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Lyoo, Kwang Soo,Hong, Sung Woo,Song, Myeong Jun,Hur, Wonhee,Choi, Jung Eun,Piao, Lian-Shu,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Park, Jung Wha,Choi, Sang Wook,Yoon, Seung Kew S. Karger 2011 Intervirology Vol.54 No.6
<P>The aim of this study was to determine the prevalence of hepatitis B virus (HBV) subgenotypes, the spectrum of mutations in the precore/core region through phylogenetic analysis, and the relevance of viral characteristics in disease progression in Korean patients.</P>
류광수 ( Kwang-soo Lyoo ) 대한인수공통전염병학회 2017 창립총회 및 학술대회 초록집 Vol.2017 No.1
Coxiella burnetii is a zoonotic agent and causes coxiellosis, which is a cause of reproductive failure in a range of animal species, including abortion and stillbirth and Q fever, which is most often characterized by an acute flu-like illness, mild pneumonia, and/or hepatitis in humans. While livestock are well recognized worldwide as a source of infection, the zoonotic risk of C. burnetii infection in companion animals such as dogs may be overlooked. For serological diagnosis, indirect immunofluorescent assay (IFA) and enzyme-linked immunosorbent assay (ELISA) are generally considered good methods for prevalence surveys of coxiellosis. In this study, we conducted a nationwide survey of the seroprevalence of previous exposure to C. burnetii in dogs, dairy cattle, and Korean native cattle (a primarily beef breed) in South Korea. Serum samples obtained from 3087 Korean native cattle, 1224 dairy cattle, and 1023 dogs were collected from eight provinces in South Korea, and IFA and ELISA were performed to test for seropositivity. The prevalence of C. burnetii was 1.7% in Korean native cattle, 10.5% in dairy cattle, and 2.9% in dogs. This is the first report identifying previous exposure to C. burnetii in South Korean dogs. Furthermore, the presence of C. burnetii antibodies in companion and feral dogs indicates that dogs can be a potential reservoir species for zoonotic risk of C. burnetii infection in South Korea. Therefore, more detailed studies aiming to clarify epidemiological factors should be performed in the future.
Virulence of a novel reassortant canine H3N2 influenza virus in ferret, dog and mice models
( Woonsung Na ),( Kwang-soo Lyoo ),( Minjoo Yeom ),( Dae-gwin Jeong ),( Daesub Song ),( Chang-ung Kim ),( Jeong-ki Kim ),( Daesub Song ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
The outbreak of a canine influenza virus (CIV) H3N2 reassortanted from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infection for potential zoonotic transmission of influenza viruses to humans. In this study, we assessed the virulence of a novel CIV H3N2 (VC378) from a pdm H1N1 and CIV H3N2 coinfected dog in ferrets, dogs, and mice. Significantly enhanced virulence of VC378 was demonstrated in mice, although the transmissibility and pathogenicity of VC378 were similar to those of classic H3N2 in ferrets and dogs. This is notable because mice inoculated with an equivalent dose of classic CIV H3N2 showed no clinical signs and no lethality. We found that the PA and NS gene segments of VC378 were introduced from pdmH1N1, and these genes included amino acid substitutions; PAP224S and NS-I123V, that were previously found to be associated with virulence enhancement in mice. Thus, we speculate that the natural reassortment of CIV between pdm H1N1 and CIV H3N2 can confer virulence and that continuous surveillance is needed to monitor the evolution of CIV in companion animals.
한경수,류광수,박봉균,Han, Kyung-soo,Lyoo, Kwang-soo,Park, Bong-kyun 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.1
The 2,078 blood samples from 148 swine farms were collected and tested by IFA for porcine reproductive and respiratory syndrome(PRRS) virus antibody to know what type of PRRS prevails by the area. Clinically reproductive form of PRRS occurred in swine farms of 3/27, 3/87, and 2/34 in eastern, central and western areas, but the seroprevalence of those areas was different as 6.5%, 23.3%, and 17.6%, respectively. However, respiratory form of PRRS occurred more frequently, and the number of farms manifested with the respiratory form of PRRS in the eastern, central and western areas was 22/27, 71/87, and 30/34, respectively. The seroprevalence of that form of PRRS in the eastern, central and western areas was 52.2%, 67.1%, and 51.6%, respectively. Subsequently mixed form of PRRS occurred more frequently in the central area and the number of farms of eastern, central and western areas was 2/27, 13/87, and 2/34, respectively. The PRRS seroprevalence of the eastern, central and western areas was 58.6%, 54.0%, and 19.2%, respectively. Collectively the PRRS seroprevalence of eastern, central and western areas was 43.8%, 59.3%, and 38.2%, respectively. Overall seroprevalence of PRRS in Korea was 51.8%. In conclusion, the reproductive or the respiratory form of PRRS has been still in trouble in the Korean swine industry and PRRS control measures have to be taken in consideration.
( Jeong Ki Kim ),( Jeong Hyun Nam ),( Kwang Soo Lyoo ),( Hyoungjoon Moon ),( Woonsung Na ),( Eun Jung Song ),( Minjoo Yeom ),( Sang Mu Shim ),( Dae Gwin Jeong ),( Dong Jun An ),( Bo Kyu Kang ),( Daesu 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
H3N2 canine influenza virus emerged in South Korea in 2007 and subsequently spread to China and Thailand, causing epidemic or endemic respiratory diseases in dogs. Through intermammalian species transmission, the virus has also infected cats. However, no direct evidence of significant genetic evolution has been reported since its first emergence. Here, we describe in depth the genetic and molecular characteristics of the ancestral strain (i.e., the first virus isolate from South Korea) of the H3N2 canine influenza virus currently circulating in East Asia.
Kim, Kiju,Choi, Jong-Young,Lyoo, Kwang-Soo,Hahn, Tae-Wook The Korean Society of Veterinary Science 2018 大韓獸醫學會誌 Vol.58 No.3
The capsid protein of porcine circovirus type 2 (PCV2) encoded by open reading frame 2 (ORF2) is important for neutralizing activity against PCV2 infection. This study investigated the heterogeneity of the ORF2 gene of PCV2 isolated in Korea during 2016-2017. The results revealed that PCV2d is currently the predominant genotype. Moreover, comparison of ORF2 from 17 PCV2 isolates revealed 88.3-100% homology at the nucleotide (deduced amino acid 86.3-100%) level. Interestingly, 61.5% (8/13) of the PCV2d isolates had glycine at position 210. These data provide a useful information for PCV2 epidemiology in Korea.