韓國人 乳癌組織의 Estrogen 受容體의 檢索

金政徹,李洙定,鄭泰浩,朴朗韻,黃一愚 慶北大學校 醫科大學 1992 慶北醫大誌 Vol.33 No.3

한국여성의 유방암에서 estrogen수용체 및 progesterone수용체의 분포를 알아보기 위하여 39례의 유방암조직에서 이를 측정하였다. Estrogen수용체는 33.3%에서 양성으로 5.42에서 230.02f㏖/㎎ protein까지의 값을 나타내었고 progesterone수용체는 5.34내지 66.60f㏖/㎎ protein의 함량을 가진 56.4%에서 양성이었다. 폐경기 이전은 폐경기 이후에 비해 estrogen수용체와 progesterone수용체가 모두 양성인 경우가 더 많았고 모두 음성인 경우는 더 적었으며 환자의 연령이 50세 이하인 경우의 progesterone수용체 양성율은 50세 이상의 경우보다 두배 이상 높았다. 또한 액와임파절전이가 전혀없는 경우가 1개이상 전이된 경우보다 훨씬 높은 estrogen수용체 양성율을 보였으며 TNM병기 Ⅱ는 병기Ⅱ나 Ⅳ보다 estrogen수용체 및 progesterone수용체 양성율이 더 높은 것으로 나타났다. 한편 조직학적 유형과 호르몬 수용체와의 관계는 대부분이 infiltrating ductal carcinoma인 까닭에 의미 있는 결과를 얻지 못하였다. 이상의 결과에서 나타난 estrogen수용체 및 progesterone수용체와 유방암의 여러 임상적 병리조직학적 측면들과의 상관관계로 미루어 볼 때 임상검사실에서의 통상적인 호르몬수용체 측정법 확립은 유방암의 치료 및 예후판단에 매우 유용하리라 기대된다. The levels of estrogen receptors (ER) ad Progesterone receptors (PR) in 39 breast cancer tissues have been determined and a correlation of both receptor levels with the histopathologic findings and clinical features was attempted. The ER levels ranged from 0 to 230.02 fmol/㎎ cytosol protein and the PR levels ranged from 0 to 66.60 fmol/㎎ cytosol protein. 33% of the specimens were ER+ and 56% were PR+. The group younger than 50 years had a higher percentage of positive PR status. The positive rate of ER showed no significant difference between pre and postmenopause, while those of PR was decreased from 67% in pre-to 41% in postmenopause. 82% of the histologic type were infiltrating ductal carcinoma and 74% of patients were stage Ⅱ of TNM classification. These results indicated that there was strong correlation between age, menopausal status, axillary lymph node metastasis, TNM stage and receptor status.

Caspase 9 promoter polymorphisms and risk of primary lung cancer

Park, Jae Yong,Park, Jung Min,Jang, Jin Sung,Choi, Jin Eun,Kim, Kyung Mee,Cha, Sung Ick,Kim, Chang Ho,Kang, Young Mo,Lee, Won Kee,Kam, Sin,Park, Rang Woon,Kim, In San,Lee, Jae-Tae,Jung, Tae Hoon IRL Press 2006 Human molecular genetics Vol.15 No.12

<P>Caspase-9 (CASP-9) is an initiator CASP in the apoptosome-driven apoptosis pathway and plays an important role in the development and progression of cancer. Polymorphisms in the promoter region of the <I>CASP-9</I> gene may influence the promoter activity of this gene, thereby modulating susceptibility to lung cancer. To test this hypothesis, we examined the association of four polymorphisms [−1263A>G, −905T>G, −712C>T and −293_−275delCGTGAGGTCAGTGCGGGGA (−293del)] in the <I>CASP-9</I> promoter with the risk of lung cancer in a Korean population. The <I>CASP-9</I> genotypes were determined in 432 lung cancer patients and 432 healthy controls that were frequency-matched for age and gender. The −1263 GG genotype was associated with a significantly decreased risk of lung cancer compared with the −1263 AA genotype or combined −1263 AA+AG genotype [adjusted odds ratio (OR)=0.64, 95% confidence interval (95% CI)=0.42–0.98, <I>P</I>=0.04 and adjusted OR=0.67, 95% CI=0.46–0.97, <I>P</I>=0.01, respectively]. For the −712C>T polymorphism, individuals with at least one −712T allele were at a significantly increased risk of lung cancer compared with those harboring the −712 CC genotype (adjusted OR=1.42, 95% CI=1.06–1.89, <I>P</I>=0.02). Consistent with the results of genotype analyses, the −1263G/−712C (G-C) haplotype was associated with a significantly decreased risk of lung cancer [adjusted OR=0.59, 95% CI=0.47–0.75, <I>P</I> and Bonferroni corrected <I>P</I> (<I>P</I><SUB>c</SUB>)<0.001]. Moreover, the risk of lung cancer decreased in a dose-dependent manner as the number of the G-C haplotypes increased (adjusted OR=0.60, 95% CI=0.45–0.81, <I>P</I>=0.0007 and <I>P</I><SUB>c</SUB>=0.0014 for the G-C heterozygotes and adjusted OR=0.34, 95% CI=0.17–0.68, <I>P</I>=0.0023 and <I>P</I><SUB>c</SUB>=0.0046 for the G-C homozygotes; <I>P</I><SUB>trend</SUB><0.001). The promoter assay revealed the G-C haplotype to have a significantly higher promoter activity than the −1263G/−712T and −1263A/−712C haplotypes. These results suggest that <I>CASP-9</I> promoter polymorphisms affect <I>CASP-9</I> expression and contribute to genetic susceptibility to lung cancer.</P>

