만성정신분열병의 양성 및 음성증상에 대한 Lithium의 항정신병 효과

성상경,장환일,김시균 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.1

The authors investigated the antipsychotic effect of lithium in 24 chronic refractory schizophrenics with special interest in it's effects on positive and negative symptoms by a method of placebo controlled double-blined cross-over study. Subjects were divided into two sequences: Sequence 1 was Base-Lithium(4wks) -Placebo(4wks) -Lithium(4wks), and Sequence 2 was Base-Placebo(4wks) -Lithium(4wks) -Placebo(4wks). 24 schizophronics, diagnosed according to DSM-Ⅲ-R, were randomly assigned to each sequences so that each sequence had the same number of patients. SAPS(Scale for the assessment of positive symptoms) and SANS(Scale for the assessment of negative symptoms) were used for the assessment of the subjects's mental status. l) 9 of 24 Subjects(31% ) belonged to lithium-responder group : and others to lithium non-responder group. 2) In 9 lithium-responders, statistically significant improvement was noticed in “severity of hallucination as positive" symptom and in - “alogia” as negative symptom. 3) “Clothing & appearnce" among positive symptoms and “inappropriate affect" and “subjective complaint of inattentiveness" among negative symptoms changed statistically significantly in all subjects(N -24) All global ratings did not change significantly after lithium treatment.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

화상으로 인한 소구증 환자의 치험례

지재휴,이병준,김영균,김수관,황경곤,여환호,박인순 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Deep burns of the face & lips often lead to scarring and contraction of the circum-oral tissues with a marked reduction in the size of the oral aperture. Such burns most commonly caused by electrical contact, for example, children sucking electric plugs, or as a result of chemical burns and the exposture to flame. Once having burns, burned tissue may contract and reduce considerably the size and mobility of the mouth ; therefore bring up the resultant functional disturbance, verbal difficulty, even disgestive difficulty, and poor appearance, which fall into difficulty in social acceptability, caused by burns. In our department, 2 patients who were complain of functional limitations and esthetic problem owing to scar contracture, were visited, and we treated this microstomia with scar excision, graft and flap technique, and postoperative intensive physical therapy. We obtained relatively favorable results, thus report this cases with literature review.

구강 악안면 연조직 결손 재건을 위한 진피 지방 이식의 이용 : 증례보고

김수관,박노승,이병준,황경곤,여환호,김영균 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Soft tissue defects in oral & maxillofacial region caused by tumor resection, trauma, congenital deformities have been treated in autogenous soft tissue flap, allogenic material, free dermal graft, fascia graft. Of these methods, autogenous dermis graft had initially been applied in hernia treatment at the beginning of nineteenth century and have been applied in soft tissue augmentation coverage of vital structure, dead space removal and reconstruction of fascia. A fat graft is used in reconstruction of orbit at the enucleation, restoration of facial contours, etc. In this case, patient with chin soft tissue defect in traffic accident was treated in autogenous dermis-fat graft from patient's abdominal and gluteal region. Chin defect was recons ructed favorably. There was no severe atrophy of grafted area 12 months postoperatively. We will report the result that is favorable esthetically with literature review.

Effect of Pulsed Electromagnetic Field Stimulation on the Early Bone Consolidation After Distraction Osteogenesis in Rabbit Mandible Model

( Kyung Kyun Hwang ),( Tae Hyung Cho ),( Yun Mi Song ),( Do Kyun Kim ),( Sung Hee Han ),( In Sook Kim ),( Soon Jung Hwang ) 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.2S

Synthetic Polymer Membranes as a Proxy of Skins in Permeation Studies of Biologically Active Compounds

Hwang, Yoon-Kyun,Choi, Jang-Won,Hwang, Cheng-Hwan,Park, Woo-Ram,Park, Ki-Dong,Suh, Kyung-Do,Kim, Jin-Woong 한국고분자학회 2012 Macromolecular Research Vol.20 No.4

This study provides a practical approach that can afford evaluation of drug compound permeability through the skin in which synthetic polymer membranes are used as a proxy. For this, permeation behaviors of a variety of drug molecules through the synthetic membranes were characterized under the iontophoresis condition as well as passive delivery. As a proof of concept, the permeability of caffeine and $Triamiondil^{TM}$, both of which are model drug compounds, through the membranes correlated with conventional use of porcine skin. The synthetic polymer membranes showed similar drug permeation patterns to that of the porcine skin, which allowed us to apply them to an alternate to the animal skin. Moreover, the application of iontophoresis to the device system enabled the drug molecules to pass through both the polymer membranes and porcine skin. Our study also verified that drug permeation is substantially influenced by the current direction that likely drives either electrorepulsion or electroosmosis under iontophoretic conditions.

