방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

순비기나무 (Vitex rotundifolia L. f.) 삽수 종류 및 생장조정제 처리에 따른 발근율

Jeong Yeob Kim,Yoon Ki Hong,Song Hee Ahn,Jung Seob Moon,Eun Seok Park,Hee June Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : This study was conducted to developed the propagation method by cutting for mass cultivation of Vitex roundifolia. We were pitched the cutting two times and treated plant growth regulators to enhance the rooting percentage. Vitex roundifolia is live in beach sandy soil south of Hwanghae-Do and Gangwon-Do. Vitex roundifolia have been used to bath foam. It is good for aromatic plant. It has 0.8% essential oil content in leaf and flower. Major components of essential oil were alpha-Pinene, Sabinene, beta-Pinen, 1,8-cineole, d-Limone. Despite the superior usability, it had not yet been made by the artificial cultivation Methods and Results : We were pitched the cutting of a first-year branch on June 5, which was greenwood cutting and July 17, which was semi-hardwood cutting at Kwangseung-ri beach, Gochanggun, Jeonbuk. The length of cutting was 10cm. It had 3~4 nodes, we stuck a cutting remain 2 nodes above ground on ordinary raise seedling soil. Rooting percentage was measured at 60 days after stuck a cutting. Rooting percentage was higher greenwoody cutting(95%) than semi-hardwood cutting(57.6%). In green wood cutting, there was no significance with plant growth, but chemical injury was occurred in IBA 5,000ppm. In semi-hardwood cutting, there was significance with plant growth regulators. The rooting percentages of all the treat were higher than control(no treatment). Rooting percentage was the highest in NAA 5,000ppm treated. Conclusion : Greenwood cutting method was more proper to propagation for Vitex roundifolia than semi-hardwood cutting. The optimum time to cutting for Vitex roundifolia propagation was the early in June. If miss a time to propagation Rooting percent was elevated by plant growth regulator.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

傷寒論 第28條에 대한 文獻的 考察

金俊錡 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.1

傷寒論 第 28條는 病機의 分析과 主治처방의 構成에 대해서 歷代 傷寒論 注釋家와 現代 中醫學者間에 많은 논란이 있는 條文이다. 本 論文은 28條에 대하여 表邪의 有無와 主治處方의 錯簡說 등에 대한 歷代 注釋을 檢討하였다. 論者는 이러한 論難을 咳嗽하기 위한 方法으로 有關 處方에 대한 方後注文과 傷寒論의 條文 配列 順序의 意味에 根據하여 本條가 水飮內停證에 속하며 계지거계가복령백출탕이 本證의 主治處方임을 論證하였다. Many arguments on the interpretation of the 28th articles of Shanghanlun(傷寒論) which deals with the analysis of pathogenesis and the constitution of the chief prescription, have been made between the previous interpretators and moderm chinese medical scholars. In this paper I have examined the previous comments on the 28th article by focusing on the existence of Biaoxie(表邪) and the misunderstanding of the chief prescription Based upon the meanings of the annotated explanation about the related prescription and the article arrangement of Shanghanlun(傷寒論), my analysis shows that the 28th article belongs to the symptoms of Shuiyinneitingzheng(水飮內停證) and therefore Guizhiquguijiafulingbaizhutang(계지거계가복령백출탕) should be chief prescription for the symptoms.

순막반응의 조건화에 관여하는 신경회로에서의 부외전핵의 역할

김현택,이두현,최준식,김기석 한국심리학회 1990 한국심리학회지 생물 및 생리 Vol.2 No.1

토끼의 소뇌 중간핵에서 순막조건화 기간동안 다단위 기록을 하였다. 다단위 활동은 학습의 초기에는 조건자극과 무조건자극에 대한 유발반응만을 보였으나 학습이 진행됨에 따라 증가하였다. 이 다단위 활동을 회기별로 16msec bin 히스토그램을 작성하여 회기별 순막반응 평균치와 교차 상관값을 구하니 상당한 정도의 상관을 보였으며 더우기 다단위 활동의 히스토그램이 평균화된 순막반응을 수십 msec 앞섰다. 이런 결과는 중간핵의 다단위 활동이 학습의 신경적 지표가 되며 중간핵은 순막조건화의 신경적 근저가 될 수 있음을 보여주었다. 몇몇 연구에서는 부외전핵 또는 외전핵에 무조건 자극으로 전기자극을 주어 순막조건화가 가능하였다고 보고하고 있으므로 본 연구는 이 부외전핵이 단순한 반응의 출력핵에 불과한지 또는 습득된 순막조건화의 파지에 필요한지를 밝히고자 하였다. 그래서 조건화정도의 지표로서 행동적 순막반응과 중간핵 다단위 활동의 히스토그램을 관찰하면서 학습이 진행된후 부외전핵을 손상시켰다. 손상후 행동적 순막반응은 크게 감소하거나 사라졌지만 중간핵에서의 다단위 활동은 여전히 형성된 순막조건화가 건재함을 보여 주었다. 이 결과로서 부외전핵은 단순운동출력핵이며 순막조건화의 파지에 관여하는 부위가 아니라고 결론지었다. Multiple unit activity(MUA) was recorded from the cerebellar dentato-interpositus nucleus during classical conditioning of the nictitating membrane response(NMR) in the rabbit with a tone conditioned stimulus(CS) and an airpuff unconditioned stimulus(US). The MUA was processed to 16msec bin histogram and the NMR was averaged in each session respectively. The result showed that The averaged NMR was highly correlated with the histogram and that the histogram of MUA preceded the averaged NMR by several tens millisecond. This supports the previous reports that dentato-interpositus nucleus may be the neural substrate of the NMR conditioning. In some studies, it was reported that the stimulation of accessory abducens nucleus as US can support the NMR conditioning. So, one purpose of this study was the examination of the role of accessory abducens nucleus in the NMR conditioning. Following days of aquisition, the nucleus was lesioned electrolytically. The result showed that the lesion abolished both conditioned and unconditioned responses, but MUA recorded from deutatointerpositus nucleus maintains the same level as it prior to lesion. Results suggest that accessory abducens nucleus is merely motor output nucleus and isn't involved in the retention of the NMR conditioning.

Re-188이 표지된 황 교질(Sulfur Colloid)/리피오돌(Lipiodol)의 제조와 생체내 분포

김영주,정재민,김석기,손미원,이동수,정준기,이명철 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

목적: 리피오돌은 간암환자의 간동맥으로 투여시 암에 많이 섭취된다. 이 연구에서는 Re-188-황 교질/리피오돌을 제조하여 생체내분포를 보았다. 재료 및 방법: Re-188-황 교질/리피오돌을 마우스의 꼬리정맥으로 주사한후 1 시간 후에 생체내 분포를 확인하였다. 간암을 유발시킨 백서의 좌심실로 Re-188-황 교질/리피오돌을 주사하고 5 분후의 생체내 분포와 간의 자가방사사진을 보았다. 결과: Re-188-황 교질/리피오돌을 마우스의 꼬리정맥으로 주사한 후 1시간(n=3)섭취율(% ID/organ)은 간에서 5.2±0.7, 폐는 91.0±1.7이었다. 간암을 유발시킨 백서의 좌심실로 Re-188-황 교질/리피오돌을 주사한 후 5 분(n=4)의 정상간의 섭취율(% ID/g)은 0.41±0.28, 간암은 1.88±1.57, 폐는 1.65±1.54였으며, 자가방사사진에서도 간암부위의 섭취가 정상적인 간조직 보다 증가되었다. 결론: Re-188-황 교질/리피오돌을 동맥으로 투여시 간암부위의 섭취가 정상적인 간조직보다 많아 간암치료용 방사성의약품으로서 사용할 수 있음을 알았다. Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting agent was investigated. Materials and Methods: Re-188-sulfur colloid was prepared, harvested by centrifugation, washed with organic solvent and then suspended into lipiodol. Biodistribution of Re-188-sulfur colloid in normal saline and its suspension in lipiodol in mice after 1 hr of injection through the tail vein were investigated. Biodistribution and autoradiography of tumor-bearing liver was acquired after 5 min post-injection into left ventricle of the tumor-inoculated rats. Results: After 1 hr of injection with Re-188-sulfur colloid suspension in lipiodol through the tail vein in normal mice (n=3), the uptakes in the liver and lung were 5.2±0.7 and 91.0±1.7% ID/organ, respectively. After 5 min of injection with Re-188-sulfur colloid suspention in lipiodol through the left ventricle in the tumor-inoculated rats (n=4), uptakes in the normal liver, hepatoma, and lung were 0.41±0.28, 1.88±1.57, and 1.65±1.54% ID/organ, respectively. And autoradiography of hepatoma showed increased uptake than normal liver tissues. Conclusion: Re-188-sulfur colloid suspension in lipiodol injected through the artery shows higher uptake in the hepatoma than normal liver tissue that indicates the feasibility as a new radiopharmaceutical for therapy of hepatoma.

Cu/ZnO 촉매에 의한 Acrylonitrile의 水化反應

金基泰,尹奇俊,鄭泰秀 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.1

Acrylamide was prepared by catalytic hydration of acrylonitrile. In the process of hydration of acrylonitrile, ethylene cyanohydrine was produced as a by-product. Cu/ZnO was used as the catalyst for the reaction. Cu/ZnO was prepared by reduction of Cu/ZnO with hydrogen flowing at 350℃. The reaction was carried out in the suspension of the pretreated catalyst. A simple batch reactor was used with reaction times of several hours at 70℃, 60℃, and 50℃. The results of this study are as follows: 1. The catalytic hydration of acrylonitrile is a pseudo first-order reaction. 2. The reaction products were acrylamide and ethylene cyanohydrin. The selectivity of ethylene cyanohydrin with the Cu/ZnO used in this experiment was higher than those with such catalysts as Cu, Cu/ZnO, Cu/MgO, and copper chromite which had been used by other workers. 3. The reaction rate equations are as follows: -r_AN = 9.42 x 10 exp(4)·e^[(-13,000)/RT]·C_AN(mole/l·min) r_AM = -8.68 x 10 exp(6)·e^[(-17,500/RT]·C_AN(mole/l·min) r_ECH = 4.29 x l0 exp(3)·e^[(-11,200/RT]·C_AN(mole/l·min)

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

高脂肪性食餌로 因한 高脂血症 白鼠에 首烏延壽丹이 미치는 影響

金庸柱,최달영,김준기,박원환 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

This study was done in order to investigate the effect of Suoyensudan on hyperlipidemia. Results: 1. The level of serum total cholesterol was decreased with the significance in the sample groups as compared with the control groups. 2. The level of serum HDL-cholesterol was increased with significance in sample groups as compared with the control groups. 3. The level of serum phospholipid was increased with significance in Sample 1 group as compared with Control 1 group, but Sample 2 group did not show significance as compared with Control 2 group. 4. The level of serum β-lipoprotein was decreased with the significance in Control 1 group, but control 2 group did not show significance. 5. Rate of total cholesterol vs. HDL-cholesterol and total cholesterol vs phospholipid were increased in the sample groups as compared with the control groups. Conclusion; It is considered that Suoyensudan respectively had recovering effect on the Hyperlipidemia induced by cholesterol in male rats. So it can be use to prvent and treat hyperlipidemia and related deseases.