Salpingitis Isthmica Nodosa의 임상적 연구

강길전,이오성,이기환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

A clinical study was performed to evaluate the significance of 77 patients with salpingitis isthmica nodosa(SIN)who were confirmed on surgical specimens. The results were as follows. 1. The prevalence age of SIN was 30 decade. 2. The suspicious causative factor was not found from past history. 3. Bilaterality was found only 1/3 of cases. 4. Nearly twenty percent of SIN patients was found as ectopic tubal pregnancy. Accordingly, if HSG is suggestive of SIN, microsurgical removal of SIN lesion will be preventive measure for ectopic pregnancy. 5. Nearly one quarter of SIN patients was found as infertility. Accordingly, if HSG is suggestive of SIN and all infertility work-up are normal, microsurgical correction of SIN will be valuable.

젊은 무월경환자의 골밀도에 관한 연구

강길전,이기환,박윤석 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To examine the impact of amenorrhea on bone mineral density in women of reproductive age, 22 amenorrheic women aged 16-40 were studied Bone mineral density in the lumbar spine(L1-L4) as measured by dual energy X ray absorptiometry. The amenorrheic group showed a mean reduction in bone mineral density of 155 as compared with controls. Bone loss was related to the duration of amenorrhea and the severity of estrogen deficiency rather than to the underlying diagnosis. Patients with a history of fracture had significantly lower bone density than those without a history of fracture. In conclusion, amenorrhea in young women should be investigated and treated to prevent bone mineral loss. Menopausal women with a past history of amenorrhea should be considered to be at high risk of osteoporois.

암의 식이요법 : 항산화제를 중심으로 About Antioxidant Therapy

강길전 한국정신과학학회 2002 한국정신과학회 학술대회 논문집 Vol.16 No.-

그 동안 수 십 년에 걸친 암의 역학 조사에 의하면 암은 주로 환경요인, 음식, 생활습관, 스트레스 및 유전인자와 밀접한 관계가 있는 것으로 알려져 있다. 이 중에서 음식이 암의 원인으로 차지하는 부분은 약 30%~50% 정도로 알려져 있고 음식이 암을 유발하는 근저에는 과잉 프리래디칼(free radical)이 작용하고 있음이 밝혀졌다. 따라서 체내에서 발생하는 과잉 프리래디칼을 잘 처리할 수만 있다면 암을 예방할 수 있을 것이라는 기대를 갖게 되었다, 이리하여 영양 종양학(nutritional oncology) 및 분자교정 종양학(orthomolecular oncology) 및 프리래티칼학(free radical)이라는 새로운 분야가 등장하여 꾸준히 발전하고 있으며, 또한 영양만으로 질병을 치료 하는 영양치료 클리닉(nutritional clinic)도 많이 생기고 있는 실정이다. 우리 나라에서도 기초의 학, 약학 및 생물학 분야 동에서 활성산소에 관한 많은 연구가 진행되고 있다. 그러나 주류의학의 종양학자들은 항산화제를 암 환자의 치료에 병합치료 하는 것을 반대하고 있는 실정이다. 따라서 이러한 논쟁의 중심에 있는 항산화제와 암의 치료라는 주제를 가지고 고찰하였다.

비만이 생식기능에 미치는 영향

강길전 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To examine the relationship between obesity and reproduction, 20 obese women and 20 agematched normal menstruating worsen were compared. Serum FSH, LH, PRL, testostosteron, progesterone, estradiol, cortisol and DHEAS during follicular phase were measured by RIA. The obtained results were as follows: 1. The indirect evidence of GnRH was significanlty elevated in obese women. 2. Th serum level of LH was significantly elevated in obese women, but serum FSH and prolactin were not significantly changed in obese group. 3. The serum level of progesterone was significantly decreased in obese women and testosterone level was significantly elevated in obese women. But the serum level of estradiol was not changed. 4. The serum level of DHEAS was significantly elevated in obese women, but cortisol level was not changed Thus, obseity is associated with abnormalities in hormonal balance, especially in hypothalamic GnRII, LH and adrenal DHEAS.

부분포상기태의 임상·조직학적 연구

姜吉田 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

This study was undertaken to investigate the clinical and pathological characterisitics partial hydatidiform mole. During past three years period, 13 patients with partial hydatidiform mole observed at this department of Chungnam National University Hospital. The obtained results were as follows: 1. Age of 23% of patients was over 40 years old. 2. The uterine size was small for date in 84.6% of patients. 3. No patient had theca lutein cysts. 4. Preevacuation urine HCG level was 1,000-10,000 IU/L in 69.2% of patients. No patient showed excess of 100,000 IU/L. 5. The preevacuation diagnosis in about 54% by sonogram was either missed abortion or complete hydatidiform mole. 6. After evacuation, one (7.7%) patient developed nonmetastatic persistent trophoblastic disease.

