암 환자의 우울과 통증 : 일 예비적 연구

양문정,전양환,한상익,한치화,엄현석 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 암 환자에서 우울과 통증의 정도, 우울과 통증에 영향을 줄 수 있는 요인들을 조사하고, 우울과 통증사이에 어떤 연관이 있는지 알아보고자 하였다. 방 법 : 종양내과에 입원한 암 환자 25명(남자 : 10명, 여자 :15명)을 대상으로 하여 내과 병록지 거모, 환자 및 가족과의 면담을 시행하였다. 정신과적 진단은 DSM-IV진단 기준에 의하였으며, 우울의 정도는 Hamilton Rating Scale for Depression(HRSD)로 평가하였고 통증의 유무를 평가한 뒤, 통증이 있는 경우 Brief Pain Inventory(BPI)를 시행하여 통증의 강도(최대, 최소,평균,현재), 통증에 의한 기능 방해 정도, 진통제에 의한 호전정도를 점수로 평가하였다. 결 과 : 전체 환자중 주요 우울증이 32%(8명), 경도 우울증이 16%(4명), 적응장애가 16%(4명)이었다. HRSD점수는 통증의 최대강도, 평균강도, 현재강도, 통증에 의한 기능방해정도와 유의한 상관관계가 있었으나, 통증의 최소강도, 진통제에 의한 호전 정도와는 유의한 상관관계가 없었으며, 이환 기간과 HRSD점수 및 통증 점수 사이에도 유의한 상관관계가 없었다. 성별, 종교, 암의전이여부,병황의 인식 여부에 따라 HRSD점수와 통증 점수에 차이가 없었으나, 현재 미혼 또는 사별 상태에 있는 환자들에서 결혼하여 배우자가 있는 환자들보다 HRSD점수와 통증의 최소강도, 평균강도가 유의하게 높았다. 결 론 : 암환자에게서는 우울증과 통증이 있는 경우가 많았다. 우울증과 통증간에 밀접한 상관관계가 있음을 알수 있었다. 본 연구의 결과는 암 환자에서 우울증과 통증에 대한 보다 적극적인 평가와 개입이 이루어져야 함을 시사하는 것이다. Objective : This study was designed to evaluate how much depression and pain symptoms could be shown, what kink of factors affect them, and whether the correlation between them could be or not in patients with cancer. Methods : The subjects were composed of 25 patients with cancer who admitted a the department of oncology(male:10, female :15). We reviewed the medical record and interviewed patients and their family. A psychiatric diagnosis was made according to the criteria of the DSM-IV, and depressive symptoms were evaluated by Hamilton Rating Scale for Depression(HRSD). The intensity of pain(maximal, minimal, mean, present), disability due to pain, te effects of analgesics were measured by Brief Pain Inventory(BPI). Results : 32% of patients had major depressive disorders, 16% of patients had depressive disorders, NOS and 16% of the patients had adjustment disorders. The score of HRSD was significantly correlated wit the maximal intensity, mean intensity and present intensity of pain and disability due to pain, but not with minimal intensity and the effects of analgesics. Depression and pain were not correlated with duration of illness. Scores of depression and pain did not differ in sex, religion, metastasis, and the knowledge of illness. The widowed or unmarried patients showed significantly higher scores than patients living with the spouse in HRSD, minimal intensity and mean intensity of pain. Conclusion : In patients with cancer, depression and pain were highly prevalant. The relationship between depression and pain was shown in patients with cancer. These results suggest that more active evaluation and intervention of depression and pain should be carried out in patients with cancer.

한우 성별에 따른 등심의 육질특성 비교

최정석, 정동순, 최석현, 이상화, 김종희, 최양일 忠北大學校 農業科學硏究所 2011 農業科學硏究 Vol.27 No.4

-본문참고-

중이기형을 동반한 안이척수이형성 증후군에서 시행한 난원창 개창술 1예

조양선,정유석,이종찬,추광철 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.12

기계적 합금화에 의해 제조된 고규소 Al-Si 합금 나노 결정의 특성

이정일,김일호,홍태환,어순철,양계준,석현광,한만갑,최국선,김준수 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

High silicon Al-Si alloys with nanocrystalline structures have been produced by mechanical alloying process. Microstructural changes of the Al-Si alloys were investigated by scanning electron microscopy and the transmission electron microscopy. X-ray diffraction analysis was also made to characterize the lattice constant, crystallite size and misfit strain. It was found that the effective milling time by attrition milling was about 12hours for Al-70 wt%Si alloy system. The Al and Si crystallites were reduced to about 30 nm and 70 nm, respectively, by the mechanical alloying for more than 12hours. The misfit strains increased with milling time UD to 240 hours, and saturated to 5.73×10^(-3) for Al and Si crystallites, respectively.

經皮經肝膽湃液術의 放射線學的 考察

全石吉,朱亮求,金洪,禹聖龜,徐修之,金玉培,許定旭 啓明大學校 醫科大學 1987 계명의대학술지 Vol.6 No.1

Percutaneous transhepatic biliary drainage(PTBD) was performed 40 times in 38 patients with obstructive jaundice, from January, 1986 to May at Department of Radiology, Keimyung University School of Medicine. The PTBD is to decrease serum bilirubin level, promote liver function, effectively decompress the severely obstructed biliary tree prior to surgery and palliates the clinical problems in patient with non-operable malignant obstruction and control sepsis effectively. The results were as follow: The cause of obstructive jaundice included 35 malignant diseases and 3 benign diseases. Malignant disease were 23 cases of bile duct carcinoma, 5 cases of hepatoma, 5 cases of pancreas carcinoma and 2 cases of metastasis. The most common level of obstruction was distal common bile duct in 13 cases. The most common indication of PTBD was palliative drainage of obstruction secondary to malignant tumor in 26 cases. The drainage type was internal i 12 cases and external in 24 cases. The most common complication was high fever in 7 cases. The successful drainage with effective decrease in the level of serum bilirubin was observed in 30 cases, ineffective drainage in 4 cases.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

개선된 하프변환을 이용한 훼손된 타원 검출

강창원,양환석,이정재,김남중,이웅기 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

This paper considers the problem of detecting elliptical curves using Advanced Hough transform. Storage and efficiency problems are over come by decomposing the problem into two stages. The first stage uses a novel constraint as the basis for a Randomined Hough transform to detect the ellipse centre while the second stage finds the remaning parameters using simple but efficient focusing implementation of the Advaned Hough transform. The method is applicable in many situations where previous Hough transform schemes would fail. Results are demonstrated for comolicated image data containing several occluding ellipses.