A Case of Hypothyroidism and Type 2 Diabetes Associated with Type V Hyperlipoproteinemia and Eruptive Xanthomas

Park Jeong Rang,Jung Tae Sik,Jung Jung Hwa,Lee Gyeong Won,Kim Me Ae,Park Ki Jong,김덕룡,장세호,Chung Soon Il,Hahm Jong Ryeal 대한의학회 2005 Journal of Korean medical science Vol.20 No.3

Primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. To date, there have been only a few case reports of type 2 diabetes patients with both type V hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. We report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type V hyperlipoproteinemia and eruptive xanthomas. We found rouleaux formation of RBCs in peripheral blood smear, elevated TSH, and low free T4 level, and dyslipidemia (total cholesterol 18.1 mM/L, triglyceride 61.64 mM/L, HDL 3.0 mM/L, and LDL 2.54 mM/L). She has taken fenofibrate, levothyroxine, and oral hypoglycemic agent for 4 months. After treatment, both TSH level and lipid concentration returned to normal range, and her yellowish skin nodules have also disappeared.

A Survived case of Cardiac Rupture after Myocardial Infarction

( Jung Rang Park ),( Soo Nung Choi ),( Tae Jung Kwen ),( So Ra Park ),( Jung Rang Kwang ),( Sung Ji Park ),( Chung Han Kwak ),( Jin Yong Hwang ) 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

Screening of Foliar Herbicides Application for Control and Management of Henbit Deadnettle (Lamium amplexicaule L.) in Korea

Eun-Jung Park,Arjun Adhikari,Lee-Rang Kim,Eun-Hae Kwon,Ki-Yong Kim,In-Jung Lee 한국잡초학회 2021 Weed & Turfgrass Science Vol.10 No.2

Herbicides application to control invasive weeds is crucial for its proper management. However, the physiological response for susceptibility or tolerance of any weed species may differ vastly according to the type of herbicides application. Hence, appropriate type of herbicide selection with optimum doses would play a prominent role to control the weed incidence and distribution on any ecological state. Since, L. amplexicaule is rapidly invading the Korean productive land, it has generated a possible threat for eco-system as well as agricultural production. Considering these facts, we have screened different herbicides and estimated the appropriate doses to control L. amplexicaule. Our results showed that, Glufosinate P rapidly disintegrated the chlorophyll content as compared to other herbicides and significantly dropped the morphological attributes such as root length, shoot length and fresh biomass of L. amplexicaule plants. Moreover, two-fold application of glufosinate P could minimize 94% growth rate of L. amplexicaule. Hence, the current results recommend two-fold application of glufosinate P for optimum control of L. amplexicaule.

A TGF-β-Inducible Cell Adhesion Molecule, βig-h3, Is Downregulated in Melorheostosis and Involved in Osteogenesis

Kim, Jung-Eun,Kim, Eui-Hyun,Han, Eun-Hee,Park, Rang-Woon,Park, Il-Hyung,Jun, Soo-Han,Kim, Jung-Chul,Young, Marian F.,Kim, In-San 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

Melorheostosis is a rare bone disease characterized by linear hyperostosis and asscociated soft tissue adnormalities.The skin overlying the involved bone lesion is often tense, shiny, erythematous,and scleodermatous. In order to look for genes differentially expressed between the normal and involved skin, we cultured skin fibroblasts from the skin lesions of several afflicted patients and identified differentially expressed genes by reverse dot-blot hybridization. We found that the genes human TGF-β-induced gene product(βig-h3),osteoblast-specific factor2, osteonectin, fibronectin, and typeⅠcollagen were all downregulated in the affected skin fibroblast, with βig-h3 the most significantly affected.The expression of βig-h3 was induced by TGF-βin both affected and normal fibroblast.In an effort to determine the mechansim of bone and skin adnormalitied in melorheostosis, we made recombinant βig-h3. Both immobilized and soluble recombinant βig-h3 proteins with or without an RGD motif inhibited bone nodule formation of osteoblasts in vitro. Taken together,our results suggest that altered expression of several adhesion proteins may contribute to the development of hyperostosis and concomitant soft tissue adnormalities of melorheostosis, with βig-h3 in particular playing an important role in osteogenesis.J.cell.biochem.77:169-178,2000.

