Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

뇌경색 발병후 병발된 만성 애역(Chronic hiccup)의 뜸치료 1례

전우현,김진석,홍종희,홍상선,박석규,김진성,류봉하,류기원,박재우,Jeon, Woo-Hyeon,Kim, Jin-Seok,Hong, Jong-Hee,Hong, Sang-Sun,Park, Seok-Kyu,Kim, Jin-Seong,Ryu, Bong-Ha,Ryu, Ki-Won,Park, Jae-Woo 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1

Hiccups, also known as singultus, are spasmodic involuntary contractions of respiratory muscles that shorten respiration. The characteristic sound is caused by rapid closure of the glottis. In oriental medicine, the mechanism of hiccups is "reversed flow of Ki". Hiccups have been associated with neoplasm, infections, seizures, diabetes. renal failure, alcohol ingestion, various drugs, and ischemic events of the myocardium or central nervous system. We present a case of chronic hiccups after cerebral infarction that was successfully treated using moxibustion therapy.

전자 도서관과 교육 분야 응용

홍기천,오일석 全北大學校 敎育大學院 2000 敎育論叢 Vol.20 No.-

The construction and usage of digital library are rapidly increasing all over the world. This paper introduces the concept of digital library and describes the present state of national library, private library, and university library in Korea. Additionally the library of Chonbuk national university is presented in detail. Finally we discuss how digital library can be used in the educational field.

성견 치조골 결손부에 자가골이식과 조직유도재생막을 이용한 치주치료시 치유효과에 관한 비교연구

홍기석,김종여,정진형 단국대학교 치의학연구소 1993 논문집 Vol.5 No.-

The goal of periodontal therapy is the regeneration of the periodontium lost by periodontal disease. The purpose of this study was to evaluate the regenerative potential of the autogenous bone graft and guided tissue regeneration in the treatment of periodontal bony defect in dogs. Experimental periodontitis were induced in the mandibular left 3rd premolar and right 3rd and 4th premolars of 5 dogs using orthodontic ligature wire. After 6 weeks, the ligature wire removed, surgical procedure were performed as follows. 1) control group : Flap operation(Mn.Lt 3rd premolar) 2) experimental group Ⅰ: Flap operation + autogenous bone graft (Mn.Rt. 3rd premolar) 3) experimental group Ⅱ : Flap operation + Gore-Tex membrane (Mn.Rt. 4th premoalr) Thereafter, dogs were sacrificed on the 1,2,4,8,16th week and the specimens were prepared and stained with hematoxyline-eosin stain for the light microscopic examination. The results of this study were as follows. 1. The apical migration of junctional epithelium was most remarkable in the flap operation and the experimental group Ⅱ was less than the experimental group Ⅰ. 2. In the formation of new alveolar bone, it was found in experimental groupⅠ,Ⅱ and experimental group Ⅰ is more than Ⅱ. In the control group, few bone formation was found. 3. In the formation of new cementum, it was found in experimental group Ⅰ,Ⅱ and experimental group Ⅱ is more thanⅠ. So, the periodontal therapy combined with autogenous and guided tissue regeneration will be produce the periodontal regeneration.

대학생 축구선수의 등속성 체간근력과 대퇴근력 및 거퇴근력과의 관련성

박기용,홍석민,최경훈,추근도 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to investigate the relationships among trunk muscle, knee, and ankle strengths using Cybex770, the isokinetic muscle functioning measurement device. 41 K and Y University soccer players who did not have any experience about back pain or spine surgery were recruited as subjects. The results of the study were as follows. 1. Trunk extension was significantly higher than trunk flexion and muscle strength was diminished with increasing load speed. 2. Trunk flexion/extension ratio was well balanced at 30。/sec but this balance was broken with increasing load speed. 3. At 60。/sec of load speed, the knee extension and flexion of the left side were higher than those of the right side. 4. At 60。/sec of load speed, the ipsilateral muscle strengths of the left knee were well balanced but those of the right side were imbalanced. 5. At 60。/sec of load spped, the ratio of bilateral muscle strength of knee was -18.5±32.3% and this implies the possibility of knee injury. 6. Plantalflexion and dorsiflexion of the right ankle were higher than those of the left side, and dorsiflexion/plantalflexion ratio of the left side was higher than that of the right side. 7. The ratio of bilateral muscle strength of ankle at 60。/sec of load speed represented a balanced muscle development but this balance was broken with increasing load speed.8. There were partially significant relationships between trunk muscle and knee strengths. and between knee and ankle strengths. In conclusion, the trunk muscle strength of soccer player might be a very important factor to improve performance. In addition. a training technique which considering strength and speed is needed to develop not static but dynamic strength. This training not only develops well balanced muscle strength but also protects sport injury. Thus, the isokinetic training of trunk could improve the trunk muscle strength. and increase the ability of flexion/extension of knee and ankle.

