http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
SOCS3 Regulates BAFF in Human Enterocytes under Ribosomal Stress
Do, Kee Hun,Choi, Hye Jin,Kim, Juil,Park, Seong-Hwan,Kim, Ki-Hyung,Moon, Yuseok The American Association of Immunologists, Inc. 2013 JOURNAL OF IMMUNOLOGY Vol.190 No.12
<P>Although the activation of B cells in the gastrointestinal tract is of great importance in the context of immunity to pathogens and mucosal inflammatory diseases, little is known about the mechanisms responsible for the local activation of B cells in the subepithelial area of the intestine. Epithelium-derived BAFF is the major modulator of B cell development and Ig class switching. The present study was performed to address the molecular mechanism of BAFF expression in gut epithelial cells in the presence of proinflammatory stimuli. Inflammation-induced BAFF expression in mucosal epithelial cells might be responsible for diverse mucosa-associated diseases linked to intestinal inflammation and autoimmunity. Although BAFF was marginally expressed in unstimulated epithelial cells, BAFF mRNA was significantly upregulated by proinflammatory IFN-γ. Furthermore, IFN-γ triggered JAK/STAT1 signals via the cytokine receptor, which contributed to epithelial BAFF upregulation. In terms of signaling intervention, ribosomal insult attenuated IFN-γ–activated JAK/STAT signal transduction and subsequent BAFF induction in gut epithelial cells. Ribosomal insults led to the superinduction of SOCS3 by enhancing its mRNA stability via HuR RNA-binding protein. Upregulated SOCS3 then contributed to the blocking of the JAK/STAT-linked signal, which mediated BAFF suppression by ribosomal stress. All of these findings show that ribosomal stress–induced SOCS3 plays a novel regulatory role in epithelial BAFF production, suggesting that epithelial ribosomal dysfunction in association with SOCS3 may be a promising therapeutic point in BAFF-associated human mucosal diseases.</P>
기도형,신승헌 한국산업안전학회 1996 한국안전학회지 Vol.11 No.4
The purpose of this study is to obtain an effective enclosing method for noise reduction of press machine operating in a manufacturing company located in Taegu region. Noise level of the machine is about 95∼120 dB which is higher than legal standards by industrial safety and health law. In this study, two experiments were conducted to achieve the above purpose. In the first experiment in which the effects of three independent variables-type and depth of sound-absorbing materials, and depth of air space-on noise level was investigated, it was found that depth of sound-absorbing materials and air space was significant at α =-0.01. In the second experiment studying relationship between depth of sound-absorbing materials and air space and noise level, it was shown that noise level lowered as depth of sound-absorbing materials and air space became thick. Based on these results, two alternatives of enclosing method adequate for the selected company's noise characteristics were suggested.
Highly Enantioselective Rh-catalyzed Transfer Hydrogenation of α-Functionalized Arylketones
Do-Min Lee,Se Hun Kwak,Kee-In Lee 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
Asymmetric transfer hydrogenation of α-functionalized arylketones has been studied. The chiral Rh-catalyst effectively performed in transfer hydrogenation of α-mesyloxyketones with an azeotropic mixture of formic acid/triethylamine to produce optically active 1-arylethandiols with excellent enantioselectivity.
3D dosimetry by compass program with array detector for volumetric modulated arc therapy
Hyun Do Huh,Sang Hyoun Choi,Sang Hyoun Choi,Hun Jeong Kim,Seong Hoon Kim,Young Hoon Ji,Kum Bae Kim,Dong oh Shin,Suk Lee,Jang Bo Shim,Sam Ju Cho,Sang Hoon Lee,Kwang Hwan Cho,Chul Kee Min 대한방사선방어학회 2011 대한방사선방어학회 학술발표회 논문요약집 Vol.2011 No.11
Highly Enantioselective Rh-catalyzed Transfer Hydrogenation of α-Functionalized Arylketones
Lee, Do-Min,Kwak, Se-Hun,Lee, Kee-In Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
Asymmetric transfer hydrogenation of α-functionalized arylketones has been studied. The chiral Rh-catalyst effectively performed in transfer hydrogenation of $\alpha$-mesyloxyketones with an azeotropic mixture of formic acid/triethylamine to produce optically active 1-arylethandiols with excellent enantioselectivity.