송아지고기 소시지와 시중에 판매되는 우육과 돈육 소시지 제품의 저장특성 비교

이주호, 최정석, 이현진, 정구용, 최양일 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1

This study was undertaken to compare the storage characteristics between veal sausage and commercial pork and beef sausages in Korean domestic market. We manufactured 3_types of sausages and purchased 2_types of sausages in the market: T1(B-company product), T2(O-company product) and we made T3(smoked veal sausage), T4(smoked veal sausage with pepper) and T5(cooked veal sausage) products. During 20 days of storage at 4oC, T5 showed significantly higher in TBA value and VBN value (p<0.05). But TBA and VBN values showed normal range in all products. T3, T4, and T5 showed higher total microbial count than T1 and T2 (p<0.05). According to the result, beef and pork sausages in the market showed different total microbial count and VBN values from those made in laboratory. This result could be come from the different additives used and manufacturing processes. However, all products can be stored up to 20 days in the cooler.

육우 비선호 부위를 활용한 육우햄의 품질특성

이주호, 최정석, 정준영, 최양일 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.3

This study was undertaken to compare the quality characteristics of dairy beef ham. Dairy beef hams were manufactured using non-preferred portion (top round). 5 treatments were prepared: T1(beef 50% + pork emulsion 50%), T2(beef 65%emulsion 35%), T3(beef 80%emulsion 20%), T4(beef 90%emulsion 10%), T5(beef 100%emulsion 0%). In chemical composition, dairy beef content increases, moisture content was increased, fat content was decreased. In the meat quality characteristics, T5 showed higher (p<0.05) water holding capacity value than the others. Dairy beef content increases, product loss and cooking loss were decreased. In hunter color, dairy beef content increases, redness was increased. In texture profile analysis, T4 and T5 were significantly higher than the others. As a result, dairy beef ham with 80~90% dairy beef and 10~20% pork emulsion has low fat content, high product yield and superior texture profile, which could be developed as a dairy beef hams using non-preferred portion.

사람 위선암에서 cathepsin L의 발현증가

홍원선,홍석일,박인철,손영숙,정훈용,양석균,김해련,민영일 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

cathepsin L은 lysosomal cysteine 단백분해효소로서 기저막(basement membrane)과 세포외기질(extracellular matrix)을 파괴하여 암세포의 침윤과 전이에 중요한 역할을 하는 물질로 알려져 있다. 이러한 cathepsin L에 대한 mRNA 발현도를 5개의 사람 위선암(gastric adenocarcinoma) 세포주와 5명의 위선암 환자에서 채취한 조직에서 방사능으로 표지된 cathepsin L특이 cDNA를 사용한 Northern blot법으로 측정하였다. 위암의 전이병소에서 수립한 세포주인 SNU-5, SNU-16, MKN-45와 Kato Ⅲ에서는 cathepsin L mRNA가 발현되었으나 원발병소에서 수립한 AGS 세포주에서는 mRNA의 발현이 관찰되지 않았다. 5명의 위암 환자에서는 원발병소, 전이가 확인된 임파절 및 암 근처 정상 위점막에서 각각 조직을 채취하여 cathepsin L mRNA의 발현을 측정하였다. 원발병소와 전이병소에서는 모두 cathepsin L mRNA가 발현되었으나 정상 위점막조직에서는 전예에서 mRNA 발현이 관찰되지 않았다. 한편 mRNA의 발현도는 1예에서는 전이병소가 원발병소에 비해 높았으나, 2예에서는 전이병소에서 발현도가 낮았으며, 나머지 2예에서는 원발병소와 전이병소 사이에 차이가 없어, 원발병소와 전이병소 사이에 mRNA의 발현도의 일관성 있는 경향은 관찰되지 않았다. 이상의 결과는 cathepsin L은 위암의 발생과 진행에 있어 암세포의 침윤과 전이를 촉진하는 것 이외에 또 다른 역할을 할 가능성을 시사하고 있다고 사료된다. Cathepsin L, a lysosomal cysteine protease, is known to play an important role in cancer invasion and metastasis by degrading the components of basement membrane and extracellular matrix. The mRNA expression of cathepsin L was determined by Northern blot analysis using a radiolabeled cDNA specific for cathepsin L in five human gastric adenocarcinoma cell lines and five surgical specimens of primary gastric adenocarcinomas, their metastatic lymph nodes and matched adjacent normal mucosae. The mRNA of cathepsin L was expressed in all of the four cell lines established from the metastatic sites, SNU-5, SNU-16, MKN-45 and Kato Ⅲ, while not detected in one cell line established from the primary site, AGS. The mRNA was expressed in all of the five primary and five metastatic cancer specimens tested, while it was not detected in all matched normal mucosae. The intensities of the mRNA expressions, however, did not show the consistent pattern between primary sites and metastatic lymph nodes. These results suggest that cathepsin L may have the other function in addition to facilitation of the invasion and metastasis during the development and progression of stomach cancer.