유한/경계요소법에 의한 격자결합기의 해석

김홍석,정종우,백정기 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

A combined FEM/BEM approach is used to analyze the plane wave diffraction and coupling characteristics of rectangular gratings. The numerical results compared well with those obtained by other methods. The combined approach allows a reduction in memory size with reasonable numerical complexity, when compared with the FEM or the BEM. The algorithm can be applied to arbitrarily shaped gratings.

대두 및 대두발효식품의 항돌연변이성

윤기도,권동진,홍석산,김수일,정건섭 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.4

To investigate the inhibitory effect of soybean and Korean traditional fermented soybean products on the chemically induced mutagenesis, we extracted soybean, Kanjang, Doenjang, Kochujang, and Chonkukjang with water, methanol and hexane. Inhibitory effect of extracts was assayed by the SOS chromotest using Escherichia coli PQ37 as a test strain. 4-nitroquinoline-1-oxide(4NQO), N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), and aflatoxin B_1(AFB_1) were used as mutagens. Methanol extracts showed relatively higher inhibitory effect than water and hexane extracts. Methanol extracts of soybea, Doenjang, Kochujang, and Chongkukjang showed inhibitory effect of 68.4, 96.3, 17.5, and 100.9%, against MNNG, and 28.6, 109.1, 41.3, and 101.8% against AFB_1., respectively. Doenjang methanol extract showed inhibitory effect of 51.0, 96.3, and 109.1% against 4NQO, MNNG, and AFB_1. Inhibitory effect of heat-treated Doenjang and Chongkukjang methanol extracts on the mutagenicity of MNNG and AFB_1 was remained over 95% of the inhibitory effect of heat-untreated extracts, demonstrating the heat stability of the potent antimutagenic activity.

하수 2차 처리수 재이용을 위한 저압 및 중압 고도산화시스템의 성능평가

안규홍,안석,맹승규,김기팔,홍준석,정민우,권지향,Ahmed, Zubair 대한상하수도학회 2003 상하수도학회지 Vol.17 No.4

In the present study, the feasibility of UV/H₂O₂ systems was investigated using low and medium-pres sure lamps on biologically treated wastewater effluents for secondary effluent reclamation. Two types of UV lamps were used as the light sources (a 33W lowpressure mercury lamp and a 350-W mediumpressure mercury lamp). The results from these UV systems showed that the removal of organic compounds could be achieved in the contact time of longer than 30min (i.e., low UV doses). Efficiencies of color removal and disinfection were far better than those of organic matters measured as TOC, DOC and TCOD_(cr). In the low pressure lamp UV system, it has been found that DOC and color removals were 60.9 and 86.2% with 50㎎/L of H₂O₂ and contact times of 30 minute, respectively. Whereas, with the mediumpressure lamp UV system, TOC, DOC and color removal were 27.1, 5.6 and 95% with 14.3㎎/L of H₂O₂ and 14 minute of contact times, respectively. Both systems could be applied for the reclamation of secondary effluent treated with biological treatment processes.

水産專門大學 漁業科 敎育課程 開發硏究

裵錫悌,宋之浩,李吉來,鄭興基,洪聖根,趙鳳坤,朴種洙 군산대학교 1983 群山水産專門大學 硏究報告 Vol.17 No.1

In order to develop the curriculum of the fishery department in the fisheries Jr. college, We have collected and analyzed the domistic and foreign data adquated to the fishey department under the international trend, also we gathered the opinion from the inquiring paper investigation and consultation to the industrial field, concerned college and graduate during the 6 month from September 1982. The fishery department curriculum in fisheries Jr. college will be industrialized with the concerned technics and knowledge in relation to speciality of maritime affairs. Accordingly, we have developed the adquate curriculum which is practical and can be cultivated the technician to adopt in the industrial society.

자외선/과산화수소 고도산화공정에 의한 하수 2차 처리수 중의 용존유기물 분해에 미치는 부유물질과 과산화수소 농도의 영향

안규홍,이석헌,안석,김기팔,정민우,맹승규 대한상하수도학회 2002 상하수도학회지 Vol.16 No.3

Secondary effluent of activated sludge process was treated by UV/H_2O_2 advanced oxidation process to investigate the effect of suspended matter and H_2O_2 concentration. With low dosage of UV radiation, the concentration of the dissolved organic compounds measured as DOC could be increased with and without hydrogen peroxide. It was suggested that the cause of DOC increase in treated samples was the decomposition of suspended microbial particles and the incomplete oxidation of dissolved organic compounds. The removal of suspended solid significantly enhanced the degradation of DOC in both UV and catalyzed UV oxidation. Color and odor of secondary effluent was effectively removed. Turbidity was decreased by oxidation and the particle size distribution was shifted to lower range. With increased H_2O_2 dosage (30∼120mg/l), the removal of DOC was enhanced. To obtain the required quality meeting the regulated level for water reuse, additional treatment for turbidity rejection was required.