites were loaded with doxorubicin (DOX) forhepatocellular carcinoma (HCC) therapy. The X-ray diffraction (XRD) patterns proved that the nanocompositeswere crystalline with diffraction peaks at 2h = 35.44 corresponding to (311) plane of Fe3O4. Thein vitro test demonstrated cell viability of above 90% revealing that MSNCs-F127 were biocompatible andnontoxic to the HEK293T and HepG2 cell lines; however, the MSNCs-F127-DOX formulations exhibited asignificant therapeutic effect against HepG2 cells. A pH-responsive drug release was detected, showing aHiguchi kinetic model at acidic and physiological conditions which demonstrated the best correlationcoefficient with R2 values of 0.969, and 0.932, respectively. The highest level of cell inhibitory rate, necrosis,and apoptosis in mice treated with MSNCs-F127-DOX was achieved by in vivo experiment, hematoxylinand eosin (H&E), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)staining. The in vivo experiment revealed a significant tumor inhibition after treatment with MSNCs-F127-DOX. The prepared MSNCs-F127-DOX formulations could be utilized as an innovative drug deliverysystem (DDS) for anticancer therapy for several cancer types.
Sikhumbuzo Charles Kunene,KUEN-SONG LIN,Meng-Tzu Weng,Maria Janina Carrera Espinoza,Chun-Ming Wu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
In this study, a series of thermo- and pH-dependent doxorubicin (DOX) carriers based on magnetic graphenenanosheets (MGNSs), functionalized by poly(N-isopropylacrylamide) (PNIPAM) and polyethylenemine(PEI) nanogel, targeting liver cancer cells were formulated. The temperature phase transitions of thecarriers can be tuned as a function of pH to the intended value in the range of 38–42 C. In vitro studiesshowed a high cell viability of above 90% at all doses of MGNSs and MGNS-nanogel against HEK293T normaland HepG2 cancerous cells, confirming the biocompatibility and nontoxicity of the carriers. In comparison,the MGNS-nanogel-DOX demonstrated a sufficient therapeutic effect towards HepG2 cell line. The cell viability results showed enhanced efficacy of the drug released by means of applied magneticfield (AMF). Moreover, an efficient cellular intake of the carriers into the HepG2 cells was achieved. Additionally, the achieved low DOX release at a lower temperature and neutral pH can retain the drugin the carriers until reaching the targeted sites. Nevertheless, the high drug release showed that therelease was triggered by high temperature and acidic pH. Hence, the developed thermo- and pHtunableMGNS-nanogel-DOX showed a high potential for microenvironment stimulus-prompted drugdelivery and cancer cell suppression.
( Shu-chen Wei ),( Chien-chih Tung ),( Meng-tzu Weng ),( Jau-min Wong ) 대한장연구학회 2018 Intestinal Research Vol.16 No.4
Background/Aims: Fecal calprotectin (fC) level is a predictive marker of mucosal healing for patients with inflammatory bowel disease (IBD). Home fC tests are now available. We evaluated the performance of the smartphone-based IBDoc home testing system in patients with IBD and obtained their feedback as an objective patient-reported outcome. Methods: This prospective study enrolled consecutive patients with IBD in clinical remission. fC in the same stool sample was assessed by using both the laboratory test (Quantum Blue calprotectin test) and home test (IBDoc). The correlation between the 2 tests was analyzed using the Pearson method. In addition, the patients were asked to fill a questionnaire based on their experience. Results: Fifty-one patients with IBD (68 tests and 49 questionnaires) were included. The correlation between Quantum Blue test and IBDoc was good (r=0.776, P< 0.0001). After the test, 56% patients found IBDoc easy to perform, and 96% were satisfied with it. Thirty-nine patients (80%) had a strong ( >70%) probability to use it for future monitoring if the price was acceptable. By using 250 μg/g as the cutoff, the agreement between home test and laboratory results was 80%, and by using 600 μg/g as the cutoff, the agreement increased to 92%. Conclusions: The correlation between the laboratory and home tests was good. Most patients found the home test to be feasible and easy to use and preferred it over laboratory test and endoscopy for monitoring. Therefore, the home test could be used as an objective patient-reported outcome. (Intest Res 2018;16:546-553)
Ndumiso Vukile Mdlovu,KUEN-SONG LIN,Meng-Tzu Weng,Chi-Cheng Hsieh,You-Sheng Lin,Maria Janina Carrera Espinoza 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.102 No.-
Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, accounting for about 75% of allliver cancers. It is the third most common basis for cancer mortality worldwide, and unfortunately, itstreatment is often limited by the shortage of appropriate therapeutic options and side effects causedby the current treatment methods. To overcome this, doxorubicin (DOX)-loaded pH-/thermoresponsivemagnetic mesoporous nanocarriers were formulated and evaluated for their in vitro anticanceractivity against HCC. These nanocarriers consist of iron oxide (IO) nanoparticles conjugated withSBA-15 (S15) and Pluronic F127 (PF) to form IOS15 nanocomposites and IOS15@PF nanocarriers. The preparednanocarriers were superparamagnetic with saturation magnetizations of IOS15 and IOS15@PFbeing 76.3 and 72.1 emu/g, respectively. Small-angle neutron/X-ray scattering (SANS/SAXS) studiesshowed that the developed nanocarriers are temperature-sensitive and possess hexagonally arrangedstructures. Cell viability studies demonstrated that IOS15@PF@DOX nanocomplexes induced more apoptosisor necrosis. A temperature (69% release after 48 h)- and pH (70% release after 48 h)-dependent DOXrelease was observed, whereby more DOX was released at a high temperature of 42 C and pH value of5.4. Thus, the developed nanocarriers possess great potential for use in the targeted delivery of conventionalchemotherapeutic drugs with enhanced efficiency.
Sikhumbuzo Charles Kunene,Kuen-Song Lin,Meng-Tzu Weng,Maria Janina Carrera Espinoza,You-Sheng Lin,Yi-Ting Lin 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
In this study, versatile homotypic-targeting and PEGylated magnetite hollow nanostructures (MHNs) thatare pH-responsive used as doxorubicin (DOX) nanocarriers are demonstrated. Cancer cell membrane(CM) and polyethylene glycol (PEG) functionalization through benzoic imine bonds endows DOXconjugatednanocarriers with enhanced tumor accumulation and penetration, biomimetic-targetingspecificity, as well as on-demand drug release, which improves their antitumor efficacy. The characteristicdiffraction peaks of magnetite nanocarriers at 35 indexed as (311) plane of magnetite can beobserved. Hierarchical mesoporous nanostructures with specific pore size distributions of approximately99.9, 97.2, and 95.6%, were developed. In vitro studies revealed that drug-free nanostructures exhibitedexcellent biocompatibility with more than 95% cell viability. In contrast, drug-conjugated nanostructuresdemonstrated high therapeutic effect, pH-responsive drug release, and enhanced intracellular uptake inHepG2 cells. In vivostudies showed that the MHNC–DOX–PEG/CM formulations displayed the best antitumorefficacy, with the lowest tumor volume and weight. Furthermore, significantly large apoptotic andnecrotic areas were identified in the tumor tissues from the DOX-conjugated groups, but no noticeableinflammation or hemorrhage was observed in the main organs. Therefore, these results suggest thatthe formulated nanostructures have great potential for cancer therapies.