김치로부터 분리된 Leuconostoc sp. strain YSK 균주에 의한 덱스트란 생산 조건의 최적화

황승균(Seung Kyun Hwang),홍준택(Jun Taek Hong),정경환(Kyung Hwan Jung),장병철(Byung Chul Chang),황경숙(Kyung Suk Hwang),신정희(Jung Hee Shin),임성팔(Sung Paal Yim),유선균(Sun Kyun Yoo) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

본 연구는 발효 김치 액으로부터 덱스트란 생산 균주를 분리하고 생산 최적 생산 조건을 설정하기 위하여 반응표면분석법을 이용하였다. 발효 조건의 독립변수들은 배양 온도, pH, 효모 추출물의 농도, 온도, 기질의 농도로 정하고 Box-Benken 디자인를 이용하여 실험을 설계하였다. 최종 분리된 균주는 Leuconost℃ sp. strain SKY로 잠정적으로 명하였다. 연구 결과 덱스트란 생산은 3.90 - 22.40 g/l이고, 균체량 생산은 0.69-2.85 g/l, 수율은 0.10-0.64, 생산 속도 0.16-0.85 g/l-hr의 범위에서 분석이 되었다. 표면반응분석 결과 덱스트란 생산에 가장 영향을 미치는 것은 배양 pH이고 다음에 효모 추출물의 농도 그리고 온도의 순으로 나타났다. 균체량 생산에 가장 영향을 미치는 것은 배양 pH이고 다음에 효모 추출물의 농도 그리고 온도의 순으로 나타났다. 생산 수율에 가장 영향을 미치는 것은 배양 pH 이고 다음에 효모 추출물의 농도 그리고 온도의 순으로 나타났다. 덱스트란 생산 속도에 가장 영향을 미치는 것은 배양 pH이고 다음에 효모 추출물의 농도 그리고 온도의 순으로 나타났다. 결론적으로 최적 생산 조건은 온도는 27-28℃이고, pH는 7.0이며, 효묘 추출물은 6-7%의 범위에서 결정이 되었다. 이러한 조건에서 생산된 덱스트란양은 22g/l이고, 생산 수율은 약 60%정도이며, 생산 속도는 0.8g/l/hr이었다. A bacterium producing non- or partially digestible dextran was isolated from kimchi broth by enrichment culture technique. The bacterium was identified tentatively as Leuconostoc sp. strain SKY. We established the response surface methodology (Box-Behnken design) to optimize the principle parameters such as culture pH, temperature, and yeast extract concentration for maximizing production of dextran. The ranges of parameters were determined based on prior screening works done at our laboratory and accordingly chosen as 5.5, 6.5, and 7.5 for pH, 25, 30, and 35℃ for temperature, and 1, 5, and 9 g/l yeast extract. Initial concentration of sucrose was 100 g/l. The mineral medium consisted of 3.0 g KH₂PO₄, 0.01 g FeSO₄ㆍH₂O, 0.01 g MnSO₄ㆍ4H₂O, 0.2 g MgSO₄ㆍ7H₂O, 0.01 g NaCl, and 0.05 g CaCO₃ per 1 liter deionized water. The optimum values of pH and temperature, and yeast extract concentration were obtained at pH (around 7.0), temperature (27 to 28℃), and yeast extract (6 to 7 g/l). The best dextran yield was 60% (dextran/g sucrose). The best dextran productivity was 0.8 g/h-l.

Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

HWANG, Young Sun,HAN, Sang-Sun,KIM, Ki-Rim,Ye-Jin, LEE,Sun-Kyung, LEE,Kwang-Kyun, PARK,Won-Yoon, CHUNG Faculdade de Odontologia de Bauru da Universidade 2015 Journal of applied oral science Vol.23 No.1

<P>Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231<SUP>Luc+</SUP>) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.</P>

관상동맥조영술상 정상인 환자에서 흉통의 원인으로 식도 운동장애에 관한 연구

황흥곤,김경수,김정현,임헌길,이방헌,이정균 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.2

We conducted a prospective study to evaluate the importance of esophageal abnormality as a potential cause of recurrent non-cardiac chest pain in patients with normal or near normal coronary angiography including patients with variant angina, patients with syndrome X and also pateints with sighificant coronary artery disease. Standard esophageal manometry including edrophonium provocation test and acid perfusion test was performed in 50 patients with chest pain. The prevalence of esophageal motility disorder was 73%(8/11) in patients with variant angina, 67%(8/12) in patients with syndrome X, 86%(6/7) in patients with non-cardiac disease respectively. To evaluate the cause of spontaneous chest pain two chnnel ambulatory Holter monitoring, and esophageal motility and pH recording tests were perfromed simultaneously for 24 hours for the 16 patients with daily substernal pain and normal coronary angiography including 5 patients with daily substernal pain and normal coronary angiography including 5 patients with variant angina (group A), 5 patient with syndrome X(group B) and 6 patients with non-cardiac disease (group C). Each patient exeperienced more than one episode of spontaneous chest pain and the number of chest pain episode in each group was 22 in group A, 27 in group B, and 28 in group C respectively. The number of patinets with the chest pain and the frequency of the chest pain associated with gastroesophageal reflux were 4 and 29%(8/28) in group C. And the number of pateints with the abnormal motility were 2 and 14% (3/22) respectively in group A, 1 and 15%(4/27) in group B, and 4 and 29% (8/28) in group C. One patient in group A and two patients in group B experienced chest pain associated wkth gastroesophageal reflux and abnormal motility, but even a sigle episode of chest pain was not associated with gastroesophageal reflux and with abnormal motility simutaneously. So the number of patients with the chest pain and the frequency of the chest pain associated with esophageal desorder were 5 and 78% (17/22) respectively in group A, 3 and 48% (13/27) in group B, and 6 58% (16/28) in group C. On the contrary, the number of patients with the chest pain and the frequency of the chest pain associated with ST change in 24 hours Holter monitoringwere 3 and 18% (4/22) respectively in group A, 1 and 4% (1/27) in group B, and there was none in group C. In conclusion, esophageal disorders frequectly contribute to chest pain in patiects with variant angina, syndrome X and non-cardiac disease, so making a accurate diagnosis of the cause of chest pain may be beneficial to patient, and ambulatory esophageal motility and pH monitoring is useful in evaluation of chest pain.

S-490 sarcoidosis presenting as pancreatitis, duodenal ulcer and severe acute kidney injury

( Kyun Young Kim ),( Bong Gyu Kwak ),( Suyun Oh ),( Won Seok Park ),( Yoon Kyung Chang ),( Suk Young Kim ),( Hyeon Seok Hwang ),( Yu Ah Hong ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Sarcoidosis is a multisystemic inflammatory disease characterized by the presence of noncaseating granulomas, mainly the lung and lymph nodes. We report an interesting case of sarcoidosis simultaneously involving the gastrointestinal tract, pancreas, and kidney and presenting as severe acute kidney injury (AKI). A 41-year-old man was admitted to our hospital with anorexia and weight loss over several months. Four months ago, he was diagnosed with idiopathic acute pancreatitis and recovered after steroid treatment. At that time, abdominal computed tomography (CT) showed diffuse pancreas swelling without solid mass. We started hemodialysis due to severe AKI with hypercalcemia and renal biopsy was performed. The histopathology indicated granulomatous interstitial nephritis with diffuse interstitial inflammation and noncaseating granulomas. Esophagogastroduodenoscopy revealed ulcerative and edematous mucosa on the stomach and the second part of the duodenum. Chest CT showed a slight interstitial pattern but definite hilar lymphadenopathy was not observed. Noncaseating granulomas were observed on microscopic examination in stomach, duodenum and bronchus. There was no involvement of sarcoidosis in any other organs. He received pulse methylprednisolone followed by maintenance prednisone therapy. After 2 months of treatment, renal function and hypercalcemia were improved. We suggest that renal sarcoidosis can manifest without typical pulmonary involvement and unusual extrathoracic organ involvement occurs with renal sarcoidosis presenting as severe AKI. Active enforcement of biopsy for suspicious lesions including kidney would provide the diagnostic clue in sarcoidosis with unusual manifestation and it supports the histological evidence of granulomas consistent with sarcoidosis. Keywords: sarcoidosis; kidney; pancreas; duodenum