보문 : 여성의 신체부위 및 신장에 관한 성별 선호도 비교

박정랑 ( Jung Rang Park ),박숙현 ( Sook Hyun Park ) 한국의류학회 2010 한국의류학회지 Vol.34 No.3

Slide Session : OS-ALG-07 ; Allergy : in Murine Model of Asthma A Six-Year Study on the Changes in Pollen Counts and Sensitization Rates in South Korea

( Hye Jung Park ),( Kyung Hee Park ),( Jae Hyun Lee ),( Jung Won Park ),( Chein Soo Hong ),( Kyu Rang Kim ),( Mae Ja Han ),( Hosoeng Choe ),( Jae Won Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The amount of airborne pollen is considered to be related to sensitization rates. The sensitization rates to tree pollen significantly increased and those to grass and weed pollen decreased over the last 30 years in South Korea. We evaluated short term changes of sensitization rates and the correlation with pollen counts. Methods: We assessed the number of pollen grains collected in Seoul. Tree pollen of the 15 species, weed pollen of the 8 species and grass were studied from January 1, 2007 to December 31, 2013. We retrospectively reviewed the results of 4,442 skinprick tests (SPTs) to 33 common inhalant allergens conducted in the Severance Hospital allergy clinics in Seoul from January 1, 2008 to December 31, 2013. Results: The pollen counts of tree, especially pine and corylus, and grass significantly decreased, as years go by. SPT results showed that the skin reactivity to grass significantly increased from 6.9% in 2008 to 14.0% in 2013. The sensitization rates to tree and weed pollen had no changes. In the details, the sensitization rates to Walnut, Popular, Bermuda, Timothy and Dandelion significantly increased. There was significant correlation between rate of change in pollen counts and sensitization rates to oak and hop J (Humulus japonicus). However, the others showed no correlation. Conclusions: Decrease tendency of pollen counts was observed in Seoul, over the seven years. Some species showed significant correlation between pollen counts and sensitization rates over the six years.

Poster Session : PS 1517 ; Rheumatology : Mucosal-Associated Invariant T Cells Are Numerically and Functionally Defl cient in SLE and Their Defl ciency Refl ect Disease Activity

( Ki Jeong Park ),( Young Nan Cho ),( Hye Mi Jin ),( Kyung Eun Lee ),( Jeong Won Lee ),( Jeong Hwa Kang ),( Hyun Ju Jung ),( Yi Rang Yim ),( Jung Ho Choi ),( Dong Jin Park ),( Sung Ji Lee ),( Tae Jong 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of MAIT cells remains enigmatic in autoimmune diseases. Here, we examined the level and function of MAIT cells in patients with rheumatic diseases. Methods: Patients with systemic lupus erythematosus (SLE; n = 54), rheumatoid arthritis (RA; n = 66), Behcet`s disease (n = 9), ankylosing spondylitis (n = 21), and healthy controls (n = 136) were enrolled in the study. MAIT cell, cytokine and programmed death-1 (PD-1) levels were measured by fiow cytometry. Results: Circulating MAIT cell levels were significantly reduced in SLE and RA patients. In particular, this MAIT cell deficiency was more prominent in CD8+ and double-negative T cell subsets, and significantly correlated with disease activity, such as SLE disease activity index (SLEDAI) and 28-joint disease activity score (DAS28). Interestingly, MAIT cell frequency was significantly correlated with natural killer T (NKT) cell frequency in SLE patients. IFN-γ production in MAIT cells was impaired in SLE patients, which was due to an intrinsic defect in the Ca2+/calcineurin/NFAT1 signaling pathway. In SLE patients, MAIT cells were poorly activated by a-galactosylceramide- stimulated NKT cells, thereby showing the dysfunction between MAIT cells and NKT cells. Notably, an elevated expression of PD-1 in MAIT cells and NKT cells was associated with SLE. In RA patients, MAIT cell levels were significantly higher in synovial fiuid than in peripheral blood. Conclusions: Our study primarily demonstrates that MAIT cells are numerically and functionally deficient in SLE. In addition, we report a novel finding that this MAIT cell deficiency is associated with NKT cell deficiency and elevated PD-1 expression. These abnormalities possibly contribute to dysregulated mucosal immunity in SLE.

안정형 협심증과 급성 관상동맥 증후군 환자에서 경동맥의 재형성

박정랑 ( Jeong Rang Park ),권태정 ( Tae Jung Kwon ),강영란 ( Young Ran Kang ),박소라 ( So Ra Park ),고진신 ( Jin Sin Kho ),임성일 ( Sung Il Im ),박성지 ( Sung Ji Park ),곽충환 ( Chung Hwan Kwak ),황진용 ( Jin Yong Hwang ) 대한내과학회 2006 대한내과학회지 Vol.71 No.3

목적: 불안정하고 염증이 활발한 동맥경화반에서는 보상적인 혈관의 양성 재형성이 일어난다. 급성 관상동맥 증후군 환자에서 일어나는 관상동맥의 양성 혈관재형성이 전신적 염증반응에 의해 경동맥의 혈관 재형성에도 영향을 미칠 것이라는 것을 유추해 볼 수 있다. 이에 저자는 급성 관상동맥 증후군과 만성 안정형 협심증환자에서 경동맥과 상지동맥구조의 차이를 관찰하여 급성 관상동맥 증후군에서 발생하는 관상동맥의 염증으로 인한 혈관재형성이 총경동맥에서도 발생하는가를 알아 보고자 본 연구를 시행하였다. 방법: 급성 관상동맥 증후군 74명과 안정형 협심증 31명을 대상으로 B-mode 초음파 검사를 사용하여 양측 총경동맥의 IMT, LD, IAD를 측정하였다. 양성재형성 은 IMT>1 mm이면서 IAD>8 mm인 경우, 음성재형성은 IMT>1 mm이고 IAD<7 mm일 때, 그 외의 경우를 무재형성이라 정의하여 비교하였다. 결과: 급성 관상동맥 증후군과 안정형 협심증 양 군에서 IMTmax, LD, IAD는 차이가 없었고, 우총경동맥과 좌총경동맥 각각의 양성재형성, 음성재형성, 무재형성 또한 차이가 없었다. 양 총경동맥의 동맥경화반의 존재유무, 동맥경화반의 특징의 비교에도 두 군의 차이는 없었다. 총경동맥의 재형성지표인 IAD/LD는 IMTmax와 의미있는 상관관계를 보였다(우총경동맥의 IMTmax과 IAD/LD의 상관계수 r=0.797 p<0.001, 좌총경동맥의 IMTmax와 IAD/LD의 상관계수 r=0.860, p<0.001).결론: 급성 관상동맥 증후군 환자와 안정형 협심증 환자를 비교했을 때 총경동맥의 특징에 차이가 없었다. 따라서 혈관의 재형성 과정은 급성 관상동맥 증후군과 같은 전신적인 염증에 의해 진행되는 전신적인 변화보다 주로 국소적인 혈역학적 인자가 더 중요하게 관여하는 것으로 생각되어지며 더 많은 환자에서의 연구가 진행되어야 할 것으로 생각된다. Background: Acute adaptive vascular remodeling occurs in active and unstable inflammatory plaques. It has been suggested that the adaptive coronary vascular remodeling, in patients with acute coronary syndrome (ACS), may be systemic and may show similar vascular remodeling in the carotid arteries. We investigated the ultrasonographic features of the common carotid artery (CCA) to determine whether the arterial expansive remodeling found in the coronary artery occurs in the carotid arteries of patients with ACS. Methods: We measured lumen diameter (LD), interadventitial diameter (IAD) and intima media thickness (IMT) using a B-mode ultrasound in both common carotid arteries in patients with ACS (N=74) and chronic stable angina (CSA) (N=31). Positive remodeling was arbitrarily defined as an IMTmax>1 mm and IAD>8 mm and negative remodeling as an IMTmax>1 mm and IAD<7 mm. Other values were defined as no remodeling. Results: There were no significant differences in LD IAD and maximal IMT of the right CCA and the left CCA in comparisons between the ACS and the CSA patient groups. There were no differences for number of cases with no remodeling or differences in positive and negative remodeling in the right common carotid artery and left common carotid artery in comparisons between the ACS and CSA patient groups. . Presence of plaque in both common carotid arteries showed similar frequency in the ACS and CSA patient groups. The characteristics of carotid artery plaques were not different in the two groups. The remodeling index (IAD/LD) was correlated with IMTmax (right CCA r=0.797, p<0.001; left CCA r=0.860, p<0.001). Conclusions: The common carotid arterial structure of ACS patients was not different from that of CSA patients. Therefore, these results suggest that the expansive arterial remodeling, due to coronary inflammatory plaques, appears to take place locally rather than systemically.(Korean J Med 71:266-275, 2006)