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( Keum Han Noh ),( Mahesh Raj Nepal ),( Ki Sun Jeong ),( Sun-a Kim ),( Yeon Ji Um ),( Chae Shin Seo ),( Mi Jeong Kang ),( Pil Hoon Park ),( Won Ku Kang ),( Hye Gwang Jeong ),( Tae Cheon Jeong ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia.Because baicalein and baicalin are major components of this herb,it is important to under stand the effects of these compounds on drug metabolizing enzymes,such ascytochrome P450(CYP),for evaluating herb-drug interaction. The effects pf baocalin and baicalein on activities of ethoxyresoru- fin O-deethylase(EROD),methoxyresorufin O-demethylase(MROD),benzuloxyresorufin O-demethylase(BROD),p-nitrophenol hydroxulase and erythormycin N-demethylase were assessed in rat liver microsomes in the present study. In addition,the phar- macokinetics of caffeine and its three metabolites (i.e.,paraxanthine,theobromine and theophylline)in baicalin-treated rets were compared with untreated control.As results, EROD,MROD and MROD and BROD activities were inhibiteb by both baicalin and baicalein However,there were no significant differences in the pharmackkinetic parameters of oral caffeine and its three metablites be-tween control and baicalin-treated rats. When the plasma concantration of baicalin was determined,the maximum concentration of baicalin was below the estimated IC values observed in vitro. In conclusion,baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo, following single oral administration in rats.
Life Science : Determination of daumone in mouse plasma by HPLC/MS-MS
( Keum Han Noh ),( Jong Hee Park ),( Min Kyu Kim ),( Man Kil Jung ),( Hwa Jeong Lee ),( Kwang Il Kwon ),( Won Ku Kang ),( Hun Joo Ha ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Daumone, a pheromone secreted by Caenorhabditis elegans, is an essential regulator of chemosensory processes in development and aging. A quantification method using HPLC/MS-MS was developed for the determination of daumone in mouse plasma. After simple protein precipitation with acetonitrile including methaqualone (an internal standard), the analytes were chromatographed on a reversed-phase column and detected by liquid chromatography/tandem mass spectrometry with electrospray ionization. The accuracy and precision of the assay were in accordance with FDA regulations for validation of bioanalytical methods. This method was applied to measure the plasmadaumone concentrations following a 5-week repeated oral administration of daumone in mice. ⓒ 2011 John Wiley & Sons, Ltd.
The Mechanism of Antibacterial Activity of Tetrandrine Against <i>Staphylococcus aureus</i>
Lee, Young-Seob,Han, Sin-Hee,Lee, Su-Hwan,Kim, Young-Guk,Park, Chung-Berm,Kang, Ok-Hwa,Keum, Joon-Ho,Kim, Sung-Bae,Mun, Su-Hyun,Seo, Yun-Soo,Myung, Noh-Yil,Kwon, Dong-Yeul Mary Ann Liebert 2012 Foodborne pathogens and disease Vol.9 No.8
Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabilites in Rats
( Young Min Seo ),( Keum Han Noh ),( Min Jeong Kong ),( Dae Hun Lee ),( Mi Jeong Kang ),( Yurng Dong Jahng ),( Won Ku Kang ),( Byeong Seon Jeong ),( Tae Cheon Jeong ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-