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Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer
Kim, Seo Ree,Shin, Kabsoo,Park, Jae Myung,Lee, Han Hong,Song, Kyo Yong,Lee, Sung Hak,Kim, Bohyun,Kim, Sang-Yeob,Seo, Junyoung,Kim, Jeong-Oh,Roh, Sang-Young,Kim, In-Ho The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.4
Purpose: Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC). Materials and Methods: We evaluated CLDN18.2, RhoGAP, and E-cadherin expression using two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line platinum-based chemotherapy between March 2015 and February 2017. Results: CLDN18.2 and E-cadherin expression was significantly lower in patients with peritoneal metastasis (PM) than those without PM at the time of diagnosis (P=0.010 and 0.013, respectively), whereas it was significantly higher in patients who never developed PM from diagnosis to death than in those who did (P=0.001 and 0.003, respectively). Meanwhile, CLDN18.2 and E-cadherin expression levels were significantly higher in patients with bone metastasis than in those without bone metastasis (P=0.010 and 0.001, respectively). Moreover, we identified a positive correlation between the expression of CLDN18.2 and E-cadherin (P<0.001), RhoGAP and CLDN18.2 (P=0.004), and RhoGAP and E-cadherin (P=0.001). Conversely, CLDN18.2, RhoGAP, and E-cadherin expression was not associated with chemotherapy response and survival. Conclusions: CLDN18.2 expression was reduced in patients with PM but significantly intact in those with bone metastasis. Furthermore, CLDN18.2 expression was positively correlated with other adherens junction molecules, which is clinically associated with mDGC and PM pathogenesis.
Kim Il-Hwan,Kang Byung-Hak,Seo Seung Hee,Park Ye Eun,Kim Gab Jung,Lee Sang Won,Jang Jun Hyeong,Jo Su Kyoung,Jeon Jun Ho,Kim Jeong-Min,Chung Yoon-Seok,Han Myung-Guk,Jung Sang-Oun,Kim Junyoung,Hwang Kyu 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.6
We report the response process of the Laboratory Analysis Task Force (LATF) for Unknown Disease Outbreaks (UDOs) at the Korea Disease Control and Prevention Agency (KDCA) during January 2020 to coronavirus disease 2019 (COVID-19), which developed as a UDO in Korea. The advanced preparedness offered by the laboratory diagnostic algorithm for UDOs related to respiratory syndromes was critical for the rapid identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enabled us to establish and expand the diagnostic capacity for COVID-19 on a national scale in a timely manner.
자유유동 내에서의 원주형 진자의 유체-구조 연성에 대한 연구
김준영(Junyoung Kim),김현성(Hyeonseong Kim),김대겸(Daegyoum Kim) 한국가시화정보학회 2015 한국가시화정보학회 학술발표대회 논문집 Vol.2015 No.12
We investigated experimentally self-excited vibration of an array of cylindrical pendulums in a uniform flow in order to find its potential application to energy harvesting. A cylindrical pendulum is fixed to a rigid upper plate via a thin elastic sheet so that it can swing perpendicularly to the free stream. Although this type of model has been studied for electrical energy generation, few studies have been conducted in order to understand the detailed physics of fluid-structure interaction. In this study, the flow pattern and dynamics of pendulums were examined by varying distance among the pendulums and free-stream fluid velocity. The interaction of an upstream bluff body and pendulums was also considered to investigate how the wake of the bluff body affects the oscillations of cylinders. With this experimental setup, the pendulums show various patterns such as stationary mode and out-of-phase oscillation mode.
김준영(Junyoung Kim),김현성(Hyeonseong Kim),김대겸(Daegyoum Kim) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
We investigated experimentally self-excited vibration of an array of cylindrical pendulums in a uniform flow in order to find its potential application to energy harvesting. A cylindrical pendulum is fixed to a rigid upper plate via a thin elastic sheet so that it can swing perpendicularly to the free stream. Although this type of model has been studied for electrical energy generation, few studies have been conducted in order to understand the detailed physics of fluidstructure interaction. In this study, the flow pattern and dynamics of pendulums were examined by varying distance among the pendulums and free-stream fluid velocity. The interaction of an upstream bluff body and pendulums was also considered to investigate how the wake of the bluff body affects the oscillations of cylinders. With this experimental setup, the pendulums show various patterns such as stationary mode and out-of-phase oscillation mode.
Distal End Force Estimation of Tendon-sheath Mechanism Using a Spring Sheath
Jeonghan Kim,Kyungnam Kim,Yechan Seo,Junyoung Park,Byung Gon Kim,Sooyong Choi,Chanwoo Kim,Daehie Hong 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.12
Tendon-sheath mechanism (TSM) is often used as a power transmission system in many applications, such as rehabilitation, wearables, and endoscopic surgery robots. It comprises a tendon for transmitting the power and a sheath to guide the tendon. The tendon passes through a narrow and harsh pathway to actuate an end-effector. Consequently, TSM exhibits highly nonlinear force transmission characteristics, resulting in poor control performance. Additionally, attaching and using a force feedback sensor at its distal end is virtually impossible in most applications owing to space constraints and safety concerns. To address these drawbacks, this study proposes a novel sensing spring wire to estimate the distal end force in TSM. Unlike existing methods, the proposed technique does not require complex hyperparameters or modeling and uses only a mechanical part to predict the force. The sensing wire is composed of the sheath. The biocompatibility, simple structure, and small size of the spring sheath facilitate convenient interaction with the existing TSM. Additionally, the spring sheath exhibits the characteristics of a spring, which ensures a linear relationship between the displacement and force. The results indicate that after calibrating the spring sensor, the distal end force can be easily determined using the proximal force despite the absence of an electrical sensor. In situations where the friction is different for each shape, when the force at the distal end was estimated using only the force at the proximal end measured by the sensor, the average RMSE was 75.91mN and the maximum error was 176.52mN. The proposed method verifies that the proximal tension and displacement data are sufficient to estimate the force.