자궁내막증의 임상적 고찰

강길전,유병대,원철,이기환 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Objective : Between 1991 and 1993 data were collected to evaluate risk factors for endometriosis. Design : A case-control study was conducted on 54 cases with laparotomically confirmed pelvic endometriosis consecutively admitted to CNUH. The control group consisted of 60 women admitted to hospital for benigh gynecologic disease. Results : No relation emerged with marital status, age at marriage, marital life, level of education, socio-economic status, age at menarche, menstrual regularity, number of spontaneous abortion, duration after last delivery, height and weight. But compared to control group, longer menstrual period, larger menstrual amount, severe menstrual pain, less number of parity, and less number of induced abortion signifcantly increased risk of endometriosis Conclusions : This study showed that frequent menstrual cycles and long period of menstruation with frequent and large amount of retrograde menstrual flow increased the risk of endometriosis.

자궁내막유착증(중증)의 임상적 연구

강길전,이기환 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The treatment of severe intrauterine synechia is not known. So if patient with severe intrauterine synechia wants pregnancy, it is doctor's dilemma. In this situation, this study was designed for develpment of new method for treatment of severe intrauterine synechia. For this study, 15 women with severe intrauterine synechia were included and about 6 years were requested from January 1991 to July 1996. Under general anesthesia, all patients were performed laparotomy and then cervical and intrauterine cavity were dilatated gradually by Hegar dilatator, while the first assistant operator guided the direction of Hegar dilatator through laparotomy opening. Finally utero-tubal junction was communicated by use of uterine sound. At this time the first assistant guided the direction of the uterine sound through laparotomy opening. With this new method of procedure, intrauterine cavity was normalized in 100%, but one or both utero-tubal junction were obstrcted in 33.3%. However, five women(33.3%) become pregnant. There was one episode od uterine perforation during this new procedure.

유즙분비증 환자의 분석

姜吉田 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Sixteen patients with galactorrhea visited the department of Obstetrics and Gynecology of Chungnam National University Hospital during the period of 18 months from September, 1983 to February, 1985. These patients were analysed to identify the high-risk factor for the pituitary tumor. The results were follows 1. Among patients with galactorrhea, the most high-risk group for the pituitary tumor was one with oligomenorrhea-amenorrhea and hyperprolactinernia. 2. The next high-risk group was the patient with galactorrhea and oligomenorrhea-amenorrhea regardless the level of serum prolactin and the third risk group was the patient with galactorrhea and hyperprolactinemia. 3. The low-risk group for the pituitary tumor was the patient with galactorrhea, but without menstrual abnormality and hyperprolactinemia. This study suggests that the menstrual pattern, the level of serum prolactin and skull X-ray study are important to identify the pituitary tumor among patients with galactorrhea.

여성 불임환자의 내분비 동태

姜吉田 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To determine the prevalence of hormonal abnormalities in infertile women, serum levels of FSH, LH, prolactin, and progesterone were estimated using RIA techniques during the midluteal phase in 58 infertile female patients. Of the patients investigated, 29(50%) had abnormal serum levels of one or more of the hormone studied. Serum progesterone level of 2 ng/ml or below which is indicative of anovulation was found in 18 (31.1%) of the patients and was the most common hormone abnormality. Hyperprolactinemia was found in 13(22.4%). Serum LH level of 21 mIU/ml or above which is indicative of polycystic ovarian disease was found in 12(20.7%), while FSH value of 21 mIU/ml or above, suggestive of ovarian failure, was found in 5(8.6%). This study shows that meansuring serum FSH, LH, prolactin, and progesterone during midluteal phase was valuable for evaluation of the infertile female patients.

임신중독증 환자의 뇨중 5-HIAA에 관한 연구

姜吉田 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

44 toxemic patients were studied for the 24 hour urinary 5-hydroxyindoleacetic acid(5-HIAA) in the department of Obstetrics and Gynecology of Chungnam National University Hospital during the period of 9 months from October, 1983 to June, 1984. The results obtained were follows; 1. The mean urinary 5-HIAA level of normal pregnant women was 3.7 mg/L. 2. The mean urinary 5-HIAA level of mild form of preeclampsia was 5.3 mg/L which was significantly increased than normal patients. 3. The mean urinary 5-HIAA level of severe form of preeclampsia was 16.8 mg/L which significantly increased than normal patients. 4. The mean urinary 5-HIAA level of CHVD with superimposed toxemia was 4.9 mg/L which was not signficantly different with normal patients. Accordingly this study demonstrated that urinary 5-HIAA excretion was increased in toxemic patients. Therefore, we could confirm that the blood level of serotonin in toxemic patients increased than normal pregnant women.