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RISS 인기검색어
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- 저자 : ( Ken Haruma ) (검색결과 3 건)
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Session 1 : Korea-Japan Joint Session ; Pathogenesis of functional dyspepsia
( Ken Haruma ) 대한소화기학회 2004 대한소화기학회 춘계학술대회 Vol.2004 No.-
In clinical practice, the concept of "gastritis" is used for not only histologic gastritis but also functional dyspepsia (FD) in Japan. Histologic gastritis induced by Helicobacter pylori (H pylori) infection is a major risk factor for peptic ulcer disease, gastric cancer, and primary gastric lymphoma. On the other hand, FD is a clinical syndrome involving upper abdominal symptoms, the causes of which cannot be identified by conventional diagnostic evaluation. Several pathophysiolgical factors, such as gastric acid secretion, gastroduodenal motility, H pylori infection, psychosocial factors, and stress, may play a role in the pathogenesis of FD. Dysmotility of the upper gastrointestinal tract has been implicated in the symptoms of FD. In the previous studies, antral hypomotility and delayed gastric emptying have been reported as major pathogenetic factors in the patients with FD. In addition, recent studies have demonstrated that gastric accommodation of fundus is one of pathological factors of FD. Although several methods have been used to evaluate gastroduodenal motility, ultrasonography (US) is a simple, non-invasive modality for the assessment of gastric emptying and antral motility in either a liquid or solid meal. In my presentation, I would like to introduce US method to evaluate gastrodunodenal motility and discuss the association between motility disorders and FD. In addition, the effects of prokinetic agents on gastroduodenal motility will be discussed.
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( Tomoari Kamada ),( Yoshinori Fujimura ),( Kensuke Gotoh ),( Hiroshi Imamura ),( Noriaki Manabe ),( Hiroaki Kusunoki ),( Kazuhiko Inoue ),( Akiko Shiotani ),( Jiro Hata ),( Ken Haruma ) 대한소화기학회 2013 Gut and Liver Vol.7 No.1
Background/Aims: There have been few studies on the efficacy of proton pump inhibitors and the doses required to treat dyspeptic symptoms observed in clinical practice. The aim of this study was to compare the efficacy of different doses of omeprazole and different administration methods in Helicobacter pylori-negative, dyspeptic patients. Methods: Patients with chronic upper abdominal symptoms within the previous 3 months were randomly divided into three groups: a daily, omeprazole 20 mg treatment group (OPZ20, n=61); a daily, omeprazole 10 mg treatment group (OPZ10, n=72); and an on-demand omeprazole 20 mg treatment group (ondemand, n=62). After 4 weeks of administration of the drug, symptom improvement rates were evaluated based on the Overall Global Severity score. Results: The rates of symptom improvement after 4 weeks of treatment were 65.6% (40/61) in the OPZ20 group, 47.2% (34/72) in the OPZ10 group, and 50.0% (31/62) in the on-demand group. The OPZ20 group exhibited a significantly higher improvement rate (p=0.034) than the OPZ10 group. The OPZ20 group had significant improvements in regurgitation, postprandial fullness, vomiting, and bloating compared with the OPZ10 group. Conclusions: Daily treatment with 20 mg of omeprazole was efficient in treating upper abdominal symptoms. Trial registration: ClinicalTrials.gov, number UMIN000002621. (Gut Liver 2013;7:16-22)
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