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Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2
<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>
문철웅,정종훈,박천국,이승일,배학연,장경식,김만우,정춘해,홍순표,이병래,김호중 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Renal ischemia is one of the most common causes of acute renal failure. Four factors related to the pathogenesis of acute renal failure are vasoconstriction, decreased glomerular filtration rate, tubular back leak of filtrate, and intratubular obstruction. The cellular response to renal ischemic insults include decreased content of adenosine trihosphate, lipid peroxidation induced membrane degradation, alteration in cellular pH, and calcium or phospholipase induced mitochondrial dysfunction. Much attention has been given to the role of increased cellular calcium as a pathogenetic contributor to cell injury during ischemia. Author studied the protective effects of calcium antagonists on cellular injury during renal ischemia in rat. To investigate the protective role of these agents, author measured the amount of malondialdehyde(MDA) and the enzyme activities of free radical scarvengers-superoxide dismutase(SOD), catalase and glutathione peroxidase from non-pretreated group and calcium antagonists pretreated groups in control, ischemia and reflow subgroups. The results were summerized as follows: 1) The amount of MDA in non-pretreated group was higher in the reflow compared with the control(<p<0.01). But, in all pretreated groups, there was no statistically difference in the amount of MDA. 2) The SOD activity in non-pretreated group was lower in both the ischemia and the reflow compared with the control (P<0.05). But, in both verapamil and trifluoperazine-pretreated groups, there was no statistically difference in the SOD activity. 3) Both catalase and glutathione peroxidase activities in non-pretreated group were lower in both the ischemia and the reflow compared with the control (P<0.05). But in all pretreated groups, there was no statically difference in both catalase and glutathione peroxidase activities. These results suggest that free radical mediated ischemic injury by renal artery clamp in rat can be protected by intraperitoneal pretreatment with calcium antagonists. As trifluoperazine has a protective effect in renal ischemia, the calcium activated calmodulin dependent enzyme may play a role in renal ischemic injury.
문기찬,성경제,고재경,장경애,안세진,최지호 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.1
Laugier-Hunziker syndrone is a rare, pigmentary disorder of the lips, oral mucosa, and nails. The absence of intestinal polyposis differentiated it from Peutz-Jeghers syndrome. We describe a 16-year-old boy with multiple, brownish, lenticular macules on the lips, oral mucosa, perianal area and anal mucosa, and on the digits of his fingers and toes, in wham intestinal polyposis was not detectable.
반용호,문준선,박경순,배경만,김종훈 東亞大學校附設 情報技術硏究所 2004 情報技術硏究所論文誌 Vol.12 No.1
The growth in interchange of business and other sensitive data has led to increasing interest in access control. Access control for XML is receiving significant attention as XML is gaining popularity for storing and exchanging information. Until now, research on XML security has been focused on the security of data communication using digital signatures or encryption technologies. As XML is also used for a data representation of data storage, XML security comes to involve not only communication security but also managerial security. In this paper, we discuss an XML access control model and propose a technique that supports not only read operations but also update operations.
Tufted Angioma와 유사한 소견을 보인 화농성 육아종
장경애,최정철,최지호,성경제,문기찬,고재경 대한피부과학회 1999 대한피부과학회지 Vol.37 No.6
Tufted angiomas are rare slowly progressive vascular lesions found typically in children and young adults, usually involving the trunk and neck. Microscopically, groups of capillary tufts, many uncanalized, were found dispersed at various levels in the dermis. Some authors regarded tufted angioma as a member of lobular capillary hemangiomas. We describe a pyogenic granuloma mimicking acquired tufted angioma on the lip in a 59-year-old woman. We suggest that a term lobular capillary hemangioma$quot; may be preferable in this case.
TiO₂ 담체상에서 귀금속 촉매의 휘발성유기화합물 산화특성
김문찬,강경호,고선환 한국공업화학회 2005 응용화학 Vol.9 No.1
In this study, monometallic Pt and bimetallic Pt-Ru, Pt-Ir were supported to TiO₂. In order to distribute metals uniformly, and Xylene, toluene and MEK were used as reactants. The monometallic or bimetallic catalysts were prepared by the excess wetness impregnation method and were characterized by XPS and BET analysis. As a result, Pt-Ru, Pt-Ir bimetallic catalysts were showed higher conversion than Pt monometallic catalyst. Pt-Ir bimetallic catalyst was showed highest conversion on the TiO₂ support. In the VOCs oxidation, Pt-Ir bimetallic catalyst had multipoint active sites, so it improved the range of Pt metal state. Therefore, bimetallic catalysts were higher conversion of VOCs than monometallic ones. In the kinetics, VOCs oxidation was appeared on the first order reaction. In this study, the use of small amount of Jr to Pt promoted oxidation conversion of VOCs.
적외선 흡수 분광법 및 DPC를 이용한 치과용 수복재의 광중합 거동 분석
정찬문,김중곤,최준호,장두옥,김경남,김광만 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1
Mechanical properties of compomers would be obtained mainly by photopolymerization by visible light irradiation. Photopolymerization behavior of two commercial compomers was investigated by FT-IR spectral analysis and differential photocalorimetry(DPC). The results obtained were as follows: 1. From FT-IR analysis, it was found that the compomer products were photocured mainly by radical polymerizations of multifunctional methacrylate monomers. Final conversion values of the polymerizations after exposure to visible light for 60 sec were 67% for Dyract and 59% for Compoglass. 2. Upon exposure the compomers exhibited autoacceleration and autodeceleration, which are usually observed in bulk polymerizations of multifunctional monomers. 3. Dyract showed higher rate of polymerization and conversion of double bond than Compoglass.