http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yong-Hoon Yoon,Sangwon Han,Osung Kwon,Kyusup Lee,Ju Hyeon Kim,Junghoon Lee,Tae Oh Kim,Jae-Hyung Roh,Pil Hyung Lee,Soo-Jin Kang,Jae-Hwan Lee,Young-Hak Kim,Cheol Whan Lee,Dae Hyuk Moon,Seung-Whan Lee 대한심장학회 2022 Korean Circulation Journal Vol.52 No.2
Background and Objectives: Studies evaluating the nature of ischemic burden of chronic total occlusion (CTO) vessels are still lacking. Methods: A total of 165 patients with single vessel CTO >2.5 mm in an epicardial coronary artery who underwent single photon emission computed tomography (SPECT) were enrolled in the study. Ischemic burden was calculated with the use of semi-quantitative SPECT analysis, and was defined as the summed difference score (SDS) divided by the maximal limit of the score (=SDS/68). Results: The mean age of the participants was 59.5 years and the CTO of the left anterior descending coronary artery (LAD), left circumplex coronary artery (LCX), and right coronary artery (RCA) accounted for 93 (56.4%), 18 (10.9%), and 54 (32.7%) patients, respectively. The median ischemic burden of the total population was 8.8%, and it was highest in the LAD CTO (10.3%) compared with the LCX (5.9%) and RCA CTO (5.9%, p<0.001). High-ischemic burden (ischemic burden >10%) was observed in 66 patients (40.0%), and in 47 patients (50.5%) of the LAD CTO. Ischemic burden was different according to the CTO location only in LAD CTO. The statistically significant predictors for high-ischemic burden were hypertension, baseline ejection fraction >45%, LAD CTO, proximal CTO location, and de novo CTO. Japanese-CTO score and Rentrop scale collateral grade were not associated with high-ischemic burden. Conclusions: Only 40% of patients with single vessel CTO had ischemic burden >10%. For CTO vessels, measurement of ischemic burden using SPECT prior to revascularization may be helpful in identifying beneficial subjects.
Reply to “Comment on ‘An Alternative Presentation of the Second Law of Thermodynamics’”
Lee, Sangyoub,Lee, Kyusup,Lee, Jiyon American Chemical Society and Division of Chemical 2016 Journal of chemical education Vol.93 No.5
<P>This letter is to respond to 'Comment on 'An Alternative Presentation of the Second Law of Thermodynamics'', which discusses some shortcomings of our approach of teaching the second law of thermodynamics.</P>
An Alternative Presentation of the Second Law of Thermodynamics
Lee, Sangyoub,Lee, Kyusup,Lee, Jiyon American Chemical Society and Division of Chemical 2015 Journal of chemical education Vol.92 No.4
<P>We present an elementary, but still quite rigorous derivation of the Clausius inequality, which sheds a new perspective on the second law. Unlike the classical approach, our derivation does not employ the Carnot cycle. The Clausius inequality follows in a straightforward way from the first law and thermodynamic stability conditions without invoking the Clausius or the Kelvin–Planck statement of the second law. The background knowledge required for this article is the same as that for the usual textbook presentation of the second law. The new presentation of the second law is, therefore, appropriate for an introductory thermodynamics course.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jceda8/2015/jceda8.2015.92.issue-4/ed5007822/production/images/medium/ed-2014-007822_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ed5007822'>ACS Electronic Supporting Info</A></P>
( Eunhee Lee ),( Kayeong Yun ),( Sieun Han ),( Bosun Joo ),( Kyusup Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The aim of this study was to suggest the most effective primary ovarian insufficiency(POI) model construction method by examining the effect of POI model on anticancer drugs. Methods: Female mice were treated with cyclophosphamide(Cy)+busulfan(Bu) mixture for 1 week to 4 weeks and Cisplatin alone for 3, 5, 10, and 14 days. The injection period to POI occurrence was observed and the period of normal recovery from POI was checked. Results: After two weeks of the Cy+Bu injection, the weight of ovary and uterus decreased sharply and the weight reductions also affect ovarian function. And ovarian function is not recovered for at least 2 weeks when POI is induced with Cy+BU for 2 weeks. After 10 days of Cisplatin injection, the weight of ovary and uterus decreased significantly and the weight reductions also affect ovarian function. After 10 to 2 weeks of treatment with cisplatin, the embryo development rate to blastocyst was 0%. Conclusion: As an ideal POI induction model, it is useful to treat Cy+Bu for 2 weeks or cisplatin for 10 days to 2 weeks.
Hyekyung Noh,Hyunjoo Lee,Seungchul Kim,Jongkil Joo,Dongsoo Suh,Kihyung Kim,Kyusup Lee 대한폐경학회 2019 대한폐경학회지 Vol.25 No.1
Objectives: Body mass index (BMI) is commonly used in epidemiological study or clinical center. However, it is not exactly correlated with body fat composition and does not reflect sex, age, or race. The aim of this article is to evaluate the validity of BMI standards relative to total body fat (TBF) and to estimate new BMI criteria that correspond to TBF for obesity, especially for Asian postmenopausal women. Methods: A total 3,936 patients were included in this cross-sectional study, including 1,565 premenopausal and 2,371 postmenopausal women. At the time of visit, demographic data were collected. We demonstrated the validity of BMI cut-point of 25 kg/m2 by using area under the curve (AUC), and presented the empirical optimal BMI cut-point by using Youden’s index and overall accuracy in both premenopausal and postmenopausal women. Results: BMI-defined obesity (≥ 25 kg/m2) represents high AUC values (> 0.9) for each TBF. In premenopausal women, TBF ≥ 38% and corresponding BMI value was 29.45 kg/m2 indicated the highest both Youden’s index and overall accuracy. In comparison, postmenopausal women who were TBF ≥ 38% showed the highest Youden’s index and overall accuracy, and corresponding BMI value was 26.45 kg/m2. Conclusions: We proposed new BMI criteria for obesity by using TBF reference. With application of bioelectrical impedance analysis, the diagnosis of obesity using BMI criteria may differ between premenopausal and postmenopausal women.
버추얼 엔진을 활용한 가솔린 엔진의 극한 환경조건 대응 매핑에의 적용 가능성 연구
박종일(Jongil Park),이동규(Dongkyu Lee),김규섭(Kyusup Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
Product development using virtual technology is getting more important in automotive industry. In engine development, virtual methodologies are widely used in emission field such as RDE. However the application for engine calibration supported by virtual model is not commonly used so far despite of its great potential. In this study, engine calibration combining experimental dataset and virtual models were investigated to find out the potential of calibration efficiency and robustness. Two cases calibration against extreme environmental conditions such as very low temperature and high altitude were investigated to apply to mass production projects. One was turbocharger boost control open-loop calibration and the other was ignition correction calibration according to coolant and intake air temperature. In both applications, the dataset from virtual models are successfully linked to existing calibrations methodology. Promising calibration DCM could be achieved in each application. It can be shown from this study that engine calibration by virtual engine at certain surrounding condition is sufficiently beneficial in terms of time and cost. After a number of validation experiences, it can be expected that some calibration can be eventually replaced by virtual methodology and its coverage will